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[182546_at]

Description Y46G5A.2 /REP_DB=WormBase Gene ID /WP=CE24292 /TR=Q9U2G3 /GB=CAB60348.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation
Cluster 6grp_total > 26      4grp_total > 05      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 234
1 2 3 4 range
A 147.2
(1.5)
A 		52.8
(-3)
A 		59.5
(-2.7)
A 		179.4
(3)
A 		127
B 112.5
(-0.2)
A 		59.8
(-3)
A 		70.8
(-2.4)
A 		174.7
(3)
P 		115
C 132.7
(-0.5)
A 		34.7
(-3)
A 		52.2
(-2.6)
A 		268.8
(3)
P 		234
avr 130.8
(0.1) 		49.1
(-3) 		60.8
(-2.6) 		207.6
(3) 		159

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 62
1 2 3 4 5 6 range
A 94.2
(3)
A 		76
(-1.6)
A 		76.2
(-1.6)
A 		80.4
(-0.5)
A 		70.5
(-3)
A 		73.5
(-2.2)
A 		24
B 75.3
(1.3)
A 		84.6
(2.4)
A 		42
(-3)
A 		53.7
(-1.5)
A 		67
(0.2)
A 		88.9
(3)
A 		47
C 104
(3)
A 		102.4
(2.8)
A 		76.7
(-0.6)
A 		71.9
(-1.2)
A 		57.9
(-3)
A 		61.3
(-2.6)
A 		46
avr 91.2
(3) 		87.7
(2.2) 		65
(-3) 		68.7
(-2.2) 		65.1
(-3) 		74.6
(-0.8) 		26
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 44
1 2 3 4 range
A 53.6
(3)
A 		11.5
(-3)
A 		15.6
(-2.4)
A 		26.3
(-0.9)
A 		42
B 35.9
(2.7)
A 		14.8
(-3)
A 		16.4
(-2.6)
A 		37.2
(3)
P 		22
C 43.9
(2.8)
A 		10
(-3)
A 		18.2
(-1.6)
A 		45.3
(3)
P 		35
avr 44.5
(3) 		12.1
(-3) 		16.7
(-2.1) 		36.3
(1.5) 		32

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 28
1 2 3 4 5 6 range
A 17.4
(-2.5)
A 		27
(3)
A 		16.6
(-3)
A 		20.4
(-0.8)
A 		21.3
(-0.3)
A 		17.9
(-2.3)
A 		10
B 26.2
(1.2)
A 		28.2
(1.7)
A 		10.2
(-3)
A 		14.2
(-2)
A 		27.2
(1.4)
A 		33.2
(3)
A 		23
C 38.5
(3)
A 		31.2
(1.2)
A 		19.5
(-1.8)
A 		14.5
(-3)
A 		18.7
(-2)
A 		20.5
(-1.5)
A 		24
avr 27.4
(2.4) 		28.8
(3) 		15.4
(-3) 		16.4
(-2.6) 		22.4
(0.1) 		23.9
(0.8) 		13
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 182546_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3019
Sequence Type Exemplar sequence
Representative Public ID Y46G5A.2 NCBI
Target Description Y46G5A.2 /REP_DB=WormBase Gene ID /WP=CE24292 /TR=Q9U2G3 /GB=CAB60348.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064307(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064307 NCBI Caenorhabditis elegans Y46G5A.2 (Y46G5A.2) mRNA, complete cds. 11/11 None
SNAP00000038983 ENSEMBL cdna:SNAP chromosome:CEL140:II:12681614:12692794:1 11/11 None
GENEFINDER00000039026 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:12681485:12686807:1 11/11 None
Y46G5A.2 ENSEMBL cdna:known chromosome:CEL140:II:12679851:12686306:1 gene:Y46G5A.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:12681627-12685677(+) 91.83 100.0
Public Domain and Genome References
Gene Title
Ensembl Y46G5A.2
Entrez Gene 174899 Entrez gene
SwissProt Q9U2G3 EMBL-EBI
WormBase CE35917 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.27395.1.S1_AT similar to heme A:farnesyltransferase cfa
DROSOPHILA_2:1634270_AT dm
DROSGENOME1:154662_AT dm
CHICKEN:GGAAFFX.12399.1.S1_S_AT similar to COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase gga
CHICKEN:GGAAFFX.21381.2.S1_S_AT similar to COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase gga
CHICKEN:GGAAFFX.882.2.S1_S_AT similar to COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase gga
HG-U133_PLUS_2:203858_S_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
HG-U133A:203858_S_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
HG-FOCUS:203858_S_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
HG-U133A_2:203858_S_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
HUGENEFL:U82010_RNA1_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
U133_X3P:G4502978_3P_S_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
U133_X3P:203858_3P_S_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
HG-U95AV2:37224_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
HG-U95E:84445_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
HG-U133_PLUS_2:239402_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
HG-U133B:239402_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
HG-U95E:76153_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
U133_X3P:HS.117298.0.A1_3P_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) hs
MOUSE430_2:1459977_X_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) mm
MOE430B:1459977_X_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) mm
MG-U74BV2:107002_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) mm
MOE430B:1429329_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) mm
MOUSE430_2:1429329_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) mm
MG-U74BV2:116152_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast), mRNA (cDNA clone MGC:47032 IMAGE:4206826) mm
MOE430B:1435380_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast), mRNA (cDNA clone MGC:47032 IMAGE:4206826) mm
MOUSE430_2:1435380_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast), mRNA (cDNA clone MGC:47032 IMAGE:4206826) mm
MOE430B:1446223_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast), mRNA (cDNA clone MGC:47032 IMAGE:4206826) mm
MOUSE430_2:1446223_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast), mRNA (cDNA clone MGC:47032 IMAGE:4206826) mm
MU19KSUBB:TC28206_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast), mRNA (cDNA clone MGC:47032 IMAGE:4206826) mm
MU19KSUBC:TC38962_AT COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast), mRNA (cDNA clone MGC:47032 IMAGE:4206826) mm
YEAST_2:1775746_AT Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6783 heme biosynthesis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8495 protoheme IX farnesyltransferase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB60348 Hypothetical protein Y46G5A.2 [Caenorhabditis elegans] emb|CAE48674.1| Hypothetical protein Y46G5A.2 [Caenorhabditis elegans] ref|NP_496708.2| Y46G5A.2 [Caenorhabditis elegans] 0.0
blast CAB60348 Hypothetical protein Y46G5A.2 [Caenorhabditis elegans] emb|CAE48674.1| Hypothetical protein Y46G5A.2 [Caenorhabditis elegans] ref|NP_496708.2| Y46G5A.2 [Caenorhabditis elegans] 1.0E-153
blast CAB60348 Hypothetical protein Y46G5A.2 [Caenorhabditis elegans] emb|CAE48674.1| Hypothetical protein Y46G5A.2 [Caenorhabditis elegans] ref|NP_496708.2| Y46G5A.2 [Caenorhabditis elegans] 1.0E-139
blast CAE63454 Hypothetical protein CBG07915 [Caenorhabditis briggsae] 1.0E-128
blast CAE63454 Hypothetical protein CBG07915 [Caenorhabditis briggsae] 1.0E-127
blast XP_786048 PREDICTED: similar to COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase [Strongylocentrotus purpuratus] 2.0E-69
Protein Domains
Database ID Description E-Value
Pfam IPR000537 EMBL-EBI UbiA prenyltransferase 1.1E-53
Pfam IPR000537 EMBL-EBI UbiA prenyltransferase 1.5E-50
Pfam IPR000537 EMBL-EBI UbiA prenyltransferase 1.1E-53
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496708.2 8 100-119,123-145,166-188,193-210,217-239,244-266,297-319,347-364
Y46G5A.2 8 100-119,123-145,166-188,193-210,217-239,244-266,297-319,347-364
SNAP00000038983 8 5-27,54-76,81-103,110-132,137-159,190-212,240-257,352-374
GENEFINDER00000039026 9 20-37,41-63,84-106,111-128,135-157,230-252,265-284,299-321,334-351
Sequence
Target Sequence 
>C. ELEGANS:182546_AT
tatttatgcaggcgtctacactccgatgaaacgttctcatatcggatgcacatgggccgg
agccgtagttggagcaattccaccactaatgggatatgctgcagccaccgggtacctgga
tccggctgcctggtgcctggcaactattcttttttcatggcaatttccacattttaatgg
tcttagctggaatttgagaggcgattatagtaaggccggctaccgcgtaatgtgtgtgac
aaatgagcggttgtgccgtgtgacgtcacttcgtcacagtgttgctctactcggattgtg
ctccatcgctgctccgcttacagacttgacaacgctcacctttgctatagattctcttcc
agtgaacgcgtacctcgtctacctatcctacaaattctacaaggctcccgacgcgaaaaa
cagtcgaaaattgttcttctactcactgttacatctgccgctggtcatgttac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TATTTATGCAGGCGTCTACACTCCG 339 661 282 Antisense
TGCCTGGCAACTATTCTTTTTTCAT 249 585 415 Antisense
ATAGTAAGGCCGGCTACCGCGTAAT 514 21 488 Antisense
TGAGCGGTTGTGCCGTGTGACGTCA 663 567 525 Antisense
ACTTCGTCACAGTGTTGCTCTACTC 654 103 549 Antisense
TCCGCTTACAGACTTGACAACGCTC 289 595 594 Antisense
AACGCTCACCTTTGCTATAGATTCT 25 147 612 Antisense
AGATTCTCTTCCAGTGAACGCGTAC 559 65 630 Antisense
GTCTACCTATCCTACAAATTCTACA 541 469 658 Antisense
TTCTTCTACTCACTGTTACATCTGC 125 691 715 Antisense
TTACATCTGCCGCTGGTCATGTTAC 504 681 730 Antisense
Sequence Source Affymetrix Proprietary Database