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[174725_at] Protein kinase C terminal domain

Description CEK020G5R_rc /REP_DB=TREMBL Accession /GB=D32735 /CHR=X /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk20g5 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 63      6grp_high1_10_10 > 36      4grp_highest_8_8 > 46      4grp_high_8_8 > 11      6grp_highest_nonorm > 67      6grp_total > 37      4grp_total > 14      6grp_highest_sub > Cu      6grp_high1_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1446
1 2 3 4 range
A 2324.7
(3)
P 		1605.8
(-2.5)
P 		1535
(-3)
P 		2213.1
(2.2)
P 		790
B 2324.5
(0.2)
P 		1752.2
(-2.2)
P 		1562.4
(-3)
P 		2980.7
(3)
P 		1418
C 2171.6
(0.7)
P 		1766.7
(-2.2)
P 		1655.3
(-3)
P 		2503.4
(3)
P 		848
avr 2273.6
(1.2) 		1708.2
(-2.2) 		1584.2
(-3) 		2565.7
(3) 		982

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 868
1 2 3 4 5 6 range
A 2361.4
(3)
P 		2222.2
(2)
P 		1526.8
(-2.8)
P 		1493.9
(-3)
P 		1943.3
(0.1)
P 		1940.3
(0.1)
P 		868
B 2326.3
(3)
P 		2239.3
(2.3)
P 		1907.2
(-0.2)
P 		1828
(-0.8)
P 		1539.5
(-3)
P 		2299.1
(2.8)
P 		787
C 2105
(1.7)
P 		2251.9
(3)
P 		1752.1
(-1.3)
P 		1614.5
(-2.5)
P 		1550.5
(-3)
P 		2183.7
(2.4)
P 		701
avr 2264.2
(3) 		2237.8
(2.7) 		1728.7
(-2.2) 		1645.5
(-3) 		1677.8
(-2.7) 		2141
(1.8) 		619
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 522
1 2 3 4 range
A 846.4
(3)
P 		348.6
(-2.7)
P 		401.3
(-2.1)
P 		324
(-3)
P 		522
B 741.3
(3)
P 		432.7
(-1.9)
P 		362.1
(-3)
P 		635.2
(1.3)
P 		379
C 718.9
(3)
P 		507.9
(-1.3)
P 		576.9
(0.1)
P 		422.1
(-3)
P 		297
avr 768.9
(3) 		429.7
(-3) 		446.8
(-2.7) 		460.4
(-2.5) 		339

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 533
1 2 3 4 5 6 range
A 435.3
(-1.7)
P 		790.3
(3)
P 		332.5
(-3)
P 		378.9
(-2.4)
P 		586.4
(0.3)
P 		472.4
(-1.2)
P 		458
B 809.4
(2.3)
P 		745.4
(1.3)
P 		463.1
(-3)
P 		484.2
(-2.7)
P 		625.5
(-0.5)
P 		857.3
(3)
P 		394
C 780.2
(3)
P 		687.1
(1.8)
P 		446
(-1.4)
P 		324.7
(-3)
P 		501.7
(-0.7)
P 		731
(2.4)
P 		456
avr 675
(1.9) 		740.9
(3) 		413.9
(-2.7) 		395.9
(-3) 		571.2
(0) 		686.9
(2.1) 		345
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 174725_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.22078
Sequence Type Exemplar sequence
Representative Public ID CEK020G5R NCBI
Target Description CEK020G5R_rc /REP_DB=TREMBL Accession /GB=D32735 /CHR=X /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk20g5 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077341(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077341 NCBI Caenorhabditis elegans F46F6.2 (F46F6.2) mRNA, complete cds. 11/11 None
F46F6.2 ENSEMBL cdna:known chromosome:CEL140:X:10397171:10402492:1 gene:F46F6.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:10402117-10402478(+) 100.0 100.0
Public Domain and Genome References
Gene Title Protein kinase C terminal domain
Ensembl F46F6.2
Entrez Gene 181244 Entrez gene
SwissProt O17874 EMBL-EBI
WormBase CE31703 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.30975.1.S1_AT similar to protein kinase N2 cfa
CANINE_2:CFAAFFX.30977.1.S1_S_AT similar to protein kinase N2 cfa
CANINE_2:CFAAFFX.30980.1.S1_S_AT similar to protein kinase N2 cfa
DROSOPHILA_2:1640417_A_AT Protein kinase related to protein kinase N dm
DROSGENOME1:142919_S_AT Protein kinase related to protein kinase N dm
CHICKEN:GGA.19651.1.S1_AT protein kinase N2 gga
CHICKEN:GGA.19651.1.S1_S_AT protein kinase N2 gga
CHICKEN:GGA.2682.1.A1_AT protein kinase N2 gga
CHICKEN:GGA.2682.1.A1_S_AT protein kinase N2 gga
CHICKEN:GGA.8657.1.S1_AT protein kinase N2 gga
HG-U133_PLUS_2:210969_AT protein kinase N2 hs
HG-U133A:210969_AT protein kinase N2 hs
HG-U133A_2:210969_AT protein kinase N2 hs
HG-U95AV2:199_S_AT protein kinase N2 hs
HC-G110:199_S_AT protein kinase N2 hs
HUGENEFL:U33052_S_AT protein kinase N2 hs
U133_X3P:G6650823_RC_3P_AT protein kinase N2 hs
U133_X3P:G6650823_RC_3P_A_AT protein kinase N2 hs
U133_X3P:HS.69171.3.A1_3P_AT protein kinase N2 hs
U133_X3P:HS.69171.2.S1_3P_A_AT protein kinase N2 hs
HG-U133A_2:212629_S_AT protein kinase N2 hs
HG-U133_PLUS_2:212629_S_AT protein kinase N2 hs
HG-U133A:212629_S_AT protein kinase N2 hs
HG-U133_PLUS_2:230400_S_AT protein kinase N2 hs
HG-U133B:230400_S_AT protein kinase N2 hs
HG-U95AV2:36835_AT protein kinase N2 hs
HG-U133_PLUS_2:216112_AT Protein kinase N2 hs
HG-U133A_2:216112_AT Protein kinase N2 hs
HG-U133A:216112_AT Protein kinase N2 hs
HU35KSUBD:RC_AA252537_AT Protein kinase N2 hs
U133_X3P:HS.69171.2.S2_3P_AT Protein kinase N2 hs
U133_X3P:HS.301390.0.S1_3P_X_AT Protein kinase N2 hs
U133_X3P:HS.301390.0.S1_3P_AT Protein kinase N2 hs
U133_X3P:216112_3P_AT Protein kinase N2 hs
HG-U133A_2:212628_AT Protein kinase N2 hs
HG-FOCUS:212628_AT Protein kinase N2 hs
HG-U133_PLUS_2:212628_AT Protein kinase N2 hs
HG-U133A:212628_AT Protein kinase N2 hs
HG-U95B:55492_AT Protein kinase N2 hs
HG-U133_PLUS_2:241271_AT Protein kinase N2 hs
HG-U133B:241271_AT Protein kinase N2 hs
HG-U95C:52487_AT Protein kinase N2 hs
HG-U95E:89563_AT Protein kinase N2 hs
HU35KSUBB:RC_H93319_AT Protein kinase N2 hs
U133_X3P:HS.34262.0.A1_3P_AT Protein kinase N2 hs
MU11KSUBB:MSA.33934.0_S_AT protein kinase N2 mm
MG-U74AV2:104503_AT protein kinase N2 mm
MG-U74BV2:109357_AT protein kinase N2 mm
MG-U74CV2:135668_AT protein kinase N2 mm
MG-U74CV2:140939_AT protein kinase N2 mm
MG-U74BV2:163931_AT protein kinase N2 mm
MG-U74CV2:170612_AT protein kinase N2 mm
MOE430B:1437296_AT protein kinase N2 mm
MOUSE430_2:1437296_AT protein kinase N2 mm
MOE430B:1437295_AT protein kinase N2 mm
MOUSE430_2:1437295_AT protein kinase N2 mm
MU19KSUBA:TC17025_AT Protein kinase N2 (Pkn2), mRNA mm
MU19KSUBA:TC23305_AT Protein kinase N2 (Pkn2), mRNA mm
MU19KSUBC:TC41027_AT Protein kinase N2 (Pkn2), mRNA mm
RG-U34A:U75358_AT protein kinase C-like 2 rn
RAE230A:1393055_AT protein kinase C-like 2 rn
RAT230_2:1393055_AT protein kinase C-like 2 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7165 signal transduction inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5622 intracellular inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA90345 Hypothetical protein F46F6.2 [Caenorhabditis elegans] emb|CAA90339.4| Hypothetical protein F46F6.2 [Caenorhabditis elegans] ref|NP_509742.2| F46F6.2 [Caenorhabditis elegans] 0.0
blast CAE70574 Hypothetical protein CBG17230 [Caenorhabditis briggsae] 0.0
blast AAF58959 CG2049-PE, isoform E [Drosophila melanogaster] ref|NP_788294.1| CG2049-PE, isoform E [Drosophila melanogaster] 1.0E-121
Protein Families
Method ID Description E-Value
hanks 1.2.14 AGC group; AGC I Diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family; pck1+ 1.0E-82
Protein Domains
Database ID Description E-Value
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 2.09999990463257
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 0.025000000372529
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 5.59999990463257
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 0.0659999996423721
Pfam IPR000861 EMBL-EBI PKN/rhophilin/rhotekin rho-binding repeat 7.6E-22
Pfam IPR000719 EMBL-EBI Protein kinase 4.9E-75
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 1.7E-15
Sequence
Target Sequence 
>C. ELEGANS:174725_AT
atattctttcatctgcattggtttttttaattcaacgtcatcgtgttttgtcattaagta
gtttaccccgtctctatttccgctttgtaatcctcaaaaattaacacattctgttaaatt
tccaccaaattattgtattgtaactttttgtagaccgcttgacgagtgcgcttattcttt
tttttgtctttttagtccaacagacttcccattttacatccatttagcccctcttttcag
ccattggtatatactggccactttttattt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATATTCTTTCATCTGCATTGGTTTT 401 19 47 Antisense
ACGTCATCGTGTTTTGTCATTAAGT 83 95 81 Antisense
TCATTAAGTAGTTTACCCCGTCTCT 429 567 97 Antisense
TCTATTTCCGCTTTGTAATCCTCAA 427 613 119 Antisense
AACACATTCTGTTAAATTTCCACCA 26 135 149 Antisense
GTAACTTTTTGTAGACCGCTTGACG 680 461 186 Antisense
GACGAGTGCGCTTATTCTTTTTTTT 292 379 207 Antisense
GTCCAACAGACTTCCCATTTTACAT 260 477 241 Antisense
CTTCCCATTTTACATCCATTTAGCC 327 217 251 Antisense
CCCCTCTTTTCAGCCATTGGTATAT 375 261 274 Antisense
GGTATATACTGGCCACTTTTTATTT 282 505 292 Antisense
Sequence Source Affymetrix Proprietary Database