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[171953_x_at] GTP-binding protein

Description AV177632_rc /REP_DB=TREMBL Accession /GB=AV177632 /FEA=Transcript Cluster /DEF=Caenorhabditis elegans cDNA clone:yk531d1 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 96      6grp_high1_10_10 > 68      4grp_highest_8_8 > 09      4grp_high_8_8 > 53      6grp_highest_nonorm > 38      6grp_total > 69      4grp_total > 58      6grp_highest_sub > Cu      6grp_cgc > 29      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 6183
1 2 3 4 range
A 6593.3
(-1.1)
P 		10805.3
(3)
P 		10054.1
(2.3)
P 		4660.6
(-3)
P 		6145
B 7333.7
(0.5)
P 		8626.6
(2.2)
P 		9228.7
(3)
P 		4709.7
(-3)
P 		4519
C 6397
(-0.3)
P 		7854.6
(2)
P 		8531.2
(3)
P 		4622.3
(-3)
P 		3909
avr 6774.7
(-0.3) 		9095.5
(2.8) 		9271.3
(3) 		4664.2
(-3) 		4607

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2773
1 2 3 4 5 6 range
A 7006.6
(1.2)
P 		6467.1
(0)
P 		5100
(-3)
P 		5845.3
(-1.4)
P 		5666.2
(-1.7)
P 		7814.4
(3)
P 		2714
B 5113.2
(-2.7)
P 		5967.8
(1.3)
P 		5041.5
(-3)
P 		5254.4
(-2)
P 		6195
(2.4)
P 		6334.6
(3)
P 		1293
C 6216
(-1.9)
P 		5984.6
(-3)
P 		6385
(-1.1)
P 		5985.3
(-3)
P 		6394.2
(-1.1)
P 		7269.6
(3)
P 		1285
avr 6111.9
(-0.8) 		6139.8
(-0.7) 		5508.8
(-3) 		5695
(-2.3) 		6085.1
(-0.9) 		7139.5
(3) 		1631
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2291
1 2 3 4 range
A 2400.6
(2.3)
P 		2345.5
(2.1)
P 		2628.3
(3)
P 		682.2
(-3)
P 		1946
B 2338.7
(3)
P 		2130.6
(2.1)
P 		2138.5
(2.1)
P 		1003.6
(-3)
P 		1335
C 2117.6
(0.7)
P 		2258.2
(1)
P 		2973.4
(3)
P 		779.4
(-3)
P 		2194
avr 2285.6
(2) 		2244.8
(1.9) 		2580.1
(3) 		821.7
(-3) 		1758

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1406
1 2 3 4 5 6 range
A 1291.6
(-2.1)
P 		2300
(3)
P 		1110.7
(-3)
P 		1482.5
(-1.1)
P 		1709.8
(0)
P 		1902.6
(1)
P 		1189
B 1779.2
(-0.4)
P 		1986.4
(0.5)
P 		1224.2
(-3)
P 		1391.7
(-2.2)
P 		2517
(3)
P 		2362.1
(2.3)
P 		1293
C 2304
(2.4)
P 		1826.1
(0)
P 		1625.1
(-0.9)
P 		1203.7
(-3)
P 		2069.1
(1.2)
P 		2433.6
(3)
P 		1230
avr 1791.6
(0.1) 		2037.5
(1.7) 		1320
(-3) 		1359.3
(-2.7) 		2098.6
(2.1) 		2232.8
(3) 		913
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 171953_x_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.27771
Sequence Type Exemplar sequence
Representative Public ID AV177632 NCBI
Target Description AV177632_rc /REP_DB=TREMBL Accession /GB=AV177632 /FEA=Transcript Cluster /DEF=Caenorhabditis elegans cDNA clone:yk531d1 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Transcript Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066968(9)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066968 NCBI Caenorhabditis elegans associated with RAN (nuclear import/export) function family member (ran-1) (ran-1) mRNA, complete cds. 9/11 A 
SNAP00000033488 ENSEMBL cdna:SNAP chromosome:CEL140:III:10746767:10747603:-1 9/11 None
GENEFINDER00000033498 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:10746767:10747603:-1 9/11 None
K01G5.4.1 ENSEMBL cdna:known chromosome:CEL140:III:10746460:10747607:-1 gene:K01G5.4 9/11 A 
K01G5.4.3 ENSEMBL cdna:known chromosome:CEL140:III:10746462:10747761:-1 gene:K01G5.4 9/11 None
K01G5.4.2 ENSEMBL cdna:known chromosome:CEL140:III:10746462:10747607:-1 gene:K01G5.4 9/11 A 
K01G5.4.4 ENSEMBL cdna:known chromosome:CEL140:III:10746472:10747610:-1 gene:K01G5.4 9/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:10746659-10747076(-) 99.19 99.19
Public Domain and Genome References
Gene Title GTP-binding protein
Gene Symbol ran-1
Ensembl K01G5.4
Entrez Gene 176503 Entrez gene
SwissProt O17915 EMBL-EBI
WormBase CE16194 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:15150_S_AT Ras-related GTP-binding protein (RAN3) at
ATH1-121501:248107_AT Ras-related GTP-binding protein (RAN3) at
CANINE:1591381_S_AT RAN, member RAS oncogene family cfa
CANINE_2:CFA.50.1.S1_S_AT RAN, member RAS oncogene family cfa
DROSOPHILA_2:1637149_S_AT Tubulin at 85D promoter construct of Kusano dm
DROSOPHILA_2:1637015_S_AT Tubulin at 85D promoter construct of Kusano dm
DROSGENOME1:153340_AT Tubulin at 85D promoter construct of Kusano dm
CHICKEN:GGA.4068.1.S1_AT RAN, member RAS oncogene family gga
CHICKEN:GGA.4068.1.S2_AT RAN, member RAS oncogene family gga
HG-U95AV2:38708_AT RAN, member RAS oncogene family hs
HG-U133_PLUS_2:200750_S_AT RAN, member RAS oncogene family hs
HG-U133A:200750_S_AT RAN, member RAS oncogene family hs
HG-FOCUS:200750_S_AT RAN, member RAS oncogene family hs
HG-U133A_2:200750_S_AT RAN, member RAS oncogene family hs
HG-U133_PLUS_2:200749_AT RAN, member RAS oncogene family hs
HG-U133A_2:200749_AT RAN, member RAS oncogene family hs
HG-U133A:200749_AT RAN, member RAS oncogene family hs
HU35KSUBA:AA436304_AT RAN, member RAS oncogene family hs
HU35KSUBB:RC_N21085_S_AT RAN, member RAS oncogene family hs
U133_X3P:G4092053_3P_X_AT RAN, member RAS oncogene family hs
U133_X3P:G4092053_3P_A_AT RAN, member RAS oncogene family hs
U133_X3P:HS.10842.0.A3_3P_AT RAN, member RAS oncogene family hs
HG-U95B:45716_AT RAN, member RAS oncogene family hs
HU35KSUBD:RC_D12123_AT RAN, member RAS oncogene family hs
HU35KSUBC:RC_AA406359_AT RAN, member RAS oncogene family hs
HU35KSUBC:RC_H23544_I_AT RAN, member RAS oncogene family hs
MOUSE430_2:1439270_X_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1439270_X_AT RAN, member RAS oncogene family mm
MOE430A:1439270_X_AT RAN, member RAS oncogene family mm
MOUSE430_2:1436490_X_AT RAN, member RAS oncogene family mm
MOE430A:1436490_X_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1436490_X_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1434578_X_AT RAN, member RAS oncogene family mm
MOE430A:1434578_X_AT RAN, member RAS oncogene family mm
MOUSE430_2:1434578_X_AT RAN, member RAS oncogene family mm
MU11KSUBA:L32751_F_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.13673.0_S_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.29092.0_F_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.27265.0_S_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.39417.0_F_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.41695.0_F_AT RAN, member RAS oncogene family mm
MU11KSUBB:MSA.12265.0_F_AT RAN, member RAS oncogene family mm
MG-U74AV2:101254_AT RAN, member RAS oncogene family mm
MG-U74AV2:102821_S_AT RAN, member RAS oncogene family mm
MOE430A:1438977_X_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1438977_X_AT RAN, member RAS oncogene family mm
MOUSE430_2:1438977_X_AT RAN, member RAS oncogene family mm
MOE430A:1433569_X_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1433569_X_AT RAN, member RAS oncogene family mm
MOUSE430_2:1433569_X_AT RAN, member RAS oncogene family mm
MOE430A:1460551_AT RAN, member RAS oncogene family mm
MOUSE430A_2:1460551_AT RAN, member RAS oncogene family mm
MOUSE430_2:1460551_AT RAN, member RAS oncogene family mm
MG-U74AV2:161839_F_AT RAN, member RAS oncogene family (Ran), mRNA mm
MU19KSUBC:TC37859_AT RAN, member RAS oncogene family (Ran), mRNA mm
MU19KSUBC:TC39303_F_AT RAN, member RAS oncogene family (Ran), mRNA mm
MU19KSUBC:TC39303_R_AT RAN, member RAS oncogene family (Ran), mRNA mm
MU19KSUBC:TC39304_AT RAN, member RAS oncogene family (Ran), mRNA mm
RG-U34C:RC_AI175528_AT RAN, member RAS oncogene family rn
RAE230A:1367590_AT RAN, member RAS oncogene family rn
RAT230_2:1367590_AT RAN, member RAS oncogene family rn
RAE230A:1389279_AT RAN, member RAS oncogene family rn
RAT230_2:1389279_AT RAN, member RAS oncogene family rn
RG-U34B:RC_AA957267_AT RAN, member RAS oncogene family rn
YEAST_2:1778781_AT GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6886 intracellular protein transport inferred from electronic annotation QuickGO AmiGO
7264 small GTPase mediated signal transduction inferred from electronic annotation QuickGO AmiGO
15031 protein transport inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5525 GTP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB07240 Hypothetical protein K01G5.4 [Caenorhabditis elegans] ref|NP_499369.1| associated with RAN (nuclear import/export) function family member (ran-1) [Caenorhabditis elegans] sp|O17915|RAN_CAEEL GTP-binding nuclear protein ran-1 emb|CAE71407.1| Hypothetical protein CBG18317 [Caenorhabditis briggsae] 1.0E-106
blast B48463 Ras-like GTP-binding protein - nematode (Onchocerca volvulus) 1.0E-100
blast P38544 GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) 1.0E-100
Protein Domains
Database ID Description E-Value
Pfam IPR001806 EMBL-EBI Ras GTPase superfamily 6.3E-69
Sequence
Target Sequence 
>C. ELEGANS:171953_X_AT
tccaccgaaagaagaacctccaatantangacatctccgcaaagtcgaactataacttcg
aaaagccattcttcgggttcgccagaaagctgctcggagatccaaacctcgagtttgtcg
caatgccagctttggctcctccagaggttcaaatggacccagccatgattgccgaatacg
aaaaggatntggacaacgccgccaaggctgatcttccagatga

BLASTn GenBank NR
Note: "n"'s represent regions that are not probed by the probe sequences.
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCCACCGAAAGAAGAACCTCCAATA 559 587 41 Antisense
GACATCTCCGCAAAGTCGAACTATA 499 369 70 Antisense
TCGAAAAGCCATTCTTCGGGTTCGC 449 599 98 Antisense
TTCTTCGGGTTCGCCAGAAAGCTGC 545 677 109 Antisense
AAAGCTGCTCGGAGATCCAAACCTC 98 125 126 Antisense
AAACCTCGAGTTTGTCGCAATGCCA 17 125 144 Antisense
TTGTCGCAATGCCAGCTTTGGCTCC 524 707 155 Antisense
GCTTTGGCTCCTCCAGAGGTTCAAA 635 303 169 Antisense
GAGGTTCAAATGGACCCAGCCATGA 294 403 184 Antisense
CCCAGCCATGATTGCCGAATACGAA 56 259 198 Antisense
CCGCCAAGGCTGATCTTCCAGATGA 138 263 239 Antisense
Sequence Source Affymetrix Proprietary Database