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   > (GO:0008150) biological_process [10287, 0][dist]
         > (GO:0009987) cellular process [6692, 0][dist]
               > (GO:0007154) cell communication [1545, 59 ][dist]
                     > (GO:0007165) signal transduction [1432, 444 ][dist]
                           > (GO:0007242) intracellular signaling cascade [580, 279 ][dist]
                                 > (GO:0007243) protein kinase cascade [18, 3 ][dist]
                                       > (GO:0007249) I-kappaB kinase/NF-kappaB cascade [0,0]
                                             -> (GO:0007250) activation of NF-kappaB-inducing kinase activity [0,0]
                                             -> (GO:0007252) I-kappaB phosphorylation [0,0]
                                             -> (GO:0007253) cytoplasmic sequestering of NF-kappaB [0,0]
                                             -> (GO:0008588) release of cytoplasmic sequestered NF-kappaB [0,0]
                                             -> (GO:0043122) regulation of I-kappaB kinase/NF-kappaB cascade [0,0]
                                             -> (GO:0043123) positive regulation of I-kappaB kinase/NF-kappaB cascade [0,0]
                                             -> (GO:0043124) negative regulation of I-kappaB kinase/NF-kappaB cascade [0,0]