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[172016_x_at] Zinc-binding metalloprotease domain

Description g2739036 /REP_DB=GenBank Identifier /GB=AF024614.1 /PROTEIN_GB=AAB97161.1 /CHR=1 /FEA=Mapped Transcript /DEF=ADAM 10
Cluster 6grp_highest_10_10 > 93      6grp_high1_10_10 > 49      4grp_highest_8_8 > 56      4grp_high_8_8 > 35      6grp_highest_nonorm > 75      6grp_total > 48      4grp_total > 44      6grp_highest_sub > Cu      6grp_cgc > 08      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 317
1 2 3 4 range
A 811.8
(0.2)
P 		909.3
(3)
P 		738.9
(-1.9)
P 		701.2
(-3)
P 		208
B 914
(3)
P 		908.7
(2.8)
P 		705.6
(-3)
P 		726.8
(-2.4)
P 		208
C 1017.9
(3)
P 		907.6
(0.1)
P 		793.2
(-2.8)
P 		787.1
(-3)
P 		231
avr 914.6
(3) 		908.5
(2.8) 		745.9
(-2.7) 		738.4
(-3) 		176

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 617
1 2 3 4 5 6 range
A 1208.2
(3)
P 		803.7
(-0.9)
P 		591
(-3)
P 		735.4
(-1.6)
P 		932.3
(0.3)
P 		1082.4
(1.8)
P 		617
B 1038.5
(2.7)
P 		790.9
(-0.8)
P 		641.3
(-3)
P 		1056.7
(3)
P 		733.4
(-1.7)
P 		1042.4
(2.8)
P 		415
C 884.6
(3)
P 		669.9
(-3)
P 		771.8
(-0.2)
P 		804.5
(0.8)
P 		783.9
(0.2)
P 		818.8
(1.2)
P 		215
avr 1043.8
(3) 		754.8
(-1.6) 		668
(-3) 		865.5
(0.2) 		816.5
(-0.6) 		981.2
(2) 		376
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 234
1 2 3 4 range
A 295.6
(3)
P 		197.4
(-0.1)
P 		193.2
(-0.2)
P 		102.6
(-3)
P 		193
B 291.5
(3)
P 		224.4
(0.1)
P 		163.5
(-2.6)
P 		154.9
(-3)
P 		137
C 336.9
(3)
P 		260.9
(0.8)
P 		276.4
(1.2)
P 		132.7
(-3)
P 		204
avr 308
(3) 		227.6
(0.3) 		211
(-0.3) 		130.1
(-3) 		178

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 260
1 2 3 4 5 6 range
A 222.7
(0.6)
P 		285.8
(3)
P 		128.7
(-3)
P 		186.5
(-0.8)
P 		281.3
(2.8)
P 		263.5
(2.1)
P 		157
B 361.4
(2.3)
P 		263.3
(-0.2)
P 		155.7
(-3)
P 		279.9
(0.2)
P 		298
(0.7)
P 		388.7
(3)
P 		233
C 327.9
(3)
P 		204.4
(-1.5)
P 		196.4
(-1.8)
P 		161.8
(-3)
P 		253.7
(0.3)
P 		274.1
(1.1)
P 		166
avr 304
(2.8) 		251.2
(0.7) 		160.3
(-3) 		209.4
(-1) 		277.7
(1.7) 		308.8
(3) 		149
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 172016_x_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.19678
Sequence Type Exemplar sequence
Representative Public ID 2739036 NCBI
Target Description g2739036 /REP_DB=GenBank Identifier /GB=AF024614.1 /PROTEIN_GB=AAB97161.1 /CHR=1 /FEA=Mapped Transcript /DEF=ADAM 10
Cluster Evidence This cluster is supported by a Mapped Transcript.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059976(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059976 NCBI Caenorhabditis elegans SUPpressor family member (sup-17) (sup-17) mRNA, complete cds. 11/11 A 
DY3.7 ENSEMBL cdna:known chromosome:CEL140:I:8801089:8805409:1 gene:DY3.7 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000022851 3/11 Cross Hyb Matching Probes None
SNAP00000022841 3/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:8801021-8805328(+) 99.88 99.88
Public Domain and Genome References
Gene Title Zinc-binding metalloprotease domain
Gene Symbol sup-17
Ensembl DY3.7
Entrez Gene 172689 Entrez gene
SwissProt O46354 EMBL-EBI
WormBase CE15751 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1605073_AT ADAM metallopeptidase domain 10 cfa
CANINE:1590101_AT ADAM metallopeptidase domain 10 cfa
CANINE_2:CFA.9442.1.A1_AT ADAM metallopeptidase domain 10 cfa
CANINE_2:CFAAFFX.25351.1.S1_AT ADAM metallopeptidase domain 10 cfa
DROSOPHILA_2:1628215_S_AT kuzbanian dm
DROSGENOME1:141542_AT kuzbanian dm
CHICKEN:GGA.1343.1.S1_AT ADAM metallopeptidase domain 10 gga
CHICKEN:GGA.1343.1.S2_AT ADAM metallopeptidase domain 10 gga
HG-U95AV2:31934_AT ADAM metallopeptidase domain 10 hs
HG-U133_PLUS_2:202604_X_AT ADAM metallopeptidase domain 10 hs
HG-U133A:202604_X_AT ADAM metallopeptidase domain 10 hs
HG-U133A_2:202604_X_AT ADAM metallopeptidase domain 10 hs
HG-U95AV2:40798_S_AT ADAM metallopeptidase domain 10 hs
HU35KSUBA:AA356049_AT ADAM metallopeptidase domain 10 hs
HUGENEFL:Z48579_AT ADAM metallopeptidase domain 10 hs
U133_X3P:G4557250_3P_A_AT ADAM metallopeptidase domain 10 hs
HG-U133A_2:214895_S_AT ADAM metallopeptidase domain 10 hs
HG-U133_PLUS_2:214895_S_AT ADAM metallopeptidase domain 10 hs
HG-U133A:214895_S_AT ADAM metallopeptidase domain 10 hs
HG-U95AV2:40797_AT ADAM metallopeptidase domain 10 hs
HG-U95D:71826_AT ADAM metallopeptidase domain 10 hs
HG-U133_PLUS_2:234131_AT ADAM metallopeptidase domain 10 hs
HG-U133B:234131_AT ADAM metallopeptidase domain 10 hs
U133_X3P:HS2.384153.1.S1_3P_AT ADAM metallopeptidase domain 10 hs
U133_X3P:HS.306566.0.S1_3P_AT ADAM metallopeptidase domain 10 hs
U133_X3P:HS.172028.0.A2_3P_AT ADAM metallopeptidase domain 10 hs
HG-U133_PLUS_2:1562137_AT ADAM metallopeptidase domain 10 hs
HG-U133A_2:202603_AT ADAM metallopeptidase domain 10 hs
HG-FOCUS:202603_AT ADAM metallopeptidase domain 10 hs
HG-U133_PLUS_2:202603_AT ADAM metallopeptidase domain 10 hs
HG-U133A:202603_AT ADAM metallopeptidase domain 10 hs
HG-U95D:68865_R_AT ADAM metallopeptidase domain 10 hs
HU35KSUBD:RC_AA243020_AT ADAM metallopeptidase domain 10 hs
MU11KSUBA:AF011379_AT a disintegrin and metallopeptidase domain 10 mm
MG-U74AV2:100751_AT a disintegrin and metallopeptidase domain 10 mm
MOE430A:1450104_AT a disintegrin and metallopeptidase domain 10 mm
MOUSE430A_2:1450104_AT a disintegrin and metallopeptidase domain 10 mm
MOUSE430_2:1450104_AT a disintegrin and metallopeptidase domain 10 mm
MOE430A:1450105_AT a disintegrin and metallopeptidase domain 10 mm
MOUSE430A_2:1450105_AT a disintegrin and metallopeptidase domain 10 mm
MOUSE430_2:1450105_AT a disintegrin and metallopeptidase domain 10 mm
MG-U74CV2:140826_AT A disintegrin and metallopeptidase domain 10 (Adam10), mRNA mm
MOUSE430_2:1460083_AT A disintegrin and metallopeptidase domain 10 (Adam10), mRNA mm
MOE430B:1460083_AT A disintegrin and metallopeptidase domain 10 (Adam10), mRNA mm
MU19KSUBB:TC28026_AT A disintegrin and metallopeptidase domain 10 (Adam10), mRNA mm
RG-U34A:Z48444CDS_AT a disintegrin and metalloprotease domain 10 rn
RAE230A:1388161_AT a disintegrin and metalloprotease domain 10 rn
RAT230_2:1388161_AT a disintegrin and metalloprotease domain 10 rn
RAE230A:1370955_AT a disintegrin and metalloprotease domain 10 rn
RAT230_2:1370955_AT a disintegrin and metalloprotease domain 10 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8237 metallopeptidase activity inferred from sequence similarity QuickGO AmiGO
8270 zinc ion binding inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB09416 Hypothetical protein DY3.7 [Caenorhabditis elegans] ref|NP_492377.1| SUPpressor family member (sup-17) [Caenorhabditis elegans] gb|AAB97161.1| ADAM 10 [Caenorhabditis elegans] 0.0
blast CAE66973 Hypothetical protein CBG12369 [Caenorhabditis briggsae] 0.0
blast XP_393114 PREDICTED: similar to ENSANGP00000012370 [Apis mellifera] 1.0E-166
Protein Domains
Database ID Description E-Value
Pfam IPR001762 EMBL-EBI Disintegrin 1.2E-29
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_492377.1 1 746-768
DY3.7 1 746-768
Sequence
Target Sequence 
>C. ELEGANS:172016_X_AT
caccaccgtatacagctgctgatcctggatcagcgatgggcggaccacgaagaggtcaca
ggaagaataagagacaaacttcttcagatgctgctggttcttcagggaatggtggcaaaa
agaagggaaagtaaacaaaaaatgttttacttccaaatcatctcacttgatatgtgctca
ttttacggttttctcccgggctttagttttaattgtcaatttttcccgtttgactattaa
attcatatatcttttcctaattgtttttttacaatgttgttccatcttgccttttccact
cctacttctttcatttccctctgacccaacacttcccttaatttgtattattcattatct
cccattccccccaagacggtgcttcagtttttccatgtactatacctaacttattggtca
agtttttcgactttatactacaggttccaatttttgtgcattcttcttttacccactttt
ttgtaattctcacatccaaattcgaggttttcaccgccgctttcaactcattttcagcct
ttgttttgttcaatc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CACCACCGTATACAGCTGCTGATCC 174 203 2732 Antisense
GATCCTGGATCAGCGATGGGCGGAC 665 415 2752 Antisense
TTCTTCAGATGCTGCTGGTTCTTCA 212 691 2811 Antisense
GTTTTACTTCCAAATCATCTCACTT 187 449 2875 Antisense
ATATGTGCTCATTTTACGGTTTTCT 580 21 2901 Antisense
TACAATGTTGTTCCATCTTGCCTTT 71 643 3001 Antisense
TGTATTATTCATTATCTCCCATTCC 172 561 3075 Antisense
GGTGCTTCAGTTTTTCCATGTACTA 147 501 3109 Antisense
TTTTTGTGCATTCTTCTTTTACCCA 347 675 3182 Antisense
CCGCTTTCAACTCATTTTCAGCCTT 490 263 3248 Antisense
TTTTCAGCCTTTGTTTTGTTCAATC 71 677 3262 Antisense
Sequence Source GenBank