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[172960_x_at] HOMOGENTISATE 1,2-DIOXYGENASE (EC 1.13.11.5) (HOMOGENTISICASE) (HOMOGENTISATE OXYGENASE) (HOMOGENTISIC ACID OXIDASE)

Description W06D4.1 /REP_DB=WormBase Gene ID /WP=CE18338 /GEN=hgo-1 /GB=CAA22255.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=HOMOGENTISATE 1,2-DIOXYGENASE (EC 1.13.11.5) (HOMOGENTISICASE) (HOMOGENTISATE OXYGENASE) (HOMOGENTISIC ACID OXIDASE)
Cluster 6grp_highest_10_10 > 26      6grp_high1_10_10 > 62      4grp_highest_8_8 > 35      4grp_high_8_8 > 56      6grp_highest_nonorm > 25      6grp_total > 62      4grp_total > 63      6grp_highest_sub > 03      6grp_cgc > 92      6grp_high1_sub > 03      6grp_cgc_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 927
1 2 3 4 range
A 3082.2
(3)
P 		2600.6
(-3)
P 		2925.7
(1.1)
P 		2701.3
(-1.7)
P 		482
B 3308
(3)
P 		2609.4
(-3)
P 		3179.6
(1.9)
P 		2763.3
(-1.7)
P 		699
C 3152.5
(3)
P 		2381.3
(-3)
P 		2804.2
(0.3)
P 		2803.4
(0.3)
P 		771
avr 3180.9
(3) 		2530.4
(-3) 		2969.8
(1.1) 		2756
(-0.9) 		651

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 5942
1 2 3 4 5 6 range
A 2849.6
(-2.4)
P 		3439.7
(-1.6)
P 		6914.3
(3)
P 		5379.5
(1)
P 		3174.4
(-1.9)
P 		2372.3
(-3)
P 		4542
B 2447.3
(-3)
P 		3816.8
(-1.5)
P 		8063.8
(3)
P 		5865.9
(0.7)
P 		3448.5
(-1.9)
P 		2474.3
(-3)
P 		5617
C 2122.2
(-3)
P 		3951.9
(0.1)
P 		5623.3
(3)
P 		5621.1
(3)
P 		2547.2
(-2.3)
P 		2622.7
(-2.1)
P 		3501
avr 2473
(-3) 		3736.1
(-1.3) 		6867.1
(3) 		5622.2
(1.3) 		3056.7
(-2.2) 		2489.8
(-3) 		4394
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 727
1 2 3 4 range
A 1122.2
(3)
P 		564.5
(-1.6)
P 		764.8
(0)
P 		395.4
(-3)
P 		727
B 1054.9
(3)
P 		644.5
(-2.3)
P 		736.8
(-1.1)
P 		588.9
(-3)
P 		466
C 1043.6
(3)
P 		684.6
(-0.8)
P 		977.3
(2.3)
P 		472.7
(-3)
P 		571
avr 1073.6
(3) 		631.2
(-1.5) 		826.3
(0.5) 		485.7
(-3) 		588

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1433
1 2 3 4 5 6 range
A 525.3
(-3)
P 		1223.3
(1.3)
P 		1505.8
(3)
P 		1364.4
(2.1)
P 		957.9
(-0.4)
P 		577.6
(-2.7)
P 		981
B 851.5
(-3)
P 		1270.5
(-0.7)
P 		1958.1
(3)
P 		1553.7
(0.8)
P 		1401.1
(-0)
P 		922.7
(-2.6)
P 		1107
C 786.6
(-3)
P 		1205.8
(0.9)
P 		1431.2
(3)
P 		1130.4
(0.2)
P 		824.2
(-2.7)
P 		878
(-2.1)
P 		645
avr 721.1
(-3) 		1233.2
(0.4) 		1631.7
(3) 		1349.5
(1.1) 		1061.1
(-0.8) 		792.8
(-2.5) 		911
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 172960_x_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2354
Sequence Type Exemplar sequence
Representative Public ID W06D4.1 NCBI
Target Description W06D4.1 /REP_DB=WormBase Gene ID /WP=CE18338 /GEN=hgo-1 /GB=CAA22255.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=HOMOGENTISATE 1,2-DIOXYGENASE (EC 1.13.11.5) (HOMOGENTISICASE) (HOMOGENTISATE OXYGENASE) (HOMOGENTISIC ACID OXIDASE)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060032(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060032 NCBI Caenorhabditis elegans HomoGentisate Oxidase family member (hgo-1) (hgo-1) mRNA, complete cds. 10/11 A 
W06D4.1 ENSEMBL cdna:known chromosome:CEL140:I:9057583:9063564:-1 gene:W06D4.1 10/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
NM_071571 1/11 Cross Hyb Matching Probes A 
GENEFINDER00000003046 2/11 Cross Hyb Matching Probes None
SNAP00000003036 2/11 Cross Hyb Matching Probes None
SNAP00000023219 1/11 Cross Hyb Matching Probes None
GENEFINDER00000023227 1/11 Cross Hyb Matching Probes None
C02A12.4.1 1/11 Cross Hyb Matching Probes None
C02A12.4.2 1/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9057593-9059506(-) 98.81 98.81
Public Domain and Genome References
Gene Title HOMOGENTISATE 1,2-DIOXYGENASE (EC 1.13.11.5) (HOMOGENTISICASE) (HOMOGENTISATE OXYGENASE) (HOMOGENTISIC ACID OXIDASE)
Gene Symbol hgo-1
Ensembl W06D4.1
Entrez Gene 172726 Entrez gene
SwissProt Q9Y041 EMBL-EBI
WormBase CE29602 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:15656_AT homogentisate 1,2-dioxygenase / homogentisicase/homogentisate oxygenase / homogentisic acid oxidase (HGO) at
ATH1-121501:248193_AT homogentisate 1,2-dioxygenase / homogentisicase/homogentisate oxygenase / homogentisic acid oxidase (HGO) at
CANINE:1587618_AT similar to Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate oxygenase) (Homogentisic acid oxidase) cfa
CANINE_2:CFA.14563.1.A1_AT similar to Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate oxygenase) (Homogentisic acid oxidase) cfa
CANINE_2:CFA.14563.1.A1_S_AT similar to Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate oxygenase) (Homogentisic acid oxidase) cfa
DROSOPHILA_2:1633492_AT homogentisate 1,2-dioxygenase dm
DROSGENOME1:146233_AT homogentisate 1,2-dioxygenase dm
CHICKEN:GGA.10831.1.S1_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) gga
HG-U133_PLUS_2:214307_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U133A:214307_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U133A_2:214307_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U95AV2:31844_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U133_PLUS_2:205221_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U133A_2:205221_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U133A:205221_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HU35KSUBD:RC_R08615_S_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HUGENEFL:AF000573_RNA1_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
U133_X3P:G4504380_3P_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
U133_X3P:HS.15113.1.S1_3P_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
U133_X3P:HS.116992.0.A1_3P_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U133A_2:214308_S_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-FOCUS:214308_S_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U133_PLUS_2:214308_S_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U133A:214308_S_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U133_PLUS_2:237029_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U133B:237029_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U95E:76149_AT homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
HG-U95D:67893_AT Homogentisate 1,2-dioxygenase (homogentisate oxidase) hs
MOUSE430_2:1452986_AT homogentisate 1, 2-dioxygenase mm
MOE430A:1452986_AT homogentisate 1, 2-dioxygenase mm
MOUSE430A_2:1452986_AT homogentisate 1, 2-dioxygenase mm
MU11KSUBA:U58988_S_AT homogentisate 1, 2-dioxygenase mm
MG-U74AV2:98582_AT homogentisate 1, 2-dioxygenase mm
RG-U34C:RC_AI232328_AT homogentisate 1, 2-dioxygenase (predicted) rn
RAE230B:1398514_AT homogentisate 1, 2-dioxygenase (predicted) rn
RAT230_2:1398514_AT homogentisate 1, 2-dioxygenase (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6559 L-phenylalanine catabolism inferred from electronic annotation QuickGO AmiGO
6570 tyrosine metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4411 homogentisate 1,2-dioxygenase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA22255 Hypothetical protein W06D4.1 [Caenorhabditis elegans] emb|CAB07848.4| Hypothetical protein W06D4.1 [Caenorhabditis elegans] ref|NP_492433.1| HomoGentisate Oxidase family member (hgo-1) [Caenorhabditis elegans] gb|AAF61419.1| homogentisate 1,2-dioxygenase [Caenorhabditis elegans] sp|Q9Y041|HGD_CAEEL Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate oxygenase) (Homogentisic acid oxidase) 0.0
blast T19626 hypothetical protein W06D4.1 - Caenorhabditis elegans 0.0
blast AAD00776 2,5 dihydroxyphenylacetate oxidase [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR005708 EMBL-EBI Homogentisate 1,2-dioxygenase 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:172960_X_AT
tcctggttccaggccaaacaaggtcattctccatttgatgttgttggttggcatggaaac
tatgttccatacaagtatgacttgaaaaagtttatggttatcaatacagtttcattcgat
cattgtgtaagtttattaattaaaatgctgattttgaaaaaggatccatcgatttttact
gttctcacagctccatctgtcaagcatggtaccgctattgctgattttgtgatttttcca
ccaagatggggttgtgccgataacactttcaggccaccatattatcacagaaactgtatg
tctgagtatatgggattaatcactggatgctatgaagcaaaagaaggaggattcaagcca
ggtggtggttcccttcattcaatgatgactccacatggacctgattttaattgttttgaa
atggcatcaaatgctgaccttaaaccacaaagagttgctgaaggaactatgtctttcatg
tttgaaagttctttgaacatggccataaccaactgggcagt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCCTGGTTCCAGGCCAAACAAGGTC 406 593 769 Antisense
ACAAGGTCATTCTCCATTTGATGTT 543 113 786 Antisense
GGATCCATCGATTTTTACTGTTCTC 483 513 930 Antisense
TTCTCACAGCTCCATCTGTCAAGCA 347 689 950 Antisense
GGTACCGCTATTGCTGATTTTGTGA 325 505 976 Antisense
GGGGTTGTGCCGATAACACTTTCAG 377 495 1016 Antisense
AACACTTTCAGGCCACCATATTATC 560 135 1030 Antisense
GATTCAAGCCAGGTGGTGGTTCCCT 545 429 1118 Antisense
GGTGGTTCCCTTCATTCAATGATGA 6 497 1132 Antisense
GATGACTCCACATGGACCTGATTTT 591 411 1152 Antisense
ACATGGCCATAACCAACTGGGCAGT 126 107 1265 Antisense
Sequence Source Affymetrix Proprietary Database