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[173861_at] Human MRE11 protein like

Description CEK133B9F /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=ZC302.1 /5_PRIME_EXT_DB=WormBase Gene ID /GB=D68586 /WB_GENE_ID=ZC302.1 /WP=CE06573 /CHR=5 /FEA=Genomic Cluster /GEN=mre-11 /DEF=Human MRE11 protein like; C.elegans cDNA clone yk133b9 : 5prime end, single read.
Cluster 6grp_highest_10_10 > 87      6grp_high1_10_10 > 77      4grp_highest_8_8 > 34      4grp_high_8_8 > 58      6grp_highest_nonorm > 93      6grp_total > 78      4grp_total > 61      6grp_highest_sub > Da      6grp_cgc > 49      6grp_high1_sub > Da      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 294
1 2 3 4 range
A 409.8
(3)
P 		282
(0.4)
P 		254.1
(-0.2)
P 		116.2
(-3)
P 		294
B 336.6
(3)
P 		254
(0.3)
P 		273.3
(0.9)
P 		154.7
(-3)
P 		182
C 267
(0.6)
P 		189.7
(-1.4)
P 		356.6
(3)
P 		129.5
(-3)
P 		227
avr 337.8
(3) 		241.9
(0.2) 		294.7
(1.7) 		133.5
(-3) 		204

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1041
1 2 3 4 5 6 range
A 204.3
(-3)
P 		231.3
(-2.8)
P 		266.7
(-2.5)
P 		238.8
(-2.7)
P 		515.4
(-0.5)
P 		953.1
(3)
P 		749
B 302.7
(-2.5)
P 		215.7
(-3)
P 		247.3
(-2.8)
P 		240.1
(-2.9)
P 		457.9
(-1.5)
P 		1199.1
(3)
P 		983
C 252.2
(-2.3)
P 		158.3
(-3)
P 		163.6
(-3)
P 		218.7
(-2.6)
P 		438.8
(-0.9)
P 		967
(3)
P 		809
avr 253.1
(-2.6) 		201.8
(-3) 		225.9
(-2.8) 		232.5
(-2.8) 		470.7
(-1.1) 		1039.7
(3) 		838
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 132
1 2 3 4 range
A 149.2
(3)
P 		61.2
(-1)
P 		66.4
(-0.8)
P 		17
(-3)
P 		132
B 107.3
(3)
P 		62.7
(-0.6)
P 		63.3
(-0.6)
P 		33
(-3)
P 		74
C 88.4
(0.9)
P 		54.5
(-1.1)
P 		124.3
(3)
P 		21.8
(-3)
P 		103
avr 115
(3) 		59.5
(-0.7) 		84.7
(1) 		23.9
(-3) 		91

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 409
1 2 3 4 5 6 range
A 37.7
(-3)
P 		82.3
(-1.6)
P 		58.1
(-2.4)
P 		60.6
(-2.3)
P 		155.5
(0.6)
P 		232.1
(3)
P 		194
B 105.3
(-2.3)
P 		71.8
(-2.8)
P 		60.1
(-3)
P 		63.6
(-2.9)
P 		186
(-1)
P 		447.1
(3)
P 		387
C 93.5
(-1.9)
P 		48.3
(-2.9)
P 		41.6
(-3)
P 		44
(-2.9)
P 		142
(-0.9)
P 		323.7
(3)
P 		282
avr 78.8
(-2.5) 		67.5
(-2.7) 		53.3
(-3) 		56.1
(-2.9) 		161.2
(-0.7) 		334.3
(3) 		281
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173861_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.25623
Sequence Type Exemplar sequence
Representative Public ID CEK133B9F NCBI
Target Description CEK133B9F /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=ZC302.1 /5_PRIME_EXT_DB=WormBase Gene ID /GB=D68586 /WB_GENE_ID=ZC302.1 /WP=CE06573 /CHR=5 /FEA=Genomic Cluster /GEN=mre-11 /DEF=Human MRE11 protein like; C.elegans cDNA clone yk133b9 : 5prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073335(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073335 NCBI Caenorhabditis elegans yeast MRE recombination/repair homolog family member (mre-11) (mre-11) mRNA, complete cds. 11/11 None
ZC302.1.1 ENSEMBL cdna:known chromosome:CEL140:V:10736538:10739429:-1 gene:ZC302.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:10736548-10739528(-) 100.0 100.0
Public Domain and Genome References
Gene Title Human MRE11 protein like
Gene Symbol mre-11
Ensembl ZC302.1
Entrez Gene 179488 Entrez gene
SwissProt Q23255 EMBL-EBI
WormBase CE37459 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:248152_AT DNA repair and meiosis protein (Mre11) at
CANINE_2:CFA.16225.1.S1_S_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) cfa
CANINE_2:CFAAFFX.7170.1.S1_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) cfa
CANINE_2:CFAAFFX.7170.1.S1_S_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) cfa
DROSOPHILA_2:1637151_AT meiotic recombination 11 dm
DROSGENOME1:153629_AT meiotic recombination 11 dm
CHICKEN:GGA.3157.1.S1_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) gga
CHICKEN:GGA.3157.1.S2_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) gga
HG-U133_PLUS_2:205395_S_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U133A_2:205395_S_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U133A:205395_S_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-FOCUS:205395_S_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HUGENEFL:U37359_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U133A:211334_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U133_PLUS_2:211334_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-FOCUS:211334_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U133A_2:211334_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
U133_X3P:G5031920_3P_S_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
U133_X3P:G13528887_3P_X_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
U133_X3P:G13528887_3P_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
U133_X3P:HS.125848.0.A1_3P_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U133_PLUS_2:242456_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U133B:242456_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U95AV2:32869_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U95AV2:32870_G_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U95AV2:39233_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U95E:73948_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
HG-U95E:89605_AT MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hs
MOUSE430_2:1441990_AT meiotic recombination 11 homolog A (S. cerevisiae) mm
MOE430B:1441990_AT meiotic recombination 11 homolog A (S. cerevisiae) mm
MU11KSUBA:U58987_S_AT meiotic recombination 11 homolog A (S. cerevisiae) mm
MG-U74AV2:94376_S_AT meiotic recombination 11 homolog A (S. cerevisiae) mm
MOE430A:1416748_A_AT meiotic recombination 11 homolog A (S. cerevisiae) mm
MOUSE430A_2:1416748_A_AT meiotic recombination 11 homolog A (S. cerevisiae) mm
MOUSE430_2:1416748_A_AT meiotic recombination 11 homolog A (S. cerevisiae) mm
MG-U74CV2:134757_AT Meiotic recombination 11 homolog A (S. cerevisiae) (Mre11a), mRNA mm
MU19KSUBB:TC26471_AT Meiotic recombination 11 homolog A (S. cerevisiae) (Mre11a), mRNA mm
RAE230A:1369445_AT meiotic recombination 11 homolog A (S. cerevisiae) rn
RAT230_2:1369445_AT meiotic recombination 11 homolog A (S. cerevisiae) rn
YEAST_2:1772731_AT Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6259 DNA metabolism inferred from electronic annotation QuickGO AmiGO
6302 double-strand break repair inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4519 endonuclease activity inferred from electronic annotation QuickGO AmiGO
4527 exonuclease activity inferred from electronic annotation QuickGO AmiGO
16787 hydrolase activity inferred from electronic annotation QuickGO AmiGO
30145 manganese ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA98292 Hypothetical protein ZC302.1 [Caenorhabditis elegans] ref|NP_505736.2| yeast MRE recombination/repair homolog family member (mre-11) [Caenorhabditis elegans] sp|Q23255|MRE11_CAEEL Double-strand break repair protein mre-11 0.0
blast CAE64875 Hypothetical protein CBG09687 [Caenorhabditis briggsae] 0.0
blast AAC78721 MRE11 homologue hMre11 [Homo sapiens] 6.0E-99
Protein Domains
Database ID Description E-Value
Pfam IPR004843 EMBL-EBI Metallo-phosphoesterase 4.6E-22
Pfam IPR007281 EMBL-EBI Mre11 DNA-binding presumed domain 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:173861_AT
ctaagtttcttctaaataattgtattttcacttatctcatttaccggtttgaatgatact
ctttcatgttcgacattctcaacctgttttatctagaatatcccgtatgaacttcttctc
tcgcccagtaaacggataaatt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CTAAGTTTCTTCTAAATAATTGTAT 82 227 2318 Antisense
ATTGTATTTTCACTTATCTCATTTA 624 3 2336 Antisense
TTCACTTATCTCATTTACCGGTTTG 614 685 2344 Antisense
TTTACCGGTTTGAATGATACTCTTT 291 673 2357 Antisense
TGATACTCTTTCATGTTCGACATTC 450 565 2371 Antisense
CATGTTCGACATTCTCAACCTGTTT 672 207 2382 Antisense
GACATTCTCAACCTGTTTTATCTAG 257 371 2389 Antisense
TTATCTAGAATATCCCGTATGAACT 147 679 2406 Antisense
ATATCCCGTATGAACTTCTTCTCTC 382 21 2415 Antisense
TCTTCTCTCGCCCAGTAAACGGATA 452 617 2431 Antisense
CTCTCGCCCAGTAAACGGATAAATT 239 231 2435 Antisense
Sequence Source Affymetrix Proprietary Database