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[176306_at]

Description Y92H12A.G /REP_DB=WormBase Gene ID /WP=CE26605 /CHR=1 /FEA=Sanger Annotation /DEF=(ST.LOUIS)
Cluster 6grp_total > 18      4grp_total > 54      6grp_cgc > 11      6grp_cgc_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 51
1 2 3 4 range
A 4.1
(-3)
A 		5.7
(-2.3)
A 		17.5
(3)
A 		14
(1.4)
A 		13
B 54.1
(3)
A 		8.6
(-2.4)
A 		8.8
(-2.3)
A 		3.1
(-3)
A 		51
C 38.4
(3)
A 		37.2
(2.8)
A 		32.8
(1.8)
A 		9.4
(-3)
A 		29
avr 32.2
(3) 		17.2
(-0.8) 		19.7
(-0.2) 		8.8
(-3) 		23

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 41
1 2 3 4 5 6 range
A 4.2
(1)
A 		5
(3)
A 		3.1
(-1.8)
A 		2.9
(-2.3)
A 		2.6
(-3)
A 		3.6
(-0.5)
A 		2
B 3.2
(-1.9)
A 		8.3
(3)
A 		3.1
(-2)
A 		3.8
(-1.4)
A 		2.1
(-3)
A 		2.1
(-3)
A 		6
C 42.9
(3)
A 		3.8
(-2.8)
A 		3.7
(-2.8)
A 		3.6
(-2.9)
A 		2.6
(-3)
A 		2.8
(-3)
A 		40
avr 16.8
(3) 		5.7
(-1.6) 		3.3
(-2.6) 		3.4
(-2.6) 		2.4
(-3) 		2.8
(-2.8) 		14
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 17
1 2 3 4 range
A 1.5
(-2.5)
A 		1.2
(-3)
A 		4.6
(3)
A 		2
(-1.6)
A 		3
B 17.3
(3)
A 		2.1
(-2.5)
A 		2
(-2.5)
A 		0.7
(-3)
A 		17
C 12.7
(3)
A 		10.7
(1.9)
A 		11.4
(2.3)
A 		1.6
(-3)
A 		11
avr 10.5
(3) 		4.7
(-0.8) 		6
(0) 		1.4
(-3) 		9

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 15
1 2 3 4 5 6 range
A 0.8
(-2.5)
A 		1.8
(3)
A 		0.7
(-3)
A 		0.7
(-3)
A 		0.8
(-2.5)
A 		0.9
(-1.9)
A 		1
B 1.1
(-2.1)
A 		2.7
(3)
A 		0.8
(-3)
A 		1
(-2.4)
A 		0.9
(-2.7)
A 		0.8
(-3)
A 		2
C 15.9
(3)
A 		1.1
(-2.8)
A 		0.9
(-2.9)
A 		0.7
(-3)
A 		0.8
(-3)
A 		0.9
(-2.9)
A 		15
avr 5.9
(3) 		1.9
(-1.7) 		0.8
(-3) 		0.8
(-3) 		0.8
(-3) 		0.9
(-2.9) 		5
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 176306_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.18645
Sequence Type Exemplar sequence
Representative Public ID Y92H12A.G NCBI
Target Description Y92H12A.G /REP_DB=WormBase Gene ID /WP=CE26605 /CHR=1 /FEA=Sanger Annotation /DEF=(ST.LOUIS)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_058465(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_058465 NCBI Caenorhabditis elegans SRC oncogene related family member (src-1) (src-1) mRNA, complete cds. 11/11 None
Y92H12A.1 ENSEMBL cdna:known chromosome:CEL140:I:1566934:1580076:1 gene:Y92H12A.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000039128 6/11 Cross Hyb Matching Probes None
GENEFINDER00000039126 4/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:1577096-1579281(+) 78.4 100.0
Public Domain and Genome References
Gene Title
Gene Symbol src-1
Ensembl Y92H12A.1
Entrez Gene 171722 Entrez gene
SwissProt Q9BKW3 EMBL-EBI
WormBase CE31390 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1604052_AT similar to protein-tyrosine kinase fyn isoform c cfa
CANINE_2:CFA.20235.1.S1_S_AT similar to protein-tyrosine kinase fyn isoform c cfa
CHICKEN:GGA.4350.1.S1_AT FYN oncogene related to SRC, FGR, YES gga
CHICKEN:GGA.4350.1.S2_AT FYN oncogene related to SRC, FGR, YES gga
HG-U133A:212486_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133A_2:212486_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133_PLUS_2:212486_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-U95AV2:2039_S_AT FYN oncogene related to SRC, FGR, YES hs
HC-G110:2039_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-U95AV2:40481_R_AT FYN oncogene related to SRC, FGR, YES hs
HG-U95AV2:40480_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133_PLUS_2:210105_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133A:210105_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-FOCUS:210105_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133A_2:210105_S_AT FYN oncogene related to SRC, FGR, YES hs
HUGENEFL:M14676_AT FYN oncogene related to SRC, FGR, YES hs
U133_X3P:G181171_3P_A_AT FYN oncogene related to SRC, FGR, YES hs
U133_X3P:HS.169370.3.A1_3P_A_AT FYN oncogene related to SRC, FGR, YES hs
U133_X3P:HS.169370.1.A2_3P_A_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133A_2:216033_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133_PLUS_2:216033_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133A:216033_S_AT FYN oncogene related to SRC, FGR, YES hs
HG-U95AV2:40479_AT FYN oncogene related to SRC, FGR, YES hs
U133_X3P:HS2.209652.1.S1_3P_X_AT FYN oncogene related to SRC, FGR, YES hs
U133_X3P:HS.208965.0.A1_3P_AT FYN oncogene related to SRC, FGR, YES hs
U133_X3P:1559101_3P_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133_PLUS_2:1559101_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133_PLUS_2:243006_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133B:243006_AT FYN oncogene related to SRC, FGR, YES hs
HG-U95D:70246_AT FYN oncogene related to SRC, FGR, YES hs
HG-U95E:70845_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133A_2:217697_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133_PLUS_2:217697_AT FYN oncogene related to SRC, FGR, YES hs
HG-U133A:217697_AT FYN oncogene related to SRC, FGR, YES hs
HU35KSUBC:RC_H96234_AT FYN oncogene related to SRC, FGR, YES hs
HU35KSUBD:RC_AA487159_AT FYN oncogene related to SRC, FGR, YES hs
U133_X3P:HS.282693.0.A1_3P_AT FYN oncogene related to SRC, FGR, YES hs
MU11KSUBA:U70324_S_AT Fyn proto-oncogene mm
MU11KSUBB:MSA.10916.0_S_AT Fyn proto-oncogene mm
MG-U74AV2:100133_AT Fyn proto-oncogene mm
MG-U74CV2:169541_I_AT Fyn proto-oncogene mm
MOE430A:1417558_AT Fyn proto-oncogene mm
MOUSE430A_2:1417558_AT Fyn proto-oncogene mm
MOUSE430_2:1417558_AT Fyn proto-oncogene mm
MOE430A:1448765_AT Fyn proto-oncogene mm
MOUSE430A_2:1448765_AT Fyn proto-oncogene mm
MOUSE430_2:1448765_AT Fyn proto-oncogene mm
MOE430B:1441647_AT Fyn proto-oncogene, mRNA (cDNA clone MGC:29134 IMAGE:3602546) mm
MOUSE430_2:1441647_AT Fyn proto-oncogene, mRNA (cDNA clone MGC:29134 IMAGE:3602546) mm
MU11KSUBB:MSA.35947.0_S_AT Fyn proto-oncogene, mRNA (cDNA clone MGC:29134 IMAGE:3602546) mm
MU19KSUBA:TC18155_S_AT Fyn proto-oncogene, mRNA (cDNA clone MGC:29134 IMAGE:3602546) mm
MU19KSUBB:TC26261_AT Fyn proto-oncogene, mRNA (cDNA clone MGC:29134 IMAGE:3602546) mm
MU19KSUBB:TC34425_AT Fyn proto-oncogene, mRNA (cDNA clone MGC:29134 IMAGE:3602546) mm
MU19KSUBB:TC34425_G_AT Fyn proto-oncogene, mRNA (cDNA clone MGC:29134 IMAGE:3602546) mm
RN-U34:RC_AI009191_AT fyn proto-oncogene rn
RG-U34A:RC_AI009191_AT fyn proto-oncogene rn
RAE230A:1373683_AT fyn proto-oncogene rn
RAT230_2:1373683_AT fyn proto-oncogene rn
RAE230A:1369103_AT fyn proto-oncogene rn
RAT230_2:1369103_AT fyn proto-oncogene rn
RAE230B:1395926_AT Fyn proto-oncogene rn
RAT230_2:1395926_AT Fyn proto-oncogene rn
RG-U34C:RC_AI230396_AT Fyn proto-oncogene rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK29735 Src oncogene related protein 1 [Caenorhabditis elegans] ref|NP_490866.3| SRC oncogene related family member (src-1) [Caenorhabditis elegans] 0.0
blast AAN31394 protein tyrosine kinase [Caenorhabditis elegans] gb|AAL84635.1| SRC-1 [Caenorhabditis elegans] 0.0
blast CAE74507 Hypothetical protein CBG22259 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 6.0E-15
hanks 2.1.14 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; MLCK-K 4.0E-69
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 2.5E-35
Pfam IPR001452 EMBL-EBI SH3 2.9E-21
Pfam IPR000719 EMBL-EBI Protein kinase 1.3E-80
Sequence
Target Sequence 
>C. ELEGANS:176306_AT
gataaatggctcacttcttcaatatcttcgaaccgacggaagcaccctcggaattcaggc
gctcgtcgatatggccgcacaaattgcgaacggaatgatgtatttggaggagaggaagct
tgtgcacagagatttggccgctcgtaacgttcttgtcggagataagatttccggagttcc
agttgttaaagttgccgactttggtttggcgcgaaaattgatggaagaggacatttacga
ggcacgaaccggcgcgaaattcccgattaaatggacggcacccgaggcggcgacttgtgg
aaattttacggtgaaaagtgatgtatggtcgtatggtatcttgttatatgagattatgac
aaagggacaggttccgtatccgggaatgcacaatcgtgaagtcgtcgaacaagtcgagct
gggctaccgtatgccaatgccacgtggctgcccggagcaaatctacgaagaagtactgct
caaatgttgggataagacgcccgatcggcggccgactttcgacactttatatcac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GATAAATGGCTCACTTCTTCAATAT 320 423 333 Antisense
ATTCAGGCGCTCGTCGATATGGCCG 667 7 385 Antisense
GCTTGTGCACAGAGATTTGGCCGCT 299 307 450 Antisense
CCGCTCGTAACGTTCTTGTCGGAGA 307 263 470 Antisense
GTTGCCGACTTTGGTTTGGCGCGAA 376 439 523 Antisense
CACGAACCGGCGCGAAATTCCCGAT 352 1 575 Antisense
GGACAGGTTCCGTATCCGGGAATGC 17 525 697 Antisense
CAAGTCGAGCTGGGCTACCGTATGC 656 183 742 Antisense
CCGTATGCCAATGCCACGTGGCTGC 33 253 759 Antisense
TGGCTGCCCGGAGCAAATCTACGAA 615 543 777 Antisense
GCCGACTTTCGACACTTTATATCAC 307 285 843 Antisense
Sequence Source Affymetrix Proprietary Database