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[177294_at]

Description Y54E10BR.B /REP_DB=WormBase Gene ID /WP=CE22464 /CHR=1 /FEA=Sanger Annotation /DEF=(ST.LOUIS) protein_id:AAF59549.1
Cluster 6grp_total > 13      4grp_total > 13      6grp_cgc > 40      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 168
1 2 3 4 range
A 45.3
(-1.5)
A 		19.9
(-2.4)
A 		4.5
(-3)
A 		172
(3)
A 		168
B 78.4
(3)
A 		61.4
(1.3)
A 		17.1
(-3)
A 		31.3
(-1.6)
A 		61
C 75.6
(-0.5)
A 		26.1
(-2.2)
A 		4.5
(-3)
A 		172.6
(3)
A 		168
avr 66.4
(-0) 		35.8
(-1.6) 		8.7
(-3) 		125.3
(3) 		117

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 40
1 2 3 4 5 6 range
A 34.1
(3)
A 		7.4
(-3)
A 		8.6
(-2.7)
A 		13.3
(-1.7)
A 		11.2
(-2.1)
A 		7.5
(-3)
A 		27
B 17.4
(-2.2)
A 		23.5
(-1.1)
A 		28.9
(-0.1)
A 		45.6
(3)
A 		16.5
(-2.3)
A 		12.9
(-3)
A 		33
C 9.5
(-2.5)
A 		46
(3)
A 		10.4
(-2.4)
A 		6.4
(-3)
A 		8.9
(-2.6)
A 		19.3
(-1)
A 		40
avr 20.3
(0.6) 		25.6
(3) 		16
(-1.3) 		21.8
(1.3) 		12.2
(-3) 		13.2
(-2.6) 		13
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 28
1 2 3 4 range
A 16.5
(0.8)
A 		4.3
(-2.2)
A 		1.2
(-3)
A 		25.2
(3)
A 		24
B 25
(3)
A 		15.2
(0.2)
A 		4
(-3)
A 		6.7
(-2.2)
A 		21
C 25
(2.1)
A 		7.5
(-1.7)
A 		1.6
(-3)
A 		29.1
(3)
A 		28
avr 22.2
(3) 		9
(-1) 		2.3
(-3) 		20.3
(2.4) 		20

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 13
1 2 3 4 5 6 range
A 6.3
(3)
A 		2.6
(-1.9)
A 		1.9
(-2.9)
A 		3.4
(-0.9)
A 		3.4
(-0.9)
A 		1.8
(-3)
A 		5
B 6.1
(-1.9)
A 		7.8
(-0.5)
A 		7
(-1.2)
A 		12.1
(3)
A 		6.7
(-1.4)
A 		4.8
(-3)
A 		7
C 3.5
(-2)
A 		14
(3)
A 		2.7
(-2.3)
A 		1.3
(-3)
A 		2.9
(-2.2)
A 		6.5
(-0.5)
A 		13
avr 5.3
(-1) 		8.1
(3) 		3.9
(-3) 		5.6
(-0.6) 		4.3
(-2.4) 		4.4
(-2.3) 		4
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 177294_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.18751
Sequence Type Exemplar sequence
Representative Public ID Y54E10BR.B NCBI
Target Description Y54E10BR.B /REP_DB=WormBase Gene ID /WP=CE22464 /CHR=1 /FEA=Sanger Annotation /DEF=(ST.LOUIS) protein_id:AAF59549.1
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_058694(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_058694 NCBI Caenorhabditis elegans Modulation Of locomotion Defective family member (mod-5) (mod-5) mRNA, complete cds. 11/11 None
GENEFINDER00000038976 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:3035171:3048515:-1 11/11 None
SNAP00000038973 ENSEMBL cdna:SNAP chromosome:CEL140:I:3035239:3059072:-1 11/11 None
Y54E10BR.7 ENSEMBL cdna:known chromosome:CEL140:I:3035239:3047795:-1 gene:Y54E10BR.7 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:3038567-3044724(-) 92.62 100.0
Public Domain and Genome References
Gene Title
Gene Symbol mod-5
Ensembl Y54E10BR.7
Entrez Gene 171879 Entrez gene
SwissProt Q9N3C7 EMBL-EBI
WormBase CE28995 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.29009.1.S1_S_AT similar to Sodium-dependent serotonin transporter (5HT transporter) (5HTT) cfa
DROSOPHILA_2:1623006_AT Serotonin transporter dm
DROSGENOME1:143621_AT Serotonin transporter dm
CHICKEN:GGA.10763.1.S1_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 gga
HG-U95AV2:34604_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 hs
HG-U133_PLUS_2:207519_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 hs
HG-U133A:207519_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 hs
HG-FOCUS:207519_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 hs
HG-U133A_2:207519_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 hs
HUGENEFL:L05568_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 hs
U133_X3P:G4507042_3P_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 hs
MU11KSUBA:AF013604_S_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 mm
MG-U74AV2:99040_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 mm
MG-U74AV2:161695_F_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 mm
MOE430A:1417150_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 mm
MOUSE430A_2:1417150_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 mm
MOUSE430_2:1417150_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 mm
RN-U34:X63253CDS_S_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 rn
RG-U34A:X63253CDS_S_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 rn
RN-U34:X63995_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 rn
RG-U34A:X63995_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 rn
RAE230A:1368348_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 rn
RAT230_2:1368348_AT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6836 neurotransmitter transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5887 integral to plasma membrane inferred from electronic annotation QuickGO AmiGO
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5328 neurotransmitter:sodium symporter activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAF59549 Modulation of locomotion defective protein 5 [Caenorhabditis elegans] ref|NP_491095.3| Modulation Of locomotion Defective family member (mod-5) [Caenorhabditis elegans] 0.0
blast AAK84832 serotonin reuptake transporter [Caenorhabditis elegans] 0.0
blast CAE60568 Hypothetical protein CBG04197 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000175 EMBL-EBI Sodium:neurotransmitter symporter 1.0E-126
Pfam IPR000175 EMBL-EBI Sodium:neurotransmitter symporter 1.0E-126
Pfam IPR000175 EMBL-EBI Sodium:neurotransmitter symporter 1.6E-69
Pfam IPR000175 EMBL-EBI Sodium:neurotransmitter symporter 1.0E-126
Pfam IPR007087 EMBL-EBI Zn-finger, C2H2 type 1.4E-4
Pfam IPR007087 EMBL-EBI Zn-finger, C2H2 type 4.1E-6
Pfam IPR007087 EMBL-EBI Zn-finger, C2H2 type 3.5E-6
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_491095.3 12 109-128,138-160,181-203,274-296,305-327,350-372,392-414,446-468,488-510,520-542,559-581,601-623
Y54E10BR.7 12 109-128,138-160,181-203,274-296,305-327,350-372,392-414,446-468,488-510,520-542,559-581,601-623
GENEFINDER00000038976 12 163-182,192-214,235-257,328-350,359-381,407-429,505-527,560-582,602-624,634-656,673-695,705-722
SNAP00000038973 11 503-525,546-568,638-660,669-691,714-736,756-778,810-832,852-874,884-906,923-945,965-987
Sequence
Target Sequence 
>C. ELEGANS:177294_AT
atgtctcttctcaccaataaaccgattaatgaggtagttggagaacacgacgcctctcta
atcttcatcgtctacccccaagctctcgcaacaatggattacagttgtttctggtctttc
atctttttcgtcatgctaatcactcttggaatcgactccacttttgctggaatcgaagca
tttatcacgggattctgtgatgagtcgaggtttttgtcgaaaaatcgaaaatggttcgtg
ctggtcatttgcatcatttattacttcctcagctttcccgctatcagctatggtggtcaa
ttcgtgatcccgttcctggatgaatatggagtttctctatcagttctgttcattgtcacc
tgcgaaatgattgcagtctgctggttttacggtgttgatcagttctcaaaagatattcgt
gctatgctgggattctatcctggaatttattggagagtctgctggacgtgttctccggtt
tttataagtgtgatattcattatgactgtctacaatagttcgttcaagccaattcaaatg
gctagctacactttccc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATGTCTCTTCTCACCAATAAACCGA 64 49 1348 Antisense
TTGGAGAACACGACGCCTCTCTAAT 197 709 1385 Antisense
TTTCGTCATGCTAATCACTCTTGGA 216 671 1473 Antisense
TGGAATCGACTCCACTTTTGCTGGA 354 547 1494 Antisense
GGTTCGTGCTGGTCATTTGCATCAT 80 507 1580 Antisense
ATCATTTATTACTTCCTCAGCTTTC 224 31 1600 Antisense
CTTTCCCGCTATCAGCTATGGTGGT 27 223 1620 Antisense
TATGGTGGTCAATTCGTGATCCCGT 662 653 1636 Antisense
TCAGTTCTGTTCATTGTCACCTGCG 461 623 1687 Antisense
TGCAGTCTGCTGGTTTTACGGTGTT 129 575 1719 Antisense
TTCAAATGGCTAGCTACACTTTCCC 314 683 1880 Antisense
Sequence Source Affymetrix Proprietary Database