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[173202_s_at] Zinc-binding metalloprotease domain

Description AV178725_rc /REP_DB=TREMBL Accession /FEA=EST Transcript /REVCOMP /GB=AV178725 /DEF=Caenorhabditis elegans cDNA clone:yk571a11 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 38      6grp_high1_10_10 > 83      4grp_highest_8_8 > 26      4grp_high_8_8 > 58      6grp_highest_nonorm > 46      6grp_total > 74      4grp_total > 60      6grp_highest_sub > 04      6grp_cgc > 76      6grp_high1_sub > 04      6grp_cgc_sub > 03_04      6grp_rule_based > S4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1147
1 2 3 4 range
A 2705.8
(1.5)
P 		2315.5
(-0.6)
P 		2994.6
(3)
P 		1847.2
(-3)
P 		1147
B 2958
(3)
P 		2589.6
(0.4)
P 		2859.4
(2.3)
P 		2102.8
(-3)
P 		855
C 2643.6
(1.6)
P 		2427.8
(-0.2)
P 		2812.7
(3)
P 		2086.9
(-3)
P 		726
avr 2769.1
(2.2) 		2444.3
(-0) 		2888.9
(3) 		2012.3
(-3) 		877

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1646
1 2 3 4 5 6 range
A 2817.1
(-3)
P 		3013.9
(-2.1)
P 		3474.8
(-0)
P 		4134.6
(3)
P 		3330.2
(-0.7)
P 		3325.1
(-0.7)
P 		1318
B 2683.3
(-3)
P 		2695.6
(-2.9)
P 		2876.8
(-1.5)
P 		3444.5
(3)
P 		3278.6
(1.7)
P 		3135.7
(0.6)
P 		761
C 2489.1
(-3)
P 		2748.1
(-1.7)
P 		3627.1
(2.8)
P 		3666.4
(3)
P 		3033.3
(-0.2)
P 		3171.7
(0.5)
P 		1177
avr 2663.2
(-3) 		2819.2
(-2.1) 		3326.2
(0.7) 		3748.5
(3) 		3214
(0) 		3210.8
(0) 		1085
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 715
1 2 3 4 range
A 985.2
(3)
P 		502.6
(-1.1)
P 		782.9
(1.3)
P 		270.4
(-3)
P 		715
B 943.3
(3)
P 		639.6
(-0.7)
P 		662.6
(-0.4)
P 		448.1
(-3)
P 		495
C 875.1
(2)
P 		698
(0.3)
P 		980.3
(3)
P 		351.9
(-3)
P 		628
avr 934.5
(3) 		613.4
(-0.3) 		808.6
(1.7) 		356.8
(-3) 		578

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 813
1 2 3 4 5 6 range
A 519.3
(-3)
P 		1071.9
(3)
P 		756.7
(-0.4)
P 		1048.6
(2.7)
P 		1004.9
(2.3)
P 		809.6
(0.2)
P 		553
B 933.7
(-0.8)
P 		897.3
(-1.1)
P 		698.6
(-3)
P 		912.3
(-1)
P 		1332
(3)
P 		1169.3
(1.5)
P 		633
C 922.6
(0.4)
P 		838.5
(-1.1)
P 		923.2
(0.4)
P 		737.3
(-3)
P 		981.5
(1.5)
P 		1061.7
(3)
P 		324
avr 791.9
(-3) 		935.9
(-0.3) 		792.8
(-3) 		899.4
(-0.9) 		1106.1
(3) 		1013.5
(1.2) 		314
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 173202_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.26659
Sequence Type Exemplar sequence
Representative Public ID AV178725 NCBI
Target Description AV178725_rc /REP_DB=TREMBL Accession /FEA=EST Transcript /REVCOMP /GB=AV178725 /DEF=Caenorhabditis elegans cDNA clone:yk571a11 : 3prime end, single read.
Cluster Evidence This cluster is supported by a EST Transcript.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060181(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060181 NCBI Caenorhabditis elegans Farnesylated-proteins Converting Enzyme (FACE) family member (fce-1) (fce-1) mRNA, complete cds. 11/11 A 
SNAP00000037409 ENSEMBL cdna:SNAP chromosome:CEL140:I:9719328:9720839:-1 11/11 None
GENEFINDER00000037412 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:9719328:9720839:-1 11/11 None
C04F12.10 ENSEMBL cdna:known chromosome:CEL140:I:9719185:9720840:-1 gene:C04F12.10 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9719203-9719481(-) 86.33 90.0
Public Domain and Genome References
Gene Title Zinc-binding metalloprotease domain
Gene Symbol fce-1
Ensembl C04F12.10
Entrez Gene 172820 Entrez gene
SwissProt Q9XVE5 EMBL-EBI
WormBase CE19683 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:13962_AT CAAX protease, putative (STE24) at
ATH1-121501:255569_AT CAAX protease, putative (STE24) at
CANINE_2:CFAAFFX.5443.1.S1_AT similar to CAAX prenyl protease 1 homolog (Prenyl protein-specific endoprotease 1) (Farnesylated-proteins converting enzyme 1) (FACE-1) (Zinc metalloproteinase Ste24 homolog) cfa
DROSOPHILA_2:1624905_AT dm
DROSGENOME1:142548_AT dm
CHICKEN:GGAAFFX.561.1.S1_AT similar to CAAX prenyl protease 1 homolog (Prenyl protein-specific endoprotease 1) (Farnesylated-proteins converting enzyme 1) (FACE-1) (Zinc metalloproteinase Ste24 homolog) gga
HG-U133_PLUS_2:202939_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HG-U133A:202939_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HG-FOCUS:202939_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HG-U133A_2:202939_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HU35KSUBB:RC_W32176_S_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HU35KSUBD:RC_D60639_AT zinc metallopeptidase (STE24 homolog, yeast) hs
U133_X3P:G5032128_3P_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HG-U95AV2:33912_AT zinc metallopeptidase (STE24 homolog, yeast) hs
MG-U74BV2:111407_AT zinc metallopeptidase, STE24 homolog (S. cerevisiae) mm
MOE430A:1427923_AT zinc metallopeptidase, STE24 homolog (S. cerevisiae) mm
MOUSE430A_2:1427923_AT zinc metallopeptidase, STE24 homolog (S. cerevisiae) mm
MOUSE430_2:1427923_AT zinc metallopeptidase, STE24 homolog (S. cerevisiae) mm
MG-U74CV2:135209_AT Farnesylated-proteins converting enzyme-1 (Face-1 gene) mm
MU19KSUBB:TC31991_AT Farnesylated-proteins converting enzyme-1 (Face-1 gene) mm
RAE230A:1399085_AT Zinc metalloproteinase, STE24 homolog (S. cerevisiae) (predicted) rn
RAT230_2:1399085_AT Zinc metalloproteinase, STE24 homolog (S. cerevisiae) (predicted) rn
RG-U34C:RC_AI175477_AT Zinc metalloproteinase, STE24 homolog (S. cerevisiae) (predicted) rn
YEAST_2:1779388_AT Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4222 metalloendopeptidase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03839 Hypothetical protein C04F12.10 [Caenorhabditis elegans] ref|NP_492582.1| Farnesylated-proteins Converting Enzyme (FACE) family member (fce-1) [Caenorhabditis elegans] 0.0
blast CAE60244 Hypothetical protein CBG03817 [Caenorhabditis briggsae] 0.0
blast XP_707999 PREDICTED: similar to Zinc metalloproteinase (STE24 homolog, yeast) isoform 2 [Danio rerio] 1.0E-105
Protein Domains
Database ID Description E-Value
Pfam IPR001915 EMBL-EBI Peptidase M48, Ste24p 1.2E-41
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_492582.1 5 63-85,147-166,173-195,307-329,342-364
C04F12.10 5 63-85,147-166,173-195,307-329,342-364
SNAP00000037409 5 63-85,147-166,173-195,307-329,342-364
GENEFINDER00000037412 5 63-85,147-166,173-195,307-329,342-364
Sequence
Target Sequence 
>C. ELEGANS:173202_S_AT
ttggaatggttattcactcccgttctgctgaatttggagctgacgagtttgctgctaacc
tcggacacggagaaaatcttattggagctttgaccaagcttggtgttgacaatctgtcga
tgcctatcaatgactcactctactcatggtgcactcacacacatcctccagttgttgaaa
gagtagctgctgttagagccttcca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTGGAATGGTTATTCACTCCCGTTC 482 707 15 Antisense
TCACTCCCGTTCTGCTGAATTTGGA 609 627 28 Antisense
GGAGCTGACGAGTTTGCTGCTAACC 469 521 50 Antisense
TGCTGCTAACCTCGGACACGGAGAA 588 579 64 Antisense
GACCAAGCTTGGTGTTGACAATCTG 83 385 106 Antisense
GACAATCTGTCGATGCCTATCAATG 16 365 122 Antisense
GATGCCTATCAATGACTCACTCTAC 299 415 133 Antisense
TGACTCACTCTACTCATGGTGCACT 40 571 145 Antisense
TACTCATGGTGCACTCACACACATC 278 645 155 Antisense
TCACACACATCCTCCAGTTGTTGAA 250 629 169 Antisense
GAGTAGCTGCTGTTAGAGCCTTCCA 159 399 195 Antisense
Sequence Source Affymetrix Proprietary Database