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[173836_at] zinc metalloprotease

Description C62880 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=T24A11.3 /5_PRIME_EXT_DB=WormBase Gene ID /GB=C62880 /WB_GENE_ID=T24A11.3 /WP=CE02359 /CHR=3 /FEA=Genomic Cluster /GEN=toh-1 /DEF=zinc metalloprotease; C.elegans cDNA clone yk296d6 : 5prime end, single read.
Cluster 6grp_highest_10_10 > 19      6grp_high1_10_10 > 92      4grp_highest_8_8 > 10      4grp_high_8_8 > 55      6grp_highest_nonorm > 81      6grp_total > 83      4grp_total > 56      6grp_highest_sub > 05      6grp_cgc > 87      6grp_high1_sub > 04_05      6grp_cgc_sub > 05      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 479
1 2 3 4 range
A 177.3
(-2.7)
P 		402
(0.3)
P 		610.3
(3)
P 		151.9
(-3)
P 		458
B 167.3
(-2.8)
P 		497.1
(1.3)
P 		629.4
(3)
P 		150
(-3)
P 		479
C 198
(-2.5)
P 		473.5
(1.4)
P 		589.2
(3)
P 		162.2
(-3)
P 		427
avr 180.9
(-2.7) 		457.5
(1) 		609.6
(3) 		154.7
(-3) 		455

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 217
1 2 3 4 5 6 range
A 213.5
(-3)
P 		309
(0)
P 		278.7
(-0.9)
P 		293.9
(-0.4)
P 		402.4
(3)
P 		303.1
(-0.2)
P 		189
B 211.9
(-2)
P 		278.5
(0.3)
P 		185.5
(-3)
P 		352.1
(3)
P 		336.1
(2.4)
P 		261.5
(-0.3)
P 		167
C 204.5
(-3)
P 		249.9
(-1.2)
P 		300.4
(0.8)
P 		357.2
(3)
P 		352.4
(2.8)
P 		246.7
(-1.3)
P 		153
avr 210
(-3) 		279.1
(-0.3) 		254.9
(-1.2) 		334.4
(1.9) 		363.6
(3) 		270.4
(-0.6) 		154
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 183
1 2 3 4 range
A 64.6
(-1.1)
P 		87.3
(-0.2)
P 		159.5
(3)
P 		22.2
(-3)
P 		137
B 53.3
(-1.9)
P 		122.8
(1.8)
P 		145.8
(3)
P 		32
(-3)
P 		114
C 65.5
(-1.7)
P 		136.1
(0.7)
P 		205.3
(3)
P 		27.4
(-3)
P 		178
avr 61.1
(-1.6) 		115.4
(0.7) 		170.2
(3) 		27.2
(-3) 		143

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 97
1 2 3 4 5 6 range
A 39.4
(-3)
P 		109.9
(2.2)
P 		60.7
(-1.4)
P 		74.5
(-0.4)
P 		121.4
(3)
P 		73.8
(-0.5)
P 		82
B 73.7
(-1.1)
P 		92.7
(0.1)
P 		45.1
(-3)
P 		93.3
(0.2)
P 		136.5
(3)
P 		97.5
(0.4)
P 		91
C 75.8
(-2.4)
P 		76.3
(-2.4)
P 		76.5
(-2.3)
P 		71.8
(-3)
P 		114
(3)
P 		82.6
(-1.5)
P 		42
avr 63
(-2.8) 		93
(0.1) 		60.8
(-3) 		79.9
(-1.2) 		124
(3) 		84.6
(-0.7) 		63
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173836_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.24375
Sequence Type Exemplar sequence
Representative Public ID C62880 NCBI
Target Description C62880 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=T24A11.3 /5_PRIME_EXT_DB=WormBase Gene ID /GB=C62880 /WB_GENE_ID=T24A11.3 /WP=CE02359 /CHR=3 /FEA=Genomic Cluster /GEN=toh-1 /DEF=zinc metalloprotease; C.elegans cDNA clone yk296d6 : 5prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_065368(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_065368 NCBI Caenorhabditis elegans TOllisH (Tolloid and BMP-1 family) family member (toh-1) (toh-1) mRNA, complete cds. 11/11 None
T24A11.3 ENSEMBL cdna:known chromosome:CEL140:III:3804750:3809008:-1 gene:T24A11.3 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:3804775-3807715(-) 99.87 99.87
Public Domain and Genome References
Gene Title zinc metalloprotease
Gene Symbol toh-1
Ensembl T24A11.3
Entrez Gene 175491 Entrez gene
SwissProt Q22710 EMBL-EBI
WormBase CE35909 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88882 Hypothetical protein T24A11.3 [Caenorhabditis elegans] ref|NP_497769.3| TOllisH (Tolloid and BMP-1 family) family member (toh-1) [Caenorhabditis elegans] sp|Q22710|NAS26_CAEEL Zinc metalloproteinase nas-26 precursor (Nematode astacin 26) (Tollish protein 1) 0.0
blast CAE64502 Hypothetical protein CBG09229 [Caenorhabditis briggsae] 0.0
blast CAE61297 Hypothetical protein CBG05121 [Caenorhabditis briggsae] 9.0E-71
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 6.1E-52
Pfam IPR000859 EMBL-EBI CUB 4.9E-5
Sequence
Target Sequence 
>C. ELEGANS:173836_AT
cgccggcaagcctaaattcattttctagttcttctactccttcccatttctctcgaatcc
caggctttttgttattgatctctttgttctgttttcccagtttttcaaaatacaattcct
ttattacgcccccggtgacctacaaattaaatgctcagtttcaggtttcctctcccaaac
accctcgaatttctgtatatttctgcctctaatttttaataattgtccgttttcccttat
ttttgcatttcttgtcaactaatttttgtttcactttcatttttatacggg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CGCCGGCAAGCCTAAATTCATTTTC 475 255 1178 Antisense
TTCATTTTCTAGTTCTTCTACTCCT 435 689 1194 Antisense
CTCTCGAATCCCAGGCTTTTTGTTA 243 227 1227 Antisense
GGCTTTTTGTTATTGATCTCTTTGT 70 539 1240 Antisense
TATTGATCTCTTTGTTCTGTTTTCC 678 665 1250 Antisense
CCCGGTGACCTACAAATTAAATGCT 75 1 1308 Antisense
TTAAATGCTCAGTTTCAGGTTTCCT 80 683 1324 Antisense
TCCCAAACACCCTCGAATTTCTGTA 265 595 1350 Antisense
ATTTCTGTATATTTCTGCCTCTAAT 242 17 1366 Antisense
TTTTTGCATTTCTTGTCAACTAATT 343 675 1417 Antisense
TGTTTCACTTTCATTTTTATACGGG 28 561 1444 Antisense
Sequence Source Affymetrix Proprietary Database