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[173976_at] PH (pleckstrin homology) domain

Description AV202821 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=Y49E10.19 /5_PRIME_EXT_DB=WormBase Gene ID /GB=AV202821 /WB_GENE_ID=Y49E10.19 /WP=CE22234 /CHR=3 /FEA=Genomic Cluster /DEF=PH (pleckstrin homology) domain; Caenorhabditis elegans cDNA clone:yk555c6 : 5prime end, single read.
Cluster 6grp_highest_10_10 > 96      6grp_high1_10_10 > 68      4grp_highest_8_8 > 32      4grp_high_8_8 > 43      6grp_highest_nonorm > 93      6grp_total > 69      4grp_total > 52      6grp_highest_sub > Cu      6grp_cgc > 29      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 245
1 2 3 4 range
A 425.5
(3)
P 		345.3
(0.3)
P 		326.7
(-0.3)
P 		245.2
(-3)
P 		180
B 370.2
(0.7)
P 		441.5
(3)
P 		432
(2.7)
P 		252.6
(-3)
P 		189
C 392.7
(-0.4)
P 		490.5
(3)
P 		356
(-1.7)
P 		318.7
(-3)
P 		172
avr 396.1
(1.8) 		425.8
(3) 		371.6
(0.9) 		272.2
(-3) 		154

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 620
1 2 3 4 5 6 range
A 436.5
(-0.5)
P 		374.3
(-1.1)
P 		192
(-3)
P 		242.6
(-2.5)
P 		374.4
(-1.1)
P 		771.5
(3)
P 		580
B 430
(0.3)
P 		275.2
(-1.6)
P 		151.3
(-3)
P 		307.8
(-1.2)
P 		360.9
(-0.6)
P 		665
(3)
P 		514
C 388.1
(-0.4)
P 		354.3
(-1)
P 		226.6
(-3)
P 		240
(-2.8)
P 		412.4
(-0)
P 		604.2
(3)
P 		378
avr 418.2
(-0.2) 		334.6
(-1.2) 		190
(-3) 		263.5
(-2.1) 		382.6
(-0.6) 		680.2
(3) 		490
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 119
1 2 3 4 range
A 154.9
(3)
P 		75
(-1)
P 		85.4
(-0.5)
P 		35.9
(-3)
P 		119
B 118.1
(3)
P 		109
(2.2)
P 		100.1
(1.3)
P 		53.8
(-3)
P 		64
C 130
(2.2)
P 		141
(3)
P 		124.1
(1.8)
P 		53.7
(-3)
P 		87
avr 134.3
(3) 		108.3
(1.2) 		103.2
(0.8) 		47.8
(-3) 		87

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 211
1 2 3 4 5 6 range
A 80.5
(-1.4)
P 		133.1
(0.8)
P 		41.8
(-3)
P 		61.5
(-2.2)
P 		113
(-0.1)
P 		187.8
(3)
P 		146
B 149.6
(0.2)
P 		91.6
(-1.4)
P 		36.7
(-3)
P 		81.5
(-1.7)
P 		146.6
(0.1)
P 		248
(3)
P 		211
C 143.9
(0.7)
P 		108.1
(-0.7)
P 		57.7
(-2.6)
P 		48.3
(-3)
P 		133.4
(0.3)
P 		202.3
(3)
P 		154
avr 124.7
(-0.2) 		110.9
(-0.7) 		45.4
(-3) 		63.8
(-2.3) 		131
(0.1) 		212.7
(3) 		167
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173976_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.23945
Sequence Type Exemplar sequence
Representative Public ID AV202821 NCBI
Target Description AV202821 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=Y49E10.19 /5_PRIME_EXT_DB=WormBase Gene ID /GB=AV202821 /WB_GENE_ID=Y49E10.19 /WP=CE22234 /CHR=3 /FEA=Genomic Cluster /DEF=PH (pleckstrin homology) domain; Caenorhabditis elegans cDNA clone:yk555c6 : 5prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067223(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067223 NCBI Caenorhabditis elegans ANIllin (actin binding protein) family member (ani-1) (ani-1) mRNA, complete cds. 11/11 None
Y49E10.19 ENSEMBL cdna:known chromosome:CEL140:III:12446241:12453077:-1 gene:Y49E10.19 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:12446262-12453056(-) 100.0 100.0
Public Domain and Genome References
Gene Title PH (pleckstrin homology) domain
Gene Symbol ani-1
Ensembl Y49E10.19
Entrez Gene 176672 Entrez gene
SwissProt Q9XTT4 EMBL-EBI
WormBase CE33878 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1606077_AT similar to anillin, actin binding protein (scraps homolog, Drosophila) cfa
CANINE_2:CFA.20116.1.S1_S_AT similar to anillin, actin binding protein (scraps homolog, Drosophila) cfa
CANINE_2:CFA.3333.1.A1_AT similar to anillin, actin binding protein (scraps homolog, Drosophila) cfa
CANINE_2:CFAAFFX.5799.1.S1_S_AT similar to anillin, actin binding protein (scraps homolog, Drosophila) cfa
DROSOPHILA_2:1637214_A_AT scraps dm
DROSGENOME1:154201_AT scraps dm
CHICKEN:GGA.3212.2.S1_S_AT similar to anillin, actin binding protein (scraps homolog, Drosophila); anillin (Drosophila Scraps homolog), actin binding protein gga
CHICKEN:GGAAFFX.23783.1.S1_AT similar to anillin, actin binding protein (scraps homolog, Drosophila); anillin (Drosophila Scraps homolog), actin binding protein gga
HU35KSUBB:RC_AA133250_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HU35KSUBC:RC_AA347193_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
U133_X3P:HS2.62180.1.S1_3P_S_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
U133_X3P:HS.62180.0.S2_3P_A_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HG-U133_PLUS_2:1552619_A_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HG-U133_PLUS_2:222608_S_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HG-U133B:222608_S_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HG-U95B:46194_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HG-U95E:77096_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
MU11KSUBA:C78101_RC_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MU11KSUBA:AA673431_RC_F_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MG-U74AV2:96784_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MG-U74CV2:134014_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MOE430A:1433543_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MOUSE430A_2:1433543_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MOUSE430_2:1433543_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MOE430B:1439648_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MOUSE430_2:1439648_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MU19KSUBA:TC24486_AT Anillin, actin binding protein (scraps homolog, Drosophila) (Anln), mRNA mm
MU19KSUBB:TC27078_AT Anillin, actin binding protein (scraps homolog, Drosophila) (Anln), mRNA mm
Protein Similarities
Method ID Description E-Value
blast CAB11565 Hypothetical protein Y49E10.19 [Caenorhabditis elegans] ref|NP_499624.2| ANIllin (actin binding protein) family member (ani-1) [Caenorhabditis elegans] 0.0
blast CAE66422 Hypothetical protein CBG11691 [Caenorhabditis briggsae] 0.0
blast CAA61954 actin binding protein [Drosophila melanogaster] 1.0E-32
Protein Domains
Database ID Description E-Value
Pfam IPR001849 EMBL-EBI Pleckstrin-like 1.8E-9
Sequence
Target Sequence 
>C. ELEGANS:173976_AT
ccccttttttgcaagctttgtgcctgtatgtatcccccagtttttcccctcagatttttt
ttgacaaataatcaaatgttttattattattctcgttacttctctctctctctccatgtt
tagcttccttcttttctagaatttactcccttcttttttaatcaatacatcactgtccca
ttatcattattccactctttttgggcctttttcgatttattcgaaaattttagtttcaca
gtgcc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CCCCTTTTTTGCAAGCTTTGTGCCT 477 261 3636 Antisense
TTGCAAGCTTTGTGCCTGTATGTAT 283 703 3644 Antisense
TCCCCTCAGATTTTTTTTGACAAAT 87 597 3680 Antisense
ATTATTATTCTCGTTACTTCTCTCT 545 13 3718 Antisense
TGTTTAGCTTCCTTCTTTTCTAGAA 357 561 3752 Antisense
TCTTTTCTAGAATTTACTCCCTTCT 453 615 3765 Antisense
TTAATCAATACATCACTGTCCCATT 386 685 3793 Antisense
AATACATCACTGTCCCATTATCATT 61 173 3799 Antisense
CACTGTCCCATTATCATTATTCCAC 688 197 3806 Antisense
CATTATTCCACTCTTTTTGGGCCTT 181 215 3820 Antisense
TCGAAAATTTTAGTTTCACAGTGCC 700 599 3856 Antisense
Sequence Source Affymetrix Proprietary Database