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[172068_x_at]

Description g5031477 /REP_DB=GenBank Identifier /GB=AF154004.1 /PROTEIN_GB=AAD38186.1 /CHR=1 /FEA=Mapped Transcript /DEF=cyclin-dependent kinase 7 homolog
Cluster 6grp_highest_10_10 > 79      6grp_high1_10_10 > 97      4grp_highest_8_8 > 48      4grp_high_8_8 > 42      6grp_highest_nonorm > 84      6grp_total > 96      4grp_total > 45      6grp_highest_sub > In      6grp_cgc > 68      6grp_high1_sub > In      6grp_cgc_sub > In      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 271
1 2 3 4 range
A 576
(3)
P 		330.9
(-3)
P 		481
(0.7)
P 		521.4
(1.7)
P 		245
B 424.5
(-1.2)
P 		602.3
(3)
P 		350.1
(-3)
P 		353.6
(-2.9)
P 		252
C 586.8
(3)
P 		545.1
(1.6)
P 		531.4
(1.1)
P 		409
(-3)
P 		178
avr 529.1
(3) 		492.8
(0.8) 		454.2
(-1.4) 		428
(-3) 		101

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 756
1 2 3 4 5 6 range
A 369.1
(-3)
P 		551.2
(-0.4)
P 		543.1
(-0.5)
P 		789.8
(3)
P 		783.7
(2.9)
P 		765.1
(2.6)
P 		421
B 302
(-2.2)
P 		425.4
(-1.3)
P 		206.5
(-3)
P 		530.7
(-0.4)
P 		578.4
(-0)
P 		962.1
(3)
P 		756
C 691.3
(2.7)
P 		610.7
(-0.7)
P 		630.8
(0.1)
P 		555.2
(-3)
P 		655
(1.2)
P 		699.2
(3)
P 		144
avr 454.1
(-3) 		529.1
(-1.7) 		460.1
(-2.9) 		625.2
(-0.1) 		672.4
(0.7) 		808.8
(3) 		355
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 141
1 2 3 4 range
A 209.7
(3)
P 		71.8
(-3)
P 		125.7
(-0.7)
P 		76.3
(-2.8)
P 		138
B 135.4
(1.9)
P 		148.8
(3)
P 		81.1
(-2.5)
P 		75.4
(-3)
P 		73
C 194.3
(3)
P 		156.7
(1.2)
P 		185.2
(2.6)
P 		69
(-3)
P 		125
avr 179.8
(3) 		125.8
(-0.1) 		130.7
(0.2) 		73.6
(-3) 		106

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 309
1 2 3 4 5 6 range
A 68
(-3)
P 		196
(1.6)
P 		118.3
(-1.2)
P 		200.3
(1.7)
P 		236.5
(3)
P 		186.3
(1.2)
P 		169
B 105.1
(-1.9)
P 		141.6
(-1.2)
P 		50.2
(-3)
P 		140.6
(-1.2)
P 		235
(0.6)
P 		358.8
(3)
P 		309
C 256.2
(3)
P 		186.3
(0.1)
P 		160.6
(-1)
P 		111.7
(-3)
P 		212
(1.2)
P 		234.1
(2.1)
P 		145
avr 143.1
(-1.7) 		174.6
(-0.4) 		109.7
(-3) 		150.9
(-1.4) 		227.8
(1.7) 		259.7
(3) 		150
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 172068_x_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.19634
Sequence Type Exemplar sequence
Representative Public ID 5031477 NCBI
Target Description g5031477 /REP_DB=GenBank Identifier /GB=AF154004.1 /PROTEIN_GB=AAD38186.1 /CHR=1 /FEA=Mapped Transcript /DEF=cyclin-dependent kinase 7 homolog
Cluster Evidence This cluster is supported by a Mapped Transcript.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_058551(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_058551 NCBI Caenorhabditis elegans Cyclin-Dependent Kinase family member (cdk-7) (cdk-7) mRNA, complete cds. 11/11 A 
Y39G10AL.3.2 ENSEMBL cdna:known chromosome:CEL140:I:2281538:2291184:-1 gene:Y39G10AL.3 11/11 A 
Y39G10AL.3.1 ENSEMBL cdna:known chromosome:CEL140:I:2281544:2291092:-1 gene:Y39G10AL.3 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000028488 5/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:2281537-2291184(-) 99.67 99.67
Public Domain and Genome References
Gene Title
Gene Symbol cdk-7
Ensembl Y39G10AL.3
Entrez Gene 171784 Entrez gene
SwissProt Q9Y0G1 EMBL-EBI
WormBase CE30320 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:255909_AT cell division protein kinase, putative at
CANINE_2:CFAAFFX.12456.1.S1_S_AT similar to Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) cfa
DROSOPHILA_2:1630144_AT Cyclin-dependent kinase 7 dm
DROSGENOME1:143832_AT Cyclin-dependent kinase 7 dm
HG-U133_PLUS_2:211297_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HG-U133A:211297_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HG-FOCUS:211297_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HG-U133A_2:211297_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HG-U95AV2:1969_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HC-G110:1969_S_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HG-U95AV2:33317_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
HUGENEFL:L20320_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
U133_X3P:G348242_3P_A_AT cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) hs
MOE430A:1451741_A_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MOUSE430A_2:1451741_A_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MOUSE430_2:1451741_A_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MU11KSUBA:U11822_S_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MG-U74AV2:160658_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MOE430A:1424257_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MOUSE430A_2:1424257_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MOUSE430_2:1424257_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) mm
MU19KSUBA:TC19803_AT Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase), mRNA (cDNA clone MGC:6069 IMAGE:3585145) mm
MU19KSUBB:TC32409_S_AT Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase), mRNA (cDNA clone MGC:6069 IMAGE:3585145) mm
RAT230_2:1388171_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RAE230A:1388171_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RT-U34:X83579_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RG-U34A:X83579_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RG-U34C:RC_AI175830_AT cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RAE230B:1397324_AT Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
RAT230_2:1397324_AT Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) rn
YEAST_2:1769904_AT Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
6468 protein amino acid phosphorylation inferred from sequence similarity QuickGO AmiGO
9299 mRNA transcription inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
4693 cyclin-dependent protein kinase activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK68887 Cyclin-dependent kinase family protein 7 [Caenorhabditis elegans] ref|NP_490952.2| Cyclin-Dependent Kinase family member (cdk-7) [Caenorhabditis elegans] gb|AAD38186.1| cyclin-dependent kinase 7 homolog [Caenorhabditis elegans] 0.0
blast CAE60292 Hypothetical protein CBG03876 [Caenorhabditis briggsae] 1.0E-167
blast NP_001790 cyclin-dependent kinase 7 [Homo sapiens] gb|AAH00834.1| Cyclin-dependent kinase 7 [Homo sapiens] gb|AAM77799.1| cyclin-dependent kinase 7 [Homo sapiens] sp|P50613|CDK7_HUMAN Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) emb|CAA55785.1| MO15/CDK-activating kinase (CAK) [Homo sapiens] emb|CAA54793.1| CDK activating kinase [Homo sapiens] emb|CAA54508.1| Cdk-activating kinase [Homo sapiens] gb|AAA36657.1| protein serine/threonine kinase 1.0E-104
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-77
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 4.0E-80
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 9.8E-94
Sequence
Target Sequence 
>C. ELEGANS:172068_X_AT
ctcgattcttcggatctccaaacagaaattacactcatcaggttgtgacaagatggtatc
gagcccctgagttgctctttggagcacgttcctatggagttggaattgatatttggtcgg
ttggatgtatcattgccgaattgttgttgagaaatccaatattccctggtgaaagtgaca
ttgatcaactcgtgaaaatcttcaatattctcggatgtccaacaccagaaacatggccaa
atatgactgaaatgaacagttatgtcattattaaaccacagacggagtatatggctctaa
attactatttctcggctgctccgcaagatttgctcgatttgatggcgggaatgtggacat
ttgacccaataaaacgtctgacttgtactcaatctcttcaaatggaatatttccgaactc
aaccattctgctgccttgacgaagagcttccacttccgaaaaaacaacagccacagaaga
gatctcgacggcttgacgacgatggaactcgccccgttcgacgattgaattttgattaac
aaaattccatattttaccctctattttatcgatt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CTCGATTCTTCGGATCTCCAAACAG 141 233 613 Antisense
TGACAAGATGGTATCGAGCCCCTGA 410 571 658 Antisense
GCTCTTTGGAGCACGTTCCTATGGA 120 299 686 Antisense
ATATTCTCGGATGTCCAACACCAGA 192 19 817 Antisense
CTAAATTACTATTTCTCGGCTGCTC 685 225 909 Antisense
GTCTGACTTGTACTCAATCTCTTCA 532 471 988 Antisense
TATTTCCGAACTCAACCATTCTGCT 136 661 1020 Antisense
TGCTGCCTTGACGAAGAGCTTCCAC 616 581 1041 Antisense
GATCTCGACGGCTTGACGACGATGG 91 417 1093 Antisense
TCGCCCCGTTCGACGATTGAATTTT 337 597 1121 Antisense
TATTTTACCCTCTATTTTATCGATT 189 663 1162 Antisense
Sequence Source GenBank