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[173855_at] 2-oxoglutarate dehydrogenase

Description CEK038H9R_rc /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=T22B11.5 /5_PRIME_EXT_DB=WormBase Gene ID /GB=D33968 /WB_GENE_ID=T22B11.5 /WP=CE28486 /CHR=4 /FEA=Genomic Cluster /DEF=2-oxoglutarate dehydrogenase; C.elegans cDNA clone yk38h9 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 40      6grp_high1_10_10 > 05      4grp_highest_8_8 > 42      4grp_high_8_8 > 48      6grp_highest_nonorm > 20      6grp_total > 05      4grp_total > 63      6grp_highest_sub > De      6grp_high1_sub > De      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1199
1 2 3 4 range
A 1693.5
(3)
P 		1033.9
(-1.4)
P 		1183.6
(-0.4)
P 		792.9
(-3)
P 		901
B 1475.2
(1.9)
P 		1249.3
(-1.6)
P 		1543.2
(3)
P 		1161.1
(-3)
P 		382
C 1991.7
(3)
P 		1384.3
(-1.5)
P 		1554.3
(-0.2)
P 		1176.3
(-3)
P 		815
avr 1720.1
(3) 		1222.5
(-1.4) 		1427
(0.4) 		1043.4
(-3) 		677

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1502
1 2 3 4 5 6 range
A 1240
(0.2)
P 		1732.4
(3)
P 		1014.4
(-1.1)
P 		680.1
(-3)
P 		943
(-1.5)
P 		987.1
(-1.2)
P 		1052
B 1435.7
(3)
P 		1008.6
(-0.1)
P 		948.4
(-0.5)
P 		1055.3
(0.2)
P 		854.6
(-1.2)
P 		607
(-3)
P 		829
C 2109.2
(3)
P 		1034.5
(-1.3)
P 		1031.1
(-1.3)
P 		667.5
(-2.8)
P 		1139
(-0.9)
P 		612.5
(-3)
P 		1497
avr 1595
(3) 		1258.5
(0.7) 		998
(-1.2) 		801
(-2.5) 		978.9
(-1.3) 		735.5
(-3) 		860
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 543
1 2 3 4 range
A 616.6
(3)
P 		224.4
(-1.7)
P 		309.4
(-0.7)
P 		116.1
(-3)
P 		501
B 470.4
(3)
P 		308.6
(-1.4)
P 		357.6
(-0)
P 		247.4
(-3)
P 		223
C 659.3
(3)
P 		398
(-0.4)
P 		541.7
(1.5)
P 		198.3
(-3)
P 		461
avr 582.1
(3) 		310.3
(-1.1) 		402.9
(0.3) 		187.3
(-3) 		395

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 648
1 2 3 4 5 6 range
A 228.6
(-2.2)
P 		616.1
(3)
P 		220.9
(-2.3)
P 		172.5
(-3)
P 		284.6
(-1.5)
P 		240.3
(-2.1)
P 		444
B 499.5
(3)
P 		335.7
(-0.6)
P 		230.3
(-2.9)
P 		279.5
(-1.8)
P 		347.2
(-0.3)
P 		226.4
(-3)
P 		273
C 781.8
(3)
P 		315.7
(-1.3)
P 		262.4
(-1.8)
P 		134.2
(-3)
P 		368.6
(-0.8)
P 		205
(-2.3)
P 		648
avr 503.3
(3) 		422.5
(1.4) 		237.9
(-2.2) 		195.4
(-3) 		333.5
(-0.3) 		223.9
(-2.4) 		308
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173855_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.24973
Sequence Type Exemplar sequence
Representative Public ID CEK038H9R NCBI
Target Description CEK038H9R_rc /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=T22B11.5 /5_PRIME_EXT_DB=WormBase Gene ID /GB=D33968 /WB_GENE_ID=T22B11.5 /WP=CE28486 /CHR=4 /FEA=Genomic Cluster /DEF=2-oxoglutarate dehydrogenase; C.elegans cDNA clone yk38h9 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068216(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068216 NCBI Caenorhabditis elegans T22B11.5 (T22B11.5) mRNA, complete cds. 11/11 None
T22B11.5 ENSEMBL cdna:known chromosome:CEL140:IV:4696908:4704002:-1 gene:T22B11.5 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:4696924-4703982(-) 100.0 100.0
Public Domain and Genome References
Gene Title 2-oxoglutarate dehydrogenase
Ensembl T22B11.5
Entrez Gene 177235 Entrez gene
SwissProt O61199 EMBL-EBI
WormBase CE28486 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:247155_AT 2-oxoglutarate dehydrogenase E1 component, putative / oxoglutarate decarboxylase, putative / alpha-ketoglutaric dehydrogenase, putative at
ATGENOME1:19225_AT 2-oxoglutarate dehydrogenase E1 component, putative / oxoglutarate decarboxylase, putative / alpha-ketoglutaric dehydrogenase, putative at
ATGENOME1:19226_G_AT 2-oxoglutarate dehydrogenase E1 component, putative / oxoglutarate decarboxylase, putative / alpha-ketoglutaric dehydrogenase, putative at
CANINE:1605747_AT similar to oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) isoform 1 precursor cfa
CANINE_2:CFA.18679.1.S1_S_AT similar to oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) isoform 1 precursor cfa
DROSOPHILA_2:1632526_S_AT Neural conserved at 73EF dm
DROSGENOME1:141810_AT Neural conserved at 73EF dm
HU35KSUBA:HUM_ALU_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HU35KSUBB:HUM_ALU_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HU35KSUBC:HUM_ALU_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HU35KSUBD:HUM_ALU_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HUGENEFL:HUM_ALU_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HC-G110:HUM_ALU_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HUGENEFL:D10523_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U133A:201282_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U133_PLUS_2:201282_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-FOCUS:201282_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U133A_2:201282_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
U133_X3P:G4505492_3P_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
U133_X3P:1554151_3P_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U133_PLUS_2:1554151_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U133_PLUS_2:1554152_A_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U95AV2:40470_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U95E:78194_AT oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U133_PLUS_2:239234_AT Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U133B:239234_AT Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U95E:83427_AT Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
HG-U95D:86689_AT Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
U133_X3P:HS.296098.0.A1_3P_AT Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) hs
MOE430A:1451274_AT oxoglutarate dehydrogenase (lipoamide) mm
MOUSE430A_2:1451274_AT oxoglutarate dehydrogenase (lipoamide) mm
MOUSE430_2:1451274_AT oxoglutarate dehydrogenase (lipoamide) mm
MG-U74AV2:96879_AT oxoglutarate dehydrogenase (lipoamide) mm
MG-U74BV2:107924_AT oxoglutarate dehydrogenase (lipoamide) mm
MOE430B:1445632_AT Oxoglutarate dehydrogenase (lipoamide), mRNA (cDNA clone IMAGE:4983309) mm
MOUSE430_2:1445632_AT Oxoglutarate dehydrogenase (lipoamide), mRNA (cDNA clone IMAGE:4983309) mm
MU19KSUBB:TC32561_AT Oxoglutarate dehydrogenase (lipoamide), mRNA (cDNA clone IMAGE:4983309) mm
MU19KSUBC:TC39628_AT Oxoglutarate dehydrogenase (lipoamide), mRNA (cDNA clone IMAGE:4983309) mm
RAE230B:1397782_AT Similar to oxoglutarate dehydrogenase (lipoamide) rn
RAT230_2:1397782_AT Similar to oxoglutarate dehydrogenase (lipoamide) rn
RAE230B:1398072_AT Similar to oxoglutarate dehydrogenase (lipoamide) rn
RAT230_2:1398072_AT Similar to oxoglutarate dehydrogenase (lipoamide) rn
YEAST_2:1769462_AT Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
16624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB94185 Hypothetical protein T22B11.5 [Caenorhabditis elegans] ref|NP_500617.1| T22B11.5 [Caenorhabditis elegans] 0.0
blast CAE58572 Hypothetical protein CBG01737 [Caenorhabditis briggsae] 0.0
blast EAA44211 ENSANGP00000025238 [Anopheles gambiae str. PEST] gb|EAA10813.2| ENSANGP00000013033 [Anopheles gambiae str. PEST] ref|XP_316395.2| ENSANGP00000013033 [Anopheles gambiae str. PEST] ref|XP_316393.2| ENSANGP00000025238 [Anopheles gambiae str. PEST] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001017 EMBL-EBI Dehydrogenase, E1 component 4.7E-86
Pfam IPR005475 EMBL-EBI Transketolase, central region 1.3E-69
Sequence
Target Sequence 
>C. ELEGANS:173855_AT
aaggcctaaatctctacgaattgacagattttttttgatattttttgctcttttttcctg
tgtccccagttctgttttactccttttttacttttctgctcgtccttgtactcttttctc
tcgaattctcacaggctttattgatgttttttcattgattagtatatagggtagtgtgaa
gttttaggtttaatctcatccgccgcccgagtccccgtcctctttgtgcctccccgtttt
tttcttctgtcattatcattttcccacacgcaattttaatatgcatgctctctcttcctc
attttccagtgaagagagctaaattttttgatatgaacgtattttcctcaacacattttt
attcatcat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAGGCCTAAATCTCTACGAATTGAC 568 149 3122 Antisense
ATTGATGTTTTTTCATTGATTAGTA 256 5 3261 Antisense
TTTTAGGTTTAATCTCATCCGCCGC 257 95 3303 Antisense
TTTTCTTCTGTCATTATCATTTTCC 347 677 3361 Antisense
TCATTTTCCCACACGCAATTTTAAT 28 619 3377 Antisense
TTTAATATGCATGCTCTCTCTTCCT 285 673 3396 Antisense
CTCTCTTCCTCATTTTCCAGTGAAG 140 231 3411 Antisense
TTCCTCATTTTCCAGTGAAGAGAGC 74 701 3416 Antisense
GATATGAACGTATTTTCCTCAACAC 436 425 3451 Antisense
GAACGTATTTTCCTCAACACATTTT 641 347 3456 Antisense
TCCTCAACACATTTTTATTCATCAT 293 591 3466 Antisense
Sequence Source Affymetrix Proprietary Database