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[173846_at] FYVE zinc finger

Description C64657 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=VF11C1L.1 /5_PRIME_EXT_DB=WormBase Gene ID /GB=C64657 /WB_GENE_ID=VF11C1L.1 /WP=CE18979 /CHR=X /FEA=Genomic Cluster /GEN=ppk-3 /DEF=FYVE zinc finger; C.elegans cDNA clone yk357f7 : 5prime end, single read.
Cluster 6grp_high1_10_10 > 36      4grp_highest_8_8 > 45      4grp_high_8_8 > 01      6grp_total > 26      4grp_total > 15      6grp_cgc > 14      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 252
1 2 3 4 range
A 256.2
(3)
P 		90.4
(-3)
P 		163
(-0.4)
P 		204.8
(1.1)
P 		166
B 312.5
(3)
P 		252.7
(0.7)
P 		153.3
(-3)
P 		286.4
(2)
P 		159
C 307.3
(1.3)
P 		220.7
(-3)
P 		297.9
(0.8)
P 		342.8
(3)
P 		122
avr 292
(3) 		187.9
(-3) 		204.7
(-2) 		278
(2.2) 		104

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 201
1 2 3 4 5 6 range
A 290.9
(2.3)
P 		306.9
(3)
P 		258.2
(0.9)
P 		180.6
(-2.3)
M 		184.7
(-2.1)
P 		164.4
(-3)
M 		143
B 329.3
(3)
P 		283
(1.5)
P 		164.1
(-2.5)
A 		228.6
(-0.4)
P 		149.1
(-3)
P 		220.7
(-0.6)
P 		180
C 277
(2.7)
P 		284.3
(3)
P 		161.4
(-1.7)
M 		127.9
(-3)
P 		192.4
(-0.5)
P 		264.8
(2.3)
P 		156
avr 299.1
(3) 		291.4
(2.6) 		194.6
(-2.1) 		179
(-2.8) 		175.4
(-3) 		216.6
(-1) 		124
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 84
1 2 3 4 range
A 93.3
(3)
P 		19.6
(-3)
P 		42.6
(-1.1)
P 		30
(-2.2)
P 		74
B 99.6
(3)
P 		62.4
(-0.5)
P 		35.5
(-3)
P 		61
(-0.6)
P 		64
C 101.7
(2.7)
P 		63.5
(-2.3)
P 		103.8
(3)
P 		57.8
(-3)
P 		46
avr 98.2
(3) 		48.5
(-3) 		60.6
(-1.5) 		49.6
(-2.9) 		50

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 89
1 2 3 4 5 6 range
A 53.6
(-1.8)
P 		109.1
(3)
P 		56.2
(-1.6)
P 		45.8
(-2.5)
M 		55.7
(-1.6)
P 		40
(-3)
M 		69
B 114.6
(3)
P 		94.2
(1.4)
P 		39.8
(-3)
A 		60.6
(-1.3)
P 		60.6
(-1.3)
P 		82.3
(0.4)
P 		75
C 102.7
(3)
P 		86.7
(1.8)
P 		41.1
(-1.8)
M 		25.7
(-3)
P 		62.2
(-0.2)
P 		88.7
(1.9)
P 		77
avr 90.3
(2.3) 		96.7
(3) 		45.7
(-2.8) 		44
(-3) 		59.5
(-1.2) 		70.3
(-0) 		53
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173846_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.26070
Sequence Type Exemplar sequence
Representative Public ID C64657 NCBI
Target Description C64657 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=VF11C1L.1 /5_PRIME_EXT_DB=WormBase Gene ID /GB=C64657 /WB_GENE_ID=VF11C1L.1 /WP=CE18979 /CHR=X /FEA=Genomic Cluster /GEN=ppk-3 /DEF=FYVE zinc finger; C.elegans cDNA clone yk357f7 : 5prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077754(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077754 NCBI Caenorhabditis elegans PIP Kinase family member (ppk-3) (ppk-3) mRNA, complete cds. 11/11 None
VF11C1L.1 ENSEMBL cdna:known chromosome:CEL140:X:12968879:12974957:-1 gene:VF11C1L.1 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:12968889-12974958(-) 100.0 100.0
Public Domain and Genome References
Gene Title FYVE zinc finger
Gene Symbol ppk-3
Ensembl VF11C1L.1
Entrez Gene 181428 Entrez gene
SwissProt Q9XTF8 EMBL-EBI
WormBase CE18979 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:258361_AT phosphatidylinositol-4-phosphate 5-kinase family protein at
CANINE:1606162_AT similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 3 cfa
CANINE_2:CFAAFFX.21146.1.S1_S_AT similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 3 cfa
CANINE_2:CFAAFFX.21147.1.S1_AT similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 3 cfa
CANINE_2:CFAAFFX.21147.1.S1_S_AT similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 3 cfa
DROSOPHILA_2:1628190_AT dm
DROSGENOME1:141367_AT dm
CHICKEN:GGAAFFX.5553.2.S1_S_AT similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphatidylinositol-4-phosphate 5-kinase, type III; 1-phosphatidylinositol-4-phosphate 5-kinase; PtdIns(4)P-5-kinase; FYVE finger-containing phosphoinositide kina... gga
HG-U133_PLUS_2:213111_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U133A_2:213111_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U133A:213111_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U95B:42737_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HU35KSUBB:RC_R53765_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HU35KSUBB:RC_R53044_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HU35KSUBB:RC_H29209_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
U133_X3P:G6679187_3P_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
U133_X3P:HS2.406929.1.S1_3P_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
U133_X3P:HS.158135.0.S1_3P_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U133_PLUS_2:1553917_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U133_PLUS_2:1557719_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U95AV2:32085_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U95B:42738_G_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U95C:65262_R_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U95C:66571_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U133_PLUS_2:242926_AT Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U133B:242926_AT Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
HG-U95C:62598_AT Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
U133_X3P:HS.173939.0.A1_3P_AT Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III hs
MOE430A:1422994_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III mm
MOUSE430_2:1422994_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III mm
MOUSE430A_2:1422994_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III mm
MG-U74AV2:97712_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III mm
MG-U74CV2:166598_R_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III mm
MOE430B:1452994_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III mm
MOUSE430_2:1452994_AT phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III mm
MOE430B:1446974_AT Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III (Pip5k3), mRNA mm
MOUSE430_2:1446974_AT Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III (Pip5k3), mRNA mm
MU19KSUBC:TC35283_AT Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III (Pip5k3), mRNA mm
RG-U34B:RC_AI030529_AT similar to mKIAA0981 protein rn
RAE230B:1380216_AT similar to mKIAA0981 protein rn
RAT230_2:1380216_AT similar to mKIAA0981 protein rn
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
16308 1-phosphatidylinositol-4-phosphate 5-kinase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91791 Hypothetical protein VF11C1L.1 [Caenorhabditis elegans] emb|CAA19436.1| Hypothetical protein VF11C1L.1 [Caenorhabditis elegans] ref|NP_510155.1| PIP Kinase family member (ppk-3) [Caenorhabditis elegans] 0.0
blast CAE70363 Hypothetical protein CBG16921 [Caenorhabditis briggsae] 0.0
blast XP_580879 PREDICTED: similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 2 isoform 1 [Bos taurus] 3.0E-83
Protein Domains
Database ID Description E-Value
Pfam IPR002498 EMBL-EBI Phosphatidylinositol-4-phosphate 5-kinase 8.2E-48
Pfam IPR002498 EMBL-EBI Phosphatidylinositol-4-phosphate 5-kinase 2.8E-9
Pfam IPR000306 EMBL-EBI Zn-finger, FYVE type 4.1E-16
Sequence
Target Sequence 
>C. ELEGANS:173846_AT
tgtataatacccggttttcttgtgtaaaaacctgtttttttagattaattatttttctaa
tttttatgttcaattatttatgtatgatggctatcactttctcagctttttgcccggcag
cctctccccgtctaccaattcacttgttgtgattctcaacaaccgggttgaattttattg
tgtacagtttgtgtttattcccgtggcagccttattagtttgaaatcattgatgctttga
tactggtctaacttaatttctg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGTATAATACCCGGTTTTCTTGTGT 668 559 4142 Antisense
CAATTATTTATGTATGATGGCTATC 175 181 4212 Antisense
TGATGGCTATCACTTTCTCAGCTTT 575 567 4226 Antisense
CCCGTCTACCAATTCACTTGTTGTG 485 259 4268 Antisense
GTTGTGATTCTCAACAACCGGGTTG 125 437 4287 Antisense
CCGGGTTGAATTTTATTGTGTACAG 347 253 4304 Antisense
TACAGTTTGTGTTTATTCCCGTGGC 512 643 4324 Antisense
TATTCCCGTGGCAGCCTTATTAGTT 390 665 4337 Antisense
GTGGCAGCCTTATTAGTTTGAAATC 281 491 4344 Antisense
ATTGATGCTTTGATACTGGTCTAAC 428 3 4369 Antisense
TGATACTGGTCTAACTTAATTTCTG 586 563 4379 Antisense
Sequence Source Affymetrix Proprietary Database