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[175429_at] importin beta, nuclear transport factor

Description AV201032_rc /REP_DB=TREMBL Accession /GB=AV201032 /CHR=1 /FEA=Genomic Cluster /DEF=Caenorhabditis elegans cDNA clone:yk584h4 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 82      6grp_high1_10_10 > 38      4grp_highest_8_8 > 26      4grp_high_8_8 > 59      6grp_highest_nonorm > 50      6grp_total > 38      4grp_total > 60      6grp_highest_sub > Cu      6grp_cgc > 08      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 401
1 2 3 4 range
A 484.4
(1.1)
P 		344.7
(-1)
P 		611.6
(3)
P 		210.5
(-3)
P 		401
B 515.2
(3)
P 		421.8
(-0.6)
P 		418
(-0.7)
P 		359.1
(-3)
P 		156
C 452.2
(0.8)
P 		448.7
(0.7)
P 		521.9
(3)
P 		333.9
(-3)
P 		188
avr 483.9
(2.1) 		405.1
(-0.1) 		517.2
(3) 		301.2
(-3) 		216

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 448
1 2 3 4 5 6 range
A 600.7
(3)
P 		418.9
(-0.8)
P 		314.6
(-3)
P 		346.6
(-2.3)
P 		517.7
(1.3)
P 		523.3
(1.4)
P 		286
B 737.4
(3)
P 		604.9
(1.2)
P 		289.7
(-3)
P 		413.9
(-1.3)
P 		381.8
(-1.8)
P 		602.6
(1.2)
P 		448
C 664.1
(3)
P 		505.6
(-0.1)
P 		360.2
(-3)
P 		555.5
(0.9)
P 		384.6
(-2.5)
P 		557.6
(0.9)
P 		304
avr 667.4
(3) 		509.8
(0.3) 		321.5
(-3) 		438.7
(-1) 		428
(-1.2) 		561.2
(1.2) 		346
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 151
1 2 3 4 range
A 176.4
(3)
P 		74.8
(-1.2)
P 		159.9
(2.3)
P 		30.8
(-3)
P 		146
B 164.3
(3)
P 		104.2
(-1.1)
P 		96.9
(-1.6)
P 		76.5
(-3)
P 		88
C 149.7
(1.5)
P 		129
(0.5)
P 		181.9
(3)
P 		56.3
(-3)
P 		126
avr 163.5
(3) 		102.7
(-0.3) 		146.2
(2) 		54.5
(-3) 		109

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 188
1 2 3 4 5 6 range
A 110.7
(-0.1)
P 		149
(2.5)
P 		68.5
(-3)
P 		87.9
(-1.7)
P 		156.2
(3)
P 		127.4
(1)
P 		88
B 256.6
(3)
P 		201.3
(1.2)
P 		70.3
(-3)
P 		109.6
(-1.7)
P 		155.1
(-0.3)
P 		224.7
(2)
P 		186
C 246.1
(3)
P 		154.3
(-0.6)
P 		91.7
(-3)
P 		111.7
(-2.2)
P 		124.5
(-1.7)
P 		186.7
(0.7)
P 		154
avr 204.5
(3) 		168.2
(1.3) 		76.8
(-3) 		103.1
(-1.8) 		145.3
(0.2) 		179.6
(1.8) 		128
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 175429_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.20199
Sequence Type Exemplar sequence
Representative Public ID AV201032 NCBI
Target Description AV201032_rc /REP_DB=TREMBL Accession /GB=AV201032 /CHR=1 /FEA=Genomic Cluster /DEF=Caenorhabditis elegans cDNA clone:yk584h4 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059076(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059076 NCBI Caenorhabditis elegans IMportin Beta family member (imb-1) (imb-1) mRNA, complete cds. 11/11 None
F28B3.8 ENSEMBL cdna:known chromosome:CEL140:I:4920773:4926234:-1 gene:F28B3.8 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:4920831-4921111(-) 100.0 100.0
Public Domain and Genome References
Gene Title importin beta, nuclear transport factor
Gene Symbol imb-1
Ensembl F28B3.8
Entrez Gene 172110 Entrez gene
SwissProt Q9BIB8 EMBL-EBI
WormBase CE30523 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:248272_AT importin beta-2, putative at
ATH1-121501:248268_AT importin beta-2, putative at
CANINE:1583763_AT similar to karyopherin beta 1 cfa
CANINE_2:CFA.20084.1.S1_AT similar to karyopherin beta 1 cfa
CANINE_2:CFA.5370.1.A1_S_AT similar to karyopherin beta 1 cfa
CANINE_2:CFAAFFX.25527.1.S1_AT similar to karyopherin beta 1 cfa
DROSOPHILA_2:1635766_AT Female sterile (2) Ketel dm
DROSGENOME1:151755_AT Female sterile (2) Ketel dm
DROSGENOME1:143030_AT Female sterile (2) Ketel dm
CHICKEN:GGAAFFX.25255.1.S1_AT similar to karyopherin beta 1; nuclear factor p97; importin 90; importin beta-1 subunit gga
CHICKEN:GGAAFFX.26038.1.S1_AT similar to karyopherin beta 1; nuclear factor p97; importin 90; importin beta-1 subunit gga
HG-U133_PLUS_2:217027_X_AT karyopherin (importin) beta 1 hs
HG-U133A_2:217027_X_AT karyopherin (importin) beta 1 hs
HG-U133A:217027_X_AT karyopherin (importin) beta 1 hs
HG-U133A:208975_S_AT karyopherin (importin) beta 1 hs
HG-U133_PLUS_2:208975_S_AT karyopherin (importin) beta 1 hs
HG-U133A_2:208975_S_AT karyopherin (importin) beta 1 hs
HU35KSUBC:RC_AA047379_S_AT karyopherin (importin) beta 1 hs
HU35KSUBD:RC_AA181580_S_AT karyopherin (importin) beta 1 hs
HUGENEFL:L38951_AT karyopherin (importin) beta 1 hs
HG-U133A:208974_X_AT karyopherin (importin) beta 1 hs
HG-U133_PLUS_2:208974_X_AT karyopherin (importin) beta 1 hs
HG-U133A_2:208974_X_AT karyopherin (importin) beta 1 hs
U133_X3P:G893287_3P_S_AT karyopherin (importin) beta 1 hs
U133_X3P:G893287_3P_A_AT karyopherin (importin) beta 1 hs
U133_X3P:G13097743_3P_S_AT karyopherin (importin) beta 1 hs
U133_X3P:HS.283758.0.S1_3P_X_AT karyopherin (importin) beta 1 hs
U133_X3P:HS.180446.1.A1_3P_X_AT karyopherin (importin) beta 1 hs
U133_X3P:HS.180446.1.A1_3P_A_AT karyopherin (importin) beta 1 hs
U133_X3P:213507_3P_S_AT karyopherin (importin) beta 1 hs
U133_X3P:208975_3P_S_AT karyopherin (importin) beta 1 hs
HG-U133A_2:213507_S_AT karyopherin (importin) beta 1 hs
HG-U133_PLUS_2:213507_S_AT karyopherin (importin) beta 1 hs
HG-U133A:213507_S_AT karyopherin (importin) beta 1 hs
HG-U95D:75097_AT karyopherin (importin) beta 1 hs
HU35KSUBA:RC_AA121732_AT Karyopherin (importin) beta 1 hs
HU35KSUBA:H67632_AT Karyopherin (importin) beta 1 hs
HU35KSUBC:RC_N92454_AT Karyopherin (importin) beta 1 hs
HG-U133A_2:213573_AT Karyopherin (importin) beta 1 hs
HG-U133_PLUS_2:213573_AT Karyopherin (importin) beta 1 hs
HG-U133A:213573_AT Karyopherin (importin) beta 1 hs
HG-U95AV2:41196_AT Karyopherin (importin) beta 1 hs
HG-U95B:47013_AT Karyopherin (importin) beta 1 hs
HG-U133A_2:213574_S_AT Karyopherin (importin) beta 1 hs
HG-U133_PLUS_2:213574_S_AT Karyopherin (importin) beta 1 hs
HG-U133A:213574_S_AT Karyopherin (importin) beta 1 hs
HG-U133A_2:213803_AT Karyopherin (importin) beta 1 hs
HG-FOCUS:213803_AT Karyopherin (importin) beta 1 hs
HG-U133_PLUS_2:213803_AT Karyopherin (importin) beta 1 hs
HG-U133A:213803_AT Karyopherin (importin) beta 1 hs
HU35KSUBD:RC_AA481251_AT Karyopherin (importin) beta 1 hs
U133_X3P:HS.180446.2.A1_3P_A_AT Karyopherin (importin) beta 1 hs
U133_X3P:HS.180446.4.A1_3P_A_AT Karyopherin (importin) beta 1 hs
U133_X3P:HS.180446.4.A1_3P_X_AT Karyopherin (importin) beta 1 hs
MOE430A:1434357_A_AT karyopherin (importin) beta 1 mm
MOUSE430A_2:1434357_A_AT karyopherin (importin) beta 1 mm
MOUSE430_2:1434357_A_AT karyopherin (importin) beta 1 mm
MOUSE430_2:1448526_AT karyopherin (importin) beta 1 mm
MOE430A:1448526_AT karyopherin (importin) beta 1 mm
MOUSE430A_2:1448526_AT karyopherin (importin) beta 1 mm
MOE430A:1451967_X_AT karyopherin (importin) beta 1 mm
MOUSE430A_2:1451967_X_AT karyopherin (importin) beta 1 mm
MOUSE430_2:1451967_X_AT karyopherin (importin) beta 1 mm
MOE430A:1416925_AT karyopherin (importin) beta 1 mm
MOUSE430_2:1416925_AT karyopherin (importin) beta 1 mm
MOUSE430A_2:1416925_AT karyopherin (importin) beta 1 mm
MU11KSUBA:D67015_S_AT karyopherin (importin) beta 1 mm
MG-U74AV2:93111_AT karyopherin (importin) beta 1 mm
MU19KSUBB:TC33543_AT Karyopherin (importin) beta 1 (Kpnb1), mRNA mm
MU19KSUBB:TC33543_G_AT Karyopherin (importin) beta 1 (Kpnb1), mRNA mm
RG-U34A:L38644_AT karyopherin (importin) beta 1 rn
RAE230A:1368573_AT karyopherin (importin) beta 1 rn
RAT230_2:1368573_AT karyopherin (importin) beta 1 rn
RG-U34B:RC_AA851873_AT Karyopherin (importin) beta 1 rn
RG-U34B:RC_AA963087_AT Karyopherin (importin) beta 1 rn
YEAST_2:1775553_AT Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
59 protein import into nucleus, docking inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
5643 nuclear pore inferred from electronic annotation QuickGO AmiGO
5737 cytoplasm inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8565 protein transporter activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK21379 Importin beta family protein 1 [Caenorhabditis elegans] ref|NP_491477.2| IMportin Beta family member (imb-1) [Caenorhabditis elegans] 0.0
blast CAE73114 Hypothetical protein CBG20495 [Caenorhabditis briggsae] 0.0
blast NP_002256 karyopherin beta 1 [Homo sapiens] gb|AAH24045.1| Karyopherin beta 1 [Homo sapiens] gb|AAH03572.1| Karyopherin beta 1 [Homo sapiens] gb|AAH36703.1| Karyopherin beta 1 [Homo sapiens] gb|AAP88799.1| karyopherin (importin) beta 1 [Homo sapiens] gb|AAC41763.1| importin beta subunit [Homo sapiens] gb|AAX32212.1| karyopherin beta 1 [synthetic construct] sp|Q14974|IMB1_HUMAN Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90) 0.0
Protein Domains
Database ID Description E-Value
scop a.1.1.Globins All alpha proteins; Globin-like; Globin-like; Globins 1.5
Pfam IPR001494 EMBL-EBI Importin-beta, N-terminal 5.7E-22
Sequence
Target Sequence 
>C. ELEGANS:175429_AT
tatttttgtgtgtgtgacccctcattattcaaatttttctattatgattctgatttttag
cagcaattatcttcatcattttctggttgttttttgtcggtctttatcgattatcgtttt
tgcccaaatttgaaacttctaacacggtatctgacggccctatacgttatcattttgttt
cccctatttattcatcactattttttttctcaaagttttaccggctaacact

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TATTTTTGTGTGTGTGACCCCTCAT 318 663 17 Antisense
GACCCCTCATTATTCAAATTTTTCT 651 381 32 Antisense
TAGCAGCAATTATCTTCATCATTTT 602 651 74 Antisense
TTGTTTTTTGTCGGTCTTTATCGAT 599 705 103 Antisense
ATCGATTATCGTTTTTGCCCAAATT 504 35 122 Antisense
GAAACTTCTAACACGGTATCTGACG 591 355 148 Antisense
GTATCTGACGGCCCTATACGTTATC 321 453 163 Antisense
GGCCCTATACGTTATCATTTTGTTT 145 543 172 Antisense
TTGTTTCCCCTATTTATTCATCACT 535 705 191 Antisense
TTATTCATCACTATTTTTTTTCTCA 379 679 204 Antisense
TCTCAAAGTTTTACCGGCTAACACT 690 607 224 Antisense
Sequence Source Affymetrix Proprietary Database