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[173213_s_at] Zinc-binding metalloprotease domain

Description AV180904_rc /REP_DB=TREMBL Accession /FEA=EST Transcript /REVCOMP /GB=AV180904 /DEF=Caenorhabditis elegans cDNA clone:yk613f10 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 94      6grp_high1_10_10 > 59      4grp_highest_8_8 > 52      4grp_high_8_8 > 25      6grp_highest_nonorm > 86      6grp_total > 49      4grp_total > 39      6grp_highest_sub > Cu      6grp_cgc > 09      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 523
1 2 3 4 range
A 1173.8
(3)
P 		651.1
(-3)
P 		828.2
(-1)
P 		916.1
(0)
P 		523
B 948.4
(1.9)
P 		987.1
(3)
P 		781.8
(-3)
P 		983.1
(2.9)
P 		205
C 1013.3
(3)
P 		983.2
(2)
P 		954.3
(1.1)
P 		828.7
(-3)
P 		185
avr 1045.2
(3) 		873.8
(-2.4) 		854.8
(-3) 		909.3
(-1.3) 		190

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 813
1 2 3 4 5 6 range
A 1073.5
(0.7)
P 		909.9
(-0.8)
P 		661.7
(-3)
P 		769.1
(-2)
P 		1112.6
(1)
P 		1334.4
(3)
P 		673
B 1173.3
(2.6)
P 		927.7
(0.5)
P 		521
(-3)
P 		1106.6
(2)
P 		878.6
(0.1)
P 		1222.4
(3)
P 		701
C 992.6
(1.3)
P 		934.8
(0.7)
P 		700.4
(-1.7)
P 		573.4
(-3)
P 		848.3
(-0.2)
P 		1153.5
(3)
P 		580
avr 1079.8
(1.5) 		924.1
(-0.1) 		627.7
(-3) 		816.4
(-1.1) 		946.5
(0.1) 		1236.8
(3) 		609
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 293
1 2 3 4 range
A 427.4
(3)
P 		141.3
(-2.9)
P 		216.5
(-1.3)
P 		134.1
(-3)
P 		293
B 302.4
(3)
P 		243.8
(0.1)
P 		181.2
(-3)
P 		209.5
(-1.6)
P 		121
C 335.4
(3)
P 		282.7
(1.4)
P 		332.6
(2.9)
P 		139.7
(-3)
P 		196
avr 355.1
(3) 		222.6
(-1.1) 		243.4
(-0.5) 		161.1
(-3) 		194

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 341
1 2 3 4 5 6 range
A 197.9
(-1.3)
P 		323.6
(2.6)
P 		144.1
(-3)
P 		195.1
(-1.4)
P 		335.7
(3)
P 		324.9
(2.7)
P 		192
B 408.2
(2.1)
P 		308.8
(0.3)
P 		126.5
(-3)
P 		293.1
(0)
P 		357
(1.2)
P 		455.8
(3)
P 		329
C 367.9
(2.6)
P 		285.2
(0.8)
P 		178.3
(-1.6)
P 		115.3
(-3)
P 		274.5
(0.5)
P 		386.1
(3)
P 		271
avr 324.7
(1.4) 		305.9
(0.9) 		149.6
(-3) 		201.2
(-1.7) 		322.4
(1.3) 		388.9
(3) 		239
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 173213_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.26702
Sequence Type Exemplar sequence
Representative Public ID AV180904 NCBI
Target Description AV180904_rc /REP_DB=TREMBL Accession /FEA=EST Transcript /REVCOMP /GB=AV180904 /DEF=Caenorhabditis elegans cDNA clone:yk613f10 : 3prime end, single read.
Cluster Evidence This cluster is supported by a EST Transcript.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059976(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059976 NCBI Caenorhabditis elegans SUPpressor family member (sup-17) (sup-17) mRNA, complete cds. 11/11 A 
DY3.7 ENSEMBL cdna:known chromosome:CEL140:I:8801089:8805409:1 gene:DY3.7 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:8804990-8805244(+) 84.67 84.67
Public Domain and Genome References
Gene Title Zinc-binding metalloprotease domain
Gene Symbol sup-17
Ensembl DY3.7
Entrez Gene 172689 Entrez gene
SwissProt O46354 EMBL-EBI
WormBase CE15751 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1605073_AT ADAM metallopeptidase domain 10 cfa
CANINE:1590101_AT ADAM metallopeptidase domain 10 cfa
CANINE_2:CFA.9442.1.A1_AT ADAM metallopeptidase domain 10 cfa
CANINE_2:CFAAFFX.25351.1.S1_AT ADAM metallopeptidase domain 10 cfa
DROSOPHILA_2:1628215_S_AT kuzbanian dm
DROSGENOME1:141542_AT kuzbanian dm
CHICKEN:GGA.1343.1.S1_AT ADAM metallopeptidase domain 10 gga
CHICKEN:GGA.1343.1.S2_AT ADAM metallopeptidase domain 10 gga
HG-U95AV2:31934_AT ADAM metallopeptidase domain 10 hs
HG-U133_PLUS_2:202604_X_AT ADAM metallopeptidase domain 10 hs
HG-U133A:202604_X_AT ADAM metallopeptidase domain 10 hs
HG-U133A_2:202604_X_AT ADAM metallopeptidase domain 10 hs
HG-U95AV2:40798_S_AT ADAM metallopeptidase domain 10 hs
HU35KSUBA:AA356049_AT ADAM metallopeptidase domain 10 hs
HUGENEFL:Z48579_AT ADAM metallopeptidase domain 10 hs
U133_X3P:G4557250_3P_A_AT ADAM metallopeptidase domain 10 hs
HG-U133A_2:214895_S_AT ADAM metallopeptidase domain 10 hs
HG-U133_PLUS_2:214895_S_AT ADAM metallopeptidase domain 10 hs
HG-U133A:214895_S_AT ADAM metallopeptidase domain 10 hs
HG-U95AV2:40797_AT ADAM metallopeptidase domain 10 hs
HG-U95D:71826_AT ADAM metallopeptidase domain 10 hs
HG-U133_PLUS_2:234131_AT ADAM metallopeptidase domain 10 hs
HG-U133B:234131_AT ADAM metallopeptidase domain 10 hs
U133_X3P:HS2.384153.1.S1_3P_AT ADAM metallopeptidase domain 10 hs
U133_X3P:HS.306566.0.S1_3P_AT ADAM metallopeptidase domain 10 hs
U133_X3P:HS.172028.0.A2_3P_AT ADAM metallopeptidase domain 10 hs
HG-U133_PLUS_2:1562137_AT ADAM metallopeptidase domain 10 hs
HG-U133A_2:202603_AT ADAM metallopeptidase domain 10 hs
HG-FOCUS:202603_AT ADAM metallopeptidase domain 10 hs
HG-U133_PLUS_2:202603_AT ADAM metallopeptidase domain 10 hs
HG-U133A:202603_AT ADAM metallopeptidase domain 10 hs
HG-U95D:68865_R_AT ADAM metallopeptidase domain 10 hs
HU35KSUBD:RC_AA243020_AT ADAM metallopeptidase domain 10 hs
MU11KSUBA:AF011379_AT a disintegrin and metallopeptidase domain 10 mm
MG-U74AV2:100751_AT a disintegrin and metallopeptidase domain 10 mm
MOE430A:1450104_AT a disintegrin and metallopeptidase domain 10 mm
MOUSE430A_2:1450104_AT a disintegrin and metallopeptidase domain 10 mm
MOUSE430_2:1450104_AT a disintegrin and metallopeptidase domain 10 mm
MOE430A:1450105_AT a disintegrin and metallopeptidase domain 10 mm
MOUSE430A_2:1450105_AT a disintegrin and metallopeptidase domain 10 mm
MOUSE430_2:1450105_AT a disintegrin and metallopeptidase domain 10 mm
MG-U74CV2:140826_AT A disintegrin and metallopeptidase domain 10 (Adam10), mRNA mm
MOUSE430_2:1460083_AT A disintegrin and metallopeptidase domain 10 (Adam10), mRNA mm
MOE430B:1460083_AT A disintegrin and metallopeptidase domain 10 (Adam10), mRNA mm
MU19KSUBB:TC28026_AT A disintegrin and metallopeptidase domain 10 (Adam10), mRNA mm
RG-U34A:Z48444CDS_AT a disintegrin and metalloprotease domain 10 rn
RAE230A:1388161_AT a disintegrin and metalloprotease domain 10 rn
RAT230_2:1388161_AT a disintegrin and metalloprotease domain 10 rn
RAE230A:1370955_AT a disintegrin and metalloprotease domain 10 rn
RAT230_2:1370955_AT a disintegrin and metalloprotease domain 10 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8237 metallopeptidase activity inferred from sequence similarity QuickGO AmiGO
8270 zinc ion binding inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB09416 Hypothetical protein DY3.7 [Caenorhabditis elegans] ref|NP_492377.1| SUPpressor family member (sup-17) [Caenorhabditis elegans] gb|AAB97161.1| ADAM 10 [Caenorhabditis elegans] 0.0
blast CAE66973 Hypothetical protein CBG12369 [Caenorhabditis briggsae] 0.0
blast XP_393114 PREDICTED: similar to ENSANGP00000012370 [Apis mellifera] 1.0E-166
Protein Domains
Database ID Description E-Value
Pfam IPR001762 EMBL-EBI Disintegrin 1.2E-29
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_492377.1 1 746-768
DY3.7 1 746-768
Sequence
Target Sequence 
>C. ELEGANS:173213_S_AT
tacaatgttgttccatcttgccttttccactcctacttctttcatttccctctgacccaa
cacttcccttaatttgtattattcattatctcccattccccccaagacggtgcttcagtt
tttccatgtactatacctaacttattggtcaagtttttcgactttatactacaggttcca
atttttgngcattcttcttttacccacttttttgtaattctcacatccaaattcgaggtt
tt

BLASTn GenBank NR
Note: "n"'s represent regions that are not probed by the probe sequences.
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TACAATGTTGTTCCATCTTGCCTTT 70 643 24 Antisense
CAACACTTCCCTTAATTTGTATTAT 367 189 81 Antisense
TGTATTATTCATTATCTCCCATTCC 171 561 98 Antisense
CCAAGACGGTGCTTCAGTTTTTCCA 563 273 125 Antisense
GGTGCTTCAGTTTTTCCATGTACTA 146 501 132 Antisense
GTTTTTCCATGTACTATACCTAACT 159 447 141 Antisense
GTACTATACCTAACTTATTGGTCAA 238 457 151 Antisense
TATTGGTCAAGTTTTTCGACTTTAT 31 665 166 Antisense
TCGACTTTATACTACAGGTTCCAAT 273 597 181 Antisense
TACCCACTTTTTTGTAATTCTCACA 533 649 224 Antisense
TTCTCACATCCAAATTCGAGGTTTT 397 689 241 Antisense
Sequence Source Affymetrix Proprietary Database