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[171838_x_at] phosphatidylinositol 3-kinase

Description CEC7293_rc /REP_DB=TREMBL Accession /GB=C10729 /FEA=Transcript Cluster /DEF=C.elegans cDNA clone yk152c9 : 3prime end, single read.
Cluster 6grp_total > 69      4grp_total > 37      6grp_cgc > 29      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 176
1 2 3 4 range
A 142.1
(3)
A 		92.1
(0.8)
A 		6
(-3)
A 		107
(1.5)
A 		136
B 114.6
(0.2)
P 		143.2
(3)
M 		81.2
(-3)
A 		114.5
(0.2)
P 		62
C 181.9
(3)
P 		151.9
(1)
A 		93.3
(-3)
A 		131.8
(-0.4)
P 		89
avr 146.2
(3) 		129.1
(1.8) 		60.2
(-3) 		117.8
(1) 		86

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 179
1 2 3 4 5 6 range
A 139.5
(1.7)
A 		88.3
(-0.4)
P 		81
(-0.7)
P 		22.6
(-3)
A 		165.2
(2.7)
A 		173.2
(3)
P 		151
B 156.6
(1.1)
P 		80.9
(-3)
P 		171.9
(1.9)
P 		96.6
(-2.2)
A 		90.2
(-2.5)
P 		191.9
(3)
P 		111
C 88.5
(-0.7)
P 		134.9
(0.9)
A 		131.7
(0.8)
M 		19.3
(-3)
A 		154.9
(1.6)
P 		198
(3)
P 		179
avr 128.2
(0.5) 		101.4
(-0.7) 		128.2
(0.5) 		46.2
(-3) 		136.8
(0.8) 		187.7
(3) 		142
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 59
1 2 3 4 range
A 51.7
(3)
A 		20
(-0.8)
A 		1.6
(-3)
A 		15.7
(-1.3)
A 		50
B 36.5
(3)
P 		35.4
(2.6)
M 		18.8
(-3)
A 		24.4
(-1.1)
P 		18
C 60.2
(3)
P 		43.7
(0.4)
A 		32.5
(-1.4)
A 		22.2
(-3)
P 		38
avr 49.5
(3) 		33
(-0.1) 		17.6
(-3) 		20.8
(-2.4) 		32

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 68
1 2 3 4 5 6 range
A 25.7
(-0.3)
A 		31.4
(0.5)
P 		17.6
(-1.4)
P 		5.7
(-3)
A 		49.9
(3)
A 		42.2
(2)
P 		44
B 54.5
(0.8)
P 		26.9
(-2.8)
P 		41.7
(-0.9)
P 		25.6
(-3)
A 		36.7
(-1.6)
P 		71.6
(3)
P 		46
C 32.8
(-0.2)
P 		41.1
(0.6)
A 		33.5
(-0.2)
M 		3.9
(-3)
A 		50.1
(1.4)
P 		66.3
(3)
P 		62
avr 37.7
(0.2) 		33.1
(-0.3) 		30.9
(-0.6) 		11.7
(-3) 		45.6
(1.2) 		60
(3) 		48
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 171838_x_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.27873
Sequence Type Exemplar sequence
Representative Public ID CEC7293 NCBI
Target Description CEC7293_rc /REP_DB=TREMBL Accession /GB=C10729 /FEA=Transcript Cluster /DEF=C.elegans cDNA clone yk152c9 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Transcript Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064061(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064061 NCBI Caenorhabditis elegans AGEing alteration family member (age-1) (age-1) mRNA, complete cds. 11/11 A 
B0334.8 ENSEMBL cdna:known chromosome:CEL140:II:11519404:11526967:-1 gene:B0334.8 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000019022 7/11 Cross Hyb Matching Probes None
GENEFINDER00000019030 7/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:11519521-11519743(-) 69.06 69.06
Public Domain and Genome References
Gene Title phosphatidylinositol 3-kinase
Gene Symbol age-1
Ensembl B0334.8
Entrez Gene 174762 Entrez gene
SwissProt Q94125 EMBL-EBI
WormBase CE23506 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.17516.1.S1_S_AT similar to phosphoinositide-3-kinase, catalytic, alpha polypeptide cfa
CHICKEN:GGAAFFX.5619.1.S1_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide gga
HG-U133A:204369_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133_PLUS_2:204369_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-FOCUS:204369_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133A_2:204369_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HUGENEFL:Z29090_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
U133_X3P:G5453891_3P_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U95AV2:40704_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HU35KSUBB:RC_AA088326_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
U133_X3P:HS.122419.0.S1_3P_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
U133_X3P:HS.120905.0.S1_3P_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133_PLUS_2:231854_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133B:231854_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133_PLUS_2:235980_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133B:235980_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U95B:41969_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U95E:81657_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U95E:83177_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U95E:90039_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
MG-U74BV2:105294_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MU11KSUBA:AA420333_RC_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MU11KSUBB:MSA.241.0_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MU11KSUBB:MSA.241.0_G_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MG-U74AV2:92452_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MG-U74AV2:104461_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MG-U74BV2:107411_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430A:1460326_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430A_2:1460326_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1460326_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430A:1423144_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430A_2:1423144_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1423144_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430B:1429435_X_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1429435_X_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430B:1429434_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1429434_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430B:1453134_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1453134_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430B:1440054_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1440054_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MU19KSUBA:TC21049_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca), mRNA mm
MU19KSUBC:TC41821_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca), mRNA mm
RG-U34B:RC_AI030797_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230A:1374232_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1374232_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230B:1396411_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1396411_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230B:1382366_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1382366_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230B:1379041_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1379041_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230A:1389143_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1389143_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230B:1393499_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1393499_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RG-U34B:RC_AA964375_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RG-U34B:RC_AA997895_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7165 signal transduction inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5942 phosphoinositide 3-kinase complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4428 inositol or phosphatidylinositol kinase activity inferred from electronic annotation QuickGO AmiGO
16303 phosphatidylinositol 3-kinase activity inferred from electronic annotation QuickGO AmiGO
16773 phosphotransferase activity, alcohol group as acceptor inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91377 Hypothetical protein B0334.8 [Caenorhabditis elegans] emb|CAB57914.1| Hypothetical protein B0334.8 [Caenorhabditis elegans] ref|NP_496462.1| AGEing alteration family member (age-1) [Caenorhabditis elegans] sp|Q94125|AGE1_CAEEL Phosphatidylinositol 3-kinase age-1 (PI3-kinase) (PtdIns-3-kinase) (PI3K) (Ageing alteration protein 1) 0.0
blast AAC47459 AGE-1 [Caenorhabditis elegans] 0.0
blast CAE59483 Hypothetical protein CBG02868 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR003113 EMBL-EBI Phosphatidylinositol 3-kinase, p85-binding 3.9E-48
Pfam IPR000403 EMBL-EBI Phosphatidylinositol 3- and 4-kinase 1.5E-19
Pfam IPR000403 EMBL-EBI Phosphatidylinositol 3- and 4-kinase 2.6E-32
Pfam IPR002420 EMBL-EBI Phosphoinositide 3-kinase, C2 domain 1.2E-36
Pfam IPR001263 EMBL-EBI Phosphoinositide 3-kinase accessory domain PIK 7.3E-19
Pfam IPR000341 EMBL-EBI Phosphoinositide 3-kinase, ras-binding domain 9.8E-41
Sequence
Target Sequence 
>C. ELEGANS:171838_X_AT
cctgagctgtcgacgaaagcggatttggatcatttgaagaaaaccctcttctgngannnn
nnnnnnnnnnnnnnnnnnnnnnnnnnnnncgctggaatctacgaagaagccttcaatgga
tcatggtctaccaaaacgaattggctcttccacgcagtcaaacactactgaaacctctgt
tatctaataatataacacattccgtgtacacaaatatt

BLASTn GenBank NR
Note: "n"'s represent regions that are not probed by the probe sequences.
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CCTGAGCTGTCGACGAAAGCGGATT 200 267 13 Antisense
GAAAGCGGATTTGGATCATTTGAAG 576 359 27 Antisense
GCTGGAATCTACGAAGAAGCCTTCA 660 293 103 Antisense
GAAGCCTTCAATGGATCATGGTCTA 154 345 118 Antisense
GGATCATGGTCTACCAAAACGAATT 627 511 130 Antisense
CAAAACGAATTGGCTCTTCCACGCA 243 191 144 Antisense
TCTTCCACGCAGTCAAACACTACTG 396 617 158 Antisense
ACACTACTGAAACCTCTGTTATCTA 239 111 174 Antisense
GAAACCTCTGTTATCTAATAATATA 62 359 182 Antisense
AATATAACACATTCCGTGTACACAA 644 173 201 Antisense
AACACATTCCGTGTACACAAATATT 689 133 206 Antisense
Sequence Source Affymetrix Proprietary Database