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[173436_at] Rho-associated kinase

Description g1816619-REP_DB=GenBank Identifier /5_PRIME_EXT_ID=g1816619 /5_PRIME_EXT_DB=GenBank Identifier /CHR=1 /FEA=Genomic Cluster /GEN=let-502 /DEF=LET-502
Cluster 6grp_highest_10_10 > 97      6grp_high1_10_10 > 78      4grp_highest_8_8 > 45      4grp_high_8_8 > 01      6grp_highest_nonorm > 82      6grp_total > 58      4grp_total > 15      6grp_highest_sub > Cu      6grp_cgc > 39      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 181
1 2 3 4 range
A 436.1
(3)
P 		300.5
(-3)
P 		306.5
(-2.7)
P 		392
(1)
P 		136
B 459.4
(3)
P 		278.9
(-3)
P 		281.5
(-2.9)
P 		417.4
(1.6)
P 		181
C 366.2
(0.5)
P 		297.6
(-3)
P 		362.3
(0.3)
P 		415.8
(3)
P 		118
avr 420.6
(3) 		292.3
(-3) 		316.8
(-1.9) 		408.4
(2.4) 		128

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 404
1 2 3 4 5 6 range
A 434.3
(-0.1)
P 		385.7
(-0.9)
P 		256.6
(-3)
P 		354.3
(-1.4)
P 		390.1
(-0.8)
P 		620.2
(3)
P 		364
B 354.6
(0.6)
P 		216.2
(-3)
P 		245.7
(-2.2)
P 		407.2
(2)
P 		344.5
(0.4)
P 		444.4
(3)
P 		228
C 444.8
(2.9)
P 		233.5
(-3)
P 		399.6
(1.7)
P 		377.4
(1)
P 		317.4
(-0.6)
P 		447.7
(3)
P 		214
avr 411.2
(0.5) 		278.5
(-3) 		300.6
(-2.4) 		379.6
(-0.3) 		350.7
(-1.1) 		504.1
(3) 		226
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 101
1 2 3 4 range
A 158.8
(3)
P 		65.2
(-2.5)
P 		80.1
(-1.7)
P 		57.4
(-3)
P 		101
B 146.5
(3)
P 		68.9
(-2.7)
P 		65.2
(-3)
P 		88.9
(-1.3)
P 		81
C 121.2
(2.5)
P 		85.6
(-1.3)
P 		126.3
(3)
P 		70.1
(-3)
P 		56
avr 142.2
(3) 		73.2
(-2.9) 		90.5
(-1.4) 		72.1
(-3) 		70

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 110
1 2 3 4 5 6 range
A 80.1
(-1.5)
P 		137.2
(2.1)
P 		55.9
(-3)
P 		89.9
(-0.9)
P 		117.7
(0.9)
P 		151
(3)
P 		95
B 123.4
(0.6)
P 		71.9
(-2.3)
P 		59.7
(-3)
P 		107.9
(-0.3)
P 		140
(1.5)
P 		165.7
(3)
P 		106
C 164.9
(3)
P 		71.2
(-3)
P 		101.7
(-1)
P 		75.9
(-2.7)
P 		102.7
(-1)
P 		149.9
(2)
P 		94
avr 122.8
(0.6) 		93.4
(-1.5) 		72.4
(-3) 		91.2
(-1.6) 		120.1
(0.4) 		155.5
(3) 		83
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173436_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.22752
Sequence Type Exemplar sequence
Representative Public ID 1816619 NCBI
Target Description g1816619-REP_DB=GenBank Identifier /5_PRIME_EXT_ID=g1816619 /5_PRIME_EXT_DB=GenBank Identifier /CHR=1 /FEA=Genomic Cluster /GEN=let-502 /DEF=LET-502
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059039(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059039 NCBI Caenorhabditis elegans LEThal family member (let-502) (let-502) mRNA, complete cds. 11/11 A 
C10H11.9 ENSEMBL cdna:known chromosome:CEL140:I:4738171:4744310:-1 gene:C10H11.9 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000015963 1/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:4738192-4744311(-) 100.0 100.0
Public Domain and Genome References
Gene Title Rho-associated kinase
Gene Symbol let-502
Ensembl C10H11.9
Entrez Gene 172088 Entrez gene
SwissProt P92199 EMBL-EBI
WormBase CE08098 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.6269.1.S1_S_AT similar to Rho-associated protein kinase 2 (Rho-associated, coiled-coil containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2) cfa
CHICKEN:GGA.17943.1.S1_AT Rho-associated, coiled-coil containing protein kinase 2 gga
CHICKEN:GGA.3500.1.S1_AT Rho-associated, coiled-coil containing protein kinase 2 gga
CHICKEN:GGAAFFX.10528.1.S1_AT Rho-associated, coiled-coil containing protein kinase 2 gga
CHICKEN:GGAAFFX.10529.1.S1_AT Rho-associated, coiled-coil containing protein kinase 2 gga
HG-U133_PLUS_2:211504_X_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HG-U133A:211504_X_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HG-U133A_2:211504_X_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HU35KSUBC:RC_F13712_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HU35KSUBD:RC_AA287360_AT Rho-associated, coiled-coil containing protein kinase 2 hs
U133_X3P:G4520224_3P_A_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HU35KSUBB:RC_AA228121_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HU35KSUBC:RC_AA133756_AT Rho-associated, coiled-coil containing protein kinase 2 hs
U133_X3P:HS.58617.0.S2_3P_X_AT Rho-associated, coiled-coil containing protein kinase 2 hs
U133_X3P:HS.58617.0.S2_3P_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HG-U133A_2:202762_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HG-FOCUS:202762_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HG-U133_PLUS_2:202762_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HG-U133A:202762_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HG-U95AV2:35335_AT Rho-associated, coiled-coil containing protein kinase 2 hs
HU35KSUBB:RC_R08165_AT Rho-associated, coiled-coil containing protein kinase 2 hs
MU11KSUBA:AA423575_S_AT Rho-associated coiled-coil forming kinase 2 mm
MU11KSUBB:MSA.2966.0_S_AT Rho-associated coiled-coil forming kinase 2 mm
MG-U74AV2:98504_AT Rho-associated coiled-coil forming kinase 2 mm
MOE430A:1423592_AT Rho-associated coiled-coil forming kinase 2 mm
MOUSE430A_2:1423592_AT Rho-associated coiled-coil forming kinase 2 mm
MOUSE430_2:1423592_AT Rho-associated coiled-coil forming kinase 2 mm
MOE430A:1451041_AT Rho-associated coiled-coil forming kinase 2 mm
MOUSE430A_2:1451041_AT Rho-associated coiled-coil forming kinase 2 mm
MOUSE430_2:1451041_AT Rho-associated coiled-coil forming kinase 2 mm
MU19KSUBB:TC31219_AT Rho-associated coiled-coil forming kinase 2 (Rock2), mRNA mm
MU19KSUBC:TC37940_AT Rho-associated coiled-coil forming kinase 2 (Rock2), mRNA mm
RG-U34A:U38481_AT Rho-associated coiled-coil forming kinase 2 rn
RAE230A:1387379_AT Rho-associated coiled-coil forming kinase 2 rn
RAT230_2:1387379_AT Rho-associated coiled-coil forming kinase 2 rn
RAE230A:1372371_AT Rho-associated coiled-coil forming kinase 2 rn
RAT230_2:1372371_AT Rho-associated coiled-coil forming kinase 2 rn
RAE230B:1382512_AT Rho-associated coiled-coil forming kinase 2 rn
RAT230_2:1382512_AT Rho-associated coiled-coil forming kinase 2 rn
RG-U34B:RC_AA926209_AT Rho-associated coiled-coil forming kinase 2 rn
RG-U34B:RC_AI009363_AT Rho-associated coiled-coil forming kinase 2 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
6468 protein amino acid phosphorylation inferred from sequence similarity QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from sequence similarity QuickGO AmiGO
5524 ATP binding inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB42348 Lethal protein 502 [Caenorhabditis elegans] ref|NP_491440.1| LEThal family member (let-502) [Caenorhabditis elegans] gb|AAB42081.1| LET-502 [Caenorhabditis elegans] 0.0
blast CAE60362 Hypothetical protein CBG03960 [Caenorhabditis briggsae] 0.0
blast BAA31594.2 KIAA0619 protein [Homo sapiens] 0.0
Protein Families
Method ID Description E-Value
hanks 1.9.1 AGC group; AGC Other; DM 5.0E-82
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 5.3E-72
Sequence
Target Sequence 
>C. ELEGANS:173436_AT
tctcccatctcattttattctatttttgtgccgacagtaagtcgatttctcagggctttt
tcctgattttcctttggcgtctaccttttatgttctattcatcctcctcgacgggaattt
gagctccagcgttcgattatcaatttcagagcataagccggatctagattctctcccttt
cactcatccattgcgtgtttcatttttttttatacattcatttttacattcatttcgctt
ttccttcgctctctcttgttcccaaattttcttccacatttctcccacatcgcttacgga
tcgaactgcaatgattcccttattgttttttttcaagtcagtctatttccgtttgtaca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCTCCCATCTCATTTTATTCTATTT 416 611 3836 Antisense
AGTCGATTTCTCAGGGCTTTTTCCT 142 61 3875 Antisense
TGGCGTCTACCTTTTATGTTCTATT 441 545 3910 Antisense
TTCATCCTCCTCGACGGGAATTTGA 695 685 3933 Antisense
GAGCTCCAGCGTTCGATTATCAATT 424 387 3956 Antisense
TAAGCCGGATCTAGATTCTCTCCCT 19 639 3989 Antisense
ACTCATCCATTGCGTGTTTCATTTT 222 101 4017 Antisense
TTTTTACATTCATTTCGCTTTTCCT 354 675 4056 Antisense
TCTTGTTCCCAAATTTTCTTCCACA 30 619 4089 Antisense
TCCCACATCGCTTACGGATCGAACT 63 597 4118 Antisense
AAGTCAGTCTATTTCCGTTTGTACA 457 157 4170 Antisense
Sequence Source GenBank