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   > (GO:0008150) biological_process [10287, 0][dist]
         > (GO:0008152) metabolic process [5617, 690 ][dist]
               > (GO:0043170) macromolecule metabolic process [3980, 0][dist]
                     -> (GO:0009057) macromolecule catabolic process [248, 0][dist]
                     -> (GO:0009059) macromolecule biosynthetic process [499, 2 ][dist]
                     -> (GO:0010467) gene expression [0,0]
                     -> (GO:0010604) positive regulation of macromolecule metabolic process [0,0]
                     -> (GO:0010605) negative regulation of macromolecule metabolic process [0,0]
                     -> (GO:0043112) receptor metabolic process [6, 0][dist]
                     -> (GO:0043283) biopolymer metabolic process [2693, 0][dist]
                     -> (GO:0044259) multicellular organismal macromolecule metabolic process [0,0]
                     -> (GO:0044260) cellular macromolecule metabolic process [2289, 0][dist]
                     -> (GO:0052229) metabolism of macromolecule in other organism during symbiotic interaction [0,0]
                     -> (GO:0060255) regulation of macromolecule metabolic process [0,0]