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[173425_at] thioredoxin

Description g10443873-REP_DB=GenBank Identifier /5_PRIME_EXT_ID=g10443873 /5_PRIME_EXT_DB=GenBank Identifier /CHR=5 /FEA=Genomic Cluster /GEN=dpy-11 /DEF=thioredoxin-like protein DPY-11
Cluster 6grp_highest_10_10 > 18      6grp_high1_10_10 > 70      4grp_highest_8_8 > 09      4grp_high_8_8 > 54      6grp_highest_nonorm > 55      6grp_total > 81      4grp_total > 58      6grp_highest_sub > 04_05      6grp_cgc > 97      6grp_high1_sub > 04      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2422
1 2 3 4 range
A 1353
(-0.6)
P 		2417
(2.1)
P 		2780.3
(3)
P 		400.3
(-3)
P 		2380
B 1239.8
(-1.3)
P 		2822
(3)
P 		2771
(2.9)
P 		609.7
(-3)
P 		2212
C 1142.5
(-1.3)
P 		2218.1
(2)
P 		2537.1
(3)
P 		603.9
(-3)
P 		1933
avr 1245.1
(-1) 		2485.7
(2.4) 		2696.1
(3) 		538
(-3) 		2158

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1444
1 2 3 4 5 6 range
A 1506.5
(-1.6)
P 		1928.4
(1.4)
P 		1730.9
(0)
P 		2147.3
(3)
P 		2020
(2.1)
P 		1304.6
(-3)
P 		843
B 1512.6
(-1.1)
P 		1698.4
(-0.3)
P 		1429.2
(-1.4)
P 		2494.5
(3)
P 		1798
(0.1)
P 		1050.3
(-3)
P 		1444
C 1950.2
(1.3)
P 		1477.7
(-1.5)
P 		1802.3
(0.5)
P 		2012.3
(1.7)
P 		2223.4
(3)
P 		1231.5
(-3)
P 		992
avr 1656.4
(-0.3) 		1701.5
(-0) 		1654.1
(-0.3) 		2218
(3) 		2013.8
(1.8) 		1195.5
(-3) 		1023
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 826
1 2 3 4 range
A 492.6
(0.9)
P 		524.7
(1.2)
P 		726.8
(3)
P 		58.6
(-3)
P 		668
B 395.3
(-0.2)
P 		697
(3)
P 		642.1
(2.4)
P 		129.9
(-3)
P 		567
C 378.2
(-0.9)
P 		637.7
(1.1)
P 		884.3
(3)
P 		101.8
(-3)
P 		783
avr 422
(-0) 		619.8
(1.8) 		751.1
(3) 		96.8
(-3) 		654

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 453
1 2 3 4 5 6 range
A 277.7
(-3)
P 		685.8
(3)
P 		377
(-1.5)
P 		544.6
(0.9)
P 		609.5
(1.9)
P 		317.6
(-2.4)
P 		408
B 526.3
(-0.2)
P 		565.3
(0.4)
P 		347.1
(-3)
P 		660.7
(1.9)
P 		730.5
(3)
P 		391.7
(-2.3)
P 		383
C 722.8
(3)
P 		450.9
(-2.1)
P 		458.7
(-2)
P 		404.7
(-3)
P 		719.5
(2.9)
P 		412.3
(-2.9)
P 		318
avr 508.9
(-0.4) 		567.3
(0.7) 		394.3
(-2.6) 		536.7
(0.1) 		686.5
(3) 		373.9
(-3) 		313
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 173425_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.25140
Sequence Type Exemplar sequence
Representative Public ID 10443873 NCBI
Target Description g10443873-REP_DB=GenBank Identifier /5_PRIME_EXT_ID=g10443873 /5_PRIME_EXT_DB=GenBank Identifier /CHR=5 /FEA=Genomic Cluster /GEN=dpy-11 /DEF=thioredoxin-like protein DPY-11
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq,GenBank identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_072254(11), AF250045(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_072254 NCBI Caenorhabditis elegans F46E10.9 (thioredoxin) mRNA, complete cds. 11/11 A 
AF250045 NCBI Caenorhabditis elegans thioredoxin-like protein DPY-11 (dpy-11) mRNA, complete cds. 11/11 None
F46E10.9.2 ENSEMBL cdna:known chromosome:CEL140:V:6514179:6515942:-1 gene:F46E10.9 11/11 A 
F46E10.9.1 ENSEMBL cdna:known chromosome:CEL140:V:6514182:6515940:-1 gene:F46E10.9 11/11 A 
F46E10.9.3 ENSEMBL cdna:known chromosome:CEL140:V:6514192:6517834:-1 gene:F46E10.9 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000002139 2/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:6514178-6515943(-) 97.67 100.0
Public Domain and Genome References
Gene Title thioredoxin
Gene Symbol dpy-11
Ensembl F46E10.9
Entrez Gene 179040 Entrez gene
SwissProt Q9UAV4 EMBL-EBI
WormBase CE20819 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1604276_AT similar to Thioredoxin domain containing protein 1 precursor (Transmembrane Trx-related protein) (Thioredoxin-related transmembrane protein) cfa
CANINE_2:CFA.3002.1.S1_AT similar to Thioredoxin domain containing protein 1 precursor (Transmembrane Trx-related protein) (Thioredoxin-related transmembrane protein) cfa
CANINE_2:CFAAFFX.22542.1.S1_S_AT similar to Thioredoxin domain containing protein 1 precursor (Transmembrane Trx-related protein) (Thioredoxin-related transmembrane protein) cfa
DROSOPHILA_2:1632482_AT dm
DROSGENOME1:147810_AT dm
HG-U133_PLUS_2:208097_S_AT thioredoxin domain containing hs
HG-U133A:208097_S_AT thioredoxin domain containing hs
HG-FOCUS:208097_S_AT thioredoxin domain containing hs
HG-U133A_2:208097_S_AT thioredoxin domain containing hs
HU35KSUBB:RC_R79617_AT thioredoxin domain containing hs
HU35KSUBD:RC_AA620599_AT thioredoxin domain containing hs
U133_X3P:G13559515_3P_S_AT thioredoxin domain containing hs
U133_X3P:HS.24766.0.S2_3P_AT thioredoxin domain containing hs
HG-U133A_2:209476_AT thioredoxin domain containing hs
HG-U133_PLUS_2:209476_AT thioredoxin domain containing hs
HG-U133A:209476_AT thioredoxin domain containing hs
HG-U95AV2:34768_AT thioredoxin domain containing hs
MU11KSUBA:AA286607_S_AT thioredoxin domain containing 1 mm
MG-U74AV2:97939_AT thioredoxin domain containing 1 mm
MG-U74BV2:163528_AT thioredoxin domain containing 1 mm
MOE430A:1437143_A_AT thioredoxin domain containing 1 mm
MOUSE430A_2:1437143_A_AT thioredoxin domain containing 1 mm
MOUSE430_2:1437143_A_AT thioredoxin domain containing 1 mm
MOE430A:1451195_A_AT thioredoxin domain containing 1 mm
MOUSE430A_2:1451195_A_AT thioredoxin domain containing 1 mm
MOUSE430_2:1451195_A_AT thioredoxin domain containing 1 mm
MU19KSUBB:TC28783_AT Thioredoxin domain containing 1, mRNA (cDNA clone MGC:38565 IMAGE:5354337) mm
MU19KSUBC:TC40698_AT Thioredoxin domain containing 1, mRNA (cDNA clone MGC:38565 IMAGE:5354337) mm
RAE230A:1372067_AT thioredoxin domain containing 1 (predicted) rn
RAT230_2:1372067_AT thioredoxin domain containing 1 (predicted) rn
RG-U34C:RC_AI236083_AT Thioredoxin domain containing 1 (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5489 electron transporter activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAD14719 Dumpy : shorter than wild-type protein 11 [Caenorhabditis elegans] ref|NP_504655.1| F46E10.9 [Caenorhabditis elegans] gb|AAG17620.1| thioredoxin-like protein DPY-11 [Caenorhabditis elegans] 1.0E-113
blast CAE71898 Hypothetical protein CBG18956 [Caenorhabditis briggsae] 1.0E-109
Protein Domains
Database ID Description E-Value
scop a.3.1.monodomain cytochrome c All alpha proteins; Cytochrome c; Cytochrome c; monodomain cytochrome c 1.60000002384186
Pfam IPR006662 EMBL-EBI Thioredoxin type domain 1.5E-13
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_504655.1 1 176-198
AAG17620.1 1 176-198
F46E10.9.2 1 176-198
F46E10.9.1 1 176-198
F46E10.9.3 1 176-198
Sequence
Target Sequence 
>C. ELEGANS:173425_AT
gtaaattctatgcaacttccaaaaaccccaattgttttaccttttgtgcatcttgttatt
ttatttcaaattataatttaaaaacttcaaaatgtttcatatttatcccaaaccagcagt
ctctgccccaagtttttgaattttaaaaaatttgttaattataagtattgccgtccccca
agatatatataagtcacttcttcctatgggttcccgtcttttttgtctcttttgttttca
ccaatgcttctctccttctgcgcatttcatttcggactctgcaacgacgacacgtaatta
aagcgacatctcttgctgcgagagccagtcggtgctggtcgagtgtgtgttcgctttggc
gtcgtcacgccttctttccctgctgcttttcgctcctcattcaatgcattgatccgtttg
tccgtttttttgtcctctgctttctctcaaatatttcac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTAAATTCTATGCAACTTCCAAAAA 66 461 754 Antisense
ATTGTTTTACCTTTTGTGCATCTTG 190 5 784 Antisense
TTGTGCATCTTGTTATTTTATTTCA 401 709 797 Antisense
TTTATCCCAAACCAGCAGTCTCTGC 675 673 855 Antisense
AGTCTCTGCCCCAAGTTTTTGAATT 154 59 871 Antisense
CTTCTGCGCATTTCATTTCGGACTC 30 221 1008 Antisense
ATTTCGGACTCTGCAACGACGACAC 522 13 1022 Antisense
CGACACGTAATTAAAGCGACATCTC 467 251 1041 Antisense
TTTCGCTCCTCATTCAATGCATTGA 217 671 1141 Antisense
AATGCATTGATCCGTTTGTCCGTTT 462 165 1156 Antisense
CTCTGCTTTCTCTCAAATATTTCAC 572 231 1188 Antisense
Sequence Source GenBank