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[174169_at] guanylate cyclase

Description C53107_rc /REP_DB=TREMBL Accession /GB=C53107 /CHR=2 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk316d1 : 3prime end, single read.
Cluster 6grp_total > 77      4grp_total > 38      6grp_cgc > 58      6grp_cgc_sub > In      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 64
1 2 3 4 range
A 9.1
(-2.3)
A 		5.1
(-3)
A 		19.1
(-0.4)
A 		37.8
(3)
A 		33
B 48.3
(3)
A 		8.6
(-2.6)
A 		5.8
(-3)
A 		11.3
(-2.2)
A 		43
C 68.1
(3)
A 		43.1
(0.7)
A 		3.8
(-3)
A 		16.1
(-1.9)
A 		64
avr 41.8
(3) 		18.9
(-1.3) 		9.6
(-3) 		21.7
(-0.7) 		32

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 98
1 2 3 4 5 6 range
A 10.4
(-3)
A 		22.3
(-2.2)
A 		19.4
(-2.4)
A 		31.4
(-1.7)
A 		36
(-1.4)
A 		104.8
(3)
P 		94
B 30.5
(-2)
A 		39.1
(-1.4)
A 		17.1
(-3)
A 		66.2
(0.6)
A 		52.2
(-0.4)
A 		97.9
(3)
P 		81
C 6.9
(-3)
A 		51.9
(-0.1)
A 		25
(-1.8)
A 		38.1
(-1)
A 		48.5
(-0.3)
A 		100.6
(3)
A 		94
avr 15.9
(-3) 		37.8
(-1.5) 		20.5
(-2.7) 		45.2
(-0.9) 		45.6
(-0.9) 		101.1
(3) 		85
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 21
1 2 3 4 range
A 3.3
(-0)
A 		1.1
(-3)
A 		5
(2.3)
A 		5.5
(3)
A 		4
B 15.4
(3)
A 		2.1
(-2.7)
A 		1.3
(-3)
A 		2.4
(-2.5)
A 		14
C 22.5
(3)
A 		12.4
(0.1)
A 		1.3
(-3)
A 		2.7
(-2.6)
A 		21
avr 13.7
(3) 		5.2
(-1.6) 		2.5
(-3) 		3.5
(-2.5) 		11

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 35
1 2 3 4 5 6 range
A 1.9
(-3)
A 		7.9
(-1.5)
A 		4.2
(-2.4)
A 		8
(-1.4)
A 		10.9
(-0.7)
A 		25.5
(3)
P 		24
B 10.6
(-1.8)
A 		13
(-1.4)
A 		4.2
(-3)
A 		17.5
(-0.5)
A 		21.2
(0.2)
A 		36.5
(3)
P 		32
C 2.6
(-3)
A 		15.8
(-0.5)
A 		6.4
(-2.3)
A 		7.7
(-2)
A 		15.7
(-0.5)
A 		33.7
(3)
A 		31
avr 5
(-3) 		12.2
(-1.4) 		4.9
(-3) 		11.1
(-1.6) 		15.9
(-0.6) 		31.9
(3) 		27
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 174169_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.20734
Sequence Type Exemplar sequence
Representative Public ID C53107 NCBI
Target Description C53107_rc /REP_DB=TREMBL Accession /GB=C53107 /CHR=2 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk316d1 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062594(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062594 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-12) (gcy-12) mRNA, complete cds. 11/11 None
F08B1.2 ENSEMBL cdna:known chromosome:CEL140:II:5312090:5317234:1 gene:F08B1.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:5316848-5317253(+) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Gene Symbol gcy-12
Ensembl F08B1.2
Entrez Gene 173902 Entrez gene
SwissProt Q19187 EMBL-EBI
WormBase CE27920 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1626977_AT Guanylyl cyclase at 76C dm
DROSOPHILA_2:1630560_S_AT Guanylyl cyclase at 76C dm
DROSOPHILA_2:1626925_AT Guanylyl cyclase at 76C dm
DROSGENOME1:143732_AT Guanylyl cyclase at 76C dm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK68301 Guanylyl cyclase protein 12 [Caenorhabditis elegans] ref|NP_494995.1| Guanylyl CYclase family member (gcy-12) [Caenorhabditis elegans] 0.0
blast T15968 hypothetical protein F08B1.2 - Caenorhabditis elegans 0.0
blast CAE59078 Hypothetical protein CBG02368 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.2E-23
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.9E-83
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 1.1E-22
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_494995.1 1 594-616
F08B1.2 1 594-616
Sequence
Target Sequence 
>C. ELEGANS:174169_AT
gaggatccagttgggcaaatcgactaactgctcttgtccctgcatgtccatttcaacgtc
cttctgatcatatgaaccttcgcttcgaaccatccaacctctcatcttccgactcgacta
gtgaagaatactt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGGATCCAGTTGGGCAAATCGACT 475 403 129 Antisense
GGGCAAATCGACTAACTGCTCTTGT 675 493 141 Antisense
CAAATCGACTAACTGCTCTTGTCCC 424 193 144 Antisense
CCATTTCAACGTCCTTCTGATCATA 6 271 176 Antisense
AACGTCCTTCTGATCATATGAACCT 170 145 183 Antisense
GTCCTTCTGATCATATGAACCTTCG 220 477 186 Antisense
GATCATATGAACCTTCGCTTCGAAC 555 419 194 Antisense
ATATGAACCTTCGCTTCGAACCATC 134 11 198 Antisense
TCTCATCTTCCGACTCGACTAGTGA 447 613 228 Antisense
TCATCTTCCGACTCGACTAGTGAAG 376 621 230 Antisense
CCGACTCGACTAGTGAAGAATACTT 616 261 237 Antisense
Sequence Source Affymetrix Proprietary Database