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[173508_at] acyl-CoA dehydrogenase

Description g4455126 /REP_DB=GenBank Identifier /5_PRIME_EXT_ID=C02B10.1 /5_PRIME_EXT_DB=WormBase Gene ID /WB_GENE_ID=C02B10.1 /WP=CE16798 /CHR=4 /FEA=Genomic Cluster /GEN=C02B10.1 /DEF=isovaleryl-CoA dehydrogenase precursor; acyl-CoA dehydrogenase
Cluster 6grp_highest_10_10 > 86      6grp_high1_10_10 > 77      4grp_highest_8_8 > 21      4grp_high_8_8 > 23      6grp_highest_nonorm > 78      6grp_total > 79      4grp_total > 16      6grp_highest_sub > Da      6grp_high1_sub > Da      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2964
1 2 3 4 range
A 2159.9
(-2.3)
P 		1877.9
(-3)
P 		2845.5
(-0.6)
P 		4275
(3)
P 		2397
B 1807.1
(-3)
P 		2732.3
(-1.1)
P 		3223.7
(-0.1)
P 		4771.2
(3)
P 		2964
C 2106.6
(-3)
P 		2806.5
(-1.1)
P 		2863.1
(-0.9)
P 		4285.8
(3)
P 		2179
avr 2024.5
(-3) 		2472.2
(-1.9) 		2977.4
(-0.6) 		4444
(3) 		2420

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1242
1 2 3 4 5 6 range
A 1248.4
(-2.8)
P 		1526.3
(-1.2)
P 		1342.4
(-2.3)
P 		1223
(-3)
P 		1689.5
(-0.2)
P 		2217
(3)
P 		994
B 1377.3
(-2.6)
P 		1685.3
(-0.7)
P 		1580.4
(-1.3)
P 		1306
(-3)
P 		1563.5
(-1.4)
P 		2289.6
(3)
P 		984
C 1439.3
(-0.9)
P 		1445.9
(-0.9)
P 		1494.9
(-0.6)
P 		1047.8
(-3)
P 		1639.9
(0.2)
P 		2168
(3)
P 		1120
avr 1355
(-2.1) 		1552.5
(-0.9) 		1472.6
(-1.4) 		1192.3
(-3) 		1631
(-0.5) 		2224.9
(3) 		1033
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 609
1 2 3 4 range
A 786.4
(3)
P 		407.6
(-3)
P 		743.9
(2.3)
P 		625.8
(0.5)
P 		379
B 576.3
(-3)
P 		674.8
(-1.7)
P 		747
(-0.7)
P 		1016.8
(3)
P 		441
C 697.3
(-3)
P 		806.9
(-0.8)
P 		997.9
(3)
P 		722.7
(-2.5)
P 		301
avr 686.7
(-1.3) 		629.8
(-3) 		829.6
(3) 		788.4
(1.8) 		200

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 643
1 2 3 4 5 6 range
A 230.1
(-3)
P 		542.8
(3)
P 		292.3
(-1.8)
P 		310.2
(-1.5)
P 		509.8
(2.4)
P 		539.8
(2.9)
P 		313
B 479.2
(-1.4)
P 		561
(-0.5)
P 		383.8
(-2.6)
P 		345.9
(-3)
P 		635.2
(0.4)
P 		853.8
(3)
P 		508
C 533.5
(0.8)
P 		441.2
(-0.3)
P 		380.5
(-1)
P 		210.7
(-3)
P 		530.7
(0.7)
P 		725.8
(3)
P 		515
avr 414.3
(-1.2) 		515
(0.2) 		352.2
(-2.1) 		288.9
(-3) 		558.6
(0.9) 		706.5
(3) 		418
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173508_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.25022
Sequence Type Exemplar sequence
Representative Public ID 4455126 NCBI
Target Description g4455126 /REP_DB=GenBank Identifier /5_PRIME_EXT_ID=C02B10.1 /5_PRIME_EXT_DB=WormBase Gene ID /WB_GENE_ID=C02B10.1 /WP=CE16798 /CHR=4 /FEA=Genomic Cluster /GEN=C02B10.1 /DEF=isovaleryl-CoA dehydrogenase precursor; acyl-CoA dehydrogenase
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068319(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068319 NCBI Caenorhabditis elegans C02B10.1 (C02B10.1) mRNA, complete cds. 11/11 A 
C02B10.1.1 ENSEMBL cdna:known chromosome:CEL140:IV:5086852:5088854:-1 gene:C02B10.1 11/11 None
C02B10.1.2 ENSEMBL cdna:known chromosome:CEL140:IV:5086908:5088856:-1 gene:C02B10.1 10/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:5086868-5088831(-) 97.17 100.0
Public Domain and Genome References
Gene Title acyl-CoA dehydrogenase
Ensembl C02B10.1
Entrez Gene 177281 Entrez gene
SwissProt O44446 EMBL-EBI
WormBase CE16798 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:252570_AT isovaleryl-CoA-dehydrogenase (IVD) at
CANINE:1601848_AT similar to Isovaleryl-CoA dehydrogenase, mitochondrial precursor (IVD) cfa
CANINE:1593796_AT similar to Isovaleryl-CoA dehydrogenase, mitochondrial precursor (IVD) cfa
CANINE_2:CFA.17221.1.S1_AT similar to Isovaleryl-CoA dehydrogenase, mitochondrial precursor (IVD) cfa
CANINE_2:CFAAFFX.14407.1.S1_S_AT similar to Isovaleryl-CoA dehydrogenase, mitochondrial precursor (IVD) cfa
DROSOPHILA_2:1635996_AT dm
DROSGENOME1:148414_AT dm
CHICKEN:GGAAFFX.2907.1.S1_AT similar to Isovaleryl-CoA dehydrogenase, mitochondrial precursor (IVD) gga
HG-U95AV2:37342_S_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133_PLUS_2:203682_S_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133A:203682_S_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133A_2:203682_S_AT isovaleryl Coenzyme A dehydrogenase hs
HU35KSUBA:HUM_ALU_AT isovaleryl Coenzyme A dehydrogenase hs
HU35KSUBB:HUM_ALU_AT isovaleryl Coenzyme A dehydrogenase hs
HU35KSUBC:HUM_ALU_AT isovaleryl Coenzyme A dehydrogenase hs
HU35KSUBD:HUM_ALU_AT isovaleryl Coenzyme A dehydrogenase hs
HUGENEFL:HUM_ALU_AT isovaleryl Coenzyme A dehydrogenase hs
HC-G110:HUM_ALU_AT isovaleryl Coenzyme A dehydrogenase hs
HU35KSUBC:RC_AA052980_AT isovaleryl Coenzyme A dehydrogenase hs
HUGENEFL:M34192_AT isovaleryl Coenzyme A dehydrogenase hs
U133_X3P:G6031167_3P_A_AT isovaleryl Coenzyme A dehydrogenase hs
U133_X3P:HS.77510.2.S1_3P_A_AT isovaleryl Coenzyme A dehydrogenase hs
U133_X3P:HS.279789.5.A1_3P_X_AT isovaleryl Coenzyme A dehydrogenase hs
U133_X3P:HS.279789.5.A1_3P_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133A_2:216958_S_AT isovaleryl Coenzyme A dehydrogenase hs
HG-FOCUS:216958_S_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133_PLUS_2:216958_S_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133A:216958_S_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133_PLUS_2:225311_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133B:225311_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U95C:63548_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U95E:78746_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U95E:81819_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133A_2:203681_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133_PLUS_2:203681_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U133A:203681_AT isovaleryl Coenzyme A dehydrogenase hs
HG-U95D:81299_AT Isovaleryl Coenzyme A dehydrogenase hs
HG-U95D:82627_AT Isovaleryl Coenzyme A dehydrogenase hs
HU35KSUBD:RC_C20983_AT Isovaleryl Coenzyme A dehydrogenase hs
MG-U74AV2:104153_AT isovaleryl coenzyme A dehydrogenase mm
MOE430A:1449001_AT isovaleryl coenzyme A dehydrogenase mm
MOUSE430A_2:1449001_AT isovaleryl coenzyme A dehydrogenase mm
MOUSE430_2:1449001_AT isovaleryl coenzyme A dehydrogenase mm
MOE430A:1418238_AT isovaleryl coenzyme A dehydrogenase mm
MOUSE430A_2:1418238_AT isovaleryl coenzyme A dehydrogenase mm
MOUSE430_2:1418238_AT isovaleryl coenzyme A dehydrogenase mm
MG-U74BV2:163080_AT Isovaleryl coenzyme A dehydrogenase, mRNA (cDNA clone MGC:25950 IMAGE:4237982) mm
MU19KSUBA:TC19952_AT Isovaleryl coenzyme A dehydrogenase, mRNA (cDNA clone MGC:25950 IMAGE:4237982) mm
MU19KSUBA:TC21619_AT Isovaleryl coenzyme A dehydrogenase, mRNA (cDNA clone MGC:25950 IMAGE:4237982) mm
MU19KSUBB:TC27946_AT Isovaleryl coenzyme A dehydrogenase, mRNA (cDNA clone MGC:25950 IMAGE:4237982) mm
MU19KSUBB:TC30901_AT Isovaleryl coenzyme A dehydrogenase, mRNA (cDNA clone MGC:25950 IMAGE:4237982) mm
RG-U34A:J05031_G_AT isovaleryl coenzyme A dehydrogenase rn
RG-U34A:J05031_AT isovaleryl coenzyme A dehydrogenase rn
RG-U34A:RC_AI102838_S_AT isovaleryl coenzyme A dehydrogenase rn
RG-U34B:RC_AI011196_S_AT isovaleryl coenzyme A dehydrogenase rn
RAE230A:1370232_AT isovaleryl coenzyme A dehydrogenase rn
RAT230_2:1370232_AT isovaleryl coenzyme A dehydrogenase rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3995 acyl-CoA dehydrogenase activity inferred from electronic annotation QuickGO AmiGO
16491 oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB92016 Hypothetical protein C02B10.1 [Caenorhabditis elegans] ref|NP_500720.1| C02B10.1 [Caenorhabditis elegans] gb|AAD21088.1| isovaleryl-CoA dehydrogenase precursor [Caenorhabditis elegans] 0.0
blast CAE72737 Hypothetical protein CBG19978 [Caenorhabditis briggsae] 0.0
blast CAG10520 unnamed protein product [Tetraodon nigroviridis] 1.0E-159
Protein Families
Method ID Description E-Value
ec ACDM_DROME (Q9VSA3) Probable acyl-CoA dehydrogenase, medium-chain specific, mitochondrial precursor (EC 1.3.99.3) (MCAD) 1.0E-139
Protein Domains
Database ID Description E-Value
Pfam IPR006090 EMBL-EBI Acyl-CoA dehydrogenase, C-terminal 3.2E-60
Pfam IPR006091 EMBL-EBI Acyl-CoA dehydrogenase, central domain 1.3E-62
Pfam IPR006092 EMBL-EBI Acyl-CoA dehydrogenase, N-terminal 6.4E-49
Sequence
Target Sequence 
>C. ELEGANS:173508_AT
gaatactccaactaataatttgcccagtgatctctgtttgttttcaaattcttcaaagga
gcttttcatctgaaggcccgctcgtcttaaattgtgactataaaccggtcgattccccct
atagcgtttaattat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAATACTCCAACTAATAATTTGCCC 376 327 1259 Antisense
CTAATAATTTGCCCAGTGATCTCTG 606 227 1270 Antisense
ATTTGCCCAGTGATCTCTGTTTGTT 535 17 1276 Antisense
GCCCAGTGATCTCTGTTTGTTTTCA 415 287 1280 Antisense
GTGATCTCTGTTTGTTTTCAAATTC 638 483 1285 Antisense
GTTTTCAAATTCTTCAAAGGAGCTT 629 447 1298 Antisense
AAGGAGCTTTTCATCTGAAGGCCCG 302 161 1314 Antisense
GAGCTTTTCATCTGAAGGCCCGCTC 161 385 1317 Antisense
GGCCCGCTCGTCTTAAATTGTGACT 98 543 1333 Antisense
TGTGACTATAAACCGGTCGATTCCC 547 545 1351 Antisense
GATTCCCCCTATAGCGTTTAATTAT 4 431 1369 Antisense
Sequence Source GenBank