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[186893_at]

Description F35H12.3 /REP_DB=WormBase Gene ID /WP=CE24946 /GEN=sel-12 /GB=AAK39230.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation
Cluster 6grp_highest_10_10 > 21      6grp_high1_10_10 > 13      6grp_highest_nonorm > 80      6grp_total > 14      4grp_total > 62      6grp_highest_sub > De      6grp_cgc > 30      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 171
1 2 3 4 range
A 237.9
(3)
P 		227.2
(1.4)
P 		197.6
(-3)
P 		224.4
(1)
A 		40
B 259
(3)
M 		144.9
(-1.4)
P 		221.2
(1.6)
P 		101.9
(-3)
A 		157
C 272.4
(3)
P 		225.6
(0.8)
P 		200.4
(-0.3)
P 		142.7
(-3)
A 		130
avr 256.4
(3) 		199.2
(-0.4) 		206.4
(0) 		156.3
(-3) 		100

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 119
1 2 3 4 5 6 range
A 247.3
(3)
P 		221.1
(1.7)
P 		217.3
(1.5)
P 		188
(0)
P 		160.4
(-1.4)
P 		127.9
(-3)
P 		119
B 176.5
(0.6)
P 		201.4
(2.7)
P 		160.6
(-0.7)
P 		205
(3)
P 		132.6
(-3)
P 		167.9
(-0.1)
P 		72
C 210.5
(3)
P 		193.9
(0.4)
P 		171.5
(-3)
P 		177.2
(-2.1)
P 		173.1
(-2.8)
P 		171.6
(-3)
P 		39
avr 211.4
(3) 		205.5
(2.4) 		183.1
(-0) 		190.1
(0.7) 		155.4
(-3) 		155.8
(-3) 		56
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 69
1 2 3 4 range
A 86.6
(3)
P 		49.3
(-1.2)
P 		51.7
(-0.9)
P 		32.8
(-3)
A 		54
B 82.6
(3)
M 		35.8
(-1.6)
P 		51.2
(-0.1)
P 		21.7
(-3)
A 		61
C 90.2
(3)
P 		64.9
(0.7)
P 		69.8
(1.1)
P 		24.1
(-3)
A 		66
avr 86.5
(3) 		50
(-0.6) 		57.6
(0.1) 		26.2
(-3) 		60

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 48
1 2 3 4 5 6 range
A 45.6
(-1.2)
P 		78.6
(3)
P 		47.3
(-1)
P 		47.7
(-0.9)
P 		48.4
(-0.8)
P 		31.1
(-3)
P 		48
B 61.4
(1.8)
P 		67
(3)
P 		39
(-3)
P 		54.3
(0.3)
P 		53.9
(0.2)
P 		62.6
(2.1)
P 		28
C 78
(3)
P 		59.2
(0.3)
P 		43.6
(-1.9)
P 		35.6
(-3)
P 		56
(-0.1)
P 		57.4
(0.1)
P 		42
avr 61.7
(1.4) 		68.3
(3) 		43.3
(-3) 		45.9
(-2.4) 		52.8
(-0.7) 		50.4
(-1.3) 		25
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 186893_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.18247
Sequence Type Exemplar sequence
Representative Public ID F35H12.3 NCBI
Target Description F35H12.3 /REP_DB=WormBase Gene ID /WP=CE24946 /GEN=sel-12 /GB=AAK39230.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_075774(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_075774 NCBI Caenorhabditis elegans Suppressor/Enhancer of Lin-12 family member (sel-12) (sel-12) mRNA, complete cds. 11/11 None
SNAP00000028608 ENSEMBL cdna:SNAP chromosome:CEL140:X:915872:920069:1 11/11 None
GENEFINDER00000028614 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:915872:920069:1 11/11 None
F35H12.3 ENSEMBL cdna:known chromosome:CEL140:X:915872:918284:1 gene:F35H12.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:915871-918157(+) 100.0 100.0
Public Domain and Genome References
Gene Title
Gene Symbol sel-12
Ensembl F35H12.3
Entrez Gene 180441 Entrez gene
SwissProt P52166 EMBL-EBI
WormBase CE24946 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:19553_AT presenilin family protein at
ATH1-121501:263484_AT presenilin family protein at
CANINE_2:CFA.107.1.S1_AT presenilin 1 (Alzheimer disease 3) cfa
CANINE_2:CFAAFFX.25711.1.S1_S_AT presenilin 1 (Alzheimer disease 3) cfa
CHICKEN:GGA.3864.1.S1_AT presenilin 1 (Alzheimer disease 3) gga
CHICKEN:GGA.3864.1.S2_AT presenilin 1 (Alzheimer disease 3) gga
HG-U133_PLUS_2:207782_S_AT presenilin 1 (Alzheimer disease 3) hs
HG-U133A:207782_S_AT presenilin 1 (Alzheimer disease 3) hs
HG-U133A_2:207782_S_AT presenilin 1 (Alzheimer disease 3) hs
HG-U95AV2:641_AT presenilin 1 (Alzheimer disease 3) hs
HC-G110:641_AT presenilin 1 (Alzheimer disease 3) hs
HG-U95AV2:642_S_AT presenilin 1 (Alzheimer disease 3) hs
HC-G110:642_S_AT presenilin 1 (Alzheimer disease 3) hs
HG-U95AV2:35658_AT presenilin 1 (Alzheimer disease 3) hs
HG-U133A_2:203460_S_AT presenilin 1 (Alzheimer disease 3) hs
HG-U133A:203460_S_AT presenilin 1 (Alzheimer disease 3) hs
HG-U133_PLUS_2:203460_S_AT presenilin 1 (Alzheimer disease 3) hs
HG-FOCUS:203460_S_AT presenilin 1 (Alzheimer disease 3) hs
HU35KSUBA:HUM_ALU_AT presenilin 1 (Alzheimer disease 3) hs
HU35KSUBB:HUM_ALU_AT presenilin 1 (Alzheimer disease 3) hs
HU35KSUBC:HUM_ALU_AT presenilin 1 (Alzheimer disease 3) hs
HU35KSUBD:HUM_ALU_AT presenilin 1 (Alzheimer disease 3) hs
HUGENEFL:HUM_ALU_AT presenilin 1 (Alzheimer disease 3) hs
HC-G110:HUM_ALU_AT presenilin 1 (Alzheimer disease 3) hs
HU35KSUBB:RC_H03361_AT presenilin 1 (Alzheimer disease 3) hs
HU35KSUBC:RC_W86875_AT presenilin 1 (Alzheimer disease 3) hs
HUGENEFL:U40380_AT presenilin 1 (Alzheimer disease 3) hs
HUGENEFL:L76517_AT presenilin 1 (Alzheimer disease 3) hs
HUGENEFL:L76528_S_AT presenilin 1 (Alzheimer disease 3) hs
U133_X3P:G7549814_3P_A_AT presenilin 1 (Alzheimer disease 3) hs
U133_X3P:G7549812_3P_A_AT presenilin 1 (Alzheimer disease 3) hs
U133_X3P:HS2.334580.2.S1_3P_A_AT presenilin 1 (Alzheimer disease 3) hs
U133_X3P:HS2.334580.1.S1_3P_AT presenilin 1 (Alzheimer disease 3) hs
HG-U133_PLUS_2:1559206_AT presenilin 1 (Alzheimer disease 3) hs
HG-U133_PLUS_2:1567443_X_AT presenilin 1 (Alzheimer disease 3) hs
HU35KSUBA:RC_AA454019_AT Presenilin 1 (Alzheimer disease 3) hs
U133_X3P:HS.166941.0.A1_3P_AT Presenilin 1 (Alzheimer disease 3) hs
U133_X3P:HS.16648.0.A1_3P_AT Presenilin 1 (Alzheimer disease 3) hs
U133_X3P:HS.128490.0.S1_3P_AT Presenilin 1 (Alzheimer disease 3) hs
HG-U133_PLUS_2:226577_AT Presenilin 1 (Alzheimer disease 3) hs
HG-U133B:226577_AT Presenilin 1 (Alzheimer disease 3) hs
HG-U133_PLUS_2:238816_AT Presenilin 1 (Alzheimer disease 3) hs
HG-U133B:238816_AT Presenilin 1 (Alzheimer disease 3) hs
HG-U133_PLUS_2:242875_AT Presenilin 1 (Alzheimer disease 3) hs
HG-U133B:242875_AT Presenilin 1 (Alzheimer disease 3) hs
HG-U95B:54683_AT Presenilin 1 (Alzheimer disease 3) hs
HG-U95D:77381_AT Presenilin 1 (Alzheimer disease 3) hs
HG-U95D:82580_AT Presenilin 1 (Alzheimer disease 3) hs
HG-U133_PLUS_2:1567440_AT Presenilin 1 (Alzheimer disease 3) hs
MOUSE430_2:1420261_AT presenilin 1 mm
MOUSE430A_2:1420261_AT presenilin 1 mm
MOE430A:1420261_AT presenilin 1 mm
MOUSE430A_2:1425549_AT presenilin 1 mm
MOUSE430_2:1425549_AT presenilin 1 mm
MOE430A:1425549_AT presenilin 1 mm
MU11KSUBA:AF007560-2_G_AT presenilin 1 mm
MU11KSUBA:AF007560-2_AT presenilin 1 mm
MU11KSUBB:MSA.43187.0_S_AT presenilin 1 mm
MG-U74AV2:102201_S_AT presenilin 1 mm
MG-U74AV2:161450_R_AT presenilin 1 mm
MOE430A:1421853_AT presenilin 1 mm
MOUSE430A_2:1421853_AT presenilin 1 mm
MOUSE430_2:1421853_AT presenilin 1 mm
MOE430A:1450399_AT presenilin 1 mm
MOUSE430A_2:1450399_AT presenilin 1 mm
MOUSE430_2:1450399_AT presenilin 1 mm
MU19KSUBB:TC29411_F_AT Presenilin 1, mRNA (cDNA clone MGC:40637 IMAGE:5133302) mm
RN-U34:D82363_S_AT presenilin 1 rn
RG-U34A:D82363_S_AT presenilin 1 rn
RG-U34B:RC_AI009495_AT presenilin 1 rn
RAE230A:1376075_AT presenilin 1 rn
RAT230_2:1376075_AT presenilin 1 rn
RAE230A:1368792_AT presenilin 1 rn
RAT230_2:1368792_AT presenilin 1 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK39230 Suppressor/enhancer of lin-12 protein 12 [Caenorhabditis elegans] ref|NP_508175.1| Suppressor/Enhancer of Lin-12 family member (sel-12) [Caenorhabditis elegans] gb|AAD50991.1| presenilin SEL-12 [Caenorhabditis elegans] sp|P52166|PSN_CAEEL Presenilin sel-12 0.0
blast E89453 protein F35H12.3 [imported] - Caenorhabditis elegans 0.0
blast AAA85511 membrane protein 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001108 EMBL-EBI Peptidase A22A, presenilin 1.0E-126
Pfam IPR010463 EMBL-EBI Protein of unknown function DUF1057 1.0E-126
Pfam IPR010463 EMBL-EBI Protein of unknown function DUF1057 5.1E-113
Pfam IPR010463 EMBL-EBI Protein of unknown function DUF1057 6.4E-80
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_508175.1 9 53-75,101-123,130-152,162-184,193-210,215-237,250-272,381-403,408-430
F35H12.3 9 53-75,101-123,130-152,162-184,193-210,215-237,250-272,381-403,408-430
SNAP00000028608 9 53-75,101-123,130-152,162-184,193-210,215-237,250-272,381-403,408-430
GENEFINDER00000028614 9 53-75,101-123,130-152,162-184,193-210,215-237,250-272,381-403,408-430
Sequence
Target Sequence 
>C. ELEGANS:186893_AT
cggcgctgatttattcgtctggagtcatctatccctacgttcttgttactgcagttgaaa
acacgacagacccccgtgaaccgacgtcgtcagactcaaatacttctacagcttttcctg
gagaggcgagttgttcatctgaaacgccaaaacggccaaaagtgaaacgaattcctcaaa
aagtgcaaatcgaatcgaatactacagcttcaacgacacaaaactctggagtaagggtgg
aacgggagctagctgctgagagaccaactgtacaagacgccaattttcacaggcacgaag
aggaagagagaggtgtgaaacttggtctgggcgacttcattttctactctgttctcctcg
gcaaggcttcatcgtactttgactggaacacgactatcgcttgttatgtggccattctta
tcggtctct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CGGCGCTGATTTATTCGTCTGGAGT 647 237 770 Antisense
ATTCGTCTGGAGTCATCTATCCCTA 552 9 782 Antisense
CCCTACGTTCTTGTTACTGCAGTTG 453 259 802 Antisense
GCAGTTGAAAACACGACAGACCCCC 450 207 820 Antisense
CCGTGAACCGACGTCGTCAGACTCA 379 263 843 Antisense
GAGCTAGCTGCTGAGAGACCAACTG 320 385 1015 Antisense
GAGACCAACTGTACAAGACGCCAAT 234 395 1029 Antisense
GAAACTTGGTCTGGGCGACTTCATT 333 357 1086 Antisense
GCAAGGCTTCATCGTACTTTGACTG 140 321 1130 Antisense
ACGACTATCGCTTGTTATGTGGCCA 570 91 1159 Antisense
TATGTGGCCATTCTTATCGGTCTCT 156 653 1174 Antisense
Sequence Source Affymetrix Proprietary Database