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[174825_at] vav proto-oncogene

Description CEK024E9R_rc /REP_DB=TREMBL Accession /GB=D32991 /CHR=X /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk24e9 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 52      6grp_high1_10_10 > 25      4grp_highest_8_8 > 49      4grp_high_8_8 > 41      6grp_highest_nonorm > 50      6grp_total > 26      4grp_total > 54      6grp_highest_sub > 01_02      6grp_cgc > 43      6grp_high1_sub > 01_02      6grp_cgc_sub > 02      6grp_total_sub > Cup      6grp_rule_based > S2      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 399
1 2 3 4 range
A 630.7
(3)
P 		422.5
(-0.7)
P 		329
(-2.4)
P 		294
(-3)
P 		337
B 551.4
(3)
P 		355.1
(-0.8)
P 		308
(-1.8)
P 		245.1
(-3)
P 		306
C 602.4
(3)
P 		361.1
(-0.9)
P 		388
(-0.5)
P 		231.4
(-3)
P 		371
avr 594.8
(3) 		379.6
(-0.8) 		341.7
(-1.5) 		256.8
(-3) 		338

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 396
1 2 3 4 5 6 range
A 709.3
(3)
P 		608.2
(1.2)
P 		488.2
(-1)
P 		376.2
(-3)
P 		477.2
(-1.2)
P 		420
(-2.2)
P 		333
B 555.6
(0.9)
P 		673.5
(3)
P 		332.7
(-3)
P 		481.3
(-0.4)
P 		363
(-2.5)
P 		519.2
(0.3)
P 		341
C 472.4
(-1)
P 		728.5
(3)
P 		379.8
(-2.4)
P 		376.5
(-2.5)
P 		351.1
(-2.9)
P 		343.9
(-3)
P 		385
avr 579.1
(1) 		670.1
(3) 		400.2
(-2.9) 		411.3
(-2.7) 		397.1
(-3) 		427.7
(-2.3) 		273
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 191
1 2 3 4 range
A 229.6
(3)
P 		91.7
(-1.4)
P 		86
(-1.6)
P 		43
(-3)
P 		187
B 175.8
(3)
P 		87.7
(-1.3)
P 		71.4
(-2.1)
P 		52.2
(-3)
P 		124
C 199.4
(3)
P 		103.8
(-0.6)
P 		135.2
(0.6)
P 		39
(-3)
P 		160
avr 201.6
(3) 		94.4
(-1.1) 		97.5
(-1) 		44.7
(-3) 		157

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 149
1 2 3 4 5 6 range
A 130.8
(-1.2)
P 		216.3
(3)
P 		106.3
(-2.5)
P 		95.4
(-3)
P 		144
(-0.6)
P 		102.2
(-2.7)
P 		121
B 193.3
(1.7)
P 		224.2
(3)
P 		80.8
(-3)
P 		127.5
(-1)
P 		147.5
(-0.2)
P 		193.6
(1.7)
P 		143
C 175.1
(1.1)
P 		222.3
(3)
P 		96.7
(-2.1)
P 		75.7
(-3)
P 		113.6
(-1.4)
P 		115.1
(-1.4)
P 		147
avr 166.4
(0.4) 		220.9
(3) 		94.6
(-3) 		99.5
(-2.8) 		135
(-1.1) 		137
(-1) 		126
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 174825_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.22105
Sequence Type Exemplar sequence
Representative Public ID CEK024E9R NCBI
Target Description CEK024E9R_rc /REP_DB=TREMBL Accession /GB=D32991 /CHR=X /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk24e9 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077153(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077153 NCBI Caenorhabditis elegans mammalian VAV (oncogene) related family member (vav-1) (vav-1) mRNA, complete cds. 11/11 None
C35B8.2 ENSEMBL cdna:known chromosome:CEL140:X:9216807:9224255:-1 gene:C35B8.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:9216825-9217175(-) 100.0 100.0
Public Domain and Genome References
Gene Title vav proto-oncogene
Gene Symbol vav-1
Ensembl C35B8.2
Entrez Gene 181153 Entrez gene
SwissProt Q18479 EMBL-EBI
WormBase CE38040 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.30313.1.S1_AT similar to Vav-2 protein cfa
CANINE_2:CFAAFFX.30313.1.S1_S_AT similar to Vav-2 protein cfa
CANINE_2:CFAAFFX.30317.1.S1_AT similar to Vav-2 protein cfa
DROSOPHILA_2:1636614_A_AT dm
DROSOPHILA_2:1635592_AT dm
DROSGENOME1:151471_AT dm
DROSGENOME1:142127_AT dm
CHICKEN:GGA.4341.1.S1_AT vav 2 oncogene gga
CHICKEN:GGA.4341.2.S1_A_AT vav 2 oncogene gga
CHICKEN:GGA.4341.2.S1_AT Vav 2 oncogene gga
HG-U133_PLUS_2:205537_S_AT vav 2 oncogene hs
HG-U133A:205537_S_AT vav 2 oncogene hs
HG-U133A_2:205537_S_AT vav 2 oncogene hs
HG-U95AV2:1704_AT vav 2 oncogene hs
HC-G110:1704_AT vav 2 oncogene hs
HG-U133_PLUS_2:205536_AT vav 2 oncogene hs
HG-FOCUS:205536_AT vav 2 oncogene hs
HG-U133A_2:205536_AT vav 2 oncogene hs
HG-U133A:205536_AT vav 2 oncogene hs
HU35KSUBA:RC_AA465240_AT vav 2 oncogene hs
HU35KSUBA:S76992_AT vav 2 oncogene hs
HUGENEFL:S76992_AT vav 2 oncogene hs
HU35KSUBA:AA412620_S_AT vav 2 oncogene hs
U133_X3P:G4507870_3P_A_AT vav 2 oncogene hs
U133_X3P:HS.4248.1.S1_3P_AT vav 2 oncogene hs
U133_X3P:HS.4248.0.S2_3P_X_AT vav 2 oncogene hs
U133_X3P:HS.4248.0.S2_3P_AT vav 2 oncogene hs
HG-U133_PLUS_2:226063_AT vav 2 oncogene hs
HG-U133B:226063_AT vav 2 oncogene hs
HG-U95B:52054_AT vav 2 oncogene hs
HG-U95B:48216_AT Vav 2 oncogene hs
HG-U95E:69369_AT Vav 2 oncogene hs
HG-U95D:70717_AT Vav 2 oncogene hs
HG-U95D:71817_AT Vav 2 oncogene hs
HU35KSUBA:RC_AA216759_AT Vav 2 oncogene hs
MG-U74AV2:92998_AT Vav2 oncogene mm
MU11KSUBA:U37017_S_AT Vav2 oncogene mm
MOE430A:1421272_AT Vav2 oncogene mm
MOUSE430A_2:1421272_AT Vav2 oncogene mm
MOUSE430_2:1421272_AT Vav2 oncogene mm
MOE430B:1435244_AT Vav2 oncogene mm
MOUSE430_2:1435244_AT Vav2 oncogene mm
MOE430B:1435065_X_AT Vav2 oncogene (Vav2), mRNA mm
MOUSE430_2:1435065_X_AT Vav2 oncogene (Vav2), mRNA mm
MOUSE430_2:1458758_AT Vav2 oncogene (Vav2), mRNA mm
MOE430B:1458758_AT Vav2 oncogene (Vav2), mRNA mm
MG-U74AV2:162035_F_AT Vav2 oncogene (Vav2), mRNA mm
MU19KSUBC:TC41468_AT Vav2 oncogene (Vav2), mRNA mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5942 phosphoinositide 3-kinase complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
16303 phosphatidylinositol 3-kinase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_509554 mammalian VAV (oncogene) related family member (vav-1) [Caenorhabditis elegans] gb|AAC46554.4| Mammalian vav (oncogene) related protein 1 [Caenorhabditis elegans] 0.0
blast AAZ66767 VAV-1 [Caenorhabditis elegans] 0.0
blast CAE69857 Hypothetical protein CBG16186 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 2.0E-24
Pfam IPR001452 EMBL-EBI SH3 1.1E-13
Pfam IPR001715 EMBL-EBI Calponin-like actin-binding 9.5E-18
Pfam IPR002219 EMBL-EBI Protein kinase C, phorbol ester/diacylglycerol binding 1.7E-8
Pfam IPR001849 EMBL-EBI Pleckstrin-like 6.3E-12
Pfam IPR000219 EMBL-EBI DH domain 8.0E-36
Sequence
Target Sequence 
>C. ELEGANS:174825_AT
ataacttcaacaacgccatcaaaacttgtgattccatctttaatttcctcattttcttcc
tcccacctaatcagctctacttcaaaagttttgtttttctgtaattctgagtgtgacagc
gctagtcattaaattgtccatttttgttatcacacaagcttttatttcatcagccacatc
atttgtagtccggttcttcttaaatcccttataacttcactttcgtttccttcttaatat
tttgctccaattgtaatgatcaacattgtcgagtccgttactttt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATAACTTCAACAACGCCATCAAAAC 479 25 31 Antisense
GATTCCATCTTTAATTTCCTCATTT 25 435 60 Antisense
AATTCTGAGTGTGACAGCGCTAGTC 195 177 133 Antisense
AGCGCTAGTCATTAAATTGTCCATT 153 83 148 Antisense
GTTATCACACAAGCTTTTATTTCAT 169 447 176 Antisense
TTATTTCATCAGCCACATCATTTGT 565 679 192 Antisense
CATCATTTGTAGTCCGGTTCTTCTT 478 213 207 Antisense
TAAATCCCTTATAACTTCACTTTCG 222 639 231 Antisense
TCACTTTCGTTTCCTTCTTAATATT 182 627 247 Antisense
GTTTCCTTCTTAATATTTTGCTCCA 421 451 255 Antisense
CAACATTGTCGAGTCCGTTACTTTT 672 187 291 Antisense
Sequence Source Affymetrix Proprietary Database