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[176388_at]

Description Y38F2AR.H /REP_DB=WormBase Gene ID /WP=CE21617 /CHR=4 /FEA=Sanger Annotation /DEF=(ST.LOUIS)
Cluster 6grp_high1_10_10 > 08      6grp_total > 29      4grp_total > 58      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 292
1 2 3 4 range
A 303.7
(-0.2)
P 		409.2
(3)
P 		340.1
(0.9)
P 		213.3
(-3)
A 		196
B 210.2
(-1.3)
P 		331
(1.6)
A 		390.8
(3)
M 		140.1
(-3)
A 		251
C 349.2
(0.5)
P 		432.1
(3)
A 		385.7
(1.6)
P 		232.7
(-3)
A 		199
avr 287.7
(-0.2) 		390.8
(3) 		372.2
(2.4) 		195.4
(-3) 		195

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 251
1 2 3 4 5 6 range
A 231
(1)
P 		177.1
(-2.8)
A 		174.1
(-3)
P 		177.3
(-2.8)
A 		236.4
(1.3)
P 		260.4
(3)
P 		86
B 342.5
(3)
P 		209.2
(-3)
P 		223.1
(-2.4)
P 		272
(-0.2)
P 		288.9
(0.6)
P 		237.6
(-1.7)
P 		133
C 404.4
(3)
P 		168.8
(-2.6)
A 		322.6
(1)
P 		153.5
(-3)
A 		329.3
(1.2)
P 		218.6
(-1.4)
P 		251
avr 326
(3) 		185
(-3) 		239.9
(-0.7) 		200.9
(-2.3) 		284.9
(1.3) 		238.9
(-0.7) 		141
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 105
1 2 3 4 range
A 110.6
(3)
P 		88.8
(1.4)
P 		88.9
(1.4)
P 		31.2
(-3)
A 		79
B 67
(0.7)
P 		81.7
(2.1)
A 		90.6
(3)
M 		29.8
(-3)
A 		61
C 115.6
(1.8)
P 		124.2
(2.4)
A 		134.4
(3)
P 		39.2
(-3)
A 		95
avr 97.7
(2.4) 		98.2
(2.5) 		104.6
(3) 		33.4
(-3) 		71

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 119
1 2 3 4 5 6 range
A 42.6
(-2.2)
P 		63
(1.5)
A 		37.9
(-3)
P 		45
(-1.7)
A 		71.3
(3)
P 		63.4
(1.6)
P 		33
B 119.2
(3)
P 		69.6
(-1.6)
P 		54.2
(-3)
P 		72
(-1.4)
P 		117.4
(2.8)
P 		88.6
(0.2)
P 		65
C 149.9
(3)
P 		51.5
(-2)
A 		82.1
(-0.4)
P 		30.9
(-3)
A 		106.6
(0.8)
P 		73.2
(-0.9)
P 		119
avr 103.9
(3) 		61.4
(-1.7) 		58.1
(-2) 		49.3
(-3) 		98.4
(2.4) 		75.1
(-0.2) 		55
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 176388_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.19312
Sequence Type Exemplar sequence
Representative Public ID Y38F2AR.H NCBI
Target Description Y38F2AR.H /REP_DB=WormBase Gene ID /WP=CE21617 /CHR=4 /FEA=Sanger Annotation /DEF=(ST.LOUIS)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067790(9)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067790 NCBI Caenorhabditis elegans Y38F2AR.7 (Y38F2AR.7) mRNA, complete cds. 9/11 A 
GENEFINDER00000033673 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:2333967:2342876:-1 9/11 None
Y38F2AR.7 ENSEMBL cdna:known chromosome:CEL140:IV:2333860:2342696:-1 gene:Y38F2AR.7 9/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000014005 3/11 Cross Hyb Matching Probes None
SNAP00000022295 2/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:2333972-2343763(-) 77.61 92.08
Public Domain and Genome References
Gene Title
Ensembl Y38F2AR.7
Entrez Gene 177021 Entrez gene
SwissProt Q95XS8 EMBL-EBI
WormBase CE37282 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1583921_AT similar to Paraplegin (Spastic paraplegia protein 7) cfa
CANINE:1583920_AT similar to Paraplegin (Spastic paraplegia protein 7) cfa
CANINE_2:CFA.11713.1.A1_AT similar to Paraplegin (Spastic paraplegia protein 7) cfa
CANINE_2:CFA.11713.1.A2_AT similar to Paraplegin (Spastic paraplegia protein 7) cfa
CANINE_2:CFAAFFX.30362.1.S1_S_AT similar to Paraplegin (Spastic paraplegia protein 7) cfa
DROSOPHILA_2:1626460_AT dm
DROSGENOME1:144043_AT dm
CHICKEN:GGA.4857.1.S1_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) gga
CHICKEN:GGA.4857.2.S1_A_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) gga
HG-U133A:202104_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133_PLUS_2:202104_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-FOCUS:202104_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133A_2:202104_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HUGENEFL:X65784_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
U133_X3P:HS.296847.2.A1_3P_A_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
U133_X3P:HS.272480.0.S1_3P_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
U133_X3P:HS.183957.0.A1_3P_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133A_2:214494_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-FOCUS:214494_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133_PLUS_2:214494_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133A:214494_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133_PLUS_2:230884_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133B:230884_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133_PLUS_2:230885_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133B:230885_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133_PLUS_2:235325_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133B:235325_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U95AV2:31673_S_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U95E:74333_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U95E:85222_R_AT spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HU35KSUBC:RC_N79813_AT Spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
U133_X3P:HS2.406971.1.S1_3P_AT Spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U133_PLUS_2:1557409_AT Spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U95B:45086_AT Spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
HG-U95D:84838_AT Spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) hs
MOUSE430_2:1427166_A_AT spastic paraplegia 7 homolog (human) mm
MOE430A:1427166_A_AT spastic paraplegia 7 homolog (human) mm
MOUSE430A_2:1427166_A_AT spastic paraplegia 7 homolog (human) mm
MG-U74BV2:109827_AT spastic paraplegia 7 homolog (human) mm
MG-U74BV2:162776_F_AT spastic paraplegia 7 homolog (human) mm
MOE430B:1441585_AT Spastic paraplegia 7 homolog (human) (Spg7), mRNA mm
MOUSE430_2:1441585_AT Spastic paraplegia 7 homolog (human) (Spg7), mRNA mm
MG-U74BV2:113826_AT Spastic paraplegia 7 homolog (human) (Spg7), mRNA mm
MU19KSUBA:TC19598_AT Spastic paraplegia 7 homolog (human) (Spg7), mRNA mm
MU19KSUBB:TC34201_AT Spastic paraplegia 7 homolog (human) (Spg7), mRNA mm
MU19KSUBB:TC34201_G_AT Spastic paraplegia 7 homolog (human) (Spg7), mRNA mm
RAT230_2:1374839_AT spastic paraplegia 7 homolog (human) rn
RAE230A:1374839_AT spastic paraplegia 7 homolog (human) rn
RAE230B:1395985_AT spastic paraplegia 7 homolog (human) rn
RAT230_2:1395985_AT spastic paraplegia 7 homolog (human) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4222 metalloendopeptidase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_500191 Y38F2AR.7 [Caenorhabditis elegans] gb|AAK68448.2| Hypothetical protein Y38F2AR.7 [Caenorhabditis elegans] 0.0
blast EAL31599 GA15413-PA [Drosophila pseudoobscura] 1.0E-137
blast XP_798395 PREDICTED: similar to Paraplegin (Spastic paraplegia protein 7) [Strongylocentrotus purpuratus] 1.0E-137
blast XP_798395 PREDICTED: similar to Paraplegin (Spastic paraplegia protein 7) [Strongylocentrotus purpuratus] 1.0E-120
blast XP_546777 PREDICTED: similar to Paraplegin (Spastic paraplegia protein 7) [Canis familiaris] 1.0E-120
Protein Domains
Database ID Description E-Value
Pfam IPR000642 EMBL-EBI Peptidase M41 2.6E-91
Pfam IPR003959 EMBL-EBI AAA ATPase, central region 2.8E-62
Pfam IPR000642 EMBL-EBI Peptidase M41 2.6E-91
Pfam IPR003959 EMBL-EBI AAA ATPase, central region 1.6E-84
Sequence
Target Sequence 
>C. ELEGANS:176388_AT
gaagtttcctgcaaacaattcctcagaattcctcaaaaatctaaaaaattttatcaaaaa
aatttttttttttgaaatttttggcccaaaattaccccaaaaagtaacaatcatcccccg
aacgtctgcagctctcggatttgctcaatattctccacgtgacaaacatctcttctcaaa
agatgagcttttcgatcgaatgtgcatgatgctcggtggccgatgtgctgagaacctgaa
attcggccgagccacgtcaggagcacaagatgacctgcaaaaagtgacaaaatcggcgta
tgctcaagtgaagctgtatggaatgagctcaattgttgggccgctatcgtttccgaatac
tgaaggatttcaaattaaaccgtattcgaaaaaattcgcgtcgacttttgatcaagaagc
cacgctgattgtggcaaaagccaacgaggcgacaactgatttgatcaaaaataatatgga
taaacttgaaacgatcgcccaggcactgctgaaacgtgaagtgctcaactatgaagatgt
caagaaactcatcggaacacccaaattcggcgacaaacacgtcattgat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAAGTTTCCTGCAAACAATTCCTCA 181 337 1371 Antisense
AATTCCTCAGAATTCCTCAAAAATC 696 177 1387 Antisense
CCACGTGACAAACATCTCTTCTCAA 694 273 1525 Antisense
TGAGCTCAATTGTTGGGCCGCTATC 668 567 1694 Antisense
GCCGCTATCGTTTCCGAATACTGAA 46 285 1710 Antisense
AGCCAACGAGGCGACAACTGATTTG 20 85 1809 Antisense
TAAACTTGAAACGATCGCCCAGGCA 36 639 1851 Antisense
CGCCCAGGCACTGCTGAAACGTGAA 316 257 1866 Antisense
GTCAAGAAACTCATCGGAACACCCA 296 463 1909 Antisense
CATCGGAACACCCAAATTCGGCGAC 107 209 1920 Antisense
ATTCGGCGACAAACACGTCATTGAT 352 9 1935 Antisense
Sequence Source Affymetrix Proprietary Database