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[173879_at] serine/threonine kinase (2 domains)

Description C66834 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=F52B5.2 /5_PRIME_EXT_DB=WormBase Gene ID /GB=C66834 /WB_GENE_ID=F52B5.2 /WP=CE24993 /CHR=1 /FEA=Genomic Cluster /DEF=serine-threonine kinase (2 domains); C.elegans cDNA clone yk233e10 : 5prime end, single read.
Cluster 6grp_total > 96      4grp_total > 50      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 66
1 2 3 4 range
A 34.3
(-3)
P 		56
(3)
A 		52.3
(2)
P 		37.9
(-2)
A 		22
B 18.4
(-0.9)
A 		48.5
(2.7)
A 		0.8
(-3)
A 		50.7
(3)
A 		50
C 48.1
(1.4)
A 		29.3
(-0.3)
A 		66
(3)
P 		0.2
(-3)
A 		66
avr 33.6
(-1.4) 		44.6
(3) 		39.7
(1) 		29.6
(-3) 		15

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 133
1 2 3 4 5 6 range
A 30.9
(-2.1)
A 		19.4
(-3)
A 		40.4
(-1.3)
A 		48
(-0.7)
A 		94.2
(3)
P 		72.6
(1.3)
M 		75
B 7.9
(-3)
A 		64.2
(-0.5)
A 		73.2
(-0.1)
P 		61.5
(-0.6)
P 		116.4
(1.9)
P 		141
(3)
P 		133
C 42.5
(-3)
P 		44.8
(-2.8)
A 		72.2
(-0.6)
M 		73.8
(-0.5)
A 		81.3
(0.1)
M 		117.5
(3)
P 		75
avr 27.1
(-3) 		42.8
(-1.9) 		61.9
(-0.5) 		61.1
(-0.6) 		97.3
(2.1) 		110.4
(3) 		83
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 23
1 2 3 4 range
A 12.5
(2.1)
P 		12.2
(1.9)
A 		13.7
(3)
P 		5.6
(-3)
A 		8
B 5.9
(-0.1)
A 		12
(3)
A 		0.2
(-3)
A 		10.8
(2.4)
A 		12
C 15.9
(1.1)
A 		8.4
(-0.8)
A 		23
(3)
P 		0
(-3)
A 		23
avr 11.4
(2.2) 		10.9
(1.8) 		12.3
(3) 		5.5
(-3) 		7

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 50
1 2 3 4 5 6 range
A 5.7
(-3)
A 		6.9
(-2.7)
A 		8.8
(-2.2)
A 		12.2
(-1.3)
A 		28.4
(3)
P 		17.7
(0.2)
M 		23
B 2.8
(-3)
A 		21.4
(-0.8)
A 		17.8
(-1.2)
P 		16.3
(-1.4)
P 		47.3
(2.4)
P 		52.6
(3)
P 		50
C 15.8
(-2.5)
P 		13.7
(-3)
A 		18.4
(-1.9)
M 		14.8
(-2.7)
A 		26.3
(-0)
M 		39.3
(3)
P 		26
avr 8.1
(-3) 		14
(-1.8) 		15
(-1.5) 		14.4
(-1.7) 		34
(2.5) 		36.5
(3) 		28
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173879_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.22858
Sequence Type Exemplar sequence
Representative Public ID C66834 NCBI
Target Description C66834 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=F52B5.2 /5_PRIME_EXT_DB=WormBase Gene ID /GB=C66834 /WB_GENE_ID=F52B5.2 /WP=CE24993 /CHR=1 /FEA=Genomic Cluster /DEF=serine-threonine kinase (2 domains); C.elegans cDNA clone yk233e10 : 5prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059858(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059858 NCBI Caenorhabditis elegans F52B5.2 (F52B5.2) mRNA, complete cds. 11/11 None
F52B5.2 ENSEMBL cdna:known chromosome:CEL140:I:8324077:8326374:-1 gene:F52B5.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:8324029-8326306(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (2 domains)
Ensembl F52B5.2
Entrez Gene 172614 Entrez gene
SwissProt Q20643 EMBL-EBI
WormBase CE24993 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA99854 Hypothetical protein F52B5.2 [Caenorhabditis elegans] ref|NP_492259.1| F52B5.2 [Caenorhabditis elegans] 1.0E-164
blast XP_624845 PREDICTED: similar to CDK-related protein kinase PNQLARE [Apis mellifera] 4.0E-27
blast NP_910092 putative protein kinase [Oryza sativa (japonica cultivar-group)] gb|AAO73290.1| putative protein kinase [Oryza sativa (japonica cultivar-group)] 5.0E-25
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-24
hanks 3.1.3 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk3 2.0E-22
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 3.5E-39
Sequence
Target Sequence 
>C. ELEGANS:173879_AT
gcacaggctaactaatttcaattattcttattactatttccaattcaattttctatttaa
ttttaaaagtacagacgaatctagaaaacaaggcctgttttgagttttaaaaagttttct
agatcaacacatttttttttgaaatttgtaagtttcccattccaattaagcactttattt
caatattgtctggttatgctatcactttcatttgctaaatatccacatatgtttatattt
ttattatattacctcaatca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCACAGGCTAACTAATTTCAATTAT 659 315 905 Antisense
AATTATTCTTATTACTATTTCCAAT 380 175 924 Antisense
CTATTTCCAATTCAATTTTCTATTT 331 223 938 Antisense
GACGAATCTAGAAAACAAGGCCTGT 541 377 978 Antisense
TTTTCTAGATCAACACATTTTTTTT 75 675 1019 Antisense
TTGTAAGTTTCCCATTCCAATTAAG 297 545 1050 Antisense
GTTTCCCATTCCAATTAAGCACTTT 307 451 1056 Antisense
TTAAGCACTTTATTTCAATATTGTC 291 685 1070 Antisense
ATTGTCTGGTTATGCTATCACTTTC 342 3 1089 Antisense
GCTATCACTTTCATTTGCTAAATAT 498 303 1102 Antisense
TATTTTTATTATATTACCTCAATCA 589 661 1140 Antisense
Sequence Source Affymetrix Proprietary Database