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[173793_at] cyctochrome c1 heme lyase

Description CEC5211 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=T06D8.6 /5_PRIME_EXT_DB=WormBase Gene ID /GB=C08521 /WB_GENE_ID=T06D8.6 /WP=CE02327 /CHR=2 /FEA=Genomic Cluster /DEF=cyctochrome c1 heme lyase; C.elegans cDNA clone yk118a1 : 5prime end, single read.
Cluster 6grp_highest_10_10 > 96      6grp_high1_10_10 > 69      4grp_highest_8_8 > 14      4grp_high_8_8 > 14      6grp_highest_nonorm > 87      6grp_total > 69      4grp_total > 09      6grp_highest_sub > Cu      6grp_cgc > 29      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1938
1 2 3 4 range
A 1370.1
(-3)
P 		1657.9
(-2)
P 		1745.7
(-1.7)
P 		3040
(3)
P 		1670
B 1281.3
(-2.9)
P 		1265.7
(-3)
P 		1412.4
(-2.5)
P 		2965.1
(3)
P 		1699
C 1102.3
(-3)
P 		1580.9
(-1.4)
P 		1737.5
(-0.8)
P 		2864.6
(3)
P 		1762
avr 1251.2
(-3) 		1501.5
(-2.1) 		1631.9
(-1.7) 		2956.6
(3) 		1705

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 646
1 2 3 4 5 6 range
A 1167.1
(0.6)
P 		1169.3
(0.7)
P 		980.6
(-3)
P 		1076.5
(-1.1)
P 		1289.1
(3)
P 		1288.8
(3)
P 		309
B 1198.9
(-1.3)
P 		1280.9
(-0.5)
P 		1105.2
(-2.3)
P 		1032.2
(-3)
P 		1277.5
(-0.5)
P 		1626.9
(3)
P 		595
C 1184.7
(-2.4)
P 		1161.5
(-3)
P 		1199
(-2)
P 		1161.7
(-3)
P 		1169.2
(-2.8)
P 		1395.8
(3)
P 		234
avr 1183.6
(-1.4) 		1203.9
(-1) 		1094.9
(-2.9) 		1090.1
(-3) 		1245.3
(-0.3) 		1437.2
(3) 		347
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 319
1 2 3 4 range
A 498.9
(3)
P 		359.9
(-3)
P 		456.4
(1.2)
P 		445
(0.7)
P 		139
B 408.6
(-1.2)
P 		312.6
(-3)
P 		327.3
(-2.7)
P 		631.9
(3)
P 		319
C 364.9
(-3)
P 		454.5
(-0.8)
P 		605.6
(3)
P 		483
(-0.1)
P 		241
avr 424.1
(-1) 		375.7
(-3) 		463.1
(0.6) 		520
(3) 		144

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 393
1 2 3 4 5 6 range
A 215.1
(-3)
P 		415.9
(3)
P 		213.6
(-3)
P 		273
(-1.2)
P 		389
(2.2)
P 		313.8
(-0)
P 		202
B 417.2
(-0.4)
P 		426.4
(-0.2)
P 		268.4
(-3)
P 		273.4
(-2.9)
P 		519
(1.4)
P 		606.7
(3)
P 		338
C 439.1
(2.3)
P 		354.4
(0.1)
P 		305.2
(-1.2)
P 		233.6
(-3)
P 		378.3
(0.7)
P 		467.3
(3)
P 		234
avr 357.1
(-0.1) 		398.9
(1.1) 		262.4
(-2.9) 		260
(-3) 		428.8
(2) 		462.6
(3) 		203
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173793_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.23349
Sequence Type Exemplar sequence
Representative Public ID CEC5211 NCBI
Target Description CEC5211 /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=T06D8.6 /5_PRIME_EXT_DB=WormBase Gene ID /GB=C08521 /WB_GENE_ID=T06D8.6 /WP=CE02327 /CHR=2 /FEA=Genomic Cluster /DEF=cyctochrome c1 heme lyase; C.elegans cDNA clone yk118a1 : 5prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064002(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064002 NCBI Caenorhabditis elegans T06D8.6 (T06D8.6) mRNA, complete cds. 11/11 None
T06D8.6.2 ENSEMBL cdna:known chromosome:CEL140:II:11234969:11236293:-1 gene:T06D8.6 11/11 None
T06D8.6.1 ENSEMBL cdna:known chromosome:CEL140:II:11234969:11236356:-1 gene:T06D8.6 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000001124 3/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:11234978-11236278(-) 100.0 100.0
Public Domain and Genome References
Gene Title cyctochrome c1 heme lyase
Gene Symbol cchl-1
Ensembl T06D8.6
Entrez Gene 174713 Entrez gene
SwissProt P53703 EMBL-EBI
WormBase CE02327 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1585361_X_AT similar to Cytochrome c-type heme lyase (CCHL) (Holocytochrome c-type synthase) cfa
CANINE:1605399_AT similar to Cytochrome c-type heme lyase (CCHL) (Holocytochrome c-type synthase) cfa
CANINE:1584682_S_AT similar to Cytochrome c-type heme lyase (CCHL) (Holocytochrome c-type synthase) cfa
CANINE_2:CFAAFFX.18006.1.S1_S_AT similar to Cytochrome c-type heme lyase (CCHL) (Holocytochrome c-type synthase) cfa
DROSOPHILA_2:1637165_AT dm
DROSGENOME1:153443_AT dm
CHICKEN:GGA.15865.1.S1_AT similar to Cytochrome c-type heme lyase (CCHL) (Holocytochrome c-type synthase) gga
CHICKEN:GGA.9645.1.S1_A_AT similar to Cytochrome c-type heme lyase (CCHL) (Holocytochrome c-type synthase) gga
HG-U95AV2:38943_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HG-U133_PLUS_2:203746_S_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HG-U133A:203746_S_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HG-U133A_2:203746_S_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HU35KSUBA:U36787_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HUGENEFL:U36787_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HU35KSUBB:RC_T89379_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
U133_X3P:G4885400_3P_A_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
U133_X3P:HS.211571.0.S2_3P_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HG-U133A_2:203745_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HG-FOCUS:203745_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HG-U133_PLUS_2:203745_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HG-U133A:203745_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
HG-U95E:90576_AT holocytochrome c synthase (cytochrome c heme-lyase) hs
MOE430A:1420889_AT holocytochrome c synthetase mm
MOUSE430A_2:1420889_AT holocytochrome c synthetase mm
MOUSE430_2:1420889_AT holocytochrome c synthetase mm
MU11KSUBB:MSA.3227.0_S_AT holocytochrome c synthetase mm
MG-U74AV2:102007_AT holocytochrome c synthetase mm
MG-U74AV2:160573_AT holocytochrome c synthetase mm
MOE430A:1420890_AT holocytochrome c synthetase mm
MOUSE430A_2:1420890_AT holocytochrome c synthetase mm
MOUSE430_2:1420890_AT holocytochrome c synthetase mm
MU19KSUBB:TC30605_AT Holocytochrome c synthetase (Hccs), mRNA mm
MU19KSUBB:TC30605_G_AT Holocytochrome c synthetase (Hccs), mRNA mm
MU19KSUBC:TC37421_AT Holocytochrome c synthetase (Hccs), mRNA mm
RG-U34B:RC_AA899828_AT similar to Hccs protein rn
RAE230A:1390408_AT similar to Hccs protein rn
RAT230_2:1390408_AT similar to Hccs protein rn
RAE230A:1377265_AT Similar to Hccs protein rn
RAT230_2:1377265_AT Similar to Hccs protein rn
YEAST_2:1777723_AT Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5739 mitochondrion inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4197 cysteine-type endopeptidase activity inferred from electronic annotation QuickGO AmiGO
4408 holocytochrome-c synthase activity inferred from electronic annotation QuickGO AmiGO
16491 oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88969 Hypothetical protein T06D8.6 [Caenorhabditis elegans] ref|NP_496403.1| T06D8.6 [Caenorhabditis elegans] sp|P53703|CCHL_CAEEL Probable cytochrome C-type heme lyase (CCHL) (Holocytochrome-C-type synthase) 1.0E-169
blast CAE59548 Hypothetical protein CBG02944 [Caenorhabditis briggsae] 1.0E-144
blast EAA06088 ENSANGP00000005619 [Anopheles gambiae str. PEST] ref|XP_310401.2| ENSANGP00000005619 [Anopheles gambiae str. PEST] 4.0E-71
Protein Domains
Database ID Description E-Value
Pfam IPR000511 EMBL-EBI Cytochrome c and c1 heme-lyase 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:173793_AT
gtcaaccattaataagtatcgcattatcatcaaaattatttccaataatttacccaccgc
tccataagcctaataacagtttcgcaattagcatatttcgtagatagattagtgttcttt
ttttccccctcgttatcattgtttgctgttaattgtcttttttctccgcatggagccccg
tttgctcatgatctttcagtgtcttccgtcaactacccgttactttactgtgt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTCAACCATTAATAAGTATCGCATT 228 463 845 Antisense
AGTATCGCATTATCATCAAAATTAT 350 63 859 Antisense
CCACCGCTCCATAAGCCTAATAACA 101 275 898 Antisense
TAAGCCTAATAACAGTTTCGCAATT 92 639 909 Antisense
GTTTCGCAATTAGCATATTTCGTAG 375 449 923 Antisense
CCCCTCGTTATCATTGTTTGCTGTT 525 261 970 Antisense
TGTTTGCTGTTAATTGTCTTTTTTC 307 561 984 Antisense
TTGTCTTTTTTCTCCGCATGGAGCC 46 705 997 Antisense
CCCGTTTGCTCATGATCTTTCAGTG 218 261 1021 Antisense
CTCATGATCTTTCAGTGTCTTCCGT 557 227 1029 Antisense
TCAACTACCCGTTACTTTACTGTGT 678 625 1053 Antisense
Sequence Source Affymetrix Proprietary Database