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[177327_at]

Description Y39G10AL.A /REP_DB=WormBase Gene ID /WP=CE25266 /CHR=1 /FEA=Sanger Annotation /DEF=(ST.LOUIS) protein_id:AAF59488.1
Cluster 6grp_total > 10      4grp_total > 05      6grp_cgc > 63      6grp_cgc_sub > 02      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 44
1 2 3 4 range
A 13
(-1.5)
A 		4.4
(-3)
A 		6.9
(-2.6)
A 		39.9
(3)
A 		36
B 27.6
(3)
A 		8.3
(-1.6)
A 		2.5
(-2.9)
A 		2.2
(-3)
A 		25
C 14.9
(-1.3)
A 		2.2
(-3)
A 		5
(-2.6)
A 		45.8
(3)
A 		44
avr 18.5
(0.4) 		5
(-3) 		4.8
(-3) 		29.3
(3) 		25

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 40
1 2 3 4 5 6 range
A 3.1
(-3)
A 		5.4
(-2.3)
A 		24.2
(3)
A 		15.1
(0.4)
A 		3
(-3)
A 		10.4
(-0.9)
A 		21
B 2.9
(-3)
A 		19.9
(2.1)
A 		7.4
(-1.7)
A 		22.9
(3)
A 		4.2
(-2.6)
A 		4.6
(-2.5)
A 		20
C 5.8
(-2.5)
A 		41.9
(3)
A 		7.4
(-2.2)
A 		4.9
(-2.6)
A 		4.1
(-2.7)
A 		2.4
(-3)
A 		40
avr 3.9
(-3) 		22.4
(3) 		13
(-0) 		14.3
(0.4) 		3.8
(-3) 		5.8
(-2.4) 		19
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 8
1 2 3 4 range
A 4.7
(1.6)
A 		1
(-3)
A 		1.8
(-2)
A 		5.8
(3)
A 		5
B 8.8
(3)
A 		2.1
(-1.8)
A 		0.6
(-2.9)
A 		0.5
(-3)
A 		8
C 4.9
(0.6)
A 		0.6
(-3)
A 		1.7
(-2.1)
A 		7.7
(3)
A 		7
avr 6.1
(3) 		1.2
(-3) 		1.4
(-2.8) 		4.7
(1.3) 		5

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 12
1 2 3 4 5 6 range
A 0.6
(-3)
A 		1.9
(-1.3)
A 		5.3
(3)
A 		3.8
(1.1)
A 		0.9
(-2.6)
A 		2.5
(-0.6)
A 		5
B 1
(-3)
A 		6.6
(3)
A 		1.8
(-2.1)
A 		6.1
(2.5)
A 		1.7
(-2.3)
A 		1.7
(-2.3)
A 		6
C 2.2
(-2.3)
A 		12.8
(3)
A 		1.9
(-2.5)
A 		1
(-2.9)
A 		1.3
(-2.8)
A 		0.8
(-3)
A 		12
avr 1.3
(-3) 		7.1
(3) 		3
(-1.2) 		3.6
(-0.6) 		1.3
(-3) 		1.7
(-2.6) 		6
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 177327_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.18764
Sequence Type Exemplar sequence
Representative Public ID Y39G10AL.A NCBI
Target Description Y39G10AL.A /REP_DB=WormBase Gene ID /WP=CE25266 /CHR=1 /FEA=Sanger Annotation /DEF=(ST.LOUIS) protein_id:AAF59488.1
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Genome Target Overlap based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade B annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_058551
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
Y39G10AL.3.2 ENSEMBL cdna:known chromosome:CEL140:I:2281538:2291184:-1 gene:Y39G10AL.3 A 
Y39G10AL.3.1 ENSEMBL cdna:known chromosome:CEL140:I:2281544:2291092:-1 gene:Y39G10AL.3 A 
NM_058551 NCBI Caenorhabditis elegans Cyclin-Dependent Kinase family member (cdk-7) (cdk-7) mRNA, complete cds. A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
NM_058550 11/11 Negative Strand Matching Probes A 
SNAP00000021533 9/11 Negative Strand Matching Probes None
GENEFINDER00000021545 9/11 Negative Strand Matching Probes None
Y39G10AL.1 11/11 Negative Strand Matching Probes A 
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:2280480-2281809(-) 100.0 100.0
Public Domain and Genome References
Gene Title
Gene Symbol cdk-7
Ensembl Y39G10AL.3
Entrez Gene 171784 Entrez gene
SwissProt Q9Y0G1 EMBL-EBI
WormBase CE30320 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:255909_AT cell division protein kinase, putative at
CANINE_2:CFAAFFX.12456.1.S1_S_AT similar to Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) cfa
DROSOPHILA_2:1630144_AT Cyclin-dependent kinase 7 dm
DROSGENOME1:143832_AT Cyclin-dependent kinase 7 dm
HG-U133_PLUS_2:211297_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HG-U133A:211297_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HG-FOCUS:211297_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HG-U133A_2:211297_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HG-U95AV2:1969_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HC-G110:1969_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HG-U95AV2:33317_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HUGENEFL:L20320_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
U133_X3P:G348242_3P_A_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
MOE430A:1451741_A_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MOUSE430A_2:1451741_A_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MOUSE430_2:1451741_A_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MU11KSUBA:U11822_S_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MG-U74AV2:160658_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MOE430A:1424257_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MOUSE430A_2:1424257_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MOUSE430_2:1424257_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MU19KSUBA:TC19803_AT Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase), mRNA (cDNA clone MGC:6069 IMAGE:3585145) mm
MU19KSUBB:TC32409_S_AT Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase), mRNA (cDNA clone MGC:6069 IMAGE:3585145) mm
RAT230_2:1388171_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RAE230A:1388171_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RT-U34:X83579_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RG-U34A:X83579_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RG-U34C:RC_AI175830_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RAE230B:1397324_AT Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RAT230_2:1397324_AT Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
YEAST_2:1769904_AT Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
6468 protein amino acid phosphorylation inferred from sequence similarity QuickGO AmiGO
9299 mRNA transcription inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
4693 cyclin-dependent protein kinase activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK68887 Cyclin-dependent kinase family protein 7 [Caenorhabditis elegans] ref|NP_490952.2| Cyclin-Dependent Kinase family member (cdk-7) [Caenorhabditis elegans] gb|AAD38186.1| cyclin-dependent kinase 7 homolog [Caenorhabditis elegans] 0.0
blast CAE60292 Hypothetical protein CBG03876 [Caenorhabditis briggsae] 1.0E-167
blast NP_001790 cyclin-dependent kinase 7 [Homo sapiens] gb|AAH00834.1| Cyclin-dependent kinase 7 [Homo sapiens] gb|AAM77799.1| cyclin-dependent kinase 7 [Homo sapiens] sp|P50613|CDK7_HUMAN Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) emb|CAA55785.1| MO15/CDK-activating kinase (CAK) [Homo sapiens] emb|CAA54793.1| CDK activating kinase [Homo sapiens] emb|CAA54508.1| Cdk-activating kinase [Homo sapiens] gb|AAA36657.1| protein serine/threonine kinase 1.0E-104
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-77
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 4.0E-80
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 9.8E-94
Sequence
Target Sequence 
>C. ELEGANS:177327_AT
gggtcgtagggaaatctcaggagctaaaactgttccactgcggcctctgggacaagttcc
agcttctcacagcaaccttcaaactctgcgttcacttcgtcaagcttatcgaaagcctgc
tcatcctgctcttcctggtactcttgccgcttcttctgctctctggccatcaaatcattc
acaatatccataagctcgcttttcaactgttcctcggaatccttgaacttctgccggatt
tcctctgcttcttttctgtgctttttcgcgagctccgagagctcgagattctcagcatgg
agcttctcct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGGTCGTAGGGAAATCTCAGGAGCT 102 403 203 Antisense
GGAGCTAAAACTGTTCCACTGCGGC 295 521 222 Antisense
TGCGGCCTCTGGGACAAGTTCCAGC 672 581 241 Antisense
AGCTTCTCACAGCAACCTTCAAACT 414 79 263 Antisense
GCGTTCACTTCGTCAAGCTTATCGA 396 291 290 Antisense
AGCTTATCGAAAGCCTGCTCATCCT 382 79 305 Antisense
CTCTCTGGCCATCAAATCATTCACA 555 229 361 Antisense
CATAAGCTCGCTTTTCAACTGTTCC 194 213 391 Antisense
TCGGAATCCTTGAACTTCTGCCGGA 702 605 416 Antisense
TTCTTTTCTGTGCTTTTTCGCGAGC 328 691 451 Antisense
AGATTCTCAGCATGGAGCTTCTCCT 237 65 488 Antisense
Sequence Source Affymetrix Proprietary Database