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[173139_s_at] serine/threonine kinase (CDC2/CDKX subfamily)

Description AV199617_rc /REP_DB=TREMBL Accession /FEA=EST Transcript /REVCOMP /GB=AV199617 /DEF=Caenorhabditis elegans cDNA clone:yk549a4 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 68      6grp_high1_10_10 > 96      4grp_highest_8_8 > 23      4grp_high_8_8 > 06      6grp_highest_nonorm > 96      6grp_total > 86      4grp_total > 02      6grp_highest_sub > In      6grp_cgc > 58      6grp_high1_sub > In      6grp_cgc_sub > In      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1732
1 2 3 4 range
A 839.1
(-2.3)
P 		799.9
(-2.4)
P 		638.2
(-3)
P 		2370.2
(3)
P 		1732
B 846.1
(-2.8)
P 		786.6
(-3)
P 		855.9
(-2.7)
P 		2272.3
(3)
P 		1486
C 724.3
(-3)
P 		777
(-2.8)
P 		723.6
(-3)
P 		2347.4
(3)
P 		1624
avr 803.2
(-2.8) 		787.8
(-2.8) 		739.2
(-3) 		2330
(3) 		1591

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 738
1 2 3 4 5 6 range
A 676.1
(-3)
P 		864.9
(-1)
P 		812.9
(-1.6)
P 		974.9
(0.1)
P 		683.4
(-2.9)
P 		1254.3
(3)
P 		578
B 691.3
(-1.7)
P 		612.3
(-2.5)
P 		569.1
(-3)
P 		899.6
(0.6)
P 		790.8
(-0.6)
P 		1116.6
(3)
P 		548
C 683.1
(-1.6)
P 		515.9
(-3)
P 		995.6
(0.9)
P 		711.8
(-1.4)
P 		1134.3
(2.1)
P 		1245.6
(3)
P 		730
avr 683.5
(-2.8) 		664.4
(-3) 		792.5
(-1.6) 		862.1
(-0.8) 		869.5
(-0.7) 		1205.5
(3) 		541
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 317
1 2 3 4 range
A 305.5
(1.6)
P 		173.6
(-2.8)
P 		166.8
(-3)
P 		347
(3)
P 		180
B 269.8
(-1.4)
P 		194.3
(-3)
P 		198.3
(-2.9)
P 		484.2
(3)
P 		290
C 239.8
(-2.4)
P 		223.4
(-3)
P 		252.2
(-2)
P 		395.8
(3)
P 		172
avr 271.7
(-0.9) 		197.1
(-3) 		205.8
(-2.8) 		409
(3) 		212

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 292
1 2 3 4 5 6 range
A 124.6
(-3)
P 		307.6
(3)
P 		177
(-1.3)
P 		247.3
(1)
P 		206.2
(-0.3)
P 		305.4
(2.9)
P 		183
B 240.5
(-0.8)
P 		203.8
(-1.6)
P 		138.2
(-3)
P 		238.3
(-0.8)
P 		321.3
(0.9)
P 		416.4
(3)
P 		278
C 253.2
(-0.6)
P 		157.4
(-2.7)
P 		253.4
(-0.6)
P 		143.1
(-3)
P 		367
(1.9)
P 		417
(3)
P 		274
avr 206.1
(-2.5) 		222.9
(-1.9) 		189.5
(-3) 		209.6
(-2.4) 		298.2
(0.4) 		379.6
(3) 		190
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 173139_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.26956
Sequence Type Exemplar sequence
Representative Public ID AV199617 NCBI
Target Description AV199617_rc /REP_DB=TREMBL Accession /FEA=EST Transcript /REVCOMP /GB=AV199617 /DEF=Caenorhabditis elegans cDNA clone:yk549a4 : 3prime end, single read.
Cluster Evidence This cluster is supported by a EST Transcript.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067382(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067382 NCBI Caenorhabditis elegans Cyclin-Dependent Kinase family member (cdk-5) (cdk-5) mRNA, complete cds. 11/11 A 
GENEFINDER00000014277 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:13464334:13465811:-1 11/11 None
T27E9.3 ENSEMBL cdna:known chromosome:CEL140:III:13464264:13465858:-1 gene:T27E9.3 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:13464264-13465016(-) 99.33 99.33
Public Domain and Genome References
Gene Title serine/threonine kinase (CDC2/CDKX subfamily)
Gene Symbol cdk-5
Ensembl T27E9.3
Entrez Gene 176774 Entrez gene
SwissProt O18142 EMBL-EBI
WormBase CE21213 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.21399.1.S1_S_AT similar to Cell division protein kinase 5 (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) cfa
CANINE_2:CFAAFFX.8027.1.S1_AT similar to Cell division protein kinase 5 (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) cfa
DROSOPHILA_2:1637085_AT Cyclin-dependent kinase 5 dm
DROSGENOME1:153451_AT Cyclin-dependent kinase 5 dm
HG-U95AV2:1206_AT cyclin-dependent kinase 5 hs
HC-G110:1206_AT cyclin-dependent kinase 5 hs
HG-U133_PLUS_2:204247_S_AT cyclin-dependent kinase 5 hs
HG-U133A_2:204247_S_AT cyclin-dependent kinase 5 hs
HG-U133A:204247_S_AT cyclin-dependent kinase 5 hs
HG-FOCUS:204247_S_AT cyclin-dependent kinase 5 hs
HU35KSUBA:X66364_AT cyclin-dependent kinase 5 hs
HUGENEFL:X66364_AT cyclin-dependent kinase 5 hs
U133_X3P:G4826674_3P_AT cyclin-dependent kinase 5 hs
HG-U95AV2:40549_AT cyclin-dependent kinase 5 hs
MU11KSUBA:D29678_S_AT cyclin-dependent kinase 5 mm
MG-U74AV2:100444_AT cyclin-dependent kinase 5 mm
MG-U74BV2:105126_AT cyclin-dependent kinase 5 mm
MOE430A:1450674_AT cyclin-dependent kinase 5 mm
MOUSE430A_2:1450674_AT cyclin-dependent kinase 5 mm
MOUSE430_2:1450674_AT cyclin-dependent kinase 5 mm
MOE430A:1422590_AT cyclin-dependent kinase 5 mm
MOUSE430A_2:1422590_AT cyclin-dependent kinase 5 mm
MOUSE430_2:1422590_AT cyclin-dependent kinase 5 mm
RT-U34:L02121_AT cyclin-dependent kinase 5 rn
RG-U34A:L02121_AT cyclin-dependent kinase 5 rn
RAE230A:1368088_AT cyclin-dependent kinase 5 rn
RAT230_2:1368088_AT cyclin-dependent kinase 5 rn
YEAST_2:1774558_AT Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5 Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB04875 Hypothetical protein T27E9.3 [Caenorhabditis elegans] ref|NP_499783.1| Cyclin-Dependent Kinase family member (cdk-5) [Caenorhabditis elegans] gb|AAD37121.1| cell division protein kinase 5 [Caenorhabditis elegans] 1.0E-170
blast CAB04875 Hypothetical protein T27E9.3 [Caenorhabditis elegans] ref|NP_499783.1| Cyclin-Dependent Kinase family member (cdk-5) [Caenorhabditis elegans] gb|AAD37121.1| cell division protein kinase 5 [Caenorhabditis elegans] 1.0E-168
blast CAE73691 Hypothetical protein CBG21202 [Caenorhabditis briggsae] 1.0E-163
blast CAE73691 Hypothetical protein CBG21202 [Caenorhabditis briggsae] 1.0E-162
blast EAA10719 ENSANGP00000018692 [Anopheles gambiae str. PEST] ref|XP_315787.2| ENSANGP00000018692 [Anopheles gambiae str. PEST] 1.0E-134
blast EAA10719 ENSANGP00000018692 [Anopheles gambiae str. PEST] ref|XP_315787.2| ENSANGP00000018692 [Anopheles gambiae str. PEST] 1.0E-132
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 8.0E-84
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 4.0E-84
hanks 3.1.6 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk5 1.0E-129
hanks 3.1.6 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk5 1.0E-131
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 8.1E-90
Pfam IPR000719 EMBL-EBI Protein kinase 2.0E-89
Sequence
Target Sequence 
>C. ELEGANS:173139_S_AT
taccatccaacgcttacatggagccaaatcgtacctaatttgaattcacgtggccgtgat
cttttacagaaacttnttgtttgcaatccagcaggaagaatcgatgccgatgcagcttta
cgccatgcgtacttcgcagacacttctgacgtcta

BLASTn GenBank NR
Note: "n"'s represent regions that are not probed by the probe sequences.
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TACCATCCAACGCTTACATGGAGCC 394 649 91 Antisense
ACATGGAGCCAAATCGTACCTAATT 326 105 106 Antisense
GTACCTAATTTGAATTCACGTGGCC 555 457 121 Antisense
TCACGTGGCCGTGATCTTTTACAGA 181 625 136 Antisense
GTGGCCGTGATCTTTTACAGAAACT 4 493 140 Antisense
TTGTTTGCAATCCAGCAGGAAGAAT 121 675 167 Antisense
AGGAAGAATCGATGCCGATGCAGCT 50 53 183 Antisense
TACGCCATGCGTACTTCGCAGACAC 149 649 209 Antisense
CATGCGTACTTCGCAGACACTTCTG 323 211 214 Antisense
GTACTTCGCAGACACTTCTGACGTC 467 459 219 Antisense
ACTTCGCAGACACTTCTGACGTCTA 590 103 221 Antisense
Sequence Source Affymetrix Proprietary Database