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[172033_x_at]

Description g2338417 /REP_DB=GenBank Identifier /GB=AF012437.1 /PROTEIN_GB=AAC47715.1 /CHR=3 /FEA=Mapped Transcript /DEF=insulin receptor homolog
Cluster 6grp_total > 67      4grp_total > 45      6grp_cgc > 38      6grp_cgc_sub > Da      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 73
1 2 3 4 range
A 64
(3)
A 		10.5
(-3)
A 		24.3
(-1.5)
A 		22.2
(-1.7)
A 		54
B 25.7
(-3)
A 		42.7
(-0.3)
A 		63
(3)
A 		50
(0.9)
A 		37
C 52.9
(-0.4)
A 		83.3
(3)
A 		29
(-3)
A 		49.3
(-0.8)
A 		54
avr 47.5
(3) 		45.5
(1.6) 		38.8
(-3) 		40.5
(-1.8) 		9

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 67
1 2 3 4 5 6 range
A 8
(-3)
A 		31.8
(-0.7)
A 		42.9
(0.4)
A 		58.4
(1.9)
A 		34.2
(-0.4)
A 		69.2
(3)
A 		61
B 37.9
(2.1)
A 		5.8
(-2.5)
A 		33.5
(1.4)
A 		4.7
(-2.7)
A 		2.5
(-3)
A 		44.5
(3)
A 		42
C 44.8
(2.4)
A 		48.6
(3)
A 		8.5
(-3)
A 		9.1
(-2.9)
A 		38.4
(1.5)
A 		44.7
(2.4)
A 		40
avr 30.2
(-1.7) 		28.7
(-2) 		28.3
(-2.1) 		24.1
(-3) 		25
(-2.8) 		52.8
(3) 		29
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 22
1 2 3 4 range
A 23.3
(3)
A 		2.3
(-3)
A 		6.4
(-1.8)
A 		3.3
(-2.7)
A 		21
B 8.2
(-3)
A 		10.6
(-0.8)
A 		14.6
(3)
A 		10.7
(-0.7)
A 		6
C 17.5
(0.5)
A 		24
(3)
A 		10.1
(-2.3)
A 		8.3
(-3)
A 		16
avr 16.3
(3) 		12.3
(0.3) 		10.4
(-1) 		7.4
(-3) 		9

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 16
1 2 3 4 5 6 range
A 1.5
(-3)
A 		11.3
(0.8)
A 		9.3
(0.1)
A 		14.8
(2.2)
A 		10.3
(0.5)
A 		16.8
(3)
A 		15
B 13.2
(1.7)
A 		1.9
(-2.7)
A 		8.1
(-0.3)
A 		1.2
(-2.9)
A 		1
(-3)
A 		16.6
(3)
A 		16
C 16.6
(3)
A 		14.8
(2.3)
A 		2.2
(-2.8)
A 		1.8
(-3)
A 		12.4
(1.3)
A 		14.9
(2.3)
A 		15
avr 10.4
(-0.4) 		9.3
(-1) 		6.5
(-2.6) 		5.9
(-3) 		7.9
(-1.8) 		16.1
(3) 		10
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 172033_x_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.19796
Sequence Type Exemplar sequence
Representative Public ID 2338417 NCBI
Target Description g2338417 /REP_DB=GenBank Identifier /GB=AF012437.1 /PROTEIN_GB=AAC47715.1 /CHR=3 /FEA=Mapped Transcript /DEF=insulin receptor homolog
Cluster Evidence This cluster is supported by a Mapped Transcript.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_065249(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_065249 NCBI Caenorhabditis elegans abnormal DAuer Formation family member (daf-2) (daf-2) mRNA, complete cds. 11/11 A 
SNAP00000010554 ENSEMBL cdna:SNAP chromosome:CEL140:III:2993926:3052047:-1 9/11 None
GENEFINDER00000010558 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:2995909:3023699:-1 9/11 None
Y55D5A.5 ENSEMBL cdna:known chromosome:CEL140:III:2995753:3028790:-1 gene:Y55D5A.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:2995752-3028797(-) 99.45 100.0
Public Domain and Genome References
Gene Title
Gene Symbol daf-2
Ensembl Y55D5A.5
Entrez Gene 175410 Entrez gene
SwissProt Q968Y9 EMBL-EBI
WormBase CE27499 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.27874.1.S1_S_AT similar to Insulin receptor precursor (IR) (CD220 antigen) cfa
CANINE_2:CFAAFFX.27879.1.S1_S_AT similar to Insulin receptor precursor (IR) (CD220 antigen) cfa
DROSOPHILA_2:1629141_AT Insulin-like receptor dm
DROSGENOME1:143734_AT Insulin-like receptor dm
CHICKEN:GGA.3580.1.S1_AT insulin receptor gga
CHICKEN:GGA.3580.2.S1_A_AT insulin receptor gga
CHICKEN:GGAAFFX.2310.1.S1_AT insulin receptor gga
HG-U133_PLUS_2:207851_S_AT insulin receptor hs
HG-U133A:207851_S_AT insulin receptor hs
HG-U133A_2:207851_S_AT insulin receptor hs
HU35KSUBA:X02160_AT insulin receptor hs
HUGENEFL:X02160_AT insulin receptor hs
HG-U95AV2:1572_S_AT insulin receptor hs
HC-G110:1572_S_AT insulin receptor hs
HUGENEFL:M10051_S_AT insulin receptor hs
U133_X3P:G4557883_3P_A_AT insulin receptor hs
U133_X3P:HS.89695.2.A1_3P_AT insulin receptor hs
HG-U133A_2:213792_S_AT insulin receptor hs
HG-FOCUS:213792_S_AT insulin receptor hs
HG-U133_PLUS_2:213792_S_AT insulin receptor hs
HG-U133A:213792_S_AT insulin receptor hs
HG-U95AV2:33162_AT insulin receptor hs
HG-U133_PLUS_2:226212_S_AT Insulin receptor hs
HG-U133B:226212_S_AT Insulin receptor hs
HU35KSUBC:RC_T47312_AT Insulin receptor hs
HU35KSUBD:RC_T79740_AT Insulin receptor hs
HU35KSUBD:RC_AA437233_AT Insulin receptor hs
U133_X3P:HS.98401.0.S1_3P_AT Insulin receptor hs
U133_X3P:HS.208334.0.S2_3P_S_AT Insulin receptor hs
U133_X3P:HS.208334.0.S1_3P_AT Insulin receptor hs
HG-U133_PLUS_2:226216_AT Insulin receptor hs
HG-U133B:226216_AT Insulin receptor hs
HG-U133_PLUS_2:226450_AT Insulin receptor hs
HG-U133B:226450_AT Insulin receptor hs
HG-U95B:47628_AT Insulin receptor hs
HG-U95C:65110_AT Insulin receptor hs
HG-U133_PLUS_2:227432_S_AT Insulin receptor hs
HG-U133B:227432_S_AT Insulin receptor hs
HG-U133_PLUS_2:243002_AT Insulin receptor hs
HG-U133B:243002_AT Insulin receptor hs
HG-U95B:44163_AT Insulin receptor hs
HG-U95D:70578_AT Insulin receptor hs
HG-U95E:70604_AT Insulin receptor hs
HG-U95D:77743_AT Insulin receptor hs
HG-U95D:88319_AT Insulin receptor hs
HU35KSUBC:RC_AA342446_S_AT Insulin receptor hs
HU35KSUBB:RC_R05296_AT Insulin receptor hs
HU35KSUBB:RC_AA056206_AT Insulin receptor hs
U133_X3P:HS.270101.0.A1_3P_AT Insulin receptor hs
U133_X3P:HS.89695.1.A1_3P_AT Insulin receptor hs
RN-U34:M29014_AT insulin receptor rn
RG-U34A:M29014_AT insulin receptor rn
RAE230A:1369051_AT insulin receptor rn
RAT230_2:1369051_AT insulin receptor rn
RG-U34C:RC_AI070496_AT Insulin receptor rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
15986 ATP synthesis coupled proton transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16469 proton-transporting two-sector ATPase complex inferred from electronic annotation QuickGO AmiGO
5887 integral to plasma membrane inferred from sequence similarity QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
4714 transmembrane receptor protein tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5006 epidermal growth factor receptor activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
46933 hydrogen-transporting ATP synthase activity, rotational mechanism inferred from electronic annotation QuickGO AmiGO
46961 hydrogen-transporting ATPase activity, rotational mechanism inferred from electronic annotation QuickGO AmiGO
5009 insulin receptor activity inferred from sequence similarity QuickGO AmiGO
5524 ATP binding inferred from sequence similarity QuickGO AmiGO
17046 peptide hormone binding inferred from sequence similarity QuickGO AmiGO
42169 SH2 domain binding inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK29947 Abnormal dauer formation protein 2 [Caenorhabditis elegans] ref|NP_497650.3| abnormal DAuer Formation family member (daf-2) [Caenorhabditis elegans] 0.0
blast AAC47715 insulin receptor homolog [Caenorhabditis elegans] 0.0
blast CAE69523 Hypothetical protein CBG15732 [Caenorhabditis briggsae] 0.0
blast AAQ90014 dauer abnormal formation-2 precursor [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR003961 EMBL-EBI Fibronectin, type III 1.7E-5
Pfam IPR003961 EMBL-EBI Fibronectin, type III 1.1E-4
Pfam IPR000719 EMBL-EBI Protein kinase 4.3E-67
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 8.2E-36
Pfam IPR003961 EMBL-EBI Fibronectin, type III 1.7E-5
Pfam IPR003961 EMBL-EBI Fibronectin, type III 1.1E-4
Pfam IPR000719 EMBL-EBI Protein kinase 4.3E-67
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 3.2E-27
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 7.9E-12
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 8.2E-36
Pfam IPR003961 EMBL-EBI Fibronectin, type III 1.7E-5
Pfam IPR003961 EMBL-EBI Fibronectin, type III 1.1E-4
Pfam IPR000719 EMBL-EBI Protein kinase 4.3E-67
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 4.3E-44
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 8.2E-36
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_497650.3 2 1182-1204,1307-1324
Y55D5A.5 2 1182-1204,1307-1324
SNAP00000010554 2 954-976,1079-1096
GENEFINDER00000010558 2 1296-1318,1421-1438
Sequence
Target Sequence 
>C. ELEGANS:172033_X_AT
ggagccggtttcggtgaagcagtacgattaactgatggtgttggaagtggacatttaaat
gatgatgattatgttgaaaaagagatatcatccatggatacgcgccggagcacgggcgcc
tcgagctcttcctacggtgttccacagacgaattggagtggaaatcgtggtgccacgtat
tatacgagtaaagctcaacaggcagcaactgcagcagcagcagcagcagcagctctccaa
cagcaacaaaatggtggtcgaggcgatcgattaactcaactacccggaactggacattta
caatcgacacgtggtggacaagatggagattatattgaaactgaaccgaaaaattataga
aataatggatctccatcgcgaaacggcaacagccgtgacattttcaacggacgttcggct
ttcggtgaaaatgagcatctaatcgaggataatgagcatcatccacttgtctgaaacccc
caaaaaatcccgcctcttaaattataaattatctcccacattatcatatctctac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGAGCCGGTTTCGGTGAAGCAGTAC 137 521 5185 Antisense
TGGATACGCGCCGGAGCACGGGCGC 459 549 5279 Antisense
TCTTCCTACGGTGTTCCACAGACGA 440 613 5311 Antisense
GGCAGCAACTGCAGCAGCAGCAGCA 55 537 5385 Antisense
GGCGATCGATTAACTCAACTACCCG 344 539 5446 Antisense
TCAACTACCCGGAACTGGACATTTA 332 631 5460 Antisense
GGACATTTACAATCGACACGTGGTG 601 525 5476 Antisense
TAATGGATCTCCATCGCGAAACGGC 157 633 5547 Antisense
CGGCAACAGCCGTGACATTTTCAAC 459 241 5568 Antisense
AATGAGCATCATCCACTTGTCTGAA 442 165 5635 Antisense
ATCTCCCACATTATCATATCTCTAC 546 33 5695 Antisense
Sequence Source GenBank