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[173908_at] guanosine-diphosphatase

Description AV203405 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=R07E4.4 /5_PRIME_EXT_DB=WormBase Gene ID /GB=AV203405 /WB_GENE_ID=R07E4.4 /WP=CE04819 /CHR=X /FEA=Genomic Cluster /DEF=guanosine-diphosphatase; Caenorhabditis elegans cDNA clone:yk576a12 : 5prime end, single read.
Cluster 6grp_highest_10_10 > 03      6grp_high1_10_10 > 22      4grp_highest_8_8 > 19      4grp_high_8_8 > 63      6grp_highest_nonorm > 75      6grp_total > 22      4grp_total > 56      6grp_highest_sub > De      6grp_cgc > 61      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 673
1 2 3 4 range
A 1024.3
(1.6)
P 		607.3
(-3)
P 		1151.8
(3)
P 		836.6
(-0.5)
P 		545
B 773.2
(-3)
P 		1021.3
(3)
P 		951.7
(1.3)
P 		862.9
(-0.8)
P 		248
C 931.5
(-3)
P 		1062.2
(-0.8)
P 		1280.2
(3)
P 		987.5
(-2)
P 		349
avr 909.7
(-2.6) 		896.9
(-3) 		1127.9
(3) 		895.7
(-3) 		232

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 488
1 2 3 4 5 6 range
A 1103.7
(3)
P 		903.5
(-0.4)
P 		844.5
(-1.5)
P 		754.5
(-3)
P 		993.1
(1.1)
P 		762.2
(-2.9)
P 		349
B 1029.7
(2.2)
P 		979.1
(1.5)
P 		995.1
(1.7)
P 		1088.9
(3)
P 		868.4
(0)
P 		642.1
(-3)
P 		447
C 634.8
(-2.6)
P 		892.4
(2.6)
P 		910.9
(3)
P 		751.3
(-0.2)
P 		635.3
(-2.6)
P 		616
(-3)
P 		295
avr 922.7
(2.9) 		925
(3) 		916.8
(2.8) 		864.9
(1.6) 		832.3
(0.8) 		673.4
(-3) 		252
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 324
1 2 3 4 range
A 372.9
(3)
P 		131.8
(-2.8)
P 		301.1
(1.3)
P 		122.5
(-3)
P 		250
B 246.6
(2.5)
P 		252.2
(3)
P 		220.5
(0.2)
P 		183.9
(-3)
P 		68
C 308.4
(0)
P 		305.4
(-0)
P 		446.2
(3)
P 		166.5
(-3)
P 		280
avr 309.3
(2.5) 		229.8
(-0.4) 		322.6
(3) 		157.6
(-3) 		165

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 207
1 2 3 4 5 6 range
A 203.5
(-2.1)
P 		321.3
(3)
P 		183.9
(-3)
P 		191.4
(-2.7)
P 		299.7
(2.1)
P 		185.6
(-2.9)
P 		137
B 358.3
(3)
P 		325.9
(1.4)
P 		241.6
(-2.9)
P 		288.4
(-0.5)
P 		352.8
(2.7)
P 		239.4
(-3)
P 		119
C 235.3
(1.2)
P 		272.3
(3)
P 		231.9
(1)
P 		151.1
(-3)
P 		205.6
(-0.3)
P 		206.2
(-0.3)
P 		121
avr 265.7
(0.5) 		306.5
(3) 		219.1
(-2.5) 		210.3
(-3) 		286
(1.7) 		210.4
(-3) 		96
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173908_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.25853
Sequence Type Exemplar sequence
Representative Public ID AV203405 NCBI
Target Description AV203405 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=R07E4.4 /5_PRIME_EXT_DB=WormBase Gene ID /GB=AV203405 /WB_GENE_ID=R07E4.4 /WP=CE04819 /CHR=X /FEA=Genomic Cluster /DEF=guanosine-diphosphatase; Caenorhabditis elegans cDNA clone:yk576a12 : 5prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076593(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076593 NCBI Caenorhabditis elegans R07E4.4 (guanosine-diphosphatase) mRNA, complete cds. 11/11 None
R07E4.4.1 ENSEMBL cdna:known chromosome:CEL140:X:5945722:5948827:-1 gene:R07E4.4 11/11 A 
R07E4.4.2 ENSEMBL cdna:known chromosome:CEL140:X:5945776:5948807:-1 gene:R07E4.4 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:5945798-5948808(-) 99.37 100.0
Public Domain and Genome References
Gene Title guanosine-diphosphatase
Gene Symbol mig-23
Ensembl R07E4.4
Entrez Gene 180860 Entrez gene
SwissProt Q21815 EMBL-EBI
WormBase CE28748 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:16257_AT nucleoside phosphatase family protein / GDA1/CD39 family protein at
ATH1-121501:266744_AT nucleoside phosphatase family protein / GDA1/CD39 family protein at
CANINE_2:CFAAFFX.14438.1.S1_AT similar to Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase4) (Uridine-diphosphatase) (UDPase) (Lysosomal apyrase-like protein of 70 kDa) cfa
CANINE_2:CFAAFFX.14438.1.S1_S_AT similar to Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase4) (Uridine-diphosphatase) (UDPase) (Lysosomal apyrase-like protein of 70 kDa) cfa
CHICKEN:GGAAFFX.247.1.S1_AT similar to guanosine-diphosphatase like protein gga
CHICKEN:GGAAFFX.247.2.S1_S_AT similar to guanosine-diphosphatase like protein gga
HG-U133A:204077_X_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U133_PLUS_2:204077_X_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U133A_2:204077_X_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HU35KSUBA:HUM_ALU_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HU35KSUBB:HUM_ALU_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HU35KSUBC:HUM_ALU_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HU35KSUBD:HUM_ALU_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HUGENEFL:HUM_ALU_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HC-G110:HUM_ALU_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HU35KSUBA:AB002390_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
U133_X3P:G4758661_3P_A_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
U133_X3P:HS2.201377.2.S1_3P_S_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
U133_X3P:HS.201377.0.S2_3P_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U133_PLUS_2:1555358_A_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U133A_2:204076_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-FOCUS:204076_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U133_PLUS_2:204076_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U133A:204076_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U95AV2:33788_AT ectonucleoside triphosphate diphosphohydrolase 4 hs
HU35KSUBC:RC_H92890_AT Ectonucleoside triphosphate diphosphohydrolase 4 hs
U133_X3P:HS2.384641.1.S1_3P_AT Ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U133_PLUS_2:1562187_AT Ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U95C:64586_AT Ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U95C:62397_AT Ectonucleoside triphosphate diphosphohydrolase 4 hs
HG-U95D:84320_AT Ectonucleoside triphosphate diphosphohydrolase 4 hs
MOUSE430_2:1447900_X_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MOE430B:1447900_X_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MOE430A:1438177_X_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MOUSE430A_2:1438177_X_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MOUSE430_2:1438177_X_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MG-U74AV2:93589_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MOE430A:1431761_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MOUSE430A_2:1431761_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MOUSE430_2:1431761_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MOE430A:1449190_A_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MOUSE430A_2:1449190_A_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MOUSE430_2:1449190_A_AT ectonucleoside triphosphate diphosphohydrolase 4 mm
MG-U74BV2:114147_AT Ectonucleoside triphosphate diphosphohydrolase 4, mRNA (cDNA clone IMAGE:4221257) mm
MU19KSUBC:TC37309_AT Ectonucleoside triphosphate diphosphohydrolase 4, mRNA (cDNA clone IMAGE:4221257) mm
RG-U34C:RC_AI176018_AT ectonucleoside triphosphate diphosphohydrolase 4 (predicted) rn
RAE230A:1375728_AT Ectonucleoside triphosphate diphosphohydrolase 4 (predicted) rn
RAT230_2:1375728_AT Ectonucleoside triphosphate diphosphohydrolase 4 (predicted) rn
YEAST_2:1775020_AT Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p Sc
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
16787 hydrolase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_508994 R07E4.4 [Caenorhabditis elegans] gb|AAA80403.2| Abnormal cell migration protein 23 [Caenorhabditis elegans] dbj|BAD02168.1| MIG-23 [Caenorhabditis elegans] sp|Q21815|MIG23_CAEEL Nucleoside-diphosphatase mig-23 (NDPase) (Abnormal cell migration protein 23) 0.0
blast T16696 hypothetical protein R07E4.4 - Caenorhabditis elegans 0.0
blast CAE68825 Hypothetical protein CBG14784 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000407 EMBL-EBI Nucleoside phosphatase GDA1/CD39 1.0E-126
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_508994.1 1 7-29
R07E4.4.1 1 7-29
R07E4.4.2 1 7-29
Sequence
Target Sequence 
>C. ELEGANS:173908_AT
gagaactttgcctagtcaatctttctaatcgtgtgtgttccaatacgtgttttattgtca
aatcacatcgcacttcaattgccttccaaagttttattgtcctgtcttttttgttagatc
ttacgggtttagtaatttatatgtgatactttttaatgtattgaaaataatttatcttga
catgtaatcagttacg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGAACTTTGCCTAGTCAATCTTTC 625 391 1673 Antisense
GCCTAGTCAATCTTTCTAATCGTGT 223 281 1682 Antisense
AATCTTTCTAATCGTGTGTGTTCCA 418 169 1690 Antisense
GTGTGTGTTCCAATACGTGTTTTAT 149 489 1703 Antisense
GTGTTTTATTGTCAAATCACATCGC 657 483 1719 Antisense
ATCACATCGCACTTCAATTGCCTTC 558 27 1734 Antisense
CGCACTTCAATTGCCTTCCAAAGTT 87 253 1741 Antisense
GCCTTCCAAAGTTTTATTGTCCTGT 413 281 1753 Antisense
TTTATTGTCCTGTCTTTTTTGTTAG 240 675 1765 Antisense
CTGTCTTTTTTGTTAGATCTTACGG 163 229 1774 Antisense
TTATCTTGACATGTAATCAGTTACG 24 679 1844 Antisense
Sequence Source Affymetrix Proprietary Database