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[172964_x_at] FKBP-type peptidyl-prolyl cis-trans isomerases

Description Y18D10A.19C /REP_DB=WormBase Gene ID /WP=CE21417 /GEN=fkb-2 /TR=Q9U2Q8 /GB=CAA22330.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=FKBP-type peptidyl-prolyl cis-trans isomerases
Cluster 6grp_highest_10_10 > 25      6grp_high1_10_10 > 51      4grp_highest_8_8 > 10      4grp_high_8_8 > 62      6grp_highest_nonorm > 28      6grp_total > 52      4grp_total > 57      6grp_highest_sub > 03      6grp_cgc > 83      6grp_high1_sub > 03      6grp_cgc_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 9621
1 2 3 4 range
A 8298.5
(-2.6)
P 		12581.5
(1)
P 		14959.2
(3)
P 		7760.8
(-3)
P 		7198
B 8642.4
(-0.7)
P 		10361.3
(0.9)
P 		12473.7
(3)
P 		6294.3
(-3)
P 		6179
C 7982
(-0.4)
P 		11387.9
(3)
P 		10665.7
(2.3)
P 		5337.8
(-3)
P 		6050
avr 8307.6
(-1.2) 		11443.6
(1.8) 		12699.5
(3) 		6464.3
(-3) 		6235

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 6751
1 2 3 4 5 6 range
A 8572.6
(-2.1)
P 		10421.6
(1.4)
P 		11248.1
(3)
P 		10703.4
(2)
P 		8120.5
(-3)
P 		8638.3
(-2)
P 		3128
B 8014.2
(-0.8)
P 		9894
(1.9)
P 		10627
(3)
P 		9495.4
(1.4)
P 		9262.9
(1)
P 		6506.9
(-3)
P 		4120
C 9823.2
(-0.2)
P 		9675.3
(-0.4)
P 		13257.6
(3)
P 		9935.5
(-0.1)
P 		10021.8
(-0)
P 		6878.9
(-3)
P 		6379
avr 8803.3
(-1) 		9997
(0.6) 		11710.9
(3) 		10044.8
(0.7) 		9135.1
(-0.5) 		7341.4
(-3) 		4370
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 3011
1 2 3 4 range
A 3021.5
(1.1)
P 		2731.1
(0.4)
P 		3910.6
(3)
P 		1136
(-3)
P 		2775
B 2756
(2.5)
P 		2559
(1.7)
P 		2890.4
(3)
P 		1341.3
(-3)
P 		1549
C 2642.3
(0.7)
P 		3274.1
(2.1)
P 		3717.3
(3)
P 		900
(-3)
P 		2817
avr 2806.6
(1.2) 		2854.7
(1.4) 		3506.1
(3) 		1125.8
(-3) 		2380

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2183
1 2 3 4 5 6 range
A 1580.3
(-3)
P 		3706.4
(3)
P 		2449.6
(-0.5)
P 		2714.6
(0.2)
P 		2450.4
(-0.5)
P 		2103.1
(-1.5)
P 		2126
B 2788.6
(-1.4)
P 		3293.3
(0.9)
P 		2580.6
(-2.3)
P 		2515
(-2.6)
P 		3763.4
(3)
P 		2426.4
(-3)
P 		1337
C 3641
(3)
P 		2952.2
(0.5)
P 		3374.3
(2)
P 		1998
(-3)
P 		3242.9
(1.5)
P 		2302.8
(-1.9)
P 		1643
avr 2670
(-0.7) 		3317.3
(3) 		2801.5
(0) 		2409.2
(-2.2) 		3152.2
(2) 		2277.4
(-3) 		1040
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 172964_x_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.366
Sequence Type Exemplar sequence
Representative Public ID Y18D10A.19C NCBI
Target Description Y18D10A.19C /REP_DB=WormBase Gene ID /WP=CE21417 /GEN=fkb-2 /TR=Q9U2Q8 /GB=CAA22330.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=FKBP-type peptidyl-prolyl cis-trans isomerases
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq,GenBank identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_001026551(11), U27353(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_001026551 NCBI Caenorhabditis elegans FK506-Binding protein family member (fkb-2) (fkb-2) mRNA, complete cds. 11/11 None
U27353 NCBI Caenorhabditis elegans rotamase (FKBP-2) mRNA, complete cds. 10/11 None
SNAP00000000430 ENSEMBL cdna:SNAP chromosome:CEL140:I:12926847:12927226:1 11/11 None
GENEFINDER00000000460 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:12926847:12927226:1 11/11 None
Y18D10A.19.2 ENSEMBL cdna:known chromosome:CEL140:I:12926840:12927397:1 gene:Y18D10A.19 11/11 None
Y18D10A.19.1 ENSEMBL cdna:known chromosome:CEL140:I:12926842:12927397:1 gene:Y18D10A.19 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
NM_001026554 2/11 Cross Hyb Matching Probes None
SNAP00000000429 2/11 Cross Hyb Matching Probes None
GENEFINDER00000000436 2/11 Cross Hyb Matching Probes None
Y18D10A.25 2/11 Cross Hyb Matching Probes A 
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:12926777-12927157(+) 100.0 100.0
Public Domain and Genome References
Gene Title FKBP-type peptidyl-prolyl cis-trans isomerases
Gene Symbol fkb-2
Ensembl Y18D10A.19
Entrez Gene 173160 Entrez gene
SwissProt Q9U2Q8 EMBL-EBI
WormBase CE21417 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1587273_AT similar to FK506-binding protein 1A cfa
CANINE_2:CFA.10988.1.S1_AT similar to FK506-binding protein 1A cfa
CANINE_2:CFAAFFX.11117.1.S1_S_AT similar to FK506-binding protein 1A cfa
DROSOPHILA_2:1638415_AT FK506-binding protein 2 dm
DROSGENOME1:143729_AT FK506-binding protein 2 dm
CHICKEN:GGA.4948.1.S1_AT FK506 binding protein 1A, 12kDa gga
HG-U133_PLUS_2:210186_S_AT FK506 binding protein 1A, 12kDa hs
HG-U133A:210186_S_AT FK506 binding protein 1A, 12kDa hs
HG-U133A_2:210186_S_AT FK506 binding protein 1A, 12kDa hs
HG-U95AV2:880_AT FK506 binding protein 1A, 12kDa hs
HC-G110:880_AT FK506 binding protein 1A, 12kDa hs
HG-U133A:210187_AT FK506 binding protein 1A, 12kDa hs
HG-U133_PLUS_2:210187_AT FK506 binding protein 1A, 12kDa hs
HG-U133A_2:210187_AT FK506 binding protein 1A, 12kDa hs
HG-U133_PLUS_2:200709_AT FK506 binding protein 1A, 12kDa hs
HG-U133A:200709_AT FK506 binding protein 1A, 12kDa hs
HG-FOCUS:200709_AT FK506 binding protein 1A, 12kDa hs
HG-U133A_2:200709_AT FK506 binding protein 1A, 12kDa hs
HUGENEFL:M34539_AT FK506 binding protein 1A, 12kDa hs
U133_X3P:G4503724_3P_S_AT FK506 binding protein 1A, 12kDa hs
U133_X3P:G13477342_3P_AT FK506 binding protein 1A, 12kDa hs
U133_X3P:HS.752.2.A1_3P_A_AT FK506 binding protein 1A, 12kDa hs
HG-U133A_2:214119_S_AT FK506 binding protein 1A, 12kDa hs
HG-U133_PLUS_2:214119_S_AT FK506 binding protein 1A, 12kDa hs
HG-U133A:214119_S_AT FK506 binding protein 1A, 12kDa hs
HG-U133_PLUS_2:236669_AT FK506 binding protein 1A, 12kDa hs
HG-U133B:236669_AT FK506 binding protein 1A, 12kDa hs
HG-U95E:74855_AT FK506 binding protein 1A, 12kDa hs
U133_X3P:HS.132890.0.A1_3P_AT FK506 binding protein 1A, 12kDa hs
MOE430A:1456196_X_AT FK506 binding protein 1a mm
MOUSE430A_2:1456196_X_AT FK506 binding protein 1a mm
MOUSE430_2:1456196_X_AT FK506 binding protein 1a mm
MOE430A:1448184_AT FK506 binding protein 1a mm
MOUSE430_2:1448184_AT FK506 binding protein 1a mm
MOUSE430A_2:1448184_AT FK506 binding protein 1a mm
MOE430A:1416036_AT FK506 binding protein 1a mm
MOUSE430A_2:1416036_AT FK506 binding protein 1a mm
MOUSE430_2:1416036_AT FK506 binding protein 1a mm
MOUSE430_2:1438795_X_AT FK506 binding protein 1a mm
MOUSE430A_2:1438795_X_AT FK506 binding protein 1a mm
MOE430A:1438795_X_AT FK506 binding protein 1a mm
MU11KSUBB:MSA.13982.0_F_AT FK506 binding protein 1a mm
MU11KSUBB:X60203_F_AT FK506 binding protein 1a mm
MU11KSUBB:MSA.2292.0_F_AT FK506 binding protein 1a mm
MU11KSUBB:MSA.19745.0_F_AT FK506 binding protein 1a mm
MG-U74AV2:160257_AT FK506 binding protein 1a mm
MOE430A:1438958_X_AT FK506 binding protein 1a mm
MOUSE430A_2:1438958_X_AT FK506 binding protein 1a mm
MOUSE430_2:1438958_X_AT FK506 binding protein 1a mm
MU19KSUBA:TC15527_F_AT FK506 binding protein 1a, mRNA (cDNA clone MGC:6253 IMAGE:3498682) mm
MU19KSUBB:TC33148_AT FK506 binding protein 1a, mRNA (cDNA clone MGC:6253 IMAGE:3498682) mm
RT-U34:RC_AI176170_AT FK506 binding protein 1a rn
RG-U34A:RC_AI176170_AT FK506 binding protein 1a rn
RAT230_2:1369621_S_AT FK506 binding protein 1a rn
RAE230A:1369621_S_AT FK506 binding protein 1a rn
RT-U34:D86641_AT FK506 binding protein 1a rn
RG-U34A:D86641_AT FK506 binding protein 1a rn
RT-U34:RC_AI228738_S_AT FK506 binding protein 1a rn
RG-U34A:RC_AI228738_S_AT FK506 binding protein 1a rn
RT-U34:RC_AA875594_S_AT FK506 binding protein 1a rn
RG-U34A:RC_AA875594_S_AT FK506 binding protein 1a rn
RAE230A:1398828_AT FK506 binding protein 1a rn
RAT230_2:1398828_AT FK506 binding protein 1a rn
RAE230A:1398829_AT FK506 binding protein 1a rn
RAT230_2:1398829_AT FK506 binding protein 1a rn
RAE230B:1392479_AT FK506-binding protein 1a rn
RAT230_2:1392479_AT FK506-binding protein 1a rn
RG-U34C:RC_AI178506_AT FK506-binding protein 1a rn
YEAST_2:1778097_AT Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6457 protein folding inferred from electronic annotation QuickGO AmiGO
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA22330 Hypothetical protein Y18D10A.19 [Caenorhabditis elegans] ref|NP_001021722.1| FK506-Binding protein family member (fkb-2) [Caenorhabditis elegans] 5.0E-57
blast AAA68610 rotamase 7.0E-57
blast AAA68610 rotamase 3.0E-56
blast CAA22330 Hypothetical protein Y18D10A.19 [Caenorhabditis elegans] ref|NP_001021722.1| FK506-Binding protein family member (fkb-2) [Caenorhabditis elegans] 3.0E-56
Protein Domains
Database ID Description E-Value
Pfam IPR001179 EMBL-EBI Peptidylprolyl isomerase, FKBP-type 4.7E-51
Sequence
Target Sequence 
>C. ELEGANS:172964_X_AT
gacagacagattctcgtcgagggcgacaacgtcaccaagccaaagaacggtcagaccgtc
acctgccactacgtgctcacccttgagaacggaaagaagatcgactcttctcgcgaccgc
ggaactccattcaagttcaagattggaaagggagaggtcatcaagggatgggaccaagga
gtcgcccagatgtcagttggtgagaagtcgaagctcaccatctctgccgatcttggctat
ggaccacgcggagtt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GACAGACAGATTCTCGTCGAGGGCG 700 367 22 Antisense
GCGACAACGTCACCAAGCCAAAGAA 405 287 44 Antisense
AAGAACGGTCAGACCGTCACCTGCC 37 153 64 Antisense
CTACGTGCTCACCCTTGAGAACGGA 690 225 90 Antisense
AAAGAAGATCGACTCTTCTCGCGAC 638 121 114 Antisense
CGACCGCGGAACTCCATTCAAGTTC 24 1 135 Antisense
GGGATGGGACCAAGGAGTCGCCCAG 68 497 186 Antisense
GAGTCGCCCAGATGTCAGTTGGTGA 696 399 200 Antisense
GAGAAGTCGAAGCTCACCATCTCTG 679 391 223 Antisense
CATCTCTGCCGATCTTGGCTATGGA 83 213 240 Antisense
TCTTGGCTATGGACCACGCGGAGTT 462 619 252 Antisense
Sequence Source Affymetrix Proprietary Database