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[173990_s_at] cathepsin-like protease

Description CEXT00396 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=T03E6.7 /5_PRIME_EXT_DB=WormBase Gene ID /GB=M79859 /WB_GENE_ID=T03E6.7 /WP=CE16333 /CHR=5 /FEA=Genomic Cluster /DEF=cathepsin-like protease; wEST00396 Mixed stage, Stratagene (cat. no. 937006) Caenorhabditis elegans cDNA clone CEMSE69 similar to Cathepsin L, mRNA sequence.
Cluster 6grp_highest_10_10 > 29      6grp_high1_10_10 > 92      4grp_highest_8_8 > 06      4grp_high_8_8 > 22      6grp_highest_nonorm > 39      6grp_total > 83      4grp_total > 16      6grp_highest_sub > 04_05      6grp_cgc > 87      6grp_high1_sub > 04_05      6grp_cgc_sub > 05      6grp_total_sub > Hat      6grp_rule_based > S5      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 10798
1 2 3 4 range
A 5891.7
(-3)
P 		10954.7
(-0.2)
P 		9914.9
(-0.8)
P 		16689.5
(3)
P 		10798
B 6062.4
(-3)
P 		8883.6
(-1.1)
P 		10782.8
(0.2)
P 		15021.5
(3)
P 		8959
C 6037.5
(-3)
P 		9156.9
(-0.9)
P 		9111.9
(-0.9)
P 		14859.2
(3)
P 		8822
avr 5997.2
(-3) 		9665.1
(-0.7) 		9936.5
(-0.5) 		15523.4
(3) 		9526

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 5848
1 2 3 4 5 6 range
A 4246.4
(-3)
P 		5288
(-1.7)
P 		6089.4
(-0.7)
P 		8915.7
(2.9)
P 		8967.6
(3)
P 		6846.4
(0.3)
P 		4721
B 4138.8
(-3)
P 		4780.7
(-2.2)
P 		7119.3
(0.9)
P 		8680.8
(3)
P 		8085.9
(2.2)
P 		5223
(-1.6)
P 		4542
C 5435.8
(-2.1)
P 		4612.7
(-3)
P 		7416.1
(0.1)
P 		8378.8
(1.2)
P 		9986.6
(3)
P 		4925.3
(-2.7)
P 		5374
avr 4607
(-3) 		4893.8
(-2.6) 		6874.9
(0.1) 		8658.4
(2.5) 		9013.4
(3) 		5664.9
(-1.6) 		4406
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1268
1 2 3 4 range
A 2145.2
(-3)
P 		2378
(0.1)
P 		2591.9
(3)
P 		2443
(1)
P 		447
B 1933.2
(-3)
P 		2194
(-1.8)
P 		2498.6
(-0.3)
P 		3201.1
(3)
P 		1268
C 1998.6
(-3)
P 		2632.7
(0.2)
P 		3175.8
(3)
P 		2505.5
(-0.4)
P 		1177
avr 2025.7
(-3) 		2401.6
(0.1) 		2755.4
(3) 		2716.5
(2.7) 		730

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2502
1 2 3 4 5 6 range
A 782.8
(-3)
P 		1880.7
(0.4)
P 		1326.1
(-1.3)
P 		2261.2
(1.6)
P 		2706
(3)
P 		1666.9
(-0.2)
P 		1923
B 1440.1
(-3)
P 		1591.3
(-2.5)
P 		1728.8
(-2.1)
P 		2299.2
(-0.2)
P 		3285.2
(3)
P 		1947.6
(-1.3)
P 		1845
C 2014.8
(-1)
P 		1407.5
(-3)
P 		1887.5
(-1.4)
P 		1685
(-2.1)
P 		3231.5
(3)
P 		1648.8
(-2.2)
P 		1824
avr 1412.6
(-3) 		1626.5
(-2.2) 		1647.5
(-2.2) 		2081.8
(-0.6) 		3074.2
(3) 		1754.4
(-1.8) 		1662
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 173990_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.25342
Sequence Type Exemplar sequence
Representative Public ID CEXT00396 NCBI
Target Description CEXT00396 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=T03E6.7 /5_PRIME_EXT_DB=WormBase Gene ID /GB=M79859 /WB_GENE_ID=T03E6.7 /WP=CE16333 /CHR=5 /FEA=Genomic Cluster /DEF=cathepsin-like protease; wEST00396 Mixed stage, Stratagene (cat. no. 937006) Caenorhabditis elegans cDNA clone CEMSE69 similar to Cathepsin L, mRNA sequence.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_074798(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_074798 NCBI Caenorhabditis elegans CathePsin L family member (cpl-1) (cpl-1) mRNA, complete cds. 11/11 None
SNAP00000008701 ENSEMBL cdna:SNAP chromosome:CEL140:V:16595329:16597927:-1 11/11 None
GENEFINDER00000008703 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:16595329:16597927:-1 11/11 None
T03E6.7.1 ENSEMBL cdna:known chromosome:CEL140:V:16595153:16597930:-1 gene:T03E6.7 11/11 None
T03E6.7.3 ENSEMBL cdna:known chromosome:CEL140:V:16595153:16598141:-1 gene:T03E6.7 11/11 None
T03E6.7.2 ENSEMBL cdna:known chromosome:CEL140:V:16595153:16597927:-1 gene:T03E6.7 11/11 None
T03E6.7.4 ENSEMBL cdna:known chromosome:CEL140:V:16595154:16597929:-1 gene:T03E6.7 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:16595176-16597928(-) 98.11 100.0
Public Domain and Genome References
Gene Title cathepsin-like protease
Gene Symbol cpl-1
Ensembl T03E6.7
Entrez Gene 180111 Entrez gene
SwissProt O45734 EMBL-EBI
WormBase CE16333 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:247627_AT cysteine proteinase, putative / AALP protein (AALP) at
DROSOPHILA_2:1625264_S_AT Cysteine proteinase-1 dm
DROSGENOME1:141762_AT Cysteine proteinase-1 dm
CHICKEN:GGA.523.1.S1_AT cathepsin L gga
HUGENEFL:X12451_AT cathepsin L hs
HG-U133A:202087_S_AT cathepsin L hs
HG-U133_PLUS_2:202087_S_AT cathepsin L hs
HG-FOCUS:202087_S_AT cathepsin L hs
HG-U133A_2:202087_S_AT cathepsin L hs
U133_X3P:G4503154_3P_A_AT cathepsin L hs
HG-U95AV2:37391_AT cathepsin L hs
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4182 carboxypeptidase A activity inferred from electronic annotation QuickGO AmiGO
4197 cysteine-type endopeptidase activity inferred from electronic annotation QuickGO AmiGO
8234 cysteine-type peptidase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB07275 Hypothetical protein T03E6.7 [Caenorhabditis elegans] ref|NP_507199.1| CathePsin L family member (cpl-1) [Caenorhabditis elegans] 0.0
blast CAE74770 Hypothetical protein CBG22599 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000668 EMBL-EBI Peptidase C1A, papain 1.0E-126
Pfam IPR000668 EMBL-EBI Peptidase C1A, papain 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:173990_S_AT
aaccacggatgcaacggaggactcatggatcaagctttcgagtacattcgtgacaaccat
ggtgtcgacaccgaggagtcatacccatacaagggacgtgacatgaagtgtcacttcaac
aagaagaccgtcggagctgatgataagggatacgttgacaccccagaaggagatgaggag
caacttaagatcgctgtcgccacccaaggaccaatctctattgctatcgacgccggacac
cgcagcttccaactttacaagaagggagtctactacgatgaggaatgctcatccgaagag
ctcgaccacggagtgcttctcgtcggatacggaaccgacccagagcacggagactactgg
attgtcaagaactcgtggggagctggatggggagagaagggatacatccgtatcgcccgt
aaccgcaacaatcactgcggagtcgccaccaaggccagttatccatt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AACCACGGATGCAACGGAGGACTCA 524 147 554 Antisense
GTGTCGACACCGAGGAGTCATACCC 76 485 615 Antisense
GATACGTTGACACCCCAGAAGGAGA 78 421 702 Antisense
AGCAACTTAAGATCGCTGTCGCCAC 124 77 732 Antisense
CCACCCAAGGACCAATCTCTATTGC 87 275 753 Antisense
ACCGCAGCTTCCAACTTTACAAGAA 301 89 792 Antisense
GAAGAGCTCGACCACGGAGTGCTTC 291 339 848 Antisense
AGTGCTTCTCGTCGGATACGGAACC 660 59 865 Antisense
AGAAGGGATACATCCGTATCGCCCG 488 73 948 Antisense
GCAACAATCACTGCGGAGTCGCCAC 626 317 978 Antisense
TCGCCACCAAGGCCAGTTATCCATT 294 599 996 Antisense
Sequence Source Affymetrix Proprietary Database