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[175043_s_at] multidrug resistance-associated protein

Description CEK010GXR_rc /REP_DB=TREMBL Accession /GB=D32324 /CHR=X /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk10g10 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 86      6grp_high1_10_10 > 67      4grp_highest_8_8 > 08      4grp_high_8_8 > 53      6grp_highest_nonorm > 94      6grp_total > 68      4grp_total > 59      6grp_highest_sub > Da      6grp_cgc > 38      6grp_high1_sub > Da      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 935
1 2 3 4 range
A 594.6
(-0.1)
P 		1063.7
(3)
P 		863.5
(1.7)
P 		168.1
(-3)
P 		896
B 482.2
(-0.4)
P 		845.1
(3)
P 		757.3
(2.2)
P 		211.3
(-3)
P 		634
C 569.3
(0.9)
P 		770.4
(2.6)
P 		814.7
(3)
P 		128.3
(-3)
P 		686
avr 548.7
(0.1) 		893.1
(3) 		811.8
(2.3) 		169.2
(-3) 		724

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1092
1 2 3 4 5 6 range
A 463.7
(-1.6)
P 		315.1
(-2.4)
P 		267
(-2.7)
P 		207.2
(-3)
P 		469.9
(-1.5)
P 		1288
(3)
P 		1081
B 437.3
(-1.9)
P 		270.8
(-3)
P 		475.7
(-1.7)
P 		374.6
(-2.3)
P 		369.6
(-2.4)
P 		1185.7
(3)
P 		915
C 339.8
(-1.9)
P 		368.4
(-1.6)
P 		248.7
(-2.6)
P 		195.8
(-3)
P 		454.3
(-0.9)
P 		947.9
(3)
P 		752
avr 413.6
(-1.9) 		318.1
(-2.6) 		330.5
(-2.5) 		259.2
(-3) 		431.3
(-1.8) 		1140.5
(3) 		881
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 262
1 2 3 4 range
A 216.5
(2.6)
P 		230.9
(3)
P 		225.7
(2.8)
P 		24.6
(-3)
P 		206
B 153.8
(1)
P 		208.7
(3)
P 		175.5
(1.8)
P 		45
(-3)
P 		164
C 188.4
(0.8)
P 		221.5
(1.6)
P 		283.9
(3)
P 		21.6
(-3)
P 		262
avr 186.2
(1.7) 		220.4
(2.8) 		228.4
(3) 		30.4
(-3) 		198

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 403
1 2 3 4 5 6 range
A 85.5
(-2.2)
P 		112.1
(-1.6)
P 		58.1
(-2.9)
P 		52.5
(-3)
P 		141.8
(-0.9)
P 		313.6
(3)
P 		261
B 152.2
(-1.9)
P 		90.1
(-3)
P 		115.5
(-2.6)
P 		99.2
(-2.8)
P 		150.2
(-2)
P 		442.1
(3)
P 		352
C 126
(-1.1)
P 		112.4
(-1.4)
P 		63.3
(-2.5)
P 		39.4
(-3)
P 		147
(-0.7)
P 		317.3
(3)
P 		278
avr 121.2
(-1.8) 		104.9
(-2.2) 		79
(-2.7) 		63.7
(-3) 		146.3
(-1.3) 		357.7
(3) 		294
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 175043_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.22268
Sequence Type Exemplar sequence
Representative Public ID CEK010GXR NCBI
Target Description CEK010GXR_rc /REP_DB=TREMBL Accession /GB=D32324 /CHR=X /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk10g10 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077257(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077257 NCBI Caenorhabditis elegans Multidrug Resistance Protein family member (mrp-4) (mrp-4) mRNA, complete cds. 11/11 None
F21G4.2 ENSEMBL cdna:known chromosome:CEL140:X:9884254:9889627:1 gene:F21G4.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:9889175-9889609(+) 100.0 100.0
Public Domain and Genome References
Gene Title multidrug resistance-associated protein
Gene Symbol mrp-4
Ensembl F21G4.2
Entrez Gene 181202 Entrez gene
SwissProt Q93552 EMBL-EBI
WormBase CE09548 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:256308_S_AT ATP-binding cassette transport protein, putative at
CANINE:1601402_AT similar to Canalicular multispecific organic anion transporter 2 (Multidrug resistance-associated protein 3) (Multi-specific organic anion tranporter-D) (MOAT-D) cfa
CANINE_2:CFAAFFX.26330.1.S1_S_AT similar to Canalicular multispecific organic anion transporter 2 (Multidrug resistance-associated protein 3) (Multi-specific organic anion tranporter-D) (MOAT-D) cfa
CHICKEN:GGAAFFX.4695.1.S1_S_AT similar to Canalicular multispecific organic anion transporter 2 (Multidrug resistance-associated protein 3) (Multi-specific organic anion tranporter-D) (MOAT-D) gga
HG-U133_PLUS_2:208161_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A:208161_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-FOCUS:208161_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A_2:208161_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95AV2:1930_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HC-G110:1930_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133_PLUS_2:209641_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A:209641_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A_2:209641_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133_PLUS_2:214979_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A_2:214979_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A:214979_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HU35KSUBA:U66674_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HU35KSUBD:RC_T40902_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:G9955971_3P_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:G4102187_3P_A_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:HS.90786.4.S1_3P_X_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:HS.90786.4.S1_3P_A_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:HS.298107.0.A1_3P_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:HS.187913.0.A1_3P_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133_PLUS_2:230682_X_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133B:230682_X_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133_PLUS_2:239217_X_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133B:239217_X_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95AV2:38261_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95C:63137_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95E:67798_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133_PLUS_2:242553_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133B:242553_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95E:85275_R_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95D:87278_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
MU11KSUBA:AA165775_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 mm
MG-U74AV2:103689_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 mm
MOE430A:1428988_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 mm
MOUSE430A_2:1428988_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 mm
MOUSE430_2:1428988_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 mm
MOUSE430_2:1443206_AT Multidrug resistance-associated protein 3 (Abcc3) mm
MOE430B:1443206_AT Multidrug resistance-associated protein 3 (Abcc3) mm
MU19KSUBA:TC17629_AT Multidrug resistance-associated protein 3 (Abcc3) mm
MU11KSUBA:D17945_RC_AT Multidrug resistance-associated protein 3 (Abcc3) mm
RT-U34:AB010467_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 rn
RG-U34A:AB010467_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 rn
RAE230A:1369698_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 rn
RAT230_2:1369698_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88549 Hypothetical protein F21G4.2 [Caenorhabditis elegans] emb|CAB02667.1| Hypothetical protein F21G4.2 [Caenorhabditis elegans] ref|NP_509658.1| Multidrug Resistance Protein family member (mrp-4) [Caenorhabditis elegans] 0.0
blast CAE58730 Hypothetical protein CBG01916 [Caenorhabditis briggsae] 0.0
blast CAE63808 Hypothetical protein CBG08354 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.9E-46
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.8E-28
Pfam IPR003439 EMBL-EBI ABC transporter 8.8E-33
Pfam IPR003439 EMBL-EBI ABC transporter 3.3E-49
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_509658.1 13 42-64,76-98,108-130,143-165,180-199,330-352,382-404,482-504,1002-1024,1056-1078,1145-1167,1239-1261,1266-1288
F21G4.2 13 42-64,76-98,108-130,143-165,180-199,330-352,382-404,482-504,1002-1024,1056-1078,1145-1167,1239-1261,1266-1288
Sequence
Target Sequence 
>C. ELEGANS:175043_S_AT
tggcctcatctgagcaactactctgctctttttttattacaccttttttcaaaacggttt
tcctcgatccccaaacgtgcacccactgctaattaaccctttaattgataactcaataag
tgtttaatttgtactaacttttccccaccacatcatattatatccccttgtatcatggtc
ccgtattttaatataatttgatgaatttcattctccacgaaaga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGGCCTCATCTGAGCAACTACTCTG 275 545 112 Antisense
CAACTACTCTGCTCTTTTTTTATTA 518 187 126 Antisense
TACTCTGCTCTTTTTTTATTACACC 208 647 130 Antisense
AAACGTGCACCCACTGCTAATTAAC 508 125 184 Antisense
TTAACCCTTTAATTGATAACTCAAT 300 679 204 Antisense
TTTCCCCACCACATCATATTATATC 178 671 251 Antisense
ACCACATCATATTATATCCCCTTGT 537 85 258 Antisense
TATTATATCCCCTTGTATCATGGTC 24 663 267 Antisense
CCTTGTATCATGGTCCCGTATTTTA 372 269 277 Antisense
ATCATGGTCCCGTATTTTAATATAA 527 29 283 Antisense
GATGAATTTCATTCTCCACGAAAGA 631 411 311 Antisense
Sequence Source Affymetrix Proprietary Database