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[174274_at] Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain.

Description C38304_rc /REP_DB=TREMBL Accession /GB=C38304 /CHR=4 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk491a5 : 3prime end, single read.
Cluster 6grp_total > 76      4grp_total > 34      6grp_cgc > 58      6grp_cgc_sub > In      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 53
1 2 3 4 range
A 36.5
(-0.9)
A 		25.4
(-3)
A 		39.1
(-0.4)
A 		57.1
(3)
M 		32
B 3.9
(-3)
A 		42.8
(3)
A 		28.6
(0.8)
A 		24.3
(0.1)
P 		39
C 21.2
(-2)
A 		51.2
(3)
A 		18.7
(-2.4)
P 		15.1
(-3)
A 		36
avr 20.5
(-3) 		39.8
(3) 		28.8
(-0.4) 		32.2
(0.6) 		19

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 107
1 2 3 4 5 6 range
A 5.2
(-2.9)
A 		28
(-1.6)
A 		3.5
(-3)
A 		26.1
(-1.7)
A 		37.6
(-1.1)
A 		110.4
(3)
P 		107
B 22.6
(-3)
A 		27.1
(-2.5)
A 		41.6
(-0.9)
A 		40.2
(-1.1)
A 		40
(-1.1)
P 		77.2
(3)
P 		55
C 3.6
(-3)
A 		39.5
(0.7)
A 		35.9
(0.3)
A 		44.4
(1.2)
A 		49
(1.6)
M 		62.3
(3)
P 		59
avr 10.5
(-3) 		31.5
(-1.3) 		27
(-1.6) 		36.9
(-0.8) 		42.2
(-0.4) 		83.3
(3) 		73
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 14
1 2 3 4 range
A 13.3
(3)
A 		5.5
(-3)
A 		10.2
(0.6)
A 		8.4
(-0.8)
M 		8
B 1.2
(-3)
A 		10.6
(3)
A 		6.6
(0.4)
A 		5.2
(-0.4)
P 		9
C 7
(-0.8)
A 		14.7
(3)
A 		6.5
(-1)
P 		2.5
(-3)
A 		12
avr 7.2
(-0.8) 		10.3
(3) 		7.8
(-0.1) 		5.4
(-3) 		5

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 28
1 2 3 4 5 6 range
A 1
(-3)
A 		9.9
(-0.9)
A 		0.8
(-3)
A 		6.6
(-1.7)
A 		11.4
(-0.6)
A 		26.9
(3)
P 		26
B 7.8
(-3)
A 		9
(-2.7)
A 		10.1
(-2.3)
A 		10.7
(-2.2)
A 		16.3
(-0.6)
P 		28.8
(3)
P 		21
C 1.3
(-3)
A 		12
(0.3)
A 		9.1
(-0.6)
A 		8.9
(-0.7)
A 		15.9
(1.5)
M 		20.8
(3)
P 		20
avr 3.4
(-3) 		10.3
(-1.1) 		6.7
(-2.1) 		8.7
(-1.6) 		14.5
(0) 		25.5
(3) 		22
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 174274_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.21260
Sequence Type Exemplar sequence
Representative Public ID C38304 NCBI
Target Description C38304_rc /REP_DB=TREMBL Accession /GB=C38304 /CHR=4 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk491a5 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070137(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070137 NCBI Caenorhabditis elegans CEll Death abnormality family member (ced-3) (ced-3) mRNA, complete cds. 11/11 A 
C48D1.2 ENSEMBL cdna:known chromosome:CEL140:IV:13198254:13204098:-1 gene:C48D1.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:13198882-13199162(-) 100.0 100.0
Public Domain and Genome References
Gene Title Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain.
Gene Symbol ced-3
Ensembl C48D1.2
Entrez Gene 178272 Entrez gene
SwissProt P42573 EMBL-EBI
WormBase CE29088 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1584802_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) cfa
CANINE_2:CFA.12400.1.A1_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) cfa
CANINE_2:CFA.6392.1.A1_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) cfa
CANINE_2:CFAAFFX.6401.1.S1_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) cfa
CANINE_2:CFAAFFX.6401.1.S1_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) cfa
CHICKEN:GGA.504.1.S1_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) gga
HG-U133A:34449_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A_2:34449_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-FOCUS:34449_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:34449_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95AV2:34449_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95AV2:1239_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HC-G110:1239_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95AV2:1240_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HC-G110:1240_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A:209812_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:209812_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A_2:209812_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A:209811_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:209811_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A_2:209811_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:208050_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A:208050_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A_2:208050_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HU35KSUBA:AA243486_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HU35KSUBA:RC_AA481283_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HU35KSUBA:U13021_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HUGENEFL:U13021_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HUGENEFL:U13022_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A:211140_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:211140_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A_2:211140_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:G4502574_3P_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:G12642589_3P_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:G12642589_3P_A_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:HS.180552.0.A2_3P_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:HS.180552.0.A2_3P_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:HS.180552.0.A1_3P_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:226036_3P_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:209811_3P_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:226032_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133B:226032_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:226036_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133B:226036_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95AV2:34448_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95B:48571_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95E:67372_AT Caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
MU11KSUBA:D28492_S_AT caspase 2 mm
MG-U74AV2:99049_AT caspase 2 mm
MG-U74AV2:161263_F_AT caspase 2 mm
MOE430A:1448165_AT caspase 2 mm
MOUSE430A_2:1448165_AT caspase 2 mm
MOUSE430_2:1448165_AT caspase 2 mm
RAE230A:1367891_A_AT caspase 2 rn
RAT230_2:1367891_A_AT caspase 2 rn
RN-U34:U34684_S_AT caspase 2 rn
RT-U34:U34684_S_AT caspase 2 rn
RG-U34A:U34684_S_AT caspase 2 rn
RN-U34:AF025671_S_AT caspase 2 rn
RG-U34A:AF025671_S_AT caspase 2 rn
RN-U34:U77933_AT caspase 2 rn
RT-U34:U77933_AT caspase 2 rn
RG-U34A:U77933_AT caspase 2 rn
RAE230A:1367890_AT caspase 2 rn
RAT230_2:1367890_AT caspase 2 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
42981 regulation of apoptosis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5622 intracellular inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5515 protein binding inferred from electronic annotation QuickGO AmiGO
30693 caspase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB61001 Hypothetical protein C48D1.2 [Caenorhabditis elegans] ref|NP_502538.1| CEll Death abnormality family member (ced-3) [Caenorhabditis elegans] gb|AAG42045.1| caspase CED-3 [Caenorhabditis elegans] gb|AAA27982.2| cell death protein [Caenorhabditis elegans] sp|P42573|CED3_CAEEL Cell death protein 3 precursor [Contains: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] 0.0
blast T20038 hypothetical protein C48D1.2 - Caenorhabditis elegans 0.0
blast CAE58645 Hypothetical protein CBG01813 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001315 EMBL-EBI CARD interaction domain 2.8E-33
Pfam IPR001309 EMBL-EBI Caspase-1, p20 4.4E-105
Sequence
Target Sequence 
>C. ELEGANS:174274_AT
ttcgcccaattagtttaaaaccatgtgtatattgttatcctatactcatttcactttatc
attctatcatttctcttcccattttcacacatttccatttctctacgataatctaaaatt
atgacgtttgtgtctcgaacgcataataattttaataactcgttttgaatttgattagtt
gttgtgcccagtatatatgtatgtactatgcttctatcaac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTCGCCCAATTAGTTTAAAACCATG 284 561 31 Antisense
AAACCATGTGTATATTGTTATCCTA 455 125 48 Antisense
GTTATCCTATACTCATTTCACTTTA 170 447 64 Antisense
CATTTCACTTTATCATTCTATCATT 568 215 77 Antisense
TTTATCATTCTATCATTTCTCTTCC 55 675 85 Antisense
TCCATTTCTCTACGATAATCTAAAA 614 591 124 Antisense
ATGACGTTTGTGTCTCGAACGCATA 469 43 151 Antisense
TGTCTCGAACGCATAATAATTTTAA 697 557 161 Antisense
GAATTTGATTAGTTGTTGTGCCCAG 14 327 197 Antisense
GTTGTTGTGCCCAGTATATATGTAT 505 437 208 Antisense
ATGTATGTACTATGCTTCTATCAAC 454 47 227 Antisense
Sequence Source Affymetrix Proprietary Database