[Home] | [Total List]

[173766_at] serine/threonine kinase

Description CEK008E9F /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=C41C4.4 /5_PRIME_EXT_DB=WormBase Gene ID /GB=D26977 /WB_GENE_ID=C41C4.4 /WP=CE01519 /CHR=2 /FEA=Genomic Cluster /DEF=serine-threonine kinase; C.elegans cDNA clone yk8e9 : 5prime end, single read.
Cluster 6grp_highest_10_10 > 97      6grp_high1_10_10 > 78      4grp_highest_8_8 > 51      4grp_high_8_8 > 24      6grp_highest_nonorm > 85      6grp_total > 59      4grp_total > 39      6grp_highest_sub > Cu      6grp_cgc > 39      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 444
1 2 3 4 range
A 868.4
(3)
P 		482.1
(-3)
P 		580.3
(-1.5)
P 		712.9
(0.6)
P 		386
B 896
(3)
P 		559.2
(-3)
P 		561.1
(-3)
P 		623.9
(-1.8)
P 		337
C 925.6
(3)
P 		610
(-2.8)
P 		626
(-2.5)
P 		600.9
(-3)
P 		325
avr 896.7
(3) 		550.4
(-3) 		589.1
(-2.3) 		645.9
(-1.3) 		346

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 542
1 2 3 4 5 6 range
A 839.5
(-0.5)
P 		710.3
(-2.1)
P 		746.4
(-1.7)
P 		640.1
(-3)
P 		990.3
(1.3)
P 		1124.3
(3)
P 		484
B 872.4
(1.8)
P 		761.2
(-0.1)
P 		581.9
(-3)
P 		875
(1.8)
P 		798.7
(0.6)
P 		947.9
(3)
P 		366
C 754.8
(-0.8)
P 		697.4
(-3)
P 		783.2
(0.3)
P 		838.7
(2.4)
P 		720.4
(-2.1)
P 		853.5
(3)
P 		156
avr 822.2
(-0.4) 		723
(-2.6) 		703.8
(-3) 		784.6
(-1.2) 		836.5
(-0.1) 		975.2
(3) 		271
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 215
1 2 3 4 range
A 316.2
(3)
P 		104.6
(-3)
P 		151.7
(-1.7)
P 		104.4
(-3)
P 		212
B 285.7
(3)
P 		138.1
(-2.7)
P 		130
(-3)
P 		133
(-2.9)
P 		156
C 306.4
(3)
P 		175.4
(-0.8)
P 		218.2
(0.4)
P 		101.3
(-3)
P 		205
avr 302.8
(3) 		139.4
(-2.2) 		166.6
(-1.3) 		112.9
(-3) 		190

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 212
1 2 3 4 5 6 range
A 154.8
(-3)
P 		252.6
(1.1)
P 		162.6
(-2.7)
P 		162.3
(-2.7)
P 		298.8
(3)
P 		273.7
(2)
P 		144
B 303.6
(1.6)
P 		253.4
(0.2)
P 		141.3
(-3)
P 		231.8
(-0.4)
P 		324.5
(2.2)
P 		353.5
(3)
P 		212
C 279.8
(2.7)
P 		212.8
(-0.7)
P 		199.3
(-1.4)
P 		168.7
(-3)
P 		233.1
(0.3)
P 		285.7
(3)
P 		117
avr 246.1
(0.4) 		239.6
(0.2) 		167.7
(-3) 		187.6
(-2.1) 		285.5
(2.2) 		304.3
(3) 		137
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173766_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.23328
Sequence Type Exemplar sequence
Representative Public ID CEK008E9F NCBI
Target Description CEK008E9F /REP_DB=TREMBL Accession /5_PRIME_EXT_ID=C41C4.4 /5_PRIME_EXT_DB=WormBase Gene ID /GB=D26977 /WB_GENE_ID=C41C4.4 /WP=CE01519 /CHR=2 /FEA=Genomic Cluster /DEF=serine-threonine kinase; C.elegans cDNA clone yk8e9 : 5prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063300(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063300 NCBI Caenorhabditis elegans IRE1 kinase related family member (ire-1) (ire-1) mRNA, complete cds. 11/11 A 
C41C4.4 ENSEMBL cdna:known chromosome:CEL140:II:8112189:8124761:-1 gene:C41C4.4 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:8112199-8124759(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase
Gene Symbol ire-1
Ensembl C41C4.4
Entrez Gene 174305 Entrez gene
WormBase CE35836 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.18320.1.S1_AT similar to endoplasmic reticulum to nucleus signalling 1 isoform 1 cfa
DROSOPHILA_2:1641293_AT dm
DROSGENOME1:150220_AT dm
CHICKEN:GGA.10887.1.S1_S_AT similar to ER to nucleus signalling 1 gga
CHICKEN:GGAAFFX.25872.1.S1_AT similar to ER to nucleus signalling 1 gga
HG-U133_PLUS_2:207061_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U133A:207061_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-FOCUS:207061_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U133A_2:207061_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U95AV2:31380_AT endoplasmic reticulum to nucleus signalling 1 hs
U133_X3P:G4557568_3P_AT endoplasmic reticulum to nucleus signalling 1 hs
U133_X3P:HS.129166.0.A1_3P_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U133_PLUS_2:235745_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U133B:235745_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U95D:69557_G_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U95E:76574_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U133_PLUS_2:239045_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U133B:239045_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95B:48236_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95C:60109_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95C:60390_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95D:69555_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95E:87738_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95D:91417_AT Endoplasmic reticulum to nucleus signalling 1 hs
HU35KSUBA:RC_D20835_AT Endoplasmic reticulum to nucleus signalling 1 hs
HU35KSUBD:RC_AA620764_AT Endoplasmic reticulum to nucleus signalling 1 hs
U133_X3P:HS.30778.0.A1_3P_AT Endoplasmic reticulum to nucleus signalling 1 hs
MOUSE430_2:1431886_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOUSE430A_2:1431886_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOE430A:1431886_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOE430A:1450176_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOUSE430_2:1450176_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOUSE430A_2:1450176_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOUSE430_2:1421240_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOUSE430A_2:1421240_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOE430A:1421240_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MG-U74BV2:107353_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MG-U74BV2:164051_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOE430B:1437119_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOUSE430_2:1437119_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MG-U74BV2:104981_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOUSE430_2:1438583_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOE430B:1438583_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOE430B:1438997_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOUSE430_2:1438997_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
RAE230A:1377213_AT Similar to protein kinase/endoribonuclease(IRE1) alpha rn
RAT230_2:1377213_AT Similar to protein kinase/endoribonuclease(IRE1) alpha rn
RG-U34A:RC_H33528_AT Similar to protein kinase/endoribonuclease(IRE1) alpha rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88100 Hypothetical protein C41C4.4 [Caenorhabditis elegans] ref|NP_495701.2| IRE1 kinase related family member (ire-1) [Caenorhabditis elegans] gb|AAL30828.1| Ser/Thr protein kinase [Caenorhabditis elegans] 0.0
blast Q09499 Putative serine/threonine-protein kinase C41C4.4 precursor 0.0
blast CAE67758 Hypothetical protein CBG13333 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
hanks 2.1.20 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; PhKgT 7.0E-27
Protein Domains
Database ID Description E-Value
Pfam IPR010513 EMBL-EBI Ribonuclease 2-5A 1.7E-74
Pfam IPR002372 EMBL-EBI Bacterial quinoprotein 6.5E-8
Pfam IPR002372 EMBL-EBI Bacterial quinoprotein 1.4E-7
Pfam IPR000719 EMBL-EBI Protein kinase 6.0E-53
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495701.2 1 5-27
C41C4.4 1 5-27
Sequence
Target Sequence 
>C. ELEGANS:173766_AT
gaacaccgattaatcactctgcaagtagtgagaatagttggatttaaccaataattatta
tataccaagtttctgggttttagaatcagttatcaatcatttaacaaagcttttcgaagt
gccgtttttgccgtttgaagaacatcgacgatgtgtttgcgtgtgtaaatttattatcat
tattctgggatttctgtccaatggtcttgtcctcatgtttcctctgtgtttatcctttaa
tgttttttcggatctctcctcgcctacctacccatttttgtcgaattatgatcccgtttc
tttttctgcatttcctatgaatgcactcccttcatatatcgtacggt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAACACCGATTAATCACTCTGCAAG 553 351 2953 Antisense
TAACAAAGCTTTTCGAAGTGCCGTT 65 633 3054 Antisense
TGCCGTTTTTGCCGTTTGAAGAACA 154 585 3072 Antisense
AACATCGACGATGTGTTTGCGTGTG 85 139 3093 Antisense
ATTTCTGTCCAATGGTCTTGTCCTC 622 15 3142 Antisense
TTTCCTCTGTGTTTATCCTTTAATG 652 669 3170 Antisense
TAATGTTTTTTCGGATCTCTCCTCG 26 637 3190 Antisense
TACCTACCCATTTTTGTCGAATTAT 123 649 3217 Antisense
AATTATGATCCCGTTTCTTTTTCTG 474 175 3236 Antisense
GCATTTCCTATGAATGCACTCCCTT 624 307 3260 Antisense
GCACTCCCTTCATATATCGTACGGT 524 315 3275 Antisense
Sequence Source Affymetrix Proprietary Database