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[174750_at] GTP-binding protein

Description CEK078E5R_rc /REP_DB=TREMBL Accession /GB=D71585 /CHR=3 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk78e5 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 72      6grp_high1_10_10 > 37      4grp_highest_8_8 > 01      4grp_high_8_8 > 45      6grp_highest_nonorm > 38      6grp_total > 27      4grp_total > 50      6grp_highest_sub > Cu      6grp_cgc > 06      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 5975
1 2 3 4 range
A 6965.3
(-1.4)
P 		11365.2
(3)
P 		10037.4
(1.7)
P 		5390
(-3)
P 		5975
B 6694.7
(-1.8)
P 		10449.5
(3)
P 		10319.2
(2.8)
P 		5801.6
(-3)
P 		4648
C 7429.3
(-0.9)
P 		10011.2
(3)
P 		8974.4
(1.4)
P 		6062.1
(-3)
P 		3949
avr 7029.8
(-1.4) 		10608.6
(3) 		9777
(2) 		5751.2
(-3) 		4857

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 3647
1 2 3 4 5 6 range
A 8165.7
(3)
P 		6249.3
(-0.2)
P 		5966.7
(-0.6)
P 		4519
(-3)
P 		5332.9
(-1.7)
P 		6373.6
(0.1)
P 		3647
B 6638.3
(3)
P 		5966
(-0.1)
P 		6220.4
(1.1)
P 		5346.5
(-3)
P 		5584
(-1.9)
P 		6440.7
(2.1)
P 		1292
C 6703.1
(3)
P 		6001.7
(1.1)
P 		5453.3
(-0.4)
P 		4527
(-3)
P 		5627.2
(0)
P 		6488.5
(2.4)
P 		2176
avr 7169
(3) 		6072.3
(0.2) 		5880.1
(-0.3) 		4797.5
(-3) 		5514.7
(-1.2) 		6434.3
(1.1) 		2372
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2339
1 2 3 4 range
A 2536.1
(2.7)
P 		2467.1
(2.5)
P 		2624
(3)
P 		789
(-3)
P 		1835
B 2134.9
(1)
P 		2580.8
(3)
P 		2391.2
(2.2)
P 		1236.3
(-3)
P 		1345
C 2459.3
(1.1)
P 		2878.3
(2.3)
P 		3127.9
(3)
P 		1022.2
(-3)
P 		2106
avr 2376.8
(1.8) 		2642.1
(2.7) 		2714.4
(3) 		1015.8
(-3) 		1699

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1574
1 2 3 4 5 6 range
A 1505.3
(-1)
P 		2222.5
(3)
P 		1299.4
(-2.1)
P 		1146.1
(-3)
P 		1609.2
(-0.4)
P 		1551.8
(-0.7)
P 		1076
B 2309.8
(2.4)
P 		1985.8
(0.5)
P 		1510.5
(-2.4)
P 		1416.1
(-3)
P 		2268.7
(2.2)
P 		2401.7
(3)
P 		986
C 2484.5
(3)
P 		1831.3
(0.5)
P 		1388
(-1.2)
P 		910.4
(-3)
P 		1820.9
(0.5)
P 		2172.1
(1.8)
P 		1574
avr 2099.9
(3) 		2013.2
(2.4) 		1399.3
(-1.5) 		1157.5
(-3) 		1899.6
(1.7) 		2041.9
(2.6) 		942
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 174750_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.20968
Sequence Type Exemplar sequence
Representative Public ID CEK078E5R NCBI
Target Description CEK078E5R_rc /REP_DB=TREMBL Accession /GB=D71585 /CHR=3 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk78e5 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066968(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066968 NCBI Caenorhabditis elegans associated with RAN (nuclear import/export) function family member (ran-1) (ran-1) mRNA, complete cds. 10/11 None
K01G5.4.1 ENSEMBL cdna:known chromosome:CEL140:III:10746460:10747607:-1 gene:K01G5.4 10/11 A 
K01G5.4.3 ENSEMBL cdna:known chromosome:CEL140:III:10746462:10747761:-1 gene:K01G5.4 10/11 None
K01G5.4.2 ENSEMBL cdna:known chromosome:CEL140:III:10746462:10747607:-1 gene:K01G5.4 10/11 A 
K01G5.4.4 ENSEMBL cdna:known chromosome:CEL140:III:10746472:10747610:-1 gene:K01G5.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:10746478-10746945(-) 100.0 100.0
Public Domain and Genome References
Gene Title GTP-binding protein
Gene Symbol ran-1
Ensembl K01G5.4
Entrez Gene 176503 Entrez gene
SwissProt O17915 EMBL-EBI
WormBase CE16194 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:15150_S_AT Ras-related GTP-binding protein (RAN3) at
ATH1-121501:248107_AT Ras-related GTP-binding protein (RAN3) at
CANINE:1591381_S_AT RAN, member RAS oncogene family cfa
CANINE_2:CFA.50.1.S1_S_AT RAN, member RAS oncogene family cfa
DROSOPHILA_2:1637149_S_AT Tubulin at 85D promoter construct of Kusano dm
DROSOPHILA_2:1637015_S_AT Tubulin at 85D promoter construct of Kusano dm
DROSGENOME1:153340_AT Tubulin at 85D promoter construct of Kusano dm
CHICKEN:GGA.4068.1.S1_AT RAN, member RAS oncogene family gga
CHICKEN:GGA.4068.1.S2_AT RAN, member RAS oncogene family gga
HG-U95AV2:38708_AT RAN, member RAS oncogene family hs
HG-U133_PLUS_2:200750_S_AT RAN, member RAS oncogene family hs
HG-U133A:200750_S_AT RAN, member RAS oncogene family hs
HG-FOCUS:200750_S_AT RAN, member RAS oncogene family hs
HG-U133A_2:200750_S_AT RAN, member RAS oncogene family hs
HG-U133_PLUS_2:200749_AT RAN, member RAS oncogene family hs
HG-U133A_2:200749_AT RAN, member RAS oncogene family hs
HG-U133A:200749_AT RAN, member RAS oncogene family hs
HU35KSUBA:AA436304_AT RAN, member RAS oncogene family hs
HU35KSUBB:RC_N21085_S_AT RAN, member RAS oncogene family hs
U133_X3P:G4092053_3P_X_AT RAN, member RAS oncogene family hs
U133_X3P:G4092053_3P_A_AT RAN, member RAS oncogene family hs
U133_X3P:HS.10842.0.A3_3P_AT RAN, member RAS oncogene family hs
HG-U95B:45716_AT RAN, member RAS oncogene family hs
HU35KSUBD:RC_D12123_AT RAN, member RAS oncogene family hs
HU35KSUBC:RC_AA406359_AT RAN, member RAS oncogene family hs
HU35KSUBC:RC_H23544_I_AT RAN, member RAS oncogene family hs
MOUSE430_2:1439270_X_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1439270_X_AT RAN, member RAS oncogene family mm
MOE430A:1439270_X_AT RAN, member RAS oncogene family mm
MOUSE430_2:1436490_X_AT RAN, member RAS oncogene family mm
MOE430A:1436490_X_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1436490_X_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1434578_X_AT RAN, member RAS oncogene family mm
MOE430A:1434578_X_AT RAN, member RAS oncogene family mm
MOUSE430_2:1434578_X_AT RAN, member RAS oncogene family mm
MU11KSUBA:L32751_F_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.13673.0_S_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.29092.0_F_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.27265.0_S_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.39417.0_F_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.41695.0_F_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.12265.0_F_AT RAN, member RAS oncogene family mm
MG-U74AV2:101254_AT RAN, member RAS oncogene family mm
MG-U74AV2:102821_S_AT RAN, member RAS oncogene family mm
MOE430A:1438977_X_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1438977_X_AT RAN, member RAS oncogene family mm
MOUSE430_2:1438977_X_AT RAN, member RAS oncogene family mm
MOE430A:1433569_X_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1433569_X_AT RAN, member RAS oncogene family mm
MOUSE430_2:1433569_X_AT RAN, member RAS oncogene family mm
MOE430A:1460551_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1460551_AT RAN, member RAS oncogene family mm
MOUSE430_2:1460551_AT RAN, member RAS oncogene family mm
MG-U74AV2:161839_F_AT RAN, member RAS oncogene family (Ran), mRNA mm
MU19KSUBC:TC37859_AT RAN, member RAS oncogene family (Ran), mRNA mm
MU19KSUBC:TC39303_F_AT RAN, member RAS oncogene family (Ran), mRNA mm
MU19KSUBC:TC39303_R_AT RAN, member RAS oncogene family (Ran), mRNA mm
MU19KSUBC:TC39304_AT RAN, member RAS oncogene family (Ran), mRNA mm
RG-U34C:RC_AI175528_AT RAN, member RAS oncogene family rn
RAE230A:1367590_AT RAN, member RAS oncogene family rn
RAT230_2:1367590_AT RAN, member RAS oncogene family rn
RAE230A:1389279_AT RAN, member RAS oncogene family rn
RAT230_2:1389279_AT RAN, member RAS oncogene family rn
RG-U34B:RC_AA957267_AT RAN, member RAS oncogene family rn
YEAST_2:1778781_AT GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6886 intracellular protein transport inferred from electronic annotation QuickGO AmiGO
7264 small GTPase mediated signal transduction inferred from electronic annotation QuickGO AmiGO
15031 protein transport inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5525 GTP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB07240 Hypothetical protein K01G5.4 [Caenorhabditis elegans] ref|NP_499369.1| associated with RAN (nuclear import/export) function family member (ran-1) [Caenorhabditis elegans] sp|O17915|RAN_CAEEL GTP-binding nuclear protein ran-1 emb|CAE71407.1| Hypothetical protein CBG18317 [Caenorhabditis briggsae] 1.0E-106
blast B48463 Ras-like GTP-binding protein - nematode (Onchocerca volvulus) 1.0E-100
blast P38544 GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) 1.0E-100
Protein Domains
Database ID Description E-Value
Pfam IPR001806 EMBL-EBI Ras GTPase superfamily 6.3E-69
Sequence
Target Sequence 
>C. ELEGANS:174750_AT
gccagctttggaggttcaaatggacccagccatgattgccgaatacgaaaaggatctgga
caacgccgccaaggctgatcttccagatgacgacgatgatctttaaacactttaaccttt
caaaatccttgttttcaaatctcacaaaaccatcccacctaaatttaccattttatacat
ttcatatgccaattaatttcttaacttaaaaataatttgcatacccaaccggtgtctaca
attcaaagtgctggcttgggtagaagaaggattgtacatttgctgtttgatcgttgtgcg
aatgaattgaagaaatggttggctcatcactctcaatctccatgattt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCCAGCTTTGGAGGTTCAAATGGAC 522 271 34 Antisense
TTTCAAATCTCACAAAACCATCCCA 248 667 166 Antisense
AAATAATTTGCATACCCAACCGGTG 396 1 243 Antisense
TTGCATACCCAACCGGTGTCTACAA 690 699 250 Antisense
TACCCAACCGGTGTCTACAATTCAA 172 1 255 Antisense
GGTGTCTACAATTCAAAGTGCTGGC 169 499 264 Antisense
TTCAAAGTGCTGGCTTGGGTAGAAG 191 685 275 Antisense
GAAGAAGGATTGTACATTTGCTGTT 176 337 296 Antisense
ATTTGCTGTTTGATCGTTGTGCGAA 700 17 311 Antisense
AGAAATGGTTGGCTCATCACTCTCA 184 73 344 Antisense
TCATCACTCTCAATCTCCATGATTT 343 621 357 Antisense
Sequence Source Affymetrix Proprietary Database