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[174764_at] Protein kinase C terminal domain

Description CEK003EZR_rc /REP_DB=TREMBL Accession /GB=D27762 /CHR=1 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk3e12 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 22      6grp_high1_10_10 > 02      4grp_highest_8_8 > 52      4grp_high_8_8 > 16      6grp_highest_nonorm > 67      6grp_total > 24      4grp_total > 39      6grp_highest_sub > De      6grp_cgc > 24      6grp_high1_sub > De      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1514
1 2 3 4 range
A 2666.5
(3)
P 		1286.9
(-3)
P 		1275.7
(-3)
P 		1663.5
(-1.3)
P 		1391
B 2373.6
(3)
P 		1324.8
(-2.2)
P 		1152.9
(-3)
P 		1655.1
(-0.5)
P 		1221
C 2334.3
(3)
P 		1370.2
(-3)
P 		1399.7
(-2.8)
P 		1617.1
(-1.5)
P 		964
avr 2458.1
(3) 		1327.3
(-2.7) 		1276.1
(-3) 		1645.2
(-1.1) 		1182

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 844
1 2 3 4 5 6 range
A 2226.6
(3)
P 		2002.9
(0.7)
P 		1738.7
(-2)
P 		1714.5
(-2.2)
P 		1646.2
(-2.9)
P 		1636.5
(-3)
P 		590
B 2151.3
(3)
P 		1991.6
(1.7)
P 		1943.4
(1.4)
P 		1741.3
(-0.2)
P 		1391.9
(-3)
P 		1731
(-0.3)
P 		759
C 1920.4
(1)
P 		2194.4
(3)
P 		2015.9
(1.7)
P 		1902.6
(0.8)
P 		1383
(-3)
P 		1681.9
(-0.8)
P 		811
avr 2099.4
(3) 		2063
(2.7) 		1899.3
(1.1) 		1786.1
(-0) 		1473.7
(-3) 		1683.1
(-1) 		626
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 727
1 2 3 4 range
A 970.9
(3)
P 		279.4
(-2.7)
P 		333.5
(-2.3)
P 		243.5
(-3)
P 		727
B 756.9
(3)
P 		327.2
(-2.3)
P 		267.2
(-3)
P 		352.7
(-2)
P 		490
C 772.7
(3)
P 		393.9
(-1.5)
P 		487.8
(-0.4)
P 		272.7
(-3)
P 		500
avr 833.5
(3) 		333.5
(-2.5) 		362.8
(-2.2) 		289.6
(-3) 		544

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 370
1 2 3 4 5 6 range
A 410.5
(-2.4)
P 		712.3
(3)
P 		378.7
(-3)
P 		434.8
(-2)
P 		496.8
(-0.9)
P 		398.4
(-2.6)
P 		334
B 748.6
(3)
P 		662.9
(1.2)
P 		471.9
(-2.8)
P 		461.2
(-3)
P 		565.5
(-0.8)
P 		645.5
(0.8)
P 		287
C 711.8
(3)
P 		669.6
(2.2)
P 		513.1
(-0.6)
P 		382.6
(-3)
P 		447.5
(-1.8)
P 		563
(0.3)
P 		329
avr 623.6
(1.6) 		681.6
(3) 		454.6
(-2.3) 		426.2
(-3) 		503.3
(-1.2) 		535.6
(-0.4) 		255
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 174764_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.20357
Sequence Type Exemplar sequence
Representative Public ID CEK003EZR NCBI
Target Description CEK003EZR_rc /REP_DB=TREMBL Accession /GB=D27762 /CHR=1 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk3e12 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059803(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059803 NCBI Caenorhabditis elegans RSK-pNinety (RSK-p90 kinase) homolog family member (rskn-2) (rskn-2) mRNA, complete cds. 11/11 None
C54G4.1 ENSEMBL cdna:known chromosome:CEL140:I:8022569:8027698:1 gene:C54G4.1 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:8027184-8027605(+) 100.0 100.0
Public Domain and Genome References
Gene Title Protein kinase C terminal domain
Gene Symbol rskn-2
Ensembl C54G4.1
Entrez Gene 172581 Entrez gene
SwissProt Q18846 EMBL-EBI
WormBase CE32338 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.26845.1.S1_S_AT similar to ribosomal protein S6 kinase, 90kDa, polypeptide 5 isoform a cfa
CANINE_2:CFAAFFX.26847.1.S1_S_AT similar to ribosomal protein S6 kinase, 90kDa, polypeptide 5 isoform a cfa
DROSOPHILA_2:1641021_A_AT Sensitized chromosome inheritance modifier dm
DROSGENOME1:153444_AT Sensitized chromosome inheritance modifier dm
CHICKEN:GGA.14856.1.S1_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 gga
CHICKEN:GGAAFFX.6763.3.S1_S_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 gga
CHICKEN:GGAAFFX.6763.4.S1_S_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 gga
HU35KSUBA:RC_AA255846_S_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HU35KSUBD:RC_N31641_I_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U133A:204635_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U133_PLUS_2:204635_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-FOCUS:204635_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U133A_2:204635_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U133A:204633_S_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U133_PLUS_2:204633_S_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U133A_2:204633_S_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
U133_X3P:G4759051_3P_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
U133_X3P:G3411156_3P_A_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
U133_X3P:HS2.109058.2.S1_3P_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U133_PLUS_2:1554319_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U95AV2:41432_AT ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U95B:48147_I_AT Ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U95B:48148_R_AT Ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U95D:72843_R_AT Ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U95D:88346_R_AT Ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HG-U95D:90417_AT Ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HU35KSUBB:RC_T99385_F_AT Ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
HU35KSUBB:RC_T99385_I_AT Ribosomal protein S6 kinase, 90kDa, polypeptide 5 hs
MOUSE430_2:1440343_AT ribosomal protein S6 kinase, polypeptide 5 mm
MOE430B:1440343_AT ribosomal protein S6 kinase, polypeptide 5 mm
MG-U74BV2:116249_AT ribosomal protein S6 kinase, polypeptide 5 mm
MG-U74BV2:116885_I_AT ribosomal protein S6 kinase, polypeptide 5 mm
MG-U74BV2:116886_F_AT ribosomal protein S6 kinase, polypeptide 5 mm
MOE430B:1431050_AT ribosomal protein S6 kinase, polypeptide 5 mm
MOUSE430_2:1431050_AT ribosomal protein S6 kinase, polypeptide 5 mm
MOE430B:1439004_AT ribosomal protein S6 kinase, polypeptide 5 mm
MOUSE430_2:1439004_AT ribosomal protein S6 kinase, polypeptide 5 mm
MOE430B:1437625_AT Ribosomal protein S6 kinase, polypeptide 5 (Rps6ka5), mRNA mm
MOUSE430_2:1437625_AT Ribosomal protein S6 kinase, polypeptide 5 (Rps6ka5), mRNA mm
RAE230B:1398582_AT Ribosomal protein S6 kinase, polypeptide 5 (predicted) rn
RAT230_2:1398582_AT Ribosomal protein S6 kinase, polypeptide 5 (predicted) rn
RG-U34B:RC_AI045780_AT Ribosomal protein S6 kinase, polypeptide 5 (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA99814 Hypothetical protein C54G4.1 [Caenorhabditis elegans] ref|NP_492204.2| RSK-pNinety (RSK-p90 kinase) homolog family member (rskn-2) [Caenorhabditis elegans] 0.0
blast CAE63694 Hypothetical protein CBG08209 [Caenorhabditis briggsae] 0.0
blast NP_004746 ribosomal protein S6 kinase, 90kDa, polypeptide 5 isoform a [Homo sapiens] sp|O75582|KS6A5_HUMAN Ribosomal protein S6 kinase alpha 5 (Nuclear mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK) gb|AAC31171.1| nuclear mitogen- and stress-activated protein kinase-1 [Homo sapiens] gb|AAD23915.1| RSK-like protein kinase RLPK [Homo sapiens] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 4.0E-58
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-62
hanks 1.5.2 AGC group; AGC V Budding yeast AGC-related; YPK1 1.0E-73
Protein Domains
Database ID Description E-Value
scop a.139.1.Type I dockerin domain All alpha proteins; Type I dockerin domain; Type I dockerin domain; Type I dockerin domain 5.30000019073486
scop a.139.1.Type I dockerin domain All alpha proteins; Type I dockerin domain; Type I dockerin domain; Type I dockerin domain 7.40000009536743
Pfam IPR000719 EMBL-EBI Protein kinase 5.6E-76
Pfam IPR000719 EMBL-EBI Protein kinase 5.1E-78
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 5.4E-10
Sequence
Target Sequence 
>C. ELEGANS:174764_AT
gtttgcgttgtgattctttcgtcctagatgctttctagtctgtactctctcattattctc
actattttacaaattttccgtcacctgacacttgtggcattgccttctctatgagtacag
ttgctgaaatgttcattgaacctgtagtgattgtcatttgttagatatttcgcatttcta
gtcaatcctctaccaattttgaaaaatattgtgattcgtgcatttcattttatgttatta
tatctagtctcatgtaaatttctaattttttataatcattttgttagatacacatatctt
tattcatccacctatccccatgtaatcttttcattgtctccagtgactccctgaactctt
gaaccatttcca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTTTGCGTTGTGATTCTTTCGTCCT 409 451 13 Antisense
TGATTCTTTCGTCCTAGATGCTTTC 278 563 23 Antisense
AGATGCTTTCTAGTCTGTACTCTCT 465 67 38 Antisense
TTACAAATTTTCCGTCACCTGACAC 602 681 79 Antisense
GTCACCTGACACTTGTGGCATTGCC 342 465 92 Antisense
GGCATTGCCTTCTCTATGAGTACAG 689 535 108 Antisense
GATATTTCGCATTTCTAGTCAATCC 176 427 176 Antisense
TCTAGTCAATCCTCTACCAATTTTG 585 611 189 Antisense
ACCTATCCCCATGTAATCTTTTCAT 541 87 322 Antisense
TCTTTTCATTGTCTCCAGTGACTCC 111 617 338 Antisense
TCCCTGAACTCTTGAACCATTTCCA 364 597 360 Antisense
Sequence Source Affymetrix Proprietary Database