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[173148_s_at] aspartyl protease

Description AU113913_rc /REP_DB=TREMBL Accession /FEA=EST Transcript /REVCOMP /GB=AU113913 /DEF=Caenorhabditis elegans cDNA clone:yk713a8 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 27      6grp_high1_10_10 > 72      4grp_highest_8_8 > 06      4grp_high_8_8 > 22      6grp_highest_nonorm > 36      6grp_total > 72      4grp_total > 17      6grp_highest_sub > 03_04      6grp_cgc > 75      6grp_high1_sub > 04      6grp_cgc_sub > 03_04      6grp_total_sub > Hat      6grp_rule_based > S4      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1661
1 2 3 4 range
A 2690.2
(-3)
P 		3153.6
(2.9)
P 		2894
(-0.4)
P 		3164.7
(3)
P 		475
B 2503.1
(-3)
P 		2929.2
(-1.5)
P 		3129.6
(-0.7)
P 		4163.8
(3)
P 		1661
C 2718.9
(-3)
P 		3105.6
(-1.2)
P 		3135.5
(-1)
P 		3986.7
(3)
P 		1268
avr 2637.4
(-3) 		3062.8
(-0.7) 		3053
(-0.8) 		3771.7
(3) 		1134

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2709
1 2 3 4 5 6 range
A 2488.1
(-3)
P 		3188.3
(-1.4)
P 		5196.6
(3)
P 		5123
(2.8)
P 		3589.2
(-0.6)
P 		2529.2
(-2.9)
P 		2709
B 2516.7
(-3)
P 		3188.9
(-1.3)
P 		4951.6
(3)
P 		4718
(2.4)
P 		3840.1
(0.3)
P 		2973.8
(-1.9)
P 		2435
C 2754.2
(-3)
P 		2875.8
(-2.7)
P 		4312.7
(1.3)
P 		4944.3
(3)
P 		4400.4
(1.5)
P 		3244.4
(-1.7)
P 		2190
avr 2586.3
(-3) 		3084.3
(-1.7) 		4820.3
(2.7) 		4928.4
(3) 		3943.2
(0.5) 		2915.8
(-2.2) 		2342
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 630
1 2 3 4 range
A 979.5
(3)
P 		684.6
(-0.4)
P 		756.6
(0.4)
P 		463.2
(-3)
P 		516
B 798.2
(-0.3)
P 		723.4
(-3)
P 		725.2
(-2.9)
P 		887.3
(3)
P 		164
C 900
(0.2)
P 		892.9
(0.1)
P 		1092.8
(3)
P 		672.2
(-3)
P 		421
avr 892.6
(3) 		767
(-0.5) 		858.2
(2.1) 		674.2
(-3) 		218

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1102
1 2 3 4 5 6 range
A 458.7
(-3)
P 		1133.9
(1.8)
P 		1131.7
(1.8)
P 		1299.3
(3)
P 		1083.1
(1.5)
P 		615.8
(-1.9)
P 		841
B 875.7
(-3)
P 		1061.4
(-1.4)
P 		1202.4
(-0.1)
P 		1249.6
(0.3)
P 		1560.2
(3)
P 		1108.9
(-1)
P 		685
C 1020.9
(-1.4)
P 		877.5
(-3)
P 		1097.6
(-0.6)
P 		994.3
(-1.7)
P 		1423.9
(3)
P 		1086.1
(-0.7)
P 		546
avr 785.1
(-3) 		1024.3
(-0.5) 		1143.9
(0.8) 		1181.1
(1.2) 		1355.7
(3) 		936.9
(-1.4) 		571
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 173148_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.27487
Sequence Type Exemplar sequence
Representative Public ID AU113913 NCBI
Target Description AU113913_rc /REP_DB=TREMBL Accession /FEA=EST Transcript /REVCOMP /GB=AU113913 /DEF=Caenorhabditis elegans cDNA clone:yk713a8 : 3prime end, single read.
Cluster Evidence This cluster is supported by a EST Transcript.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077790(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077790 NCBI Caenorhabditis elegans ASpartyl Protease family member (asp-4) (asp-4) mRNA, complete cds. 11/11 A 
SNAP00000017895 ENSEMBL cdna:SNAP chromosome:CEL140:X:13218995:13220803:-1 11/11 None
GENEFINDER00000017899 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:13218995:13221347:-1 11/11 None
R12H7.2 ENSEMBL cdna:known chromosome:CEL140:X:13218897:13221389:-1 gene:R12H7.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:13218998-13219313(-) 87.33 87.33
Public Domain and Genome References
Gene Title aspartyl protease
Gene Symbol asp-4
Ensembl R12H7.2
Entrez Gene 181444 Entrez gene
SwissProt Q21966 EMBL-EBI
WormBase CE03567 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:18903_AT aspartyl protease family protein at
ATH1-121501:255345_AT aspartyl protease family protein at
CANINE_2:CFA.17547.1.S1_AT cathepsin D (lysosomal aspartyl peptidase) cfa
CANINE_2:CFAAFFX.15770.1.S1_S_AT cathepsin D (lysosomal aspartyl peptidase) cfa
DROSOPHILA_2:1631493_AT dm
DROSGENOME1:141682_AT dm
CHICKEN:GGA.1094.1.S1_AT cathepsin D (lysosomal aspartyl peptidase) gga
HG-U95AV2:239_AT cathepsin D (lysosomal aspartyl peptidase) hs
HC-G110:239_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133_PLUS_2:200766_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-FOCUS:200766_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133A_2:200766_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133A:200766_AT cathepsin D (lysosomal aspartyl peptidase) hs
HUGENEFL:M63138_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133_PLUS_2:227886_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133B:227886_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:G4503142_3P_X_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:G4503142_3P_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:HS.121575.0.S2_3P_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:HS.121575.0.S1_3P_X_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:HS.121575.0.S1_3P_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:227863_3P_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:200766_3P_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133_PLUS_2:227863_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133B:227863_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U95E:88716_AT cathepsin D (lysosomal aspartyl peptidase) hs
MOE430A:1448118_A_AT cathepsin D mm
MOUSE430A_2:1448118_A_AT cathepsin D mm
MOUSE430_2:1448118_A_AT cathepsin D mm
MU11KSUBB:MSA.32346.0_S_AT cathepsin D mm
MU11KSUBB:X52886_S_AT cathepsin D mm
MG-U74AV2:93810_AT cathepsin D mm
MU11KSUBB:MSA.28694.0_F_AT Cathepsin D, mRNA (cDNA clone IMAGE:4500905) mm
MU19KSUBC:TC38887_AT Cathepsin D, mRNA (cDNA clone IMAGE:4500905) mm
RG-U34A:RC_AI235585_S_AT cathepsin D rn
RG-U34A:X54467_AT cathepsin D rn
RAE230A:1367651_AT cathepsin D rn
RAT230_2:1367651_AT cathepsin D rn
YEAST_2:1769365_AT Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; synthesized as a zymogen, self-activates Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4190 aspartic-type endopeptidase activity inferred from electronic annotation QuickGO AmiGO
4194 pepsin A activity inferred from electronic annotation QuickGO AmiGO
4190 aspartic-type endopeptidase activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA90633 Hypothetical protein R12H7.2 [Caenorhabditis elegans] ref|NP_510191.1| ASpartyl Protease family member (asp-4) [Caenorhabditis elegans] 0.0
blast CAE61399 Hypothetical protein CBG05258 [Caenorhabditis briggsae] 0.0
blast AAO22152 cathepsin D-like aspartic protease [Ancylostoma ceylanicum] 1.0E-179
Protein Domains
Database ID Description E-Value
Pfam IPR001461 EMBL-EBI Peptidase A1, pepsin 1.0E-126
Pfam IPR001461 EMBL-EBI Peptidase A1, pepsin 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:173148_S_AT
atgtccttaaggtttcacagggtggaaagactatttgcttgtctggatttatgggaatcg
atctcccagaacgcgttggagagctctggattcttggagatgtcttcattggaaggtact
attccgtcttcgattttgatcagaaccgtgtcggatttgctcaagctaagaccgccgatg
nccgtccagttgatccagctccacgaccattccgttctgtcttcgacaacgaaagtgagg
aatccatggaacaagacgacg

BLASTn GenBank NR
Note: "n"'s represent regions that are not probed by the probe sequences.
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATGTCCTTAAGGTTTCACAGGGTGG 174 47 13 Antisense
ACTATTTGCTTGTCTGGATTTATGG 144 103 42 Antisense
ATCTCCCAGAACGCGTTGGAGAGCT 165 31 73 Antisense
CGTTGGAGAGCTCTGGATTCTTGGA 582 247 86 Antisense
GATTCTTGGAGATGTCTTCATTGGA 244 431 101 Antisense
GGTACTATTCCGTCTTCGATTTTGA 281 503 127 Antisense
GATTTTGATCAGAACCGTGTCGGAT 694 429 144 Antisense
ACCGTGTCGGATTTGCTCAAGCTAA 14 89 157 Antisense
TTTGCTCAAGCTAAGACCGCCGATG 331 663 168 Antisense
CATTCCGTTCTGTCTTCGACAACGA 383 217 220 Antisense
GAGGAATCCATGGAACAAGACGACG 514 405 249 Antisense
Sequence Source Affymetrix Proprietary Database