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[174039_at] LET-60 RAS protein

Description g156355 /REP_DB=GenBank Identifier /CHR=4 /FEA=Genomic Cluster
Cluster 6grp_highest_10_10 > 21      6grp_high1_10_10 > 13      4grp_highest_8_8 > 41      4grp_high_8_8 > 49      6grp_highest_nonorm > 23      6grp_total > 14      4grp_total > 62      6grp_highest_sub > De      6grp_cgc > 30      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1672
1 2 3 4 range
A 2929
(3)
P 		1801.8
(-1)
P 		2305.1
(0.8)
P 		1257.3
(-3)
P 		1672
B 2723.7
(3)
P 		2438.9
(-0.1)
P 		2181.2
(-3)
P 		2420.9
(-0.3)
P 		543
C 2552.8
(3)
P 		2341.4
(1.4)
P 		2251.6
(0.7)
P 		1768.3
(-3)
P 		785
avr 2735.2
(3) 		2194
(-0.5) 		2246
(-0.2) 		1815.5
(-3) 		920

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1409
1 2 3 4 5 6 range
A 2306.7
(1.2)
P 		2360.1
(1.6)
P 		2553.8
(3)
P 		1742.2
(-3)
P 		2042.2
(-0.8)
P 		1799.6
(-2.6)
P 		812
B 3001.3
(3)
P 		2415.6
(0.1)
P 		1999.8
(-2)
P 		2436.2
(0.2)
P 		1790.8
(-3)
P 		1961
(-2.2)
P 		1211
C 2395.2
(2.9)
P 		2406.2
(3)
P 		2082.2
(0.6)
P 		2401.9
(3)
P 		1690.6
(-2.3)
P 		1592
(-3)
P 		814
avr 2567.7
(3) 		2394
(1.7) 		2211.9
(0.3) 		2193.4
(0.1) 		1841.2
(-2.6) 		1784.2
(-3) 		784
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 882
1 2 3 4 range
A 1066.4
(3)
P 		391.1
(-1.6)
P 		602.6
(-0.2)
P 		184
(-3)
P 		882
B 868.6
(3)
P 		602.3
(-1.4)
P 		505.4
(-3)
P 		515.9
(-2.8)
P 		363
C 845.1
(3)
P 		673.2
(1.1)
P 		784.8
(2.3)
P 		298.2
(-3)
P 		547
avr 926.7
(3) 		555.5
(-0.7) 		630.9
(0) 		332.7
(-3) 		594

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 619
1 2 3 4 5 6 range
A 425.2
(-3)
P 		839.4
(3)
P 		556.2
(-1.1)
P 		441.9
(-2.8)
P 		616.3
(-0.2)
P 		438.1
(-2.8)
P 		414
B 1044.3
(3)
P 		804
(0.4)
P 		485.6
(-3)
P 		645.3
(-1.3)
P 		727.6
(-0.4)
P 		731.2
(-0.4)
P 		559
C 887.8
(3)
P 		734.2
(0.7)
P 		530
(-2.3)
P 		483
(-3)
P 		547.1
(-2)
P 		533
(-2.3)
P 		405
avr 785.8
(2.9) 		792.5
(3) 		523.9
(-3) 		523.4
(-3) 		630.3
(-0.6) 		567.4
(-2) 		269
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 174039_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.21278
Sequence Type Exemplar sequence
Representative Public ID 156355 NCBI
Target Description g156355 /REP_DB=GenBank Identifier /CHR=4 /FEA=Genomic Cluster
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069812(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069812 NCBI Caenorhabditis elegans LEThal family member (let-60) (let-60) mRNA, complete cds. 11/11 A 
ZK792.6 ENSEMBL cdna:known chromosome:CEL140:IV:11688197:11691058:-1 gene:ZK792.6 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:11688282-11688554(-) 100.0 100.0
Public Domain and Genome References
Gene Title LET-60 RAS protein
Gene Symbol let-60
Ensembl ZK792.6
Entrez Gene 178104 Entrez gene
SwissProt P22981 EMBL-EBI
WormBase CE03827 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1624899_AT Ras oncogene at 85D dm
DROSGENOME1:143317_AT Ras oncogene at 85D dm
CHICKEN:GGAAFFX.24341.1.S1_AT similar to turkey K-Ras gga
HG-U95AV2:32159_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U95AV2:1940_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HC-G110:1940_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133A:204010_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133_PLUS_2:204010_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133A_2:204010_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HU35KSUBC:RC_AA425857_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HU35KSUBD:RC_AA505084_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HUGENEFL:M54968_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
U133_X3P:G4826811_3P_A_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
U133_X3P:HS2.422851.1.A1_3P_X_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
U133_X3P:HS2.422851.1.A1_3P_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
U133_X3P:HS.184050.1.A1_3P_A_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
U133_X3P:HS.184050.0.S1_3P_A_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
U133_X3P:1559203_3P_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133_PLUS_2:1559203_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133_PLUS_2:1559204_X_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133A_2:204009_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-FOCUS:204009_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133_PLUS_2:204009_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133A:204009_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133A_2:214352_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133_PLUS_2:214352_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U133A:214352_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
HG-U95D:70329_AT V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog hs
MU11KSUBB:X02452_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MG-U74AV2:97991_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MG-U74BV2:106672_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MG-U74BV2:106938_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOE430A:1426229_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOUSE430A_2:1426229_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOUSE430_2:1426229_S_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOE430A:1426228_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOUSE430A_2:1426228_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOUSE430_2:1426228_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOE430A:1434000_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOUSE430A_2:1434000_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOUSE430_2:1434000_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOE430A:1451979_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOUSE430A_2:1451979_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MOUSE430_2:1451979_AT v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mm
MU19KSUBC:TC36682_AT V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (Kras), mRNA mm
MU19KSUBC:TC36682_G_AT V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (Kras), mRNA mm
RN-U34:U09793_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
RT-U34:U09793_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
RG-U34A:U09793_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
RAE230A:1370035_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
RAT230_2:1370035_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
RAE230A:1372355_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
RAT230_2:1372355_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
RG-U34B:RC_AA944575_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
RG-U34B:RC_AI045340_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
RG-U34C:RC_AI101656_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
RG-U34C:RC_AI229416_AT Kirsten rat sarcoma viral oncogene homologue 2 (active) rn
YEAST_2:1773513_AT GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6886 intracellular protein transport inferred from electronic annotation QuickGO AmiGO
7264 small GTPase mediated signal transduction inferred from electronic annotation QuickGO AmiGO
15031 protein transport inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5525 GTP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA92630 Hypothetical protein ZK792.6 [Caenorhabditis elegans] ref|NP_502213.3| LEThal family member (let-60) [Caenorhabditis elegans] sp|P22981|LET60_CAEEL Ras protein let-60 (Lethal protein 60) 5.0E-95
blast AAA28103 ras protein 5.0E-95
blast CAE62069 Hypothetical protein CBG06092 [Caenorhabditis briggsae] 2.0E-94
Protein Domains
Database ID Description E-Value
Pfam IPR001806 EMBL-EBI Ras GTPase superfamily 3.0E-96
Sequence
Target Sequence 
>C. ELEGANS:174039_AT
ccttcctcgttttcatacaaattattggcctcatctattttcagaagttctctgaaaatt
aaattcttttgcatctgccggtcgttccgtttattttttctctgtttcctctcatttttg
tcaagtaattatttctctttcattaactataatatagatacaattagaccccatttctca
tacattttctgaacatctgaaagtttttgctccctcgtattgcattcatttttctctatt
cc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CCTTCCTCGTTTTCATACAAATTAT 623 269 13 Antisense
ATTATTGGCCTCATCTATTTTCAGA 420 13 33 Antisense
TAAATTCTTTTGCATCTGCCGGTCG 285 641 72 Antisense
CTGTTTCCTCTCATTTTTGTCAAGT 579 237 114 Antisense
AATTATTTCTCTTTCATTAACTATA 629 175 139 Antisense
GATACAATTAGACCCCATTTCTCAT 618 421 169 Antisense
AGACCCCATTTCTCATACATTTTCT 166 71 178 Antisense
TCTCATACATTTTCTGAACATCTGA 28 613 188 Antisense
AACATCTGAAAGTTTTTGCTCCCTC 663 137 204 Antisense
CTCCCTCGTATTGCATTCATTTTTC 117 235 222 Antisense
TATTGCATTCATTTTTCTCTATTCC 583 665 230 Antisense
Sequence Source GenBank