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[174218_at] Eukaryotic protein kinase domain

Description C36286_rc /REP_DB=TREMBL Accession /GB=C36286 /CHR=4 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk457b3 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 08      6grp_high1_10_10 > 80      4grp_highest_8_8 > 11      4grp_high_8_8 > 39      6grp_highest_nonorm > 54      6grp_total > 91      4grp_total > 40      6grp_high1_sub > 02_03_04_05      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 709
1 2 3 4 range
A 941.3
(-1.6)
P 		812
(-3)
P 		1379.1
(3)
P 		1199.2
(1.1)
P 		567
B 776.7
(-3)
P 		1405.8
(3)
P 		1379.8
(2.8)
P 		1289.6
(1.9)
P 		629
C 989.7
(-3)
P 		1440.2
(2.5)
P 		1485.3
(3)
P 		1081.4
(-1.9)
P 		496
avr 902.6
(-3) 		1219.3
(0.7) 		1414.7
(3) 		1190.1
(0.4) 		512

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 973
1 2 3 4 5 6 range
A 940.4
(-1.1)
P 		1119.1
(-0)
P 		1148
(0.1)
P 		1322.6
(1.2)
P 		1612.8
(3)
P 		639.7
(-3)
P 		973
B 1304
(1)
P 		1414.4
(2.1)
P 		890.4
(-3)
P 		1511
(3)
P 		1399.5
(1.9)
P 		911.9
(-2.8)
P 		621
C 953.5
(-1.6)
P 		1310.8
(1.3)
P 		899.4
(-2.1)
P 		1516.5
(3)
P 		1302
(1.2)
P 		786.7
(-3)
P 		730
avr 1066
(-0.4) 		1281.4
(1.5) 		979.3
(-1.2) 		1450
(3) 		1438.1
(2.9) 		779.4
(-3) 		671
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 342
1 2 3 4 range
A 342.7
(2.4)
P 		176.3
(-3)
P 		360.5
(3)
P 		175.5
(-3)
P 		185
B 247.7
(-3)
P 		347.2
(3)
P 		319.7
(1.3)
P 		274.8
(-1.4)
P 		100
C 327.6
(-0.4)
P 		414.1
(1.1)
P 		517.7
(3)
P 		182.3
(-3)
P 		335
avr 306
(0) 		312.5
(0.2) 		399.3
(3) 		210.9
(-3) 		188

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 413
1 2 3 4 5 6 range
A 173.4
(-2.7)
P 		398
(1.4)
P 		250
(-1.3)
P 		335.4
(0.3)
P 		486.7
(3)
P 		155.8
(-3)
P 		331
B 453.7
(1)
P 		470.8
(1.3)
P 		216.2
(-3)
P 		400.2
(0.1)
P 		568.6
(3)
P 		340
(-0.9)
P 		352
C 353.4
(0.9)
P 		400
(2.3)
P 		228.9
(-3)
P 		305
(-0.6)
P 		421.3
(3)
P 		263.4
(-1.9)
P 		192
avr 326.8
(-0.8) 		422.9
(1.4) 		231.7
(-3) 		346.9
(-0.3) 		492.2
(3) 		253.1
(-2.5) 		261
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 174218_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.21322
Sequence Type Exemplar sequence
Representative Public ID C36286 NCBI
Target Description C36286_rc /REP_DB=TREMBL Accession /GB=C36286 /CHR=4 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk457b3 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070710(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070710 NCBI Caenorhabditis elegans F11E6.8 (F11E6.8) mRNA, complete cds. 11/11 None
F11E6.8 ENSEMBL cdna:known chromosome:CEL140:IV:17444111:17450498:-1 gene:F11E6.8 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:17444157-17444438(-) 100.0 100.0
Public Domain and Genome References
Gene Title Eukaryotic protein kinase domain
Ensembl F11E6.8
Entrez Gene 178530 Entrez gene
SwissProt Q9XVQ7 EMBL-EBI
WormBase CE19788 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.10759.1.S1_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) cfa
CANINE_2:CFA.10759.1.S1_S_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) cfa
CANINE_2:CFAAFFX.17154.1.S1_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) cfa
CHICKEN:GGAAFFX.1880.1.S1_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) gga
CHICKEN:GGAAFFX.1954.1.S1_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) gga
HG-U133_PLUS_2:205455_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HG-U133A:205455_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HG-FOCUS:205455_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HG-U133A_2:205455_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HG-U95AV2:1317_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HC-G110:1317_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HUGENEFL:X70040_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
U133_X3P:G4505264_3P_X_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
U133_X3P:G4505264_3P_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
MOE430A:1420461_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) mm
MOUSE430A_2:1420461_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) mm
MOUSE430_2:1420461_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) mm
MU11KSUBA:U65949_S_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) mm
MG-U74AV2:97719_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02923 Hypothetical protein F11E6.8 [Caenorhabditis elegans] ref|NP_503111.1| F11E6.8 [Caenorhabditis elegans] 0.0
blast CAE57477 Hypothetical protein CBG00445 [Caenorhabditis briggsae] 0.0
blast XP_603857 PREDICTED: similar to macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [Bos taurus] 5.0E-69
Protein Families
Method ID Description E-Value
hanks 2.1.18 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; MRE4 5.0E-55
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 5.0E-76
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_503111.1 1 47-69
F11E6.8 1 47-69
Sequence
Target Sequence 
>C. ELEGANS:174218_AT
ttttcatttctcataaccagctacttaatactgcttcactcgtcaaaactcttcaatgtt
ttttccctacaacgggtgccttgtcgaatatgttatttttatttccgttttaggatcaat
attatctgctcaattcactcaatgttcatcaatttctatttgaaaattcatccactgcaa
ttcaggtcaaatctctcttgaacaatttcttt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTTTCATTTCTCATAACCAGCTACT 608 675 52 Antisense
CTACTTAATACTGCTTCACTCGTCA 634 225 72 Antisense
TTCACTCGTCAAAACTCTTCAATGT 353 685 86 Antisense
TCTTCAATGTTTTTTCCCTACAACG 215 615 101 Antisense
CCTACAACGGGTGCCTTGTCGAATA 533 253 117 Antisense
GGGTGCCTTGTCGAATATGTTATTT 409 497 125 Antisense
GGATCAATATTATCTGCTCAATTCA 507 509 164 Antisense
TGCTCAATTCACTCAATGTTCATCA 260 581 178 Antisense
AAATTCATCCACTGCAATTCAGGTC 414 115 215 Antisense
CTGCAATTCAGGTCAAATCTCTCTT 598 237 226 Antisense
CAAATCTCTCTTGAACAATTTCTTT 627 193 239 Antisense
Sequence Source Affymetrix Proprietary Database