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[175588_s_at] protein tyrosine kinase

Description CE354 /REP_DB=TREMBL Accession /GB=T00354 /CHR=X /FEA=Genomic Cluster /DEF=wEST01075 Early embryo, Stratagene (cat. no. 937007) Caenorhabditis elegans cDNA clone CEESE44, mRNA sequence.
Cluster 6grp_highest_10_10 > 23      6grp_high1_10_10 > 02      4grp_high_8_8 > 44      6grp_highest_nonorm > 80      6grp_total > 34      4grp_total > 51      6grp_highest_sub > 01_02_03      6grp_high1_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 214
1 2 3 4 range
A 174.8
(0.8)
P 		236.8
(3)
P 		184.8
(1.1)
P 		69
(-3)
A 		168
B 168.2
(-1.5)
P 		257.5
(3)
P 		176.6
(-1.1)
P 		138.5
(-3)
P 		119
C 235.3
(-0.2)
P 		283
(3)
P 		268.5
(2)
P 		192.5
(-3)
P 		91
avr 192.8
(-0.2) 		259.1
(3) 		210
(0.7) 		133.3
(-3) 		126

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 307
1 2 3 4 5 6 range
A 225.7
(1.6)
P 		130.1
(-2)
P 		264.5
(3)
P 		134
(-1.9)
P 		180.3
(-0.1)
P 		103.1
(-3)
P 		161
B 351.3
(1.7)
P 		351.9
(1.7)
P 		409.7
(3)
P 		138.5
(-3)
P 		152.2
(-2.7)
P 		266.7
(-0.2)
P 		271
C 223.4
(0.6)
P 		292.3
(3)
P 		171.8
(-1.2)
P 		211.2
(0.1)
P 		121.6
(-3)
P 		201.9
(-0.2)
P 		171
avr 266.8
(2.3) 		258.1
(1.9) 		282
(3) 		161.2
(-2.5) 		151.4
(-3) 		190.6
(-1.2) 		131
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 84
1 2 3 4 range
A 63.7
(3)
P 		51.4
(1.6)
P 		48.3
(1.3)
P 		10.1
(-3)
A 		54
B 53.6
(1.2)
P 		63.6
(3)
P 		40.9
(-1)
P 		29.5
(-3)
P 		34
C 77.9
(1.5)
P 		81.4
(1.8)
P 		93.6
(3)
P 		32.5
(-3)
P 		61
avr 65.1
(2.9) 		65.5
(3) 		60.9
(2.3) 		24
(-3) 		42

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 97
1 2 3 4 5 6 range
A 41.6
(0)
P 		46.3
(0.9)
P 		57.6
(3)
P 		34
(-1.4)
P 		54.4
(2.4)
P 		25.1
(-3)
P 		33
B 122.2
(3)
P 		117.1
(2.6)
P 		99.5
(1.4)
P 		36.7
(-3)
P 		61.8
(-1.2)
P 		99.5
(1.4)
P 		86
C 82.8
(2.2)
P 		89.2
(3)
P 		43.7
(-2.5)
P 		42.5
(-2.6)
P 		39.3
(-3)
P 		67.6
(0.4)
P 		50
avr 82.2
(2.7) 		84.2
(3) 		66.9
(0.8) 		37.7
(-3) 		51.8
(-1.2) 		64.1
(0.4) 		47
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 175588_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.22290
Sequence Type Exemplar sequence
Representative Public ID CE354 NCBI
Target Description CE354 /REP_DB=TREMBL Accession /GB=T00354 /CHR=X /FEA=Genomic Cluster /DEF=wEST01075 Early embryo, Stratagene (cat. no. 937007) Caenorhabditis elegans cDNA clone CEESE44, mRNA sequence.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_078268(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_078268 NCBI Caenorhabditis elegans F38E9.5 (F38E9.5) mRNA, complete cds. 11/11 A 
GENEFINDER00000030346 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:16446400:16450804:1 11/11 None
SNAP00000030335 ENSEMBL cdna:SNAP chromosome:CEL140:X:16447775:16450804:1 11/11 None
F38E9.5.2 ENSEMBL cdna:known chromosome:CEL140:X:16446115:16451250:1 gene:F38E9.5 11/11 A 
F38E9.5.1 ENSEMBL cdna:known chromosome:CEL140:X:16446115:16451248:1 gene:F38E9.5 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:16450399-16450928(+) 100.0 100.0
Public Domain and Genome References
Gene Title protein tyrosine kinase
Ensembl F38E9.5
Entrez Gene 181711 Entrez gene
SwissProt Q20173 EMBL-EBI
WormBase CE28307 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.20762.1.S1_S_AT similar to twinfilin isoform 1 cfa
CANINE_2:CFAAFFX.15169.1.S1_AT similar to twinfilin isoform 1 cfa
DROSOPHILA_2:1627488_AT twinfilin dm
DROSGENOME1:154805_AT twinfilin dm
CHICKEN:GGAAFFX.11804.1.S1_AT PTK9 protein tyrosine kinase 9 gga
CHICKEN:GGAAFFX.6023.1.S1_AT PTK9 protein tyrosine kinase 9 gga
HG-U95AV2:1064_AT PTK9 protein tyrosine kinase 9 hs
HC-G110:1064_AT PTK9 protein tyrosine kinase 9 hs
HG-U133_PLUS_2:201745_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A:201745_AT PTK9 protein tyrosine kinase 9 hs
HG-FOCUS:201745_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A_2:201745_AT PTK9 protein tyrosine kinase 9 hs
HG-U133_PLUS_2:214007_S_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A_2:214007_S_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A:214007_S_AT PTK9 protein tyrosine kinase 9 hs
HUGENEFL:U02680_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:G4506274_3P_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:HS.82643.1.S1_3P_A_AT PTK9 protein tyrosine kinase 9 hs
HG-U133_PLUS_2:214008_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A_2:214008_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A:214008_AT PTK9 protein tyrosine kinase 9 hs
HG-U133_PLUS_2:243033_AT PTK9 protein tyrosine kinase 9 hs
HG-U133B:243033_AT PTK9 protein tyrosine kinase 9 hs
HG-U133_PLUS_2:244199_AT PTK9 protein tyrosine kinase 9 hs
HG-U133B:244199_AT PTK9 protein tyrosine kinase 9 hs
HG-U95E:68000_AT PTK9 protein tyrosine kinase 9 hs
HG-U95E:69999_R_AT PTK9 protein tyrosine kinase 9 hs
HG-U95E:70002_F_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:HS.189075.0.S1_3P_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:HS.202492.0.A1_3P_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:HS.202492.0.A1_3P_X_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:HS.82643.1.A1_3P_AT PTK9 protein tyrosine kinase 9 hs
MG-U74AV2:93646_AT protein tyrosine kinase 9 mm
MG-U74BV2:162915_AT protein tyrosine kinase 9 mm
MOE430A:1420873_AT protein tyrosine kinase 9 mm
MOUSE430A_2:1420873_AT protein tyrosine kinase 9 mm
MOUSE430_2:1420873_AT protein tyrosine kinase 9 mm
MOE430A:1420875_AT protein tyrosine kinase 9 mm
MOUSE430A_2:1420875_AT protein tyrosine kinase 9 mm
MOUSE430_2:1420875_AT protein tyrosine kinase 9 mm
MOE430A:1420874_AT protein tyrosine kinase 9 mm
MOUSE430A_2:1420874_AT protein tyrosine kinase 9 mm
MOUSE430_2:1420874_AT protein tyrosine kinase 9 mm
MU19KSUBC:TC40025_AT Protein tyrosine kinase 9, mRNA (cDNA clone MGC:13938 IMAGE:3979221) mm
MU19KSUBC:TC40025_G_AT Protein tyrosine kinase 9, mRNA (cDNA clone MGC:13938 IMAGE:3979221) mm
RG-U34A:RC_AA892851_AT protein tyrosine kinase 9 (predicted) rn
RG-U34A:RC_AA892851_G_AT protein tyrosine kinase 9 (predicted) rn
RG-U34C:RC_AI171354_AT protein tyrosine kinase 9 (predicted) rn
RAE230A:1376365_AT protein tyrosine kinase 9 (predicted) rn
RAT230_2:1376365_AT protein tyrosine kinase 9 (predicted) rn
RAE230A:1371644_AT protein tyrosine kinase 9 (predicted) rn
RAT230_2:1371644_AT protein tyrosine kinase 9 (predicted) rn
RG-U34B:RC_AI043716_AT Protein tyrosine kinase 9 (predicted) rn
YEAST_2:1769481_AT Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly Sc
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
5622 intracellular inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3779 actin binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA93345 Hypothetical protein F38E9.5 [Caenorhabditis elegans] ref|NP_510669.1| F38E9.5 [Caenorhabditis elegans] 1.0E-176
blast AAA93345 Hypothetical protein F38E9.5 [Caenorhabditis elegans] ref|NP_510669.1| F38E9.5 [Caenorhabditis elegans] 1.0E-173
blast CAE69968 Hypothetical protein CBG16364 [Caenorhabditis briggsae] 1.0E-169
blast CAE69968 Hypothetical protein CBG16364 [Caenorhabditis briggsae] 1.0E-166
Protein Domains
Database ID Description E-Value
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 1.5E-6
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 2.2E-5
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 1.5E-6
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 2.2E-5
Sequence
Target Sequence 
>C. ELEGANS:175588_S_AT
ttcctcagcgctgctcagaatcaatacggagttgtcattacgaataagatggaggtagat
gctcgcgacgatctttcggagaaagcactgctcgaagtcattcaccccctcccggttgaa
gcccccaaacagttctcccgtccagctccaccacgcgccggtccacgtcgtatcacaaaa
gtctg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTCCTCAGCGCTGCTCAGAATCAAT 431 699 29 Antisense
CAGCGCTGCTCAGAATCAATACGGA 271 203 34 Antisense
GAATCAATACGGAGTTGTCATTACG 533 327 46 Antisense
ATACGGAGTTGTCATTACGAATAAG 653 1 52 Antisense
ATGGAGGTAGATGCTCGCGACGATC 53 53 77 Antisense
ATGCTCGCGACGATCTTTCGGAGAA 669 41 87 Antisense
CTCGCGACGATCTTTCGGAGAAAGC 137 233 90 Antisense
TCTTTCGGAGAAAGCACTGCTCGAA 414 615 100 Antisense
GAGAAAGCACTGCTCGAAGTCATTC 660 391 107 Antisense
CCGGTCCACGTCGTATCACAAAAGT 393 265 186 Antisense
GTCCACGTCGTATCACAAAAGTCTG 646 473 189 Antisense
Sequence Source Affymetrix Proprietary Database