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[172880_x_at] tyrosine-protein kinase

Description C55C3.4 /REP_DB=WormBase Gene ID /WP=CE06991 /TR=Q18865 /GB=AAA96169.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase
Cluster 6grp_total > 77      4grp_total > 07      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 55
1 2 3 4 range
A 22.1
(-1.6)
A 		27
(-1)
A 		8.9
(-3)
A 		64.2
(3)
A 		55
B 34.1
(3)
A 		9.1
(-3)
A 		26.5
(1.2)
A 		21.2
(-0.1)
A 		25
C 35.7
(3)
A 		11.3
(-3)
A 		29.2
(1.4)
A 		15.1
(-2.1)
A 		24
avr 30.6
(2) 		15.8
(-3) 		21.5
(-1.1) 		33.5
(3) 		18

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 121
1 2 3 4 5 6 range
A 8.8
(-2.9)
A 		7.1
(-3)
A 		38.6
(-1.1)
A 		18
(-2.3)
A 		35.4
(-1.3)
A 		107.5
(3)
P 		100
B 9.3
(-3)
A 		20.4
(-2.3)
A 		26.4
(-1.9)
A 		58.9
(0.2)
A 		84.5
(1.9)
A 		101.4
(3)
P 		92
C 8.1
(-3)
A 		33.5
(-1.7)
A 		16.2
(-2.6)
A 		10.3
(-2.9)
A 		15.8
(-2.6)
A 		128.5
(3)
P 		120
avr 8.7
(-3) 		20.3
(-2.3) 		27.1
(-1.9) 		29.1
(-1.8) 		45.2
(-0.9) 		112.5
(3) 		104
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 10
1 2 3 4 range
A 8
(1.8)
A 		5.9
(0)
A 		2.3
(-3)
A 		9.4
(3)
A 		7
B 10.9
(3)
A 		2.2
(-3)
A 		6.1
(-0.3)
A 		4.5
(-1.4)
A 		9
C 11.8
(3)
A 		3.2
(-2.5)
A 		10.2
(2)
A 		2.5
(-3)
A 		9
avr 10.2
(3) 		3.8
(-3) 		6.2
(-0.8) 		5.5
(-1.4) 		6

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 41
1 2 3 4 5 6 range
A 1.6
(-3)
A 		2.5
(-2.8)
A 		8.4
(-1.3)
A 		4.6
(-2.3)
A 		10.7
(-0.8)
A 		26.2
(3)
P 		25
B 3.2
(-3)
A 		6.8
(-2.4)
A 		6.4
(-2.4)
A 		15.6
(-0.8)
A 		34.3
(2.4)
A 		37.8
(3)
P 		35
C 3
(-2.9)
A 		10.2
(-1.8)
A 		4.1
(-2.7)
A 		2.1
(-3)
A 		5.1
(-2.6)
A 		43
(3)
P 		41
avr 2.6
(-3) 		6.5
(-2.3) 		6.3
(-2.3) 		7.4
(-2.1) 		16.7
(-0.4) 		35.7
(3) 		33
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 172880_x_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10686
Sequence Type Exemplar sequence
Representative Public ID C55C3.4 NCBI
Target Description C55C3.4 /REP_DB=WormBase Gene ID /WP=CE06991 /TR=Q18865 /GB=AAA96169.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068445(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068445 NCBI Caenorhabditis elegans C55C3.4 (C55C3.4) mRNA, complete cds. 11/11 None
SNAP00000018110 ENSEMBL cdna:SNAP chromosome:CEL140:IV:5676197:5678037:-1 11/11 None
GENEFINDER00000018125 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:5676197:5678037:-1 11/11 None
C55C3.4 ENSEMBL cdna:known chromosome:CEL140:IV:5676197:5678084:-1 gene:C55C3.4 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
NM_060425 5/11 Cross Hyb Matching Probes A 
NM_060426 2/11 Cross Hyb Matching Probes A 
GENEFINDER00000013387 5/11 Cross Hyb Matching Probes None
SNAP00000013370 5/11 Cross Hyb Matching Probes None
C35E7.10a 5/11 Cross Hyb Matching Probes A 
C35E7.10b 5/11 Cross Hyb Matching Probes A 
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:10818753-10820825(-) 96.53 96.53
chrIV:5676202-5678043(-) 100.0 100.0
Public Domain and Genome References
Gene Title tyrosine-protein kinase
Ensembl C55C3.4
Entrez Gene 177346 Entrez gene
SwissProt Q18865 EMBL-EBI
WormBase CE06991 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_500846 C55C3.4 [Caenorhabditis elegans] gb|AAA96169.1| Hypothetical protein C55C3.4 [Caenorhabditis elegans] 0.0
blast AAC17525 Hypothetical protein C35E7.10a [Caenorhabditis elegans] ref|NP_492826.1| C35E7.10a [Caenorhabditis elegans] 0.0
blast CAE63909 Hypothetical protein CBG08480 [Caenorhabditis briggsae] 1.0E-180
Protein Families
Method ID Description E-Value
hanks 1.6.2 AGC group; AGC VI phosphorylate ribosomal protein S6; RSK1N 3.0E-60
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 6.8E-16
Pfam IPR000719 EMBL-EBI Protein kinase 1.3E-57
Sequence
Target Sequence 
>C. ELEGANS:172880_X_AT
acgagttgatctaccaagctgccaatggtctcgcctacatccacgagaagaacttgatgc
atcgagatgtggctgctcgtaactgcctttatggtggtgggcaggtcaaaatcgctgatt
tcggattgtcccgtgaaggtgcggattacacgatggatctgaaaaagaaggtaccaatcc
gttggttgcctccagagaccattcgttcgggtctttatactccaaagactgacgtcttcg
cttttggagtgatggcatgggaaatcaccgaggatgggaaggagccatatccaggattca
aggttattgaggtggcaatgaaggttctccaaggataccgtatgccgttcagtccggagg
ttaacaaggagtttgcagaattcatcttgacaaaatgttggccggaaaagtatgaggatc
gtcttccaatgaaggacatttgcaagtggatgaagtcgtctgtcaaggctcaaggaggag
atactggtccaggcggaatgatgtcgaagtttggcaagaaaattaaacggtcaaactcgc
gtgagagcaagagcaaaagctcgacaatgacggctgcacatg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ACGAGTTGATCTACCAAGCTGCCAA 428 93 689 Antisense
GATGCATCGAGATGTGGCTGCTCGT 435 413 744 Antisense
CTCGTAACTGCCTTTATGGTGGTGG 443 231 764 Antisense
GGTGGTGGGCAGGTCAAAATCGCTG 153 499 781 Antisense
ATCGCTGATTTCGGATTGTCCCGTG 162 37 799 Antisense
CATTCGTTCGGGTCTTTATACTCCA 258 209 888 Antisense
TGACGTCTTCGCTTTTGGAGTGATG 171 571 918 Antisense
GGTTCTCCAAGGATACCGTATGCCG 449 507 1011 Antisense
CGTATGCCGTTCAGTCCGGAGGTTA 320 237 1027 Antisense
AAGTCGTCTGTCAAGGCTCAAGGAG 627 157 1141 Antisense
AGCTCGACAATGACGGCTGCACATG 159 81 1246 Antisense
Sequence Source Affymetrix Proprietary Database