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[187867_at] SIR

Description F46G10.3 /REP_DB=WormBase Gene ID /WP=CE02239 /TR=Q20481 /GB=CAA90547.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=SIR
Cluster 6grp_total > 25      4grp_total > 20      6grp_cgc > 33      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 156
1 2 3 4 range
A 23
(-3)
A 		59.8
(1.2)
A 		44.2
(-0.6)
A 		75.1
(3)
P 		52
B 79.8
(3)
P 		59.6
(1.4)
A 		5
(-3)
A 		36.4
(-0.5)
P 		75
C 47.9
(-1.4)
P 		11.9
(-2.8)
A 		6.1
(-3)
A 		161.4
(3)
P 		155
avr 50.2
(-0.4) 		43.8
(-0.9) 		18.4
(-3) 		91
(3) 		73

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 118
1 2 3 4 5 6 range
A 123.6
(3)
P 		71
(-0.7)
P 		70.7
(-0.7)
P 		59
(-1.5)
P 		44.9
(-2.5)
A 		38.3
(-3)
A 		85
B 73.8
(0.4)
P 		87.1
(3)
P 		58.4
(-2.7)
P 		69.6
(-0.5)
P 		56.9
(-3)
P 		66.7
(-1.1)
M 		30
C 85.6
(0.2)
P 		140.4
(3)
P 		57.7
(-1.2)
P 		51.9
(-1.5)
P 		22
(-3)
A 		34.1
(-2.4)
A 		118
avr 94.3
(2.5) 		99.5
(3) 		62.3
(-0.8) 		60.2
(-1.1) 		41.3
(-3) 		46.4
(-2.5) 		58
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 26
1 2 3 4 range
A 8.4
(-3)
A 		13
(3)
A 		11.6
(1.2)
A 		11
(0.4)
P 		5
B 25.4
(3)
P 		14.7
(0.3)
A 		1.2
(-3)
A 		7.8
(-1.4)
P 		24
C 15.8
(0.3)
P 		3.4
(-2.7)
A 		2.1
(-3)
A 		27.2
(3)
P 		25
avr 16.5
(3) 		10.4
(-0.2) 		5
(-3) 		15.3
(2.4) 		12

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 36
1 2 3 4 5 6 range
A 22.8
(2.1)
P 		25.3
(3)
P 		15.4
(-0.7)
P 		15
(-0.9)
P 		13.5
(-1.4)
A 		9.3
(-3)
A 		16
B 25.7
(1.7)
P 		29
(3)
P 		14.2
(-3)
P 		18.4
(-1.3)
P 		23.1
(0.6)
P 		24.9
(1.3)
M 		15
C 31.7
(1.1)
P 		42.9
(3)
P 		14.7
(-1.7)
P 		10.4
(-2.4)
P 		7.1
(-3)
A 		11.4
(-2.3)
A 		36
avr 26.7
(1.1) 		32.4
(3) 		14.8
(-2.9) 		14.6
(-3) 		14.6
(-3) 		15.2
(-2.8) 		18
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 187867_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17505
Sequence Type Exemplar sequence
Representative Public ID F46G10.3 NCBI
Target Description F46G10.3 /REP_DB=WormBase Gene ID /WP=CE02239 /TR=Q20481 /GB=CAA90547.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=SIR
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077819(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077819 NCBI Caenorhabditis elegans F46G10.3 (SIR) mRNA, complete cds. 11/11 None
GENEFINDER00000042672 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:13329184:13333609:1 11/11 None
SNAP00000042665 ENSEMBL cdna:SNAP chromosome:CEL140:X:13331936:13333609:1 11/11 None
F46G10.3 ENSEMBL cdna:known chromosome:CEL140:X:13331936:13333609:1 gene:F46G10.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:13331935-13333609(+) 100.0 100.0
Public Domain and Genome References
Gene Title SIR
Gene Symbol sir-2.3
Ensembl F46G10.3
Entrez Gene 185876 Entrez gene
SwissProt Q20481 EMBL-EBI
WormBase CE02239 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6342 chromatin silencing inferred from electronic annotation QuickGO AmiGO
6355 regulation of transcription, DNA-dependent inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5677 chromatin silencing complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA90547 Hypothetical protein F46G10.3 [Caenorhabditis elegans] ref|NP_510220.1| F46G10.3 [Caenorhabditis elegans] 1.0E-168
blast CAA90546 Hypothetical protein F46G10.7a [Caenorhabditis elegans] ref|NP_001024672.1| F46G10.7a [Caenorhabditis elegans] 1.0E-141
blast CAE46663 Hypothetical protein F46G10.7b [Caenorhabditis elegans] ref|NP_001024673.1| F46G10.7b [Caenorhabditis elegans] 1.0E-140
blast CAA90546 Hypothetical protein F46G10.7a [Caenorhabditis elegans] ref|NP_001024672.1| F46G10.7a [Caenorhabditis elegans] 1.0E-131
blast CAE46663 Hypothetical protein F46G10.7b [Caenorhabditis elegans] ref|NP_001024673.1| F46G10.7b [Caenorhabditis elegans] 1.0E-130
Protein Domains
Database ID Description E-Value
Pfam IPR003000 EMBL-EBI Silent information regulator protein Sir2 1.6E-94
Pfam IPR003000 EMBL-EBI Silent information regulator protein Sir2 1.2E-89
Pfam IPR003000 EMBL-EBI Silent information regulator protein Sir2 1.6E-94
Sequence
Target Sequence 
>C. ELEGANS:187867_AT
ggtctcgtagctacttgaattggccaagatttgctcaagctttacctaacttcaatcatt
acgccttatcaaaatgggaagctgctaacaaatttcattggttgatcacacaaaatgtgg
atggacttcacttaaaagcgggctcgaaaatgataacggaacttcatggcaacgctcttc
aagtaaaatgcacatcatgtgaatacatcgagacaagacaaacgtatcaagaccgcctga
attatgcaaatcctggcttcaaagagcagtttgtatctcctggacagcaagagctagatg
ctgacactgccttgccgttgggtagcgaacaagggttcaagattcccgagtgtttaaatt
gtgggggacttatgaagacagatgtaacgttgtttggggagaacctaaacactgacaaaa
ttaaagtttgtggcaagaaggtgaatgaatgcaatggagttttaacacttgggacatcgt
tggaagtgctttccggatatcagattgtcaatcatgcccatatgcaaaacaaaccaattt
tcatcgtgaacattggacctactagagctgatcagatgg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGTCTCGTAGCTACTTGAATTGGCC 420 503 248 Antisense
TTTGCTCAAGCTTTACCTAACTTCA 303 667 277 Antisense
ACTTCAATCATTACGCCTTATCAAA 180 103 296 Antisense
GACCGCCTGAATTATGCAAATCCTG 47 383 478 Antisense
GAGCAGTTTGTATCTCCTGGACAGC 514 389 511 Antisense
AGAGCTAGATGCTGACACTGCCTTG 256 69 537 Antisense
TTGGGACATCGTTGGAAGTGCTTTC 473 695 716 Antisense
GTGCTTTCCGGATATCAGATTGTCA 8 481 733 Antisense
AGATTGTCAATCATGCCCATATGCA 498 65 749 Antisense
TTCATCGTGAACATTGGACCTACTA 310 625 787 Antisense
GGACCTACTAGAGCTGATCAGATGG 517 523 802 Antisense
Sequence Source Affymetrix Proprietary Database