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[173991_at] inositol-1,4,5-triphosphate 5-phosphatase

Description CEXT00513 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=C16C2.3 /5_PRIME_EXT_DB=WormBase Gene ID /GB=M79976 /WB_GENE_ID=C16C2.3 /WP=CE17405 /CHR=1 /FEA=Genomic Cluster /DEF=inositol-1,4,5-triphosphate 5-phosphatase; wEST00513 Mixed stage, Stratagene (cat. no. 937006) Caenorhabditis elegans cDNA clone CEMSG15, mRNA sequence.
Cluster 6grp_highest_10_10 > 90      6grp_high1_10_10 > 09      4grp_highest_8_8 > 35      4grp_high_8_8 > 56      6grp_highest_nonorm > 73      6grp_total > 93      4grp_total > 63      6grp_cgc > 88      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 211
1 2 3 4 range
A 490.5
(3)
P 		299.3
(-3)
P 		403.2
(0.3)
P 		381.7
(-0.4)
P 		191
B 447.1
(3)
P 		365.1
(-3)
P 		428.4
(1.6)
P 		400
(-0.4)
P 		82
C 397.6
(-3)
P 		510.7
(3)
P 		483.8
(1.6)
P 		419.7
(-1.8)
P 		113
avr 445.1
(3) 		391.7
(-3) 		438.5
(2.3) 		400.5
(-2) 		53

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 297
1 2 3 4 5 6 range
A 455.6
(-2.3)
P 		461.1
(-2.2)
P 		446.2
(-2.6)
P 		502.8
(-1.1)
P 		661.5
(3)
P 		430.4
(-3)
P 		231
B 634.1
(3)
P 		364.8
(-3)
P 		369.5
(-2.9)
P 		511.7
(0.3)
P 		584.8
(1.9)
P 		402.4
(-2.2)
P 		269
C 517.5
(-0.4)
P 		410.9
(-3)
P 		460
(-1.8)
P 		424.7
(-2.7)
P 		652.4
(3)
P 		497
(-0.9)
P 		242
avr 535.7
(0.4) 		412.3
(-3) 		425.2
(-2.6) 		479.7
(-1.2) 		632.9
(3) 		443.3
(-2.2) 		221
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 123
1 2 3 4 range
A 178.6
(3)
P 		65
(-2.6)
P 		105.4
(-0.6)
P 		55.9
(-3)
P 		123
B 142.6
(3)
P 		90.2
(-2.5)
P 		99.3
(-1.5)
P 		85.2
(-3)
P 		57
C 131.6
(0.7)
P 		146.8
(1.7)
P 		168.6
(3)
P 		70.8
(-3)
P 		98
avr 150.9
(3) 		100.7
(-0.8) 		124.4
(1) 		70.6
(-3) 		80

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 154
1 2 3 4 5 6 range
A 84
(-3)
P 		164
(1.2)
P 		97.2
(-2.3)
P 		127.5
(-0.7)
P 		199.6
(3)
P 		104.8
(-1.9)
P 		116
B 220.7
(2.3)
P 		121.4
(-1.7)
P 		89.7
(-3)
P 		135.5
(-1.1)
P 		237.6
(3)
P 		150
(-0.6)
P 		148
C 191.8
(2.1)
P 		125.4
(-1.1)
P 		117.1
(-1.5)
P 		85.4
(-3)
P 		211.1
(3)
P 		166.4
(0.9)
P 		126
avr 165.5
(0.4) 		136.9
(-1.1) 		101.3
(-3) 		116.1
(-2.2) 		216.1
(3) 		140.4
(-1) 		115
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173991_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.22675
Sequence Type Exemplar sequence
Representative Public ID CEXT00513 NCBI
Target Description CEXT00513 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=C16C2.3 /5_PRIME_EXT_DB=WormBase Gene ID /GB=M79976 /WB_GENE_ID=C16C2.3 /WP=CE17405 /CHR=1 /FEA=Genomic Cluster /DEF=inositol-1,4,5-triphosphate 5-phosphatase; wEST00513 Mixed stage, Stratagene (cat. no. 937006) Caenorhabditis elegans cDNA clone CEMSG15, mRNA sequence.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060183(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060183 NCBI Caenorhabditis elegans OCRL (Lowe's oculocerebrorenal syndrome protein) homolog family member (ocrl-1) (ocrl-1) mRNA, complete cds. 11/11 None
C16C2.3 ENSEMBL cdna:known chromosome:CEL140:I:9723457:9736229:-1 gene:C16C2.3 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9723398-9736161(-) 100.0 100.0
Public Domain and Genome References
Gene Title inositol-1,4,5-triphosphate 5-phosphatase
Gene Symbol ocrl-1
Ensembl C16C2.3
Entrez Gene 172822 Entrez gene
SwissProt O17590 EMBL-EBI
WormBase CE17405 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:19243_AT endonuclease/exonuclease/phosphatase family protein at
ATH1-121501:263596_AT endonuclease/exonuclease/phosphatase family protein at
DROSOPHILA_2:1638197_AT dm
DROSGENOME1:141448_AT dm
CHICKEN:GGA.12952.1.S1_AT inositol polyphosphate-5-phosphatase, 75kDa gga
CHICKEN:GGAAFFX.1026.1.S1_AT inositol polyphosphate-5-phosphatase, 75kDa gga
HG-U133A_2:213643_S_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HG-U133_PLUS_2:213643_S_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HG-U133A:213643_S_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HU35KSUBC:RC_AA126095_S_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HU35KSUBD:RC_H23446_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HUGENEFL:M74161_AT inositol polyphosphate-5-phosphatase, 75kDa hs
U133_X3P:HS2.407126.1.S1_3P_X_AT inositol polyphosphate-5-phosphatase, 75kDa hs
U133_X3P:HS.182577.1.S1_3P_A_AT inositol polyphosphate-5-phosphatase, 75kDa hs
U133_X3P:HS.182577.0.S1_3P_X_AT inositol polyphosphate-5-phosphatase, 75kDa hs
U133_X3P:HS.182577.0.S1_3P_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HG-U133_PLUS_2:1563565_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HG-U133A_2:213804_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HG-U133_PLUS_2:213804_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HG-U133A:213804_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HG-U95AV2:33290_AT inositol polyphosphate-5-phosphatase, 75kDa hs
HU35KSUBC:RC_N26401_AT Inositol polyphosphate-5-phosphatase, 75kDa hs
MU11KSUBB:MSA.36373.0_F_AT inositol polyphosphate-5-phosphatase B mm
MU11KSUBB:MSA.17055.0_F_AT inositol polyphosphate-5-phosphatase B mm
MG-U74AV2:94399_AT inositol polyphosphate-5-phosphatase B mm
MG-U74AV2:94398_S_AT inositol polyphosphate-5-phosphatase B mm
MOE430A:1451330_A_AT inositol polyphosphate-5-phosphatase B mm
MOUSE430A_2:1451330_A_AT inositol polyphosphate-5-phosphatase B mm
MOUSE430_2:1451330_A_AT inositol polyphosphate-5-phosphatase B mm
MU19KSUBB:TC29132_AT Inositol polyphosphate-5-phosphatase B, mRNA (cDNA clone MGC:25218 IMAGE:4457437) mm
RG-U34C:RC_AI172296_AT inositol polyphosphate-5-phosphatase B (predicted) rn
RAE230A:1388502_AT Inositol polyphosphate-5-phosphatase B (predicted) rn
RAT230_2:1388502_AT Inositol polyphosphate-5-phosphatase B (predicted) rn
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
4437 inositol or phosphatidylinositol phosphatase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02743 Hypothetical protein C16C2.3 [Caenorhabditis elegans] ref|NP_492584.1| OCRL (Lowe's oculocerebrorenal syndrome protein) homolog family member (ocrl-1) [Caenorhabditis elegans] 0.0
blast CAE60242 Hypothetical protein CBG03815 [Caenorhabditis briggsae] 0.0
blast XP_417756 PREDICTED: similar to Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (Phosphoinositide 5-phosphatase) (5PTase) [Gallus gallus] 3.0E-83
Protein Domains
Database ID Description E-Value
scop a.4.5.Plant O-methyltransferase, N-terminal domain All alpha proteins; DNA/RNA-binding 3-helical bundle; "Winged helix" DNA-binding domain; Plant O-methyltransferase, N-terminal domain 8.60000038146973
Pfam IPR005135 EMBL-EBI Endonuclease/exonuclease/phosphatase 3.9E-41
Sequence
Target Sequence 
>C. ELEGANS:173991_AT
ggggtttatcagactttacaaatcattttttaaaacttttctaaacaaacgggtgtcata
tcgcatttttcagtttttttcgttattaacttaattttcttgatgttttattctaaactc
ttcaattaggccattacattcattcttgatatcctgtttaattttatttgccatattgta
tattcttaattatttttggttgttccttgtgatatttctatttgccccc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGGGTTTATCAGACTTTACAAATCA 378 497 2287 Antisense
AAACGGGTGTCATATCGCATTTTTC 183 127 2333 Antisense
TCATATCGCATTTTTCAGTTTTTTT 100 621 2342 Antisense
TAATTTTCTTGATGTTTTATTCTAA 681 631 2378 Antisense
TAAACTCTTCAATTAGGCCATTACA 308 641 2400 Antisense
TAGGCCATTACATTCATTCTTGATA 432 653 2413 Antisense
ATTCATTCTTGATATCCTGTTTAAT 637 11 2424 Antisense
ATCCTGTTTAATTTTATTTGCCATA 570 37 2437 Antisense
ATTTGCCATATTGTATATTCTTAAT 614 17 2452 Antisense
TTATTTTTGGTTGTTCCTTGTGATA 375 673 2476 Antisense
CCTTGTGATATTTCTATTTGCCCCC 607 269 2491 Antisense
Sequence Source Affymetrix Proprietary Database