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[187257_s_at] Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region. ; Poly(ADP-ribose) polymerase catalytic region. /// ---

Description Y71F9AL.18 /REP_DB=WormBase Gene ID /WP=CE25556 /TR=Q9N4H4 /GB=AAF36011.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation
Cluster 6grp_highest_10_10 > 88      6grp_high1_10_10 > 97      4grp_highest_8_8 > 26      4grp_high_8_8 > 59      6grp_highest_nonorm > 92      6grp_total > 97      4grp_total > 60      6grp_highest_sub > Da      6grp_cgc > 59      6grp_high1_sub > In      6grp_cgc_sub > Da      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 216
1 2 3 4 range
A 315.9
(2.4)
P 		332.8
(3)
P 		333.5
(3)
P 		151.4
(-3)
P 		182
B 256.3
(0.7)
P 		254.9
(0.6)
P 		298.8
(3)
P 		188.8
(-3)
P 		110
C 279.3
(0.7)
P 		161
(-2.6)
P 		360.8
(3)
P 		145.1
(-3)
P 		216
avr 283.8
(1.3) 		249.6
(0.1) 		331
(3) 		161.8
(-3) 		169

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 322
1 2 3 4 5 6 range
A 221.8
(-2.5)
P 		300.8
(-0.9)
P 		195.6
(-3)
P 		321
(-0.5)
P 		338.4
(-0.2)
P 		498.3
(3)
P 		303
B 219.8
(-1.9)
P 		271
(-0.6)
P 		176.2
(-3)
P 		301.1
(0.2)
P 		321.6
(0.7)
P 		410.2
(3)
P 		234
C 319.5
(-1.7)
P 		293.1
(-2.5)
P 		300.9
(-2.3)
P 		276
(-3)
P 		413.4
(1.1)
P 		476.9
(3)
P 		201
avr 253.7
(-2.3) 		288.3
(-1.4) 		224.2
(-3) 		299.4
(-1.1) 		357.8
(0.4) 		461.8
(3) 		238
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 104
1 2 3 4 range
A 115
(3)
P 		72.3
(0.2)
P 		87.2
(1.2)
P 		22.2
(-3)
P 		93
B 81.7
(3)
P 		63
(0.3)
P 		69.2
(1.2)
P 		40.2
(-3)
P 		42
C 92.4
(1)
P 		46.3
(-1.7)
P 		125.8
(3)
P 		24.5
(-3)
P 		101
avr 96.4
(3) 		60.5
(-0.2) 		94.1
(2.8) 		29
(-3) 		67

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 119
1 2 3 4 5 6 range
A 40.9
(-3)
P 		107
(1.9)
P 		42.6
(-2.9)
P 		81.4
(0)
P 		102.1
(1.6)
P 		121.3
(3)
P 		80
B 76.5
(-1.2)
P 		90.2
(-0.4)
P 		42.8
(-3)
P 		79.8
(-1)
P 		130.7
(1.8)
P 		153
(3)
P 		110
C 118.4
(0.6)
P 		89.4
(-1)
P 		76.6
(-1.8)
P 		55.5
(-3)
P 		133.8
(1.5)
P 		159.7
(3)
P 		104
avr 78.6
(-1.4) 		95.5
(-0.3) 		54
(-3) 		72.2
(-1.8) 		122.2
(1.5) 		144.7
(3) 		91
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 187257_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.194
Sequence Type Exemplar sequence
Representative Public ID Y71F9AL.18 NCBI
Target Description Y71F9AL.18 /REP_DB=WormBase Gene ID /WP=CE25556 /TR=Q9N4H4 /GB=AAF36011.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_058671(11), NM_075638(9)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_058671 NCBI Caenorhabditis elegans Poly(ADP-ribose) Metabolism Enzyme family member (pme-1) (pme-1) mRNA, complete cds. 11/11 None
NM_075638 NCBI Caenorhabditis elegans Poly(ADP-ribose) Metabolism Enzyme family member (pme-6) (pme-6) mRNA, complete cds. 9/11 None
SNAP00000005895 ENSEMBL cdna:SNAP chromosome:CEL140:I:2907858:2924714:-1 11/11 None
SNAP00000003757 ENSEMBL cdna:SNAP chromosome:CEL140:X:242291:245907:-1 9/11 None
GENEFINDER00000003764 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:242291:244812:-1 9/11 None
Y71F9AL.18 ENSEMBL cdna:known chromosome:CEL140:I:2907721:2924716:-1 gene:Y71F9AL.18 11/11 None
AC8.1 ENSEMBL cdna:known chromosome:CEL140:X:242291:252767:-1 gene:AC8.1 9/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000005899 6/11 Cross Hyb Matching Probes None
GENEFINDER00000005913 4/11 Cross Hyb Matching Probes None
SNAP00000003754 8/11 Cross Hyb Matching Probes None
GENEFINDER00000003770 7/11 Cross Hyb Matching Probes None
AC8.9 8/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:2907857-2924695(-) 100.0 100.0
Public Domain and Genome References
Gene Title Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region. ; Poly(ADP-ribose) polymerase catalytic region.

Gene Symbol pme-6
pme-1
Ensembl Y71F9AL.18
AC8.1
Entrez Gene 181803 Entrez gene
266823 Entrez gene
SwissProt Q9XUA5 EMBL-EBI
Q9N4H4 EMBL-EBI
WormBase CE33962 Wormbase
CE25556 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:16353_S_AT poly (ADP-ribose) polymerase, putative / NAD(+) ADP-ribosyltransferase, putative / poly(ADP-ribose) synthetase, putative at
ATH1-121501:264116_AT poly (ADP-ribose) polymerase, putative / NAD(+) ADP-ribosyltransferase, putative / poly(ADP-ribose) synthetase, putative at
ATGENOME1:16353_S_AT poly (ADP-ribose) polymerase, putative / NAD(+) ADP-ribosyltransferase, putative / poly(ADP-ribose) synthetase, putative at
ATH1-121501:264116_AT poly (ADP-ribose) polymerase, putative / NAD(+) ADP-ribosyltransferase, putative / poly(ADP-ribose) synthetase, putative at
CANINE:1594901_AT similar to Poly [ADP-ribose] polymerase-1 (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase-1) (Poly[ADP-ribose] synthetase-1) cfa
CANINE_2:CFA.21541.1.S1_S_AT similar to Poly [ADP-ribose] polymerase-1 (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase-1) (Poly[ADP-ribose] synthetase-1) cfa
CANINE_2:CFAAFFX.24694.1.S1_S_AT similar to Poly [ADP-ribose] polymerase-1 (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase-1) (Poly[ADP-ribose] synthetase-1) cfa
CANINE:1594901_AT similar to Poly [ADP-ribose] polymerase-1 (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase-1) (Poly[ADP-ribose] synthetase-1) cfa
CANINE_2:CFA.21541.1.S1_S_AT similar to Poly [ADP-ribose] polymerase-1 (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase-1) (Poly[ADP-ribose] synthetase-1) cfa
CANINE_2:CFAAFFX.24694.1.S1_S_AT similar to Poly [ADP-ribose] polymerase-1 (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase-1) (Poly[ADP-ribose] synthetase-1) cfa
CHICKEN:GGA.5209.1.S1_A_AT poly (ADP-ribose) polymerase family, member 1 gga
CHICKEN:GGA.5209.1.S2_AT Poly(ADP-ribose) polymerase gga
CHICKEN:GGA.5209.1.S1_A_AT poly (ADP-ribose) polymerase family, member 1 gga
CHICKEN:GGA.5209.1.S2_AT Poly(ADP-ribose) polymerase gga
HG-U133_PLUS_2:208644_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-U133A_2:208644_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-U133A:208644_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-FOCUS:208644_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-U95AV2:1287_AT poly (ADP-ribose) polymerase family, member 1 hs
HC-G110:1287_AT poly (ADP-ribose) polymerase family, member 1 hs
HUGENEFL:J03473_AT poly (ADP-ribose) polymerase family, member 1 hs
U133_X3P:G190266_3P_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-U95AV2:41146_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-U133_PLUS_2:208644_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-U133A_2:208644_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-U133A:208644_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-FOCUS:208644_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-U95AV2:1287_AT poly (ADP-ribose) polymerase family, member 1 hs
HC-G110:1287_AT poly (ADP-ribose) polymerase family, member 1 hs
HUGENEFL:J03473_AT poly (ADP-ribose) polymerase family, member 1 hs
U133_X3P:G190266_3P_AT poly (ADP-ribose) polymerase family, member 1 hs
HG-U95AV2:41146_AT poly (ADP-ribose) polymerase family, member 1 hs
MOUSE430_2:1435368_A_AT poly (ADP-ribose) polymerase family, member 1 mm
MOE430A:1435368_A_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430A_2:1435368_A_AT poly (ADP-ribose) polymerase family, member 1 mm
MU11KSUBA:AA119245_S_AT poly (ADP-ribose) polymerase family, member 1 mm
MU11KSUBB:MSA.2151.0_S_AT poly (ADP-ribose) polymerase family, member 1 mm
MG-U74AV2:101957_F_AT poly (ADP-ribose) polymerase family, member 1 mm
MOE430A:1422502_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430A_2:1422502_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430_2:1422502_AT poly (ADP-ribose) polymerase family, member 1 mm
MOE430A:1422503_S_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430A_2:1422503_S_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430_2:1422503_S_AT poly (ADP-ribose) polymerase family, member 1 mm
MOE430B:1443573_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430_2:1443573_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430_2:1435368_A_AT poly (ADP-ribose) polymerase family, member 1 mm
MOE430A:1435368_A_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430A_2:1435368_A_AT poly (ADP-ribose) polymerase family, member 1 mm
MU11KSUBA:AA119245_S_AT poly (ADP-ribose) polymerase family, member 1 mm
MU11KSUBB:MSA.2151.0_S_AT poly (ADP-ribose) polymerase family, member 1 mm
MG-U74AV2:101957_F_AT poly (ADP-ribose) polymerase family, member 1 mm
MOE430A:1422502_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430A_2:1422502_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430_2:1422502_AT poly (ADP-ribose) polymerase family, member 1 mm
MOE430A:1422503_S_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430A_2:1422503_S_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430_2:1422503_S_AT poly (ADP-ribose) polymerase family, member 1 mm
MOE430B:1443573_AT poly (ADP-ribose) polymerase family, member 1 mm
MOUSE430_2:1443573_AT poly (ADP-ribose) polymerase family, member 1 mm
RT-U34:U94340_AT ADP-ribosyltransferase 1 rn
RG-U34A:U94340_AT ADP-ribosyltransferase 1 rn
RG-U34A:RC_AA964849_AT ADP-ribosyltransferase 1 rn
RAE230A:1369969_AT ADP-ribosyltransferase 1 rn
RAT230_2:1369969_AT ADP-ribosyltransferase 1 rn
RT-U34:U94340_AT ADP-ribosyltransferase 1 rn
RG-U34A:U94340_AT ADP-ribosyltransferase 1 rn
RG-U34A:RC_AA964849_AT ADP-ribosyltransferase 1 rn
RAE230A:1369969_AT ADP-ribosyltransferase 1 rn
RAT230_2:1369969_AT ADP-ribosyltransferase 1 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6471 protein amino acid ADP-ribosylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
3950 NAD+ ADP-ribosyltransferase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAF36011 Poly(adp-ribose) metabolism enzyme protein 1 [Caenorhabditis elegans] ref|NP_491072.1| Poly(ADP-ribose) Metabolism Enzyme family member (pme-1) [Caenorhabditis elegans] sp|Q9N4H4|PME1_CAEEL Poly(ADP-ribose) polymerase pme-1 (Poly ADP-ribose metabolism enzyme 1) 0.0
blast AAM27195 poly ADP-ribose metabolism enzyme-1 [Caenorhabditis elegans] 0.0
blast CAE60586 Hypothetical protein CBG04221 [Caenorhabditis briggsae] 0.0
blast CAB05448 Hypothetical protein AC8.1 [Caenorhabditis elegans] ref|NP_508039.2| Poly(ADP-ribose) Metabolism Enzyme family member (pme-6) [Caenorhabditis elegans] sp|Q9XUA5|PME6_CAEEL Poly(ADP-ribose) polymerase pme-6 (Poly ADP-ribose metabolism enzyme 6) 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001290 EMBL-EBI Poly(ADP-ribose) polymerase, catalytic region 1.1E-70
Pfam IPR001510 EMBL-EBI Zn-finger, NAD(+) ADP-ribosyltransferase 2.1E-30
Pfam IPR004102 EMBL-EBI Poly(ADP-ribose) polymerase, regulatory domain 1.3E-31
Pfam IPR001290 EMBL-EBI Poly(ADP-ribose) polymerase, catalytic region 2.2E-69
Pfam IPR001510 EMBL-EBI Zn-finger, NAD(+) ADP-ribosyltransferase 1.5E-28
Pfam IPR004102 EMBL-EBI Poly(ADP-ribose) polymerase, regulatory domain 2.3E-37
Pfam IPR008893 EMBL-EBI WGR 1.9E-38
Pfam IPR001290 EMBL-EBI Poly(ADP-ribose) polymerase, catalytic region 2.2E-69
Pfam IPR001510 EMBL-EBI Zn-finger, NAD(+) ADP-ribosyltransferase 1.5E-28
Pfam IPR004102 EMBL-EBI Poly(ADP-ribose) polymerase, regulatory domain 2.3E-37
Pfam IPR008893 EMBL-EBI WGR 1.9E-38
Pfam IPR001290 EMBL-EBI Poly(ADP-ribose) polymerase, catalytic region 1.1E-70
Pfam IPR001290 EMBL-EBI Poly(ADP-ribose) polymerase, catalytic region 1.1E-70
Sequence
Target Sequence 
>C. ELEGANS:187257_S_AT
gaatactcacggagccactcatgatttgaaagtcgagctgattgatattctaaaactgaa
ccgagacaatgaatcgtcgaaattcaaacgacacatcggaaatcgacgtcttttgtggca
cggatcaggaaaaatgaatttcgccggaattttgggtcaaggacttcgaattgcgccacc
ggaggctccagtttctggatatatgttcggaaagggcgtctattttgctgatatgttcag
caaaagtttcttctattgcagggccaacgccaaagaagaagcatatcttctgctctgtga
cgtggcactcggcaacgtgcaacagttgatggcttcgaagaatgtttcgagacaaactct
gccagcaggcttccagtctgtgcagggactaggccgccaatgtccacgagaaattggaag
ttacaatcatccggatggttataccattccactgggcctcacttacatgcaacttcaagg
aaaacaggatgtcgattatcacttgctttataatgaattcattgtgtatgatgtcgatca
aattcagctcaagtatctcgtccg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAATACTCACGGAGCCACTCATGAT 365 325 2256 Antisense
ATCGACGTCTTTTGTGGCACGGATC 312 31 2357 Antisense
GGTCAAGGACTTCGAATTGCGCCAC 93 503 2410 Antisense
CCACCGGAGGCTCCAGTTTCTGGAT 50 275 2431 Antisense
AAGTTTCTTCTATTGCAGGGCCAAC 485 155 2499 Antisense
GAAGCATATCTTCTGCTCTGTGACG 659 341 2533 Antisense
TGACGTGGCACTCGGCAACGTGCAA 3 569 2553 Antisense
AGACAAACTCTGCCAGCAGGCTTCC 438 71 2605 Antisense
AGGCTTCCAGTCTGTGCAGGGACTA 383 53 2622 Antisense
GATGGTTATACCATTCCACTGGGCC 391 407 2689 Antisense
AAATTCAGCTCAAGTATCTCGTCCG 677 115 2795 Antisense
Sequence Source Affymetrix Proprietary Database