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[180190_at] zinc metalloprotease

Description T24A11.4 /REP_DB=WormBase Gene ID /WP=CE02360 /TR=Q22711 /GB=CAA88883.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation
Cluster 6grp_high1_10_10 > 80      4grp_high_8_8 > 22      6grp_total > 10      4grp_total > 16      6grp_cgc > 64      6grp_high1_sub > 02_03_04_05      6grp_total_sub > Hat      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 492
1 2 3 4 range
A 152.8
(-3)
P 		210.1
(-1.6)
P 		231.3
(-1.1)
P 		400
(3)
P 		247
B 113.4
(-3)
M 		278.7
(3)
P 		241.4
(1.6)
P 		240.2
(1.6)
P 		165
C 160.3
(-3)
P 		245.7
(-1.8)
P 		280.7
(-1.4)
P 		605.5
(3)
P 		445
avr 142.2
(-3) 		244.8
(-0.7) 		251.1
(-0.6) 		415.2
(3) 		273

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 188
1 2 3 4 5 6 range
A 109
(-3)
A 		170.2
(-0.1)
P 		189.1
(0.7)
P 		237.5
(3)
P 		222.6
(2.3)
P 		196.4
(1.1)
P 		129
B 156.3
(-1.3)
P 		240.9
(2.5)
P 		251.5
(3)
P 		169.6
(-0.7)
P 		243.6
(2.6)
P 		117.8
(-3)
P 		134
C 136.2
(-2.8)
P 		297.1
(3)
P 		161.7
(-1.9)
P 		185.1
(-1)
P 		130.7
(-3)
P 		130.7
(-3)
P 		166
avr 133.8
(-3) 		236.1
(3) 		200.8
(0.9) 		197.4
(0.7) 		199
(0.8) 		148.3
(-2.1) 		102
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 66
1 2 3 4 range
A 55.6
(1)
P 		45.6
(-3)
P 		60.5
(3)
P 		58.6
(2.2)
P 		15
B 36.2
(-3)
M 		68.8
(3)
P 		55.9
(0.6)
P 		51.2
(-0.2)
P 		33
C 53.1
(-3)
P 		70.6
(-0.9)
P 		97.8
(2.5)
P 		102.1
(3)
P 		49
avr 48.3
(-3) 		61.7
(0.5) 		71.4
(3) 		70.6
(2.8) 		23

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 79
1 2 3 4 5 6 range
A 20.1
(-3)
A 		60.5
(2.1)
P 		41.2
(-0.3)
P 		60.2
(2.1)
P 		67.2
(3)
P 		47.8
(0.5)
P 		47
B 54.4
(-1.9)
P 		80.2
(1)
P 		61.1
(-1.1)
P 		44.9
(-2.9)
P 		99
(3)
P 		43.9
(-3)
P 		55
C 50.5
(-1.5)
P 		90.7
(3)
P 		41.2
(-2.6)
P 		37.2
(-3)
P 		42.3
(-2.4)
P 		43.7
(-2.3)
P 		54
avr 41.7
(-3) 		77.1
(3) 		47.8
(-2) 		47.4
(-2) 		69.5
(1.7) 		45.1
(-2.4) 		35
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 180190_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7117
Sequence Type Exemplar sequence
Representative Public ID T24A11.4 NCBI
Target Description T24A11.4 /REP_DB=WormBase Gene ID /WP=CE02360 /TR=Q22711 /GB=CAA88883.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation
Annotation Method Description
Annotation Description This probe set was annotated using the Genome Target Overlap based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade B annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_065368
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
T24A11.3 ENSEMBL cdna:known chromosome:CEL140:III:3804750:3809008:-1 gene:T24A11.3 A 
NM_065368 NCBI Caenorhabditis elegans TOllisH (Tolloid and BMP-1 family) family member (toh-1) (toh-1) mRNA, complete cds. None
SNAP00000027680 ENSEMBL cdna:SNAP chromosome:CEL140:III:3805086:3808992:-1 None
GENEFINDER00000027681 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:3805086:3809008:-1 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:3807883-3809262(-) 91.28 100.0
Public Domain and Genome References
Gene Title zinc metalloprotease
Gene Symbol toh-1
Ensembl T24A11.3
Entrez Gene 175491 Entrez gene
SwissProt Q22710 EMBL-EBI
WormBase CE35909 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88882 Hypothetical protein T24A11.3 [Caenorhabditis elegans] ref|NP_497769.3| TOllisH (Tolloid and BMP-1 family) family member (toh-1) [Caenorhabditis elegans] sp|Q22710|NAS26_CAEEL Zinc metalloproteinase nas-26 precursor (Nematode astacin 26) (Tollish protein 1) 0.0
blast CAE64502 Hypothetical protein CBG09229 [Caenorhabditis briggsae] 0.0
blast CAE61297 Hypothetical protein CBG05121 [Caenorhabditis briggsae] 9.0E-71
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 6.1E-52
Pfam IPR000859 EMBL-EBI CUB 4.9E-5
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 6.1E-52
Pfam IPR000859 EMBL-EBI CUB 4.9E-5
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000027681 1 7-29
Sequence
Target Sequence 
>C. ELEGANS:180190_AT
gctccgcccaatcattattattttctctttttctctttatctctctttttttgttttttt
ttgttgtcagattctcgagacagggtcattccacagtagcccgccttctctctgtctctc
tgcgtctcctcgtgtctcggtccatcaattttttgatttgccattcttcttcctacttcc
ttttttttacttttccttgtttgtcttcaattactttaaatctaatttcaggctacctca
agcaccaatgacatcctcattggtgctaattcttgctccgttggcactggttgccatcgg
agaagccgcattcggcaatagctcgaagatctttgaaattccgggtctagaagtgatggc
ttctgataaatatccacatttcactacaattgagacagtcagcagaaccaaggttcatcg
ccaccgacgcgaggtcattgccgggcaaatctacgactggaactcgtacgaaattccatt
tcaaatatggggtggcgattgtaagtgtcttcct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCTCCGCCCAATCATTATTATTTTC 239 299 36 Antisense
GAGACAGGGTCATTCCACAGTAGCC 472 393 112 Antisense
TCGTGTCTCGGTCCATCAATTTTTT 36 607 165 Antisense
TTTTTTGATTTGCCATTCTTCTTCC 659 675 184 Antisense
ATTTCAGGCTACCTCAAGCACCAAT 678 15 260 Antisense
GACATCCTCATTGGTGCTAATTCTT 592 369 285 Antisense
GTGCTAATTCTTGCTCCGTTGGCAC 570 477 298 Antisense
CACTGGTTGCCATCGGAGAAGCCGC 382 197 320 Antisense
GCAGAACCAAGGTTCATCGCCACCG 499 311 437 Antisense
GCCGGGCAAATCTACGACTGGAACT 109 285 475 Antisense
GGGTGGCGATTGTAAGTGTCTTCCT 561 497 525 Antisense
Sequence Source Affymetrix Proprietary Database