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[175761_s_at] pyridine nucleotide-disulphide oxidoreductase

Description g5670196 /REP_DB=GenBank Identifier /GB=AF162693.1 /PROTEIN_GB=AAD46625.1 /CHR=4 /FEA=Mapped Transcript /DEF=thioredoxin reductase homolog
Cluster 4grp_high_8_8 > 25      6grp_total > 27      4grp_total > 39      6grp_cgc > 06      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 226
1 2 3 4 range
A 321.9
(3)
P 		197.1
(-1.8)
P 		165.8
(-3)
A 		174
(-2.7)
P 		156
B 347.3
(3)
P 		157.4
(-2.3)
P 		133.3
(-3)
P 		201.2
(-1.1)
P 		214
C 359.2
(3)
P 		175.3
(-2.3)
P 		150.8
(-3)
P 		230.9
(-0.7)
P 		208
avr 342.8
(3) 		176.6
(-2.2) 		150
(-3) 		202
(-1.4) 		193

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 181
1 2 3 4 5 6 range
A 174.8
(3)
P 		54
(-3)
A 		70.8
(-2.2)
A 		59
(-2.8)
A 		105.1
(-0.5)
A 		70.3
(-2.2)
A 		121
B 197.4
(3)
P 		141.2
(0.5)
P 		80.3
(-2.1)
P 		60.5
(-3)
M 		89
(-1.8)
M 		103.7
(-1.1)
P 		137
C 194.5
(3)
P 		153
(1.6)
P 		109.3
(0.1)
A 		52.9
(-1.8)
A 		16.3
(-3)
A 		134.2
(1)
P 		178
avr 188.9
(3) 		116.1
(-0.3) 		86.8
(-1.7) 		57.5
(-3) 		70.1
(-2.4) 		102.7
(-0.9) 		131
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 93
1 2 3 4 range
A 117.2
(3)
P 		42.8
(-1.9)
P 		43.4
(-1.8)
A 		25.5
(-3)
P 		92
B 110.8
(3)
P 		38.9
(-2.4)
P 		30.9
(-3)
P 		42.9
(-2.1)
P 		80
C 118.9
(3)
P 		50.4
(-2.1)
P 		52.5
(-2)
P 		38.9
(-3)
P 		80
avr 115.6
(3) 		44
(-2.4) 		42.3
(-2.5) 		35.8
(-3) 		80

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 67
1 2 3 4 5 6 range
A 32.2
(3)
P 		19.2
(-1.5)
A 		15.4
(-2.9)
A 		15
(-3)
A 		31.7
(2.8)
A 		17.1
(-2.3)
A 		17
B 68.7
(3)
P 		47
(0.5)
P 		19.5
(-2.6)
P 		16
(-3)
M 		36.1
(-0.7)
M 		38.7
(-0.4)
P 		53
C 72.1
(3)
P 		46.7
(0.7)
P 		27.8
(-1)
A 		10.6
(-2.5)
A 		5.3
(-3)
A 		44.9
(0.6)
P 		67
avr 57.7
(3) 		37.6
(0.2) 		20.9
(-2) 		13.9
(-3) 		24.4
(-1.6) 		33.6
(-0.3) 		44
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 175761_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.19856
Sequence Type Exemplar sequence
Representative Public ID 5670196 NCBI
Target Description g5670196 /REP_DB=GenBank Identifier /GB=AF162693.1 /PROTEIN_GB=AAD46625.1 /CHR=4 /FEA=Mapped Transcript /DEF=thioredoxin reductase homolog
Cluster Evidence This cluster is supported by a Mapped Transcript.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068684(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068684 NCBI Caenorhabditis elegans ThioRedoXin Reductase family member (trxr-1) (trxr-1) mRNA, complete cds. 11/11 A 
C06G3.7 ENSEMBL cdna:known chromosome:CEL140:IV:7011987:7016743:1 gene:C06G3.7 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:7013511-7016508(+) 100.0 100.0
Public Domain and Genome References
Gene Title pyridine nucleotide-disulphide oxidoreductase
Gene Symbol trxr-1
Ensembl C06G3.7
Entrez Gene 177466 Entrez gene
SwissProt Q17745 EMBL-EBI
WormBase CE34250 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1588184_AT similar to thioredoxin reductase 1 cfa
CANINE:1588072_AT similar to thioredoxin reductase 1 cfa
CANINE_2:CFA.14903.1.S1_AT similar to thioredoxin reductase 1 cfa
CANINE_2:CFA.17422.1.S1_AT similar to thioredoxin reductase 1 cfa
CANINE_2:CFA.8894.1.A1_S_AT similar to thioredoxin reductase 1 cfa
CANINE_2:CFAAFFX.3839.1.S1_S_AT similar to thioredoxin reductase 1 cfa
CANINE_2:CFAAFFX.3844.1.S1_AT similar to thioredoxin reductase 1 cfa
CHICKEN:GGAAFFX.8063.3.S1_AT thioredoxin reductase 1 gga
CHICKEN:GGAAFFX.8063.4.S1_AT thioredoxin reductase 1 gga
CHICKEN:GGAAFFX.8063.5.S1_S_AT thioredoxin reductase 1 gga
HG-U95AV2:39425_AT thioredoxin reductase 1 hs
HG-U133_PLUS_2:201266_AT thioredoxin reductase 1 hs
HG-U133A:201266_AT thioredoxin reductase 1 hs
HG-FOCUS:201266_AT thioredoxin reductase 1 hs
HG-U133A_2:201266_AT thioredoxin reductase 1 hs
HUGENEFL:X91247_AT thioredoxin reductase 1 hs
U133_X3P:G4507746_3P_AT thioredoxin reductase 1 hs
MOUSE430A_2:1421529_A_AT thioredoxin reductase 1 mm
MOUSE430_2:1421529_A_AT thioredoxin reductase 1 mm
MOE430A:1421529_A_AT thioredoxin reductase 1 mm
MU11KSUBA:AA408677_RC_S_AT thioredoxin reductase 1 mm
MG-U74AV2:99985_AT thioredoxin reductase 1 mm
MOE430A:1424487_X_AT thioredoxin reductase 1 mm
MOUSE430A_2:1424487_X_AT thioredoxin reductase 1 mm
MOUSE430_2:1424487_X_AT thioredoxin reductase 1 mm
MOE430A:1424486_A_AT thioredoxin reductase 1 mm
MOUSE430A_2:1424486_A_AT thioredoxin reductase 1 mm
MOUSE430_2:1424486_A_AT thioredoxin reductase 1 mm
RG-U34A:RC_AA891286_AT thioredoxin reductase 1 rn
RG-U34A:U63923_AT thioredoxin reductase 1 rn
RAE230A:1386958_AT thioredoxin reductase 1 rn
RAT230_2:1386958_AT thioredoxin reductase 1 rn
RAE230A:1398791_AT thioredoxin reductase 1 rn
RAT230_2:1398791_AT thioredoxin reductase 1 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5737 cytoplasm inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
15036 disulfide oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
16491 oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
16654 oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor inferred from electronic annotation QuickGO AmiGO
46872 metal ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast Q17745 Thioredoxin reductase (TR-Se) (TRR) 0.0
blast AAB03136 Thioredoxin reductase protein 1 [Caenorhabditis elegans] ref|NP_501085.2| ThioRedoXin Reductase family member (trxr-1) [Caenorhabditis elegans] gb|AAD41826.1| thioredoxin reductase [Caenorhabditis elegans] 0.0
blast CAE61785 Hypothetical protein CBG05747 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR004099 EMBL-EBI Pyridine nucleotide-disulphide oxidoreductase dimerisation domain 1.6E-42
Pfam IPR001327 EMBL-EBI FAD-dependent pyridine nucleotide-disulphide oxidoreductase 7.7E-67
Sequence
Target Sequence 
>C. ELEGANS:175761_S_AT
tcatcacctactctcttcaaaattggaccgtcggtggtcgctagtagaggcagctttgtg
acgacctttggctaaactccatcgtgagcgcctctggtctgatgcgcctccaaaacgtcc
accacccctgatgatttgtttattatagtttgcattgtattttcgaatcttcagggttgt
ttgttcttgacaattgccaatttttctaagcgaaaagtttgatttaattttattctactt
ggcaattttcaaaaacgaacaattattctcttatccagtgtttaagtatgtcctctcact
tttttttcaatttcaatcccgtacttct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCATCACCTACTCTCTTCAAAATTG 692 619 1722 Antisense
AATTGGACCGTCGGTGGTCGCTAGT 205 173 1742 Antisense
GGTCGCTAGTAGAGGCAGCTTTGTG 649 501 1757 Antisense
GCTTTGTGACGACCTTTGGCTAAAC 624 299 1774 Antisense
TTGGCTAAACTCCATCGTGAGCGCC 442 709 1789 Antisense
CACCACCCCTGATGATTTGTTTATT 104 203 1841 Antisense
GTTTGCATTGTATTTTCGAATCTTC 336 451 1869 Antisense
GAATCTTCAGGGTTGTTTGTTCTTG 205 329 1886 Antisense
GACAATTGCCAATTTTTCTAAGCGA 197 365 1910 Antisense
TAAGTATGTCCTCTCACTTTTTTTT 402 637 2004 Antisense
TTTTCAATTTCAATCCCGTACTTCT 172 675 2025 Antisense
Sequence Source GenBank