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[185235_at]

Description Y106G6H.7 /REP_DB=WormBase Gene ID /WP=CE20417 /TR=Q9XWS2 /GB=CAA21575.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation
Cluster 6grp_highest_10_10 > 63      6grp_high1_10_10 > 36      4grp_highest_8_8 > 41      4grp_high_8_8 > 49      6grp_highest_nonorm > 74      6grp_total > 36      4grp_total > 53      6grp_highest_sub > Cu      6grp_cgc > 16      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 344
1 2 3 4 range
A 619
(3)
P 		619.8
(3)
P 		511.1
(0.8)
P 		327.5
(-3)
P 		292
B 632.6
(3)
P 		557
(1.4)
P 		507.9
(0.4)
P 		342
(-3)
P 		291
C 671.4
(3)
P 		399.2
(-3)
P 		545.7
(0.2)
P 		476.1
(-1.3)
P 		272
avr 641
(3) 		525.3
(0.3) 		521.6
(0.2) 		381.9
(-3) 		259

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 376
1 2 3 4 5 6 range
A 784.9
(3)
P 		596.3
(-0.4)
P 		477.3
(-2.5)
P 		449.3
(-3)
P 		750.9
(2.4)
P 		670.1
(0.9)
P 		336
B 626.4
(-1.5)
P 		734.8
(1)
P 		589.9
(-2.3)
P 		825.1
(3)
P 		587.2
(-2.3)
P 		557.8
(-3)
P 		267
C 529.5
(-1.3)
P 		638
(1)
P 		730.9
(3)
P 		523.2
(-1.5)
P 		453.1
(-3)
P 		724.2
(2.9)
P 		278
avr 646.9
(2) 		656.4
(3) 		599.4
(-2.8) 		599.2
(-2.8) 		597.1
(-3) 		650.7
(2.4) 		59
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 178
1 2 3 4 range
A 225.4
(3)
P 		134.5
(-0.1)
P 		133.6
(-0.1)
P 		47.9
(-3)
P 		178
B 201.7
(3)
P 		137.6
(0)
P 		117.7
(-0.9)
P 		72.9
(-3)
P 		129
C 222.3
(3)
P 		114.8
(-1.5)
P 		190.2
(1.6)
P 		80.3
(-3)
P 		142
avr 216.5
(3) 		129
(-0.5) 		147.2
(0.2) 		67
(-3) 		150

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 141
1 2 3 4 5 6 range
A 144.7
(-1)
P 		212.1
(2.3)
P 		103.9
(-3)
P 		114
(-2.5)
P 		226.6
(3)
P 		163.1
(-0.1)
P 		123
B 217.9
(1.4)
P 		244.6
(3)
P 		143.2
(-3)
P 		218.5
(1.5)
P 		238.6
(2.6)
P 		208
(0.8)
P 		101
C 196.3
(1)
P 		194.7
(0.9)
P 		186
(0.5)
P 		105.2
(-3)
P 		146.6
(-1.2)
P 		242.4
(3)
P 		137
avr 186.3
(0.5) 		217.1
(3) 		144.4
(-3) 		145.9
(-2.9) 		203.9
(1.9) 		204.5
(2) 		73
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 185235_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1397
Sequence Type Exemplar sequence
Representative Public ID Y106G6H.7 NCBI
Target Description Y106G6H.7 /REP_DB=WormBase Gene ID /WP=CE20417 /TR=Q9XWS2 /GB=CAA21575.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060331(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060331 NCBI Caenorhabditis elegans yeast SEC homolog family member (sec-8) (sec-8) mRNA, complete cds. 11/11 None
SNAP00000001707 ENSEMBL cdna:SNAP chromosome:CEL140:I:10454800:10460932:1 11/11 None
GENEFINDER00000001714 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:10454800:10460052:1 11/11 None
Y106G6H.7 ENSEMBL cdna:known chromosome:CEL140:I:10454800:10460182:1 gene:Y106G6H.7 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:10454730-10459983(+) 100.0 100.0
Public Domain and Genome References
Gene Title
Gene Symbol sec-8
Ensembl Y106G6H.7
Entrez Gene 172924 Entrez gene
SwissProt Q9XWS2 EMBL-EBI
WormBase CE32512 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.2858.1.S1_AT similar to Exocyst complex component Sec8 cfa
DROSOPHILA_2:1636064_AT dm
DROSGENOME1:141611_AT dm
CHICKEN:GGA.11201.1.S1_S_AT SEC8-like 1 (S. cerevisiae) gga
CHICKEN:GGA.11201.2.S1_S_AT SEC8-like 1 (S. cerevisiae) gga
CHICKEN:GGAAFFX.5339.1.S1_AT SEC8-like 1 (S. cerevisiae) gga
HG-U133B:224926_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133_PLUS_2:224926_AT SEC8-like 1 (S. cerevisiae) hs
HU35KSUBD:RC_AA349463_AT SEC8-like 1 (S. cerevisiae) hs
U133_X3P:HS.313709.0.A1_3P_AT SEC8-like 1 (S. cerevisiae) hs
U133_X3P:HS.223829.0.A1_3P_S_AT SEC8-like 1 (S. cerevisiae) hs
U133_X3P:HS.223829.0.A1_3P_AT SEC8-like 1 (S. cerevisiae) hs
U133_X3P:HS.107394.0.S1_3P_AT SEC8-like 1 (S. cerevisiae) hs
U133_X3P:240528_3P_S_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133_PLUS_2:235974_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133B:235974_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133_PLUS_2:240528_S_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133B:240528_S_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95B:48072_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95B:48073_G_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95D:72841_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95E:91389_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133_PLUS_2:233099_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133B:233099_AT SEC8-like 1 (S. cerevisiae) hs
U133_X3P:HS2.385792.1.S1_3P_AT SEC8-like 1 (S. cerevisiae) hs
U133_X3P:HS2.352162.1.S1_3P_AT SEC8-like 1 (S. cerevisiae) hs
U133_X3P:HS2.189630.1.S1_3P_AT SEC8-like 1 (S. cerevisiae) hs
U133_X3P:HS.283859.0.S1_3P_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133_PLUS_2:1557772_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133_PLUS_2:1560483_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133_PLUS_2:1561512_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133_PLUS_2:216538_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133A_2:216538_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133A:216538_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133_PLUS_2:239264_AT SEC8-like 1 (S. cerevisiae) hs
HG-U133B:239264_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95AV2:32346_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95B:42905_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95B:46527_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95C:62870_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95C:64589_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95C:65043_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95D:67747_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95E:69163_AT SEC8-like 1 (S. cerevisiae) hs
HG-U95D:82689_AT SEC8-like 1 (S. cerevisiae) hs
HU35KSUBC:RC_H97514_AT SEC8-like 1 (S. cerevisiae) hs
HU35KSUBB:RC_R95916_AT SEC8-like 1 (S. cerevisiae) hs
HU35KSUBB:RC_T73567_AT SEC8-like 1 (S. cerevisiae) hs
HU35KSUBC:RC_N37082_AT SEC8-like 1 (S. cerevisiae) hs
HU35KSUBD:RC_H93340_AT SEC8-like 1 (S. cerevisiae) hs
U133_X3P:HS.293039.0.A1_3P_AT SEC8-like 1 (S. cerevisiae) hs
MOUSE430_2:1453977_AT SEC8-like 1 (S. cerevisiae) mm
MOUSE430A_2:1453977_AT SEC8-like 1 (S. cerevisiae) mm
MOE430A:1453977_AT SEC8-like 1 (S. cerevisiae) mm
MU11KSUBA:AF022962_AT SEC8-like 1 (S. cerevisiae) mm
MG-U74AV2:93466_AT SEC8-like 1 (S. cerevisiae) mm
MG-U74BV2:115067_AT SEC8-like 1 (S. cerevisiae) mm
MG-U74CV2:167750_AT SEC8-like 1 (S. cerevisiae) mm
MOE430A:1431062_A_AT SEC8-like 1 (S. cerevisiae) mm
MOUSE430A_2:1431062_A_AT SEC8-like 1 (S. cerevisiae) mm
MOUSE430_2:1431062_A_AT SEC8-like 1 (S. cerevisiae) mm
MOE430A:1422686_S_AT SEC8-like 1 (S. cerevisiae) mm
MOUSE430A_2:1422686_S_AT SEC8-like 1 (S. cerevisiae) mm
MOUSE430_2:1422686_S_AT SEC8-like 1 (S. cerevisiae) mm
MOE430A:1422684_A_AT SEC8-like 1 (S. cerevisiae) mm
MOUSE430A_2:1422684_A_AT SEC8-like 1 (S. cerevisiae) mm
MOUSE430_2:1422684_A_AT SEC8-like 1 (S. cerevisiae) mm
MOE430A:1422685_AT SEC8-like 1 (S. cerevisiae) mm
MOUSE430A_2:1422685_AT SEC8-like 1 (S. cerevisiae) mm
MOUSE430_2:1422685_AT SEC8-like 1 (S. cerevisiae) mm
MG-U74BV2:108278_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
MG-U74BV2:115920_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
MG-U74CV2:136742_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
MG-U74CV2:139260_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
MOE430B:1444609_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
MOUSE430_2:1444609_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
MOE430B:1445111_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
MOUSE430_2:1445111_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
MOE430B:1459706_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
MOUSE430_2:1459706_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
MU19KSUBC:TC35112_AT SEC8 (S. cerevisiae), mRNA (cDNA clone MGC:36178 IMAGE:5355276) mm
RG-U34A:U32498_AT SEC8-like 1 (S. cerevisiae) rn
RG-U34C:RC_AI070920_AT SEC8-like 1 (S. cerevisiae) rn
RAE230B:1380653_AT SEC8-like 1 (S. cerevisiae) rn
RAT230_2:1380653_AT SEC8-like 1 (S. cerevisiae) rn
RG-U34B:RC_AI060028_AT SEC8-like 1 (S. cerevisiae) rn
YEAST_2:1770342_AT Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6904 vesicle docking during exocytosis inferred from electronic annotation QuickGO AmiGO
15031 protein transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
145 exocyst inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA21575 Hypothetical protein Y106G6H.7 [Caenorhabditis elegans] ref|NP_492732.2| yeast SEC homolog family member (sec-8) [Caenorhabditis elegans] sp|Q9XWS2|SEC8_CAEEL Probable exocyst complex component Sec8 0.0
blast CAE58944 Hypothetical protein CBG02212 [Caenorhabditis briggsae] 0.0
blast AAH94262 Unknown (protein for IMAGE:6861731) [Xenopus laevis] 1.0E-80
Protein Domains
Database ID Description E-Value
Pfam IPR007191 EMBL-EBI Sec8 exocyst complex component specific domain 7.0E-26
Pfam IPR007191 EMBL-EBI Sec8 exocyst complex component specific domain 5.7E-30
Pfam IPR006696 EMBL-EBI Protein of unknown function DUF423 5.0E-40
Pfam IPR007191 EMBL-EBI Sec8 exocyst complex component specific domain 3.4E-78
Trans Membrane
ID Number Of Domains Domain Boundaries
SNAP00000001707 1 859-881
Sequence
Target Sequence 
>C. ELEGANS:185235_AT
tgataataactctgttccctcagccattgaagattgtgttcgccgcctcgaatcaattgc
tgattcttgtcttctcctgcttcacatcgaaattcgtgttcattgtttcttccatttggc
tccacttgcaaagtatcgcaatacatcatctcataatgaagttgatccagaagtagtagc
acttggaaaggatcttcatcaattccatgacaatttgaaagatgttttatcgcctgcgaa
gctttcttatgtattcgatggacttggacatctttgtgcatcattatttattcattacag
tcaattcatgccacgactcactgaagctgcaaagaaaagagtttgccgtaatgtgtgggg
agtccagcagcgcctgtcaaggatcacaaatcgtcgagaatctgatctcgatagagcccg
tgcatttttcgatttattattggacaatactcctgatggaattttggcaattgttccaga
aaagagatcccaattcacggcaaccgaactcaactacctactcgctttatcagttcgcag
tgataagacgcttgcaagtcagccaggagc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGATAATAACTCTGTTCCCTCAGCC 359 565 2109 Antisense
TTCGCCGCCTCGAATCAATTGCTGA 366 697 2147 Antisense
TCAATTGCTGATTCTTGTCTTCTCC 98 635 2161 Antisense
TTCTCCTGCTTCACATCGAAATTCG 575 691 2180 Antisense
TTATCGCCTGCGAAGCTTTCTTATG 443 679 2335 Antisense
GGACTTGGACATCTTTGTGCATCAT 271 525 2368 Antisense
CATGCCACGACTCACTGAAGCTGCA 627 209 2415 Antisense
GATAGAGCCCGTGCATTTTTCGATT 207 423 2518 Antisense
AAAGAGATCCCAATTCACGGCAACC 225 123 2589 Antisense
TCAACTACCTACTCGCTTTATCAGT 684 627 2618 Antisense
AGACGCTTGCAAGTCAGCCAGGAGC 475 69 2654 Antisense
Sequence Source Affymetrix Proprietary Database